RGD Reference Report - Pretranslational regulation of albumin synthesis in tumor-bearing mice. The role of anorexia and undernutrition. - Rat Genome Database

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Pretranslational regulation of albumin synthesis in tumor-bearing mice. The role of anorexia and undernutrition.

Authors: Andersson, CE  Lonnroth, IC  Gelin, LJ  Moldawer, LL  Lundholm, KG 
Citation: Andersson CE, etal., Gastroenterology. 1991 Apr;100(4):938-45.
RGD ID: 11035284
Pubmed: PMID:1900492   (View Abstract at PubMed)

Hepatic albumin synthesis, serum albumin turnover, and hepatic albumin messenger RNA (mRNA) content were evaluated in mice bearing a transplantable low differentiated tumor (MCG 101). Results obtained on tumor-bearing mice were compared with results obtained from non-tumor-bearing animals that were either freely fed, food restricted so that their body composition was similar to tumor-bearing animals (pair-weighed), fed a protein-free diet for 5 days, or fasted for 48 hours. Tumor-bearing animals became hypoalbuminemic (33 +/- 5 vs. 44 +/- 3 g/L in freely fed mice), which could be explained by both depressed albumin synthesis (1.95% +/- 0.20% vs. 2.67% +/- 0.27%/h in freely fed mice) and increased albumin degradation. Pair-weighed and protein-calorie malnourished controls had reductions in albumin synthesis (1.81% +/- 0.18% and 1.67% +/- 0.17%/h, respectively) similar to tumor-bearing animals, and the starved controls had the lowest synthetic rates (1.07% +/- 0.10%/h). Albumin degradation was increased only in tumor-bearing animals. Hepatic albumin mRNA in undernourished animals was less (tumor bearing, 32% +/- 5%; pair weighed, 47% +/- 4%; 48 hours fasted, 18% +/- 2%; and protein-calorie malnourished, 26% +/- 3%) than 50% of the mRNA content in the livers of freely fed control mice. Messenger RNA-directed synthesis of albumin in vitro was also depressed to a variable degree in tumor-bearing and malnourished non-tumor-bearing controls. The hypoalbuminemia in tumor-bearing animals could not be prevented by daily injections of a prostaglandin synthesis inhibitor (indomethacin, 1 microgram/g body wt), but the hepatic acute phase protein serum amyloid P decreased from 157 +/- 12 to 103 +/- 9 micrograms/mL in indomethacin-treated tumor-bearing mice (P less than 0.01). It is concluded that increased albumin degradation seen in tumor-bearing animals cannot be explained by associated malnutrition, whereas tumor-associated malnutrition can explain to a large extent the depressed albumin synthesis. Decreased albumin synthesis in tumor-bearing animals correlated in part with a decreased quantity of liver albumin mRNA. The results of the current study are consistent with either a reduced transcription of the albumin gene or a change in albumin mRNA processing and stability communicated by anorexia and malnutrition.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ALBHumanExperimental Sarcoma  ISOAlb (Mus musculus)mRNA more ...RGD 
AlbRatExperimental Sarcoma  ISOAlb (Mus musculus)mRNA more ...RGD 
AlbMouseExperimental Sarcoma  IEP mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Alb  (albumin)

Genes (Mus musculus)
Alb  (albumin)

Genes (Homo sapiens)
ALB  (albumin)


Additional Information