RGD Reference Report - [Modulation of Jianjining Recipe on differential protein expression in rats with experimental autoimmune myasthenia gravis]. - Rat Genome Database

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[Modulation of Jianjining Recipe on differential protein expression in rats with experimental autoimmune myasthenia gravis].

Authors: Liu, P  Ding, XF  Zhang, YY  Qiao, J 
Citation: Liu P, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Nov;5(6):642-6.
RGD ID: 11049469
Pubmed: PMID:17997938   (View Abstract at PubMed)

OBJECTIVE: To study the modulation of Jianjining Recipe (JJNR), a traditional Chinese compound herbal medicine for invigorating spleen and kidney on differential protein expression in spleen of rats with experimental autoimmune myasthenia gravis (EAMG). METHODS: EAMG rats were randomly divided into four groups: untreated group, JJNR-treated group, Qiangji Jianli capsule (QJJLC, a traditional Chinese compound herbal medicine)-treated group and prednisolone acetate (PA)-treated group. After therapeutic intervention with the above drugs for four consecutive weeks, the level of differential protein expression was analyzed by two-dimensional electrophoresis and matrix assisted laser desorption/ionization time-of-flight mass spectrometry. RESULTS: Twelve differential proteins were identified by comparing EAMG rats and normal rats. The levels of allograft inflammatory factor-1, peroxiredoxin I and actin-related protein 2/3 complex subunit 5 were significantly regulated by JJNR (P<0.01). These proteins were closely associated with immune response and cell movement. CONCLUSION: The results suggest that there are differential protein expressions between EAMG rats and normal rats. Furthermore, as a Chinese medicine prescription with effect of invigorating spleen and kidney, JJNR can effectively regulate the levels of some EAMG-related protein expression.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ARPC5HumanExperimental Autoimmune Myasthenia Gravis treatmentISOArpc5 (Rattus norvegicus) RGD 
Arpc5RatExperimental Autoimmune Myasthenia Gravis treatmentIEP  RGD 
Arpc5MouseExperimental Autoimmune Myasthenia Gravis treatmentISOArpc5 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Arpc5  (actin related protein 2/3 complex, subunit 5)

Genes (Mus musculus)
Arpc5  (actin related protein 2/3 complex, subunit 5)

Genes (Homo sapiens)
ARPC5  (actin related protein 2/3 complex subunit 5)


Additional Information