Sil1 (SIL1 nucleotide exchange factor)

Gene: Sil1 (SIL1 nucleotide exchange factor) Rattus norvegicus

Analyze

Symbol:

Sil1

Name:

SIL1 nucleotide exchange factor

RGD ID:

735103

Description:

Predicted to enable adenyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in protein transport. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary cerebellar degeneration. Orthologous to human SIL1 (SIL1 nucleotide exchange factor); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,5-hexanedione.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae); MGC72590; nucleotide exchange factor SIL1; SIL1 homolog, endoplasmic reticulum chaperone; SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae); similar to endoplasmic reticulum chaperone SIL1 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIL1 (SIL1 nucleotide exchange factor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sil1 (SIL1 nucleotide exchange factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sil1 (SIL1 nucleotide exchange factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIL1 (SIL1 nucleotide exchange factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIL1 (SIL1 nucleotide exchange factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sil1 (SIL1 nucleotide exchange factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIL1 (SIL1 nucleotide exchange factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIL1 (SIL1 nucleotide exchange factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sil1 (SIL1 nucleotide exchange factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RGCC (regulator of cell cycle)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Sil1 (SIL1 nucleotide exchange factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SIL1 (SIL1 nucleotide exchange factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sil1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SIL1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	sil1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sil1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	27,146,526 - 27,378,459 (-)	NCBI		GRCr8
mRatBN7.2	18	26,872,423 - 27,104,365 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	26,872,429 - 27,104,332 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	26,999,821 - 27,231,724 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	27,762,741 - 27,994,497 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	27,097,649 - 27,329,387 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	28,067,476 - 28,302,008 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	28,067,484 - 28,301,863 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	27,777,570 - 28,015,033 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	27,780,878 - 27,957,033 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	27,807,524 - 27,983,675 (-)	NCBI
Celera	18	26,607,704 - 26,838,633 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

cataract (ISO)

COVID-19 (ISO)

Developmental Disabilities (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Marinesco-Sjogren syndrome (ISO)

Neurodevelopmental Disorders (ISO)

primary cerebellar degeneration (ISO)

Prostatic Neoplasms (ISO)

STING-associated vasculopathy with onset in infancy (ISO)

X-linked intellectual disability-short stature-overweight syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,5-hexanedione (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

carbendazim (EXP)

carbon nanotube (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dinophysistoxin 1 (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

ivermectin (ISO)

methimazole (EXP)

methoxychlor (EXP)

paracetamol (EXP,ISO)

resveratrol (EXP)

sodium arsenite (EXP,ISO)

sodium dichromate (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

tetrachloroethene (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein transport (IEA)

Cellular Component

endoplasmic reticulum (IBA,IEA,ISO)

endoplasmic reticulum lumen (IEA)

Molecular Function

adenyl-nucleotide exchange factor activity (IBA,ISO)

identical protein binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP.	Chung KT, etal., J Biol Chem 2002 Dec 6;277(49):47557-63. Epub 2002 Sep 27.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:16116427	PMID:16502470

Genomics

Comparative Map Data

Sil1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	27,146,526 - 27,378,459 (-)	NCBI		GRCr8
mRatBN7.2	18	26,872,423 - 27,104,365 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	26,872,429 - 27,104,332 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	26,999,821 - 27,231,724 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	27,762,741 - 27,994,497 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	27,097,649 - 27,329,387 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	28,067,476 - 28,302,008 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	28,067,484 - 28,301,863 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	27,777,570 - 28,015,033 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	27,780,878 - 27,957,033 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	27,807,524 - 27,983,675 (-)	NCBI
Celera	18	26,607,704 - 26,838,633 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

SIL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	138,946,724 - 139,198,368 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	138,946,724 - 139,293,557 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	138,282,413 - 138,534,057 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	138,310,308 - 138,561,964 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	134,404,181 - 134,655,785 (-)	NCBI		Celera
Cytogenetic Map	5	q31.2	NCBI
HuRef	5	133,472,204 - 133,723,612 (-)	NCBI		HuRef
CHM1_1	5	137,714,967 - 137,966,619 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	139,472,860 - 139,724,442 (-)	NCBI		T2T-CHM13v2.0

Sil1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	35,399,449 - 35,632,443 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	35,399,449 - 35,632,833 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	35,266,396 - 35,499,390 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	35,266,396 - 35,499,780 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	35,426,050 - 35,658,579 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	35,392,370 - 35,624,840 (-)	NCBI		MGSCv36	mm8
Celera	18	35,722,030 - 35,955,224 (-)	NCBI		Celera
Cytogenetic Map	18	B1- B2	NCBI
cM Map	18	18.97	NCBI

Sil1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	1,392,985 - 1,583,376 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	1,322,644 - 1,583,352 (+)	NCBI	ChiLan1.0	ChiLan1.0

SIL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	134,221,096 - 134,469,295 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	132,360,647 - 132,608,705 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	134,325,451 - 134,573,398 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	140,450,758 - 140,696,688 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	140,450,891 - 140,628,703 (-)	Ensembl	panpan1.1		panPan2

SIL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	26,470,439 - 26,689,198 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	26,470,487 - 26,731,294 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	25,237,309 - 25,456,067 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	27,326,034 - 27,544,943 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	27,321,759 - 27,594,868 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	26,033,324 - 26,252,680 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	25,855,663 - 26,074,458 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	26,520,214 - 26,739,659 (-)	NCBI		UU_Cfam_GSD_1.0

Sil1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	153,291,212 - 153,549,064 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	8,060,787 - 8,320,302 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	8,062,441 - 8,320,287 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	140,878,070 - 141,118,059 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	140,884,170 - 141,118,201 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SIL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	41,611,360 - 41,855,632 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	41,609,484 - 41,855,663 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	36,035,024 - 36,272,681 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sil1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	31,708,423 - 31,935,257 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	31,709,989 - 32,015,770 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sil1
624 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	157
Count of miRNA genes:	126
Interacting mature miRNAs:	132
Transcripts:	ENSRNOT00000026895
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26548082	46969551	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26548082	46969551	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26548082	46969551	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26548082	46969551	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26548082	46969551	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26548082	46969551	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26548082	46969551	Rat

Markers in Region

D18Rat68

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	26,968,422 - 26,968,532 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	28,163,255 - 28,163,364	NCBI	Rnor6.0
Rnor_5.0	18	27,877,050 - 27,877,159	UniSTS	Rnor5.0
RGSC_v3.4	18	27,877,518 - 27,877,816	RGD	RGSC3.4
RGSC_v3.4	18	27,877,706 - 27,877,815	UniSTS	RGSC3.4
RGSC_v3.1	18	27,904,352 - 27,904,461	RGD
Celera	18	26,703,038 - 26,703,147	UniSTS
RH 3.4 Map	18	374.9	RGD
RH 3.4 Map	18	374.9	UniSTS
RH 2.0 Map	18	535.3	RGD
FHH x ACI Map	18	17.18	RGD
Cytogenetic Map	18	p11	UniSTS

D18Chm5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	27,056,864 - 27,057,108 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	28,251,694 - 28,251,935	NCBI	Rnor6.0
Rnor_5.0	18	27,965,437 - 27,965,678	UniSTS	Rnor5.0
RGSC_v3.4	18	27,966,059 - 27,966,300	UniSTS	RGSC3.4
Celera	18	26,791,461 - 26,791,702	UniSTS
Cytogenetic Map	18	p11	UniSTS

RH129926

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	26,872,430 - 26,872,644 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	28,067,485 - 28,067,698	NCBI	Rnor6.0
Rnor_5.0	18	27,777,579 - 27,777,792	UniSTS	Rnor5.0
RGSC_v3.4	18	27,780,880 - 27,781,093	UniSTS	RGSC3.4
Celera	18	26,607,706 - 26,607,919	UniSTS
RH 3.4 Map	18	374.8	UniSTS
Cytogenetic Map	18	p11	UniSTS

BI289115

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	26,897,708 - 26,897,951 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	28,092,519 - 28,092,761	NCBI	Rnor6.0
Rnor_5.0	18	27,802,254 - 27,802,496	UniSTS	Rnor5.0
RGSC_v3.4	18	27,805,815 - 27,806,057	UniSTS	RGSC3.4
Celera	18	26,632,510 - 26,632,752	UniSTS
RH 3.4 Map	18	374.8	UniSTS
Cytogenetic Map	18	p11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	18	57	41	19	41		1	39	35	39	11
Low		25					8	10	35		2		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000026895 ⟹ ENSRNOP00000026895

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	26,872,429 - 27,104,332 (-)	Ensembl
Rnor_6.0 Ensembl	18	28,067,484 - 28,301,863 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102716 ⟹ ENSRNOP00000097662

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	26,872,429 - 27,033,678 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104681 ⟹ ENSRNOP00000078831

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	26,872,432 - 27,015,859 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105808 ⟹ ENSRNOP00000081504

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	26,872,429 - 27,047,824 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107530 ⟹ ENSRNOP00000097578

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	26,872,429 - 27,051,423 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113606 ⟹ ENSRNOP00000076899

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	27,043,080 - 27,047,824 (-)	Ensembl

RefSeq Acc Id:

NM_199376 ⟹ NP_955408

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	27,146,526 - 27,378,398 (-)	NCBI
mRatBN7.2	18	26,872,429 - 27,104,302 (-)	NCBI
Rnor_6.0	18	28,067,483 - 28,301,863 (-)	NCBI
Rnor_5.0	18	27,777,570 - 28,015,033 (-)	NCBI
RGSC_v3.4	18	27,780,878 - 27,957,033 (-)	RGD
Celera	18	26,607,704 - 26,838,633 (-)	RGD

Sequence:

show sequence

GTTGGTTGCCGCTGCAGCCGCCTGGAATTGTGGGGATTGTGTCTGCCCCTAGGCTGCGGTGGAA
AGCCGAAGGTCCTGGTTATGGCTCCTCAGCACCTGCCTTCAACTAGGATGGCCCCTCAAGGAAT
GCTGCTGGGGCTGCTGTTGGCTTCCTGTTTAACTTTCTGCCTCAGTTGTCAGAACTCAAATAAT
TTTGCACTCACCAACCCAGAGAAGAGTACCCACGAGGACTCAGATACAAAGGAAACCAGAAGAG
AGGAGGAGCTGGATGCCGAAGTCCTAGAGGTGTTAAACCCAACCCAAGAGTGGCAGGCTCTTCA
ACCAGGACAGGCTGTTCCTGCAGGATCCCATGTGCGAATGAACCTACAGACTGGAGTAAACGAG
GTGAAACTCCAACAAGAAGACAAATTCCAAAGTAATTGGAAAGGATTTAAAAGAGGCAGAAGGC
TGGACATCAATACCAACACCTACACGTCTCAGGACCTCAAGAGTGCACTGGCCAAGTTCAAGGA
GGGGACAGAGATGGAGAATTCAAAGGATGAACTGGCAAGACAGGCCACGGTAAAGCAGCTCTTC
CGCCCCATCGAGGAGCTGAAGAAGGAATTTGATGAGCTGAATGTTGTTCTTGAGACTGACATGC
AGATTATGGTTCGGCTGATAAACAAGTTCAACAGCTCCAGCTCTAGCCTGGAAGAGAAGGTTGC
TGCACTCTTTGATCTTGAGTACTATGTCCATCAGATGGATAACGCACAGGACCTGCTGTCCTTT
GGTGGCCTTCAAGTGGTGATTAATGGGCTCAACAGCACAGAACCCCTGGTGAAGGAGTATGCTG
CTTTTGTGCTGGGGGCCGCCTTTTCCAGCAATCCAAAGGTCCAGGTGGAAGCCATTGAAGGAGG
AGCTCTGCAGAAGCTGCTGGTCATCCTGGCCACAGAGCAGCCTCTCCCCGCCAAGAAGAAGGTC
CTGTTTGCACTGTGCTCTTTACTTCGCCACTTCCCCTACGCCCAGCAGCAGTTCCTGAAGCTCG
GGGGGCTGCAGGTCCTCAGGAGCCTGGTGCAGGAGAAGAGTGCGAAGGTACTGGCCGTGCGAGT
GGTCACCTTGCTCTATGACCTGGTCACCGAGAAGATGTTTGCTGAGGAGGAGGCTGAGCTGACC
CAGGAGTCCTCCCCAGAGAAGCTGCAGCAGTACCGGCAGGTGCAGCTCCTGCCCGGCCTGCGGG
AACAGGGCTGGTGTGAGATCACGGCCCAGCTCCTGGCCCTTCCAGAGCACGACGCTCGGGAGAA
GGTGCTGCAGACGCTGGGCGCCCTCCTCGCCACCTGCCGGGACCGCTACCGTCAAGACCTGGAG
CTGAGCCGGACACTGGGCAGTCTCCAGGCAGAGTACCAAGCCCTGGCCTCCCTGGAGCTCCAAG
AAGGTGAAGATGACGGCTACTTCCGGGAACTGCTGGCCTCCATCGACAGCTTGGTGAAGGAGCT
AAGATGAGGCTGCCACGCTGAGACAGGACTGGATGGATGCTGCTAGTGAGAGCTCTGGTGGGCT
CTTCAGGGGACAGCAGCCAGGAGGAGGACTTCCCTACTGGGGCATGAGCTTTTTCTGGGCAGAG
CTGGCTGGGTCATTAAACAGAGACATGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

hide sequence

RefSeq Acc Id:

XM_008772025 ⟹ XP_008770247

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	27,146,526 - 27,378,459 (-)	NCBI
mRatBN7.2	18	26,872,427 - 27,104,365 (-)	NCBI
Rnor_6.0	18	28,067,476 - 28,301,962 (-)	NCBI

Sequence:

show sequence

CTGTTCTGGCAGGTTACCATTGGGCAAGATTGAGAATGACGTAATAGGCACGCGCCTTCAGATT
CAGGCAGCCACTGGCACGGCGTTTGCGCAGGAGGAGTTGGTTGCCGCTGCAGCCGCCTGGAATT
GTGGGGATTGTGTCTGCCCCTAGGCTGCGGTGGAAAGCCGAAGAATGTTTGTTGGCCATGTTCT
GTTCTGTGGAGACCAGCAAAGCTGTAAAGAGAACCCACTTCATTAAGAGACTCTAGAAGAAAAC
CTGAGCAACTCTTGGTGCTTCCCCAGGGATATGCATCTTTCCTCCTCCATACCATGCCAAAGTT
GGGCCCCAGGTCCTGGTTATGGCTCCTCAGCACCTGCCTTCAACTAGGATGGCCCCTCAAGGAA
TGCTGCTGGGGCTGCTGTTGGCTTCCTGTTTAACTTTCTGCCTCAGTTGTCAGAACTCAAATAA
TTTTGCACTCACCAACCCAGAGAAGAGTACCCACGAGGACTCAGATACAAAGGAAACCAGAAGA
GAGGAGGAGCTGGATGCCGAAGTCCTAGAGGTGTTAAACCCAACCCAAGAGTGGCAGGCTCTTC
AACCAGGACAGGCTGTTCCTGCAGGATCCCATGTGCGAATGAACCTACAGACTGGAGTAAACGA
GGTGAAACTCCAACAAGAAGACAAATTCCAAAGTAATTGGAAAGGATTTAAAAGAGGCAGAAGG
CTGGACATCAATACCAACACCTACACGTCTCAGGACCTCAAGAGTGCACTGGCCAAGTTCAAGG
AGGGGACAGAGATGGAGAATTCAAAGGATGAACTGGCAAGACAGGCCACGGTAAAGCAGCTCTT
CCGCCCCATCGAGGAGCTGAAGAAGGAATTTGATGAGCTGAATGTTGTTCTTGAGACTGACATG
CAGATTATGGTTCGGCTGATAAACAAGTTCAACAGCTCCAGCTCTAGCCTGGAAGAGAAGGTTG
CTGCACTCTTTGATCTTGAGTACTATGTCCATCAGATGGATAACGCACAGGACCTGCTGTCCTT
TGGTGGCCTTCAAGTGGTGATTAATGGGCTCAACAGCACAGAACCCCTGGTGAAGGAGTATGCT
GCTTTTGTGCTGGGGGCCGCCTTTTCCAGCAATCCAAAGGTCCAGGTGGAAGCCATTGAAGGAG
GAGCTCTGCAGAAGCTGCTGGTCATCCTGGCCACAGAGCAGCCTCTCCCCGCCAAGAAGAAGGT
CCTGTTTGCACTGTGCTCTTTACTTCGCCACTTCCCCTACGCCCAGCAGCAGTTCCTGAAGCTC
GGGGGGCTGCAGGTCCTCAGGAGCCTGGTGCAGGAGAAGAGTGCGAAGGTACTGGCCGTGCGAG
TGGTCACCTTGCTCTATGACCTGGTCACCGAGAAGATGTTTGCTGAGGAGGAGGCTGAGCTGAC
CCAGGAGTCCTCCCCAGAGAAGCTGCAGCAGTACCGGCAGGTGCAGCTCCTGCCCGGCCTGCGG
GAACAGGGCTGGTGTGAGATCACGGCCCAGCTCCTGGCCCTTCCAGAGCACGACGCTCGGGAGA
AGGTGCTGCAGACGCTGGGCGCCCTCCTCGCCACCTGCCGGGACCGCTACCGTCAAGACCTGGA
GCTGAGCCGGACACTGGGCAGTCTCCAGGCAGAGTACCAAGCCCTGGCCTCCCTGGAGCTCCAA
GAAGGTGAAGATGACGGCTACTTCCGGGAACTGCTGGCCTCCATCGACAGCTTGGTGAAGGAGC
TAAGATGAGGCTGCCACGCTGAGACAGGACTGGATGGATGCTGCTAGTGAGAGCTCTGGTGGGC
TCTTCAGGGGACAGCAGCCAGGAGGAGGACTTCCCTACTGGGGCATGAGCTTTTTCTGGGCAGA
GCTGGCTGGGTCATTAAACAGAGACATGTAGATTGTG

hide sequence

RefSeq Acc Id:

XM_017600905 ⟹ XP_017456394

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	27,146,526 - 27,362,919 (-)	NCBI
mRatBN7.2	18	26,872,427 - 27,088,836 (-)	NCBI
Rnor_6.0	18	28,067,476 - 28,288,395 (-)	NCBI

Sequence:

show sequence

GCCTCCCAAATGCTGGGATTAAAGGCATACTTCCTCCCTACCCCTGTCACCCTTGCCACCACCC
CACCTTGCTAGCAACCTTGGCTTTTTGGGACAGGGTTCTTTGTTGGGAGCTGGGTCTTGCCAGT
CAGGCTGACACTCTCCTTGGCATTGCCTATCTCTGCCTCCCCTGGCCTCCACTAAGGATGGCCT
TTATGTGGGTGCTGGGAATTAAACTGAGGCCCTCATCCTTGTGCAGGAGGTGCTTTACCAGCTA
AGCCATCTCCCCAGCCCTCAGGCTCTCCCCAGCCATGATCAGCTGTACACCAGCTGATAGCTTA
GTTATGGCTTCTGCAGACTTAGCTGCTCTCCCAGATTGTAGTTTCAGGGACTTTCATAGACATT
TGAAATTCATAAAAAGTATGAATCAGTAATTCCAGTTAGCAAACTCCAGAAACATGGCTACCAA
GTTGATTTGCGTGGATTGGTAAGAGCATTCTCTTTATAAGAAGTCAAAGCCAGCTTGCCTTTGG
AGGCAATCAGACACAGTGTGGTAGAAATCTTTTGGGTCATTGCATTGGCTGTGCCCAGGTTCAA
GCCAGTTGCTCGCTGGGAGACTTGAAAGGCTGTTTAGCCTCTTTGCTCTTATTTCCTCACTTGC
ACCCCATAGAGGCTTCAGGTATATACATAGTAAGTAGGCACATGGTCAGTGTTTTGTGCCATTT
GATCCCCTCTTCTGTCTTACTTCTTCACGCTTCCTCAGTGTCCTTCAAGGGCCGTATCTGCAAT
CTGACTAGAATATCCTTTCATATTAGGACACCAGCTGTATATACTCACCTTTAAAATCTCCTTT
ATTTTTTCTTTGCAAGCCAAGGTCCTTCTGTTACAGATTTTAGTAACAGATTCTAGTTCTTGTG
AATCACTTCCAACCCAGTATCCTTTACAGTTAGCATTTAACCTATTGTTATTTGCTGAGCACCC
ACTGTGTGTCAGATTTGTTTGGCTACTGTGTAGTGGTAAATAAGGCAGATGTGGTCTTTGTCCT
AGTAACACTTTTCTGAGCGCCCTCCTTAGCTGGCTGACTTTTGATTAATCTTGTTCCTTCTGTG
TGGTTGTCTGAATTTCCTCCTAGTCCTAGGGGACAGTGGCTCTTTGTGTTGCATGGGCTTTGCC
TACTGGCTTGCCTGCTCCCAAGAGATGAAAGCAGTTTGCTGAAGCAAAAGGAAAAAGCCCCCAG
GGCCACTACTGCCTCAGCCACACATGTCCCACGGAGCCTGTGCTTAGCATTCCTGAATGTCCCT
TTTCTCCTTGTACACAAATTATAGTGTTCACTGGTAATTTAAATTCAAATAACCTTCCACCCCC
TCTCCTCCTTTAAAAAAAAAAAGCCTGTGTATTACAGGGTAGAGGACAAAGCAGGCCAAGCCTG
GTCTCCTGGTGGGATTTGTTTTCTCTTATGTTTTTAGCTGGCTTTGCTGTGGGTGGTCTTTGCT
TTAATAGGGCTGATATGTAGTTCAGGAATATTGATATTCTGCAGTCAGAGAGTCATATCTTTTC
CAGCCTTGTTTGTCATAAACAGTGTGACAGGTAAATTCAGGGACTTTGGCTGACAGGCTTCCTG
ATTTGCCTCTTTGCTTTGGGCTCCAGACTCCATCTAGCCCCTAGTGGGCTCTGCATAAAGAAGG
CACCGTGGCCAGGATGCTGATTTTATGCTTCAAAATAGGAGCCCGGAGATAGCCTTCTGTTTTT
CCCTCCTCTCCCTATTGCCAGTTTCACTGGCAGTTGCCAAGAAATGTGTATGGGGAAGCTGGCA
GAATAGCTCTCTGGGAACCATTTATTTGAGAATACCCAGTAGAGAAACTGATTGTCCTTTTCAC
CCTCTCTTGCTGTGGTGTGACATTGTGACTTGGGACTGCTTGTTCCTCTGCATATGGTGTATGA
CACATCCAGCCTTGTTGGTGTTTTCCACAATGAATTGTTTTCTGGCTGTGCCTCCCTCGATTCC
TTCATCTTCCTGGGACAGTGGGCAGGTATGCAGACACCTCCAAAGGCCTGGTCCTGGTTATGGC
TCCTCAGCACCTGCCTTCAACTAGGATGGCCCCTCAAGGAATGCTGCTGGGGCTGCTGTTGGCT
TCCTGTTTAACTTTCTGCCTCAGTTGTCAGAACTCAAATAATTTTGCACTCACCAACCCAGAGA
AGAGTACCCACGAGGACTCAGATACAAAGGAAACCAGAAGAGAGGAGGAGCTGGATGCCGAAGT
CCTAGAGGTGTTAAACCCAACCCAAGAGTGGCAGGCTCTTCAACCAGGACAGGCTGTTCCTGCA
GGATCCCATGTGCGAATGAACCTACAGACTGGAGTAAACGAGGTGAAACTCCAACAAGAAGACA
AATTCCAAAGTAATTGGAAAGGATTTAAAAGAGGCAGAAGGCTGGACATCAATACCAACACCTA
CACGTCTCAGGACCTCAAGAGTGCACTGGCCAAGTTCAAGGAGGGGACAGAGATGGAGAATTCA
AAGGATGAACTGGCAAGACAGGCCACGGTAAAGCAGCTCTTCCGCCCCATCGAGGAGCTGAAGA
AGGAATTTGATGAGCTGAATGTTGTTCTTGAGACTGACATGCAGATTATGGTTCGGCTGATAAA
CAAGTTCAACAGCTCCAGCTCTAGCCTGGAAGAGAAGGTTGCTGCACTCTTTGATCTTGAGTAC
TATGTCCATCAGATGGATAACGCACAGGACCTGCTGTCCTTTGGTGGCCTTCAAGTGGTGATTA
ATGGGCTCAACAGCACAGAACCCCTGGTGAAGGAGTATGCTGCTTTTGTGCTGGGGGCCGCCTT
TTCCAGCAATCCAAAGGTCCAGGTGGAAGCCATTGAAGGAGGAGCTCTGCAGAAGCTGCTGGTC
ATCCTGGCCACAGAGCAGCCTCTCCCCGCCAAGAAGAAGGTCCTGTTTGCACTGTGCTCTTTAC
TTCGCCACTTCCCCTACGCCCAGCAGCAGTTCCTGAAGCTCGGGGGGCTGCAGGTCCTCAGGAG
CCTGGTGCAGGAGAAGAGTGCGAAGGTACTGGCCGTGCGAGTGGTCACCTTGCTCTATGACCTG
GTCACCGAGAAGATGTTTGCTGAGGAGGAGGCTGAGCTGACCCAGGAGTCCTCCCCAGAGAAGC
TGCAGCAGTACCGGCAGGTGCAGCTCCTGCCCGGCCTGCGGGAACAGGGCTGGTGTGAGATCAC
GGCCCAGCTCCTGGCCCTTCCAGAGCACGACGCTCGGGAGAAGGTGCTGCAGACGCTGGGCGCC
CTCCTCGCCACCTGCCGGGACCGCTACCGTCAAGACCTGGAGCTGAGCCGGACACTGGGCAGTC
TCCAGGCAGAGTACCAAGCCCTGGCCTCCCTGGAGCTCCAAGAAGGTGAAGATGACGGCTACTT
CCGGGAACTGCTGGCCTCCATCGACAGCTTGGTGAAGGAGCTAAGATGAGGCTGCCACGCTGAG
ACAGGACTGGATGGATGCTGCTAGTGAGAGCTCTGGTGGGCTCTTCAGGGGACAGCAGCCAGGA
GGAGGACTTCCCTACTGGGGCATGAGCTTTTTCTGGGCAGAGCTGGCTGGGTCATTAAACAGAG
ACATGTAGATTGTG

hide sequence

RefSeq Acc Id:

XM_039096718 ⟹ XP_038952646

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	27,146,526 - 27,356,854 (-)	NCBI
mRatBN7.2	18	26,872,427 - 27,082,564 (-)	NCBI

RefSeq Acc Id:

XM_039096720 ⟹ XP_038952648

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	27,146,526 - 27,321,908 (-)	NCBI
mRatBN7.2	18	26,872,427 - 27,047,835 (-)	NCBI

RefSeq Acc Id:

XM_039096722 ⟹ XP_038952650

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	27,146,526 - 27,186,204 (-)	NCBI
mRatBN7.2	18	26,872,427 - 26,909,522 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_955408	(Get FASTA)	NCBI Sequence Viewer
	XP_008770247	(Get FASTA)	NCBI Sequence Viewer
	XP_017456394	(Get FASTA)	NCBI Sequence Viewer
	XP_038952646	(Get FASTA)	NCBI Sequence Viewer
	XP_038952648	(Get FASTA)	NCBI Sequence Viewer
	XP_038952650	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH62050	(Get FASTA)	NCBI Sequence Viewer
	EDL76255	(Get FASTA)	NCBI Sequence Viewer
	EDL76256	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026895
	ENSRNOP00000026895.4
	ENSRNOP00000076899.1
	ENSRNOP00000078831.1
	ENSRNOP00000081504
	ENSRNOP00000081504.1
	ENSRNOP00000097578
	ENSRNOP00000097578.1
	ENSRNOP00000097662.1
GenBank Protein	Q6P6S4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_955408 ⟸ NM_199376
- Peptide Label:	precursor
- UniProtKB:	Q6P6S4 (UniProtKB/Swiss-Prot), A6J2X3 (UniProtKB/TrEMBL), A0A8I6ANJ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPQHLPSTRMAPQGMLLGLLLASCLTFCLSCQNSNNFALTNPEKSTHEDSDTKETRREEELDA EVLEVLNPTQEWQALQPGQAVPAGSHVRMNLQTGVNEVKLQQEDKFQSNWKGFKRGRRLDINTN TYTSQDLKSALAKFKEGTEMENSKDELARQATVKQLFRPIEELKKEFDELNVVLETDMQIMVRL INKFNSSSSSLEEKVAALFDLEYYVHQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGA AFSSNPKVQVEAIEGGALQKLLVILATEQPLPAKKKVLFALCSLLRHFPYAQQQFLKLGGLQVL RSLVQEKSAKVLAVRVVTLLYDLVTEKMFAEEEAELTQESSPEKLQQYRQVQLLPGLREQGWCE ITAQLLALPEHDAREKVLQTLGALLATCRDRYRQDLELSRTLGSLQAEYQALASLELQEGEDDG YFRELLASIDSLVKELR hide sequence

RefSeq Acc Id:	XP_008770247 ⟸ XM_008772025
- Peptide Label:	isoform X1
- UniProtKB:	Q6P6S4 (UniProtKB/Swiss-Prot), A6J2X3 (UniProtKB/TrEMBL), A0A8I6ANJ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPQHLPSTRMAPQGMLLGLLLASCLTFCLSCQNSNNFALTNPEKSTHEDSDTKETRREEELDA EVLEVLNPTQEWQALQPGQAVPAGSHVRMNLQTGVNEVKLQQEDKFQSNWKGFKRGRRLDINTN TYTSQDLKSALAKFKEGTEMENSKDELARQATVKQLFRPIEELKKEFDELNVVLETDMQIMVRL INKFNSSSSSLEEKVAALFDLEYYVHQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGA AFSSNPKVQVEAIEGGALQKLLVILATEQPLPAKKKVLFALCSLLRHFPYAQQQFLKLGGLQVL RSLVQEKSAKVLAVRVVTLLYDLVTEKMFAEEEAELTQESSPEKLQQYRQVQLLPGLREQGWCE ITAQLLALPEHDAREKVLQTLGALLATCRDRYRQDLELSRTLGSLQAEYQALASLELQEGEDDG YFRELLASIDSLVKELR hide sequence

RefSeq Acc Id:	XP_017456394 ⟸ XM_017600905
- Peptide Label:	isoform X1
- UniProtKB:	Q6P6S4 (UniProtKB/Swiss-Prot), A6J2X3 (UniProtKB/TrEMBL), A0A8I6ANJ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPQHLPSTRMAPQGMLLGLLLASCLTFCLSCQNSNNFALTNPEKSTHEDSDTKETRREEELDA EVLEVLNPTQEWQALQPGQAVPAGSHVRMNLQTGVNEVKLQQEDKFQSNWKGFKRGRRLDINTN TYTSQDLKSALAKFKEGTEMENSKDELARQATVKQLFRPIEELKKEFDELNVVLETDMQIMVRL INKFNSSSSSLEEKVAALFDLEYYVHQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGA AFSSNPKVQVEAIEGGALQKLLVILATEQPLPAKKKVLFALCSLLRHFPYAQQQFLKLGGLQVL RSLVQEKSAKVLAVRVVTLLYDLVTEKMFAEEEAELTQESSPEKLQQYRQVQLLPGLREQGWCE ITAQLLALPEHDAREKVLQTLGALLATCRDRYRQDLELSRTLGSLQAEYQALASLELQEGEDDG YFRELLASIDSLVKELR hide sequence

RefSeq Acc Id:

ENSRNOP00000026895 ⟸ ENSRNOT00000026895

RefSeq Acc Id:	XP_038952646 ⟸ XM_039096718
- Peptide Label:	isoform X1
- UniProtKB:	Q6P6S4 (UniProtKB/Swiss-Prot), A6J2X3 (UniProtKB/TrEMBL), A0A8I6ANJ4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038952648 ⟸ XM_039096720
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZSQ7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038952650 ⟸ XM_039096722
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000081504 ⟸ ENSRNOT00000105808

RefSeq Acc Id:

ENSRNOP00000097662 ⟸ ENSRNOT00000102716

RefSeq Acc Id:

ENSRNOP00000076899 ⟸ ENSRNOT00000113606

RefSeq Acc Id:

ENSRNOP00000078831 ⟸ ENSRNOT00000104681

RefSeq Acc Id:

ENSRNOP00000097578 ⟸ ENSRNOT00000107530

Protein Domains

Nucleotide exchange factor Fes1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P6S4-F1-model_v2	AlphaFold	Q6P6S4	1-465	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700707

Promoter ID:

EPDNEW_R11230

Type:

initiation region

Name:

Sil1_1

Description:

SIL1 nucleotide exchange factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	28,301,878 - 28,301,938	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735103	AgrOrtholog
BioCyc Gene	G2FUF-7915	BioCyc
Ensembl Genes	ENSRNOG00000019826	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026895	ENTREZGENE
	ENSRNOT00000026895.6	UniProtKB/Swiss-Prot
	ENSRNOT00000102716.1	UniProtKB/TrEMBL
	ENSRNOT00000104681.1	UniProtKB/TrEMBL
	ENSRNOT00000105808.1	UniProtKB/TrEMBL
	ENSRNOT00000107530.1	UniProtKB/TrEMBL
	ENSRNOT00000113606.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5598825	IMAGE-MGC_LOAD
InterPro	ARM-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nucleotide_exch_fac_Fes1	UniProtKB/TrEMBL
KEGG Report	rno:291673	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:72590	IMAGE-MGC_LOAD
NCBI Gene	291673	ENTREZGENE
PANTHER	NUCLEOTIDE EXCHANGE FACTOR SIL1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN FOLDING REGULATOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Fes1	UniProtKB/TrEMBL
PhenoGen	Sil1	PhenoGen
RatGTEx	ENSRNOG00000019826	RatGTEx
Superfamily-SCOP	SSF48371	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5Y965_RAT	UniProtKB/TrEMBL
	A0A8I5ZLN1_RAT	UniProtKB/TrEMBL
	A0A8I5ZSQ7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ANJ4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AT30_RAT	UniProtKB/TrEMBL
	A6J2X3	ENTREZGENE, UniProtKB/TrEMBL
	A6J2X4_RAT	UniProtKB/TrEMBL
	Q6P6S4	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-09-18	Sil1	SIL1 nucleotide exchange factor	Sil1	SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-04	Sil1	SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)	Sil1	endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-08	Sil1	endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)	MGC72590	similar to endoplasmic reticulum chaperone SIL1 homolog	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)