PRSTS213_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: PRSTS213_H (Prostate tumor susceptibility QTL 213 (human)) Homo sapiens

Symbol: PRSTS213_H
Name: Prostate tumor susceptibility QTL 213 (human)
RGD ID: 2293396
Trait: Prostate tumor susceptibility
LOD Score: Not Available
P Value: 4.0E-4
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371917,417,129 - 43,417,129RGDGRCh37
Build 361922,108,969 - 48,108,969RGDNCBI36
Cross Type: Not Available
Population Stats: Subjects recruited from urology practices in St. Louis, MO and Cleveland, OH



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Genomewide scan for prostate cancer-aggressiveness loci. Witte JS, etal., Am J Hum Genet. 2000 Jul;67(1):92-9. Epub 2000 May 24.
2. Genome-wide scan for prostate cancer susceptibility genes in the Johns Hopkins hereditary prostate cancer families. Xu J, etal., Prostate. 2003 Dec 1;57(4):320-5.

Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Peak: (D19S433)
Human AssemblyChrPosition (strand)Source
GRCh371930,417,027 - 30,417,232UniSTS
Build 361935,108,867 - 35,109,072RGD
Celera1927,110,713 - 27,110,918RGD
HuRef1926,924,414 - 26,924,615UniSTS
Marshfield Genetic Map1951.88UniSTS
Marshfield Genetic Map1951.88RGD
deCODE Assembly Map1950.82UniSTS


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general Further linkage studies with 8 additional markers narrowed the region of linkage to 2 cM which includes markers D19S875 and D19S433; evidence of allelic imbalance was also noted at this locus 2300103
qtl_map 19q12, 51.88 cM (Marshfield map); P less than 0.001 for about 5 cM 2293118
qtl_population Subjects recruited from urology practices in St. Louis, MO and Cleveland, OH 2293118
qtl_population_details 233 families with at least 2 affected brothers with Gleason scores; 326 sib pairs 2293118
qtl_statistics_details Software used: S.A.G.E. (2000); Multipoint generalized Haseman-Elston linkage test using Gleason scores 2293118