RGD Reference Report - Microarray analysis of thyroid stimulating hormone, insulin-like growth factor-1, and insulin-induced gene expression in FRTL-5 thyroid cells. - Rat Genome Database

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Microarray analysis of thyroid stimulating hormone, insulin-like growth factor-1, and insulin-induced gene expression in FRTL-5 thyroid cells.

Authors: Lee, YJ  Park do, J  Shin, CS  Park, KS  Kim, SY  Lee, HK  Park, YJ  Cho, BY 
Citation: Lee YJ, etal., J Korean Med Sci. 2007 Oct;22(5):883-90.
RGD ID: 10402110
Pubmed: PMID:17982240   (View Abstract at PubMed)
PMCID: PMC2693858   (View Article at PubMed Central)
DOI: DOI:10.3346/jkms.2007.22.5.883   (Journal Full-text)

To determine which genes are regulated by thyroid stimulating hormone (thyrotropin, TSH), insulin and insulin-like growth factor-1 (IGF-1) in the rat thyroid, we used the microarray technology and observed the changes in gene expression. The expressions of genes for bone morphogenetic protein 6, the glucagon receptor, and cyclin D1 were increased by both TSH and IGF-1; for cytochrome P450, 2c37, the expression was decreased by both. Genes for cholecystokinin, glucuronidase, beta, demethyl-Q 7, and cytochrome c oxidase, subunit VIIIa, were up-regulated; the genes for ribosomal protein L37 and ribosomal protein L4 were down-regulated by TSH and insulin. However, there was no gene observed to be regulated by all three: TSH, IGF-1, and insulin molecules studied. These findings suggest that TSH, IGF-1, and insulin stimulate different signal pathways, which can interact with one another to regulate the proliferation of thyrocytes, and thereby provide additional influence on the process of cellular proliferation.



Objects referenced in this article
Gene Coq7 coenzyme Q7, hydroxylase Rattus norvegicus

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