Coro1a (coronin 1A) - Rat Genome Database

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Gene: Coro1a (coronin 1A) Rattus norvegicus
Analyze
Symbol: Coro1a
Name: coronin 1A
RGD ID: 620009
Description: Predicted to enable cytoskeletal protein binding activity; phosphatidylinositol 3-kinase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including natural killer cell degranulation; negative regulation of actin nucleation; and negative regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including early endosome to recycling endosome transport; nerve growth factor signaling pathway; and regulation of organelle organization. Predicted to be located in several cellular components, including actin cytoskeleton; cytoplasmic vesicle; and immunological synapse. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and stereocilium tip. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Orthologous to human CORO1A (coronin 1A); PARTICIPATES IN phagocytosis pathway; tuberculosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: clipin-A; coronin, actin binding protein 1A; coronin-1A; coronin-like protein A; MGC93041; TACO; tryptophan aspartate-containing coat protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,726,129 - 190,731,133 (-)NCBIGRCr8
mRatBN7.21181,295,561 - 181,300,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,295,562 - 181,300,534 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,646,783 - 189,651,767 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,832,853 - 196,837,837 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,500,261 - 189,505,244 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,123,883 - 198,128,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,123,884 - 198,128,857 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,102,882 - 205,107,884 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,852,741 - 185,857,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,002,622 - 186,007,596 (-)NCBI
Celera1178,953,035 - 178,958,009 (-)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (ISO)
dimethylselenide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydroxyl  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
sarin  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament organization  (IBA,ISO)
biological_process  (ND)
calcium ion transport  (ISO)
cell migration  (IBA)
cell-substrate adhesion  (ISO)
cellular response to interleukin-4  (ISO)
early endosome to recycling endosome transport  (ISO)
epithelial cell migration  (ISO)
establishment of localization in cell  (ISO)
homeostasis of number of cells within a tissue  (ISO)
immunological synapse formation  (ISO)
leukocyte chemotaxis  (ISO)
natural killer cell degranulation  (ISO)
negative regulation of actin nucleation  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of vesicle fusion  (ISO)
nerve growth factor signaling pathway  (ISO)
neuron apoptotic process  (ISO)
phagocytosis  (ISO)
phagolysosome assembly  (ISO)
positive chemotaxis  (ISO)
positive regulation of T cell activation  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of T cell proliferation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of actin filament polymerization  (ISO)
regulation of actin polymerization or depolymerization  (ISO)
regulation of cell shape  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
response to cytokine  (ISO)
T cell activation  (ISO)
T cell differentiation  (NAS)
T cell homeostasis  (ISO)
T cell migration  (ISO)
T cell proliferation  (ISO)
thymocyte migration  (ISO)
uropod organization  (ISO)
vesicle fusion  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Coronin-1 expression in T lymphocytes: insights into protein function during T cell development and activation. Nal B, etal., Int Immunol 2004 Feb;16(2):231-40.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Direct interaction between p47phox and protein kinase C: evidence for targeting of protein kinase C by p47phox in neutrophils. Reeves EP, etal., Biochem J 1999 Dec 15;344 Pt 3:859-66.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7758584   PMID:9365277   PMID:9798653   PMID:11094157   PMID:12132654   PMID:12477932   PMID:15489334   PMID:15601263   PMID:15800061   PMID:16902139   PMID:17341475   PMID:17442961  
PMID:17728463   PMID:18199416   PMID:18836449   PMID:19946888   PMID:20032464   PMID:20458337   PMID:22364218   PMID:22658674   PMID:23100250   PMID:23533145   PMID:23793062   PMID:24270184  
PMID:24667537   PMID:24760828   PMID:25179994   PMID:25931508   PMID:26754646   PMID:26809475  


Genomics

Comparative Map Data
Coro1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,726,129 - 190,731,133 (-)NCBIGRCr8
mRatBN7.21181,295,561 - 181,300,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,295,562 - 181,300,534 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,646,783 - 189,651,767 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,832,853 - 196,837,837 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,500,261 - 189,505,244 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,123,883 - 198,128,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,123,884 - 198,128,857 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,102,882 - 205,107,884 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,852,741 - 185,857,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,002,622 - 186,007,596 (-)NCBI
Celera1178,953,035 - 178,958,009 (-)NCBICelera
Cytogenetic Map1q36NCBI
CORO1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,183,602 - 30,189,076 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,182,827 - 30,189,076 (+)EnsemblGRCh38hg38GRCh38
GRCh371630,194,923 - 30,200,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,102,427 - 30,107,898 (+)NCBINCBI36Build 36hg18NCBI36
Build 341630,102,448 - 30,107,898NCBI
Celera1672,594,500 - 72,599,971 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,857,375 - 27,863,041 (+)NCBIHuRef
CHM1_11631,409,355 - 31,415,021 (+)NCBICHM1_1
T2T-CHM13v2.01630,468,184 - 30,473,658 (+)NCBIT2T-CHM13v2.0
Coro1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,298,946 - 126,303,925 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,298,945 - 126,306,959 (-)EnsemblGRCm39 Ensembl
GRCm387126,699,774 - 126,704,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,699,773 - 126,707,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,843,288 - 133,848,268 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,490,922 - 126,495,902 (-)NCBIMGSCv36mm8
Celera7126,547,074 - 126,552,054 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.25NCBI
Coro1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,811,430 - 6,826,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,815,148 - 6,820,295 (-)NCBIChiLan1.0ChiLan1.0
CORO1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,926,030 - 30,931,532 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,294,286 - 35,299,847 (-)NCBINHGRI_mPanPan1
PanPan1.11630,549,880 - 30,555,093 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,550,383 - 30,556,196 (+)Ensemblpanpan1.1panPan2
CORO1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,161,850 - 18,167,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,160,601 - 18,167,818 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,740,842 - 19,746,439 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,298,321 - 18,303,918 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,298,356 - 18,303,915 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,097,136 - 18,102,732 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,012,545 - 18,018,141 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,328,371 - 18,333,968 (+)NCBIUU_Cfam_GSD_1.0
Coro1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,240,682 - 124,246,391 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,338,542 - 12,344,265 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,338,542 - 12,344,236 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CORO1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,336,898 - 18,342,396 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,336,813 - 18,342,381 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CORO1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,482,269 - 26,488,537 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,480,753 - 26,487,929 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,057,322 - 3,063,870 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Coro1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,105,153 - 13,111,357 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,106,416 - 13,111,394 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Coro1a
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:47
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000026496
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat

Markers in Region
Coro1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,296,092 - 181,296,456 (+)MAPPERmRatBN7.2
Rnor_6.01198,124,415 - 198,124,778NCBIRnor6.0
Rnor_5.01205,103,414 - 205,103,777UniSTSRnor5.0
RGSC_v3.41185,853,273 - 185,853,636UniSTSRGSC3.4
Celera1178,953,567 - 178,953,930UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 3 12 40 26 17 26 74 29 32 11
Low 31 17 15 15 8 11 6 9 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_130411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF416730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF495469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000026496   ⟹   ENSRNOP00000026496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,295,562 - 181,300,534 (-)Ensembl
Rnor_6.0 Ensembl1198,123,884 - 198,128,857 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106786   ⟹   ENSRNOP00000086349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,295,671 - 181,300,534 (-)Ensembl
RefSeq Acc Id: NM_130411   ⟹   NP_569095
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,726,129 - 190,731,103 (-)NCBI
mRatBN7.21181,295,561 - 181,300,535 (-)NCBI
Rnor_6.01198,123,883 - 198,128,857 (-)NCBI
Rnor_5.01205,102,882 - 205,107,884 (-)NCBI
RGSC_v3.41185,852,741 - 185,857,715 (-)RGD
Celera1178,953,035 - 178,958,009 (-)RGD
Sequence:
RefSeq Acc Id: XM_017588709   ⟹   XP_017444198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,726,129 - 190,731,133 (-)NCBI
mRatBN7.21181,295,561 - 181,300,566 (-)NCBI
Rnor_6.01198,123,883 - 198,128,890 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083423   ⟹   XP_038939351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,726,129 - 190,730,562 (-)NCBI
mRatBN7.21181,295,561 - 181,299,884 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_569095   ⟸   NM_130411
- UniProtKB: Q91ZN1 (UniProtKB/Swiss-Prot),   A6I9B9 (UniProtKB/TrEMBL),   A0A8I6A217 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444198   ⟸   XM_017588709
- Peptide Label: isoform X1
- UniProtKB: Q91ZN1 (UniProtKB/Swiss-Prot),   A6I9B9 (UniProtKB/TrEMBL),   A0A8I6A217 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026496   ⟸   ENSRNOT00000026496
RefSeq Acc Id: XP_038939351   ⟸   XM_039083423
- Peptide Label: isoform X1
- UniProtKB: Q91ZN1 (UniProtKB/Swiss-Prot),   A6I9B9 (UniProtKB/TrEMBL),   A0A8I6A217 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086349   ⟸   ENSRNOT00000106786
Protein Domains
DUF1899   Trimerisation motif

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZN1-F1-model_v2 AlphaFold Q91ZN1 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690408
Promoter ID:EPDNEW_R933
Type:multiple initiation site
Name:Coro1a_1
Description:coronin 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01198,128,856 - 198,128,916EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620009 AgrOrtholog
BioCyc Gene G2FUF-57430 BioCyc
Ensembl Genes ENSRNOG00000019430 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026166 UniProtKB/Swiss-Prot
  ENSRNOG00060030941 UniProtKB/Swiss-Prot
  ENSRNOG00065016779 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026496.4 UniProtKB/Swiss-Prot
  ENSRNOT00000106786.1 UniProtKB/TrEMBL
  ENSRNOT00055045187 UniProtKB/Swiss-Prot
  ENSRNOT00060053719 UniProtKB/Swiss-Prot
  ENSRNOT00065027987 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124429 IMAGE-MGC_LOAD
InterPro Coronin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trimer_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:155151 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93041 IMAGE-MGC_LOAD
NCBI Gene 155151 ENTREZGENE
PANTHER PTHR10856 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10856:SF18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trimer_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Coro1a PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019430 RatGTEx
  ENSRNOG00055026166 RatGTEx
  ENSRNOG00060030941 RatGTEx
  ENSRNOG00065016779 RatGTEx
SMART DUF1899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1900 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A217 ENTREZGENE, UniProtKB/TrEMBL
  A6I9B7_RAT UniProtKB/TrEMBL
  A6I9B9 ENTREZGENE, UniProtKB/TrEMBL
  A6I9C1_RAT UniProtKB/TrEMBL
  COR1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Coro1a  coronin 1A  Coro1a  coronin, actin binding protein 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Coro1a  coronin, actin binding protein 1A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Coro1a  coronin, actin binding protein 1A      Symbol and Name status set to provisional 70820 PROVISIONAL