Lipa (lipase A, lysosomal acid type) - Rat Genome Database

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Gene: Lipa (lipase A, lysosomal acid type) Rattus norvegicus
Analyze
Symbol: Lipa
Name: lipase A, lysosomal acid type
RGD ID: 3008
Description: Enables sterol esterase activity. Involved in fatty acid metabolic process and sterol metabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in Wolman disease and cholesterol ester storage disease. Orthologous to human LIPA (lipase A, lysosomal acid type); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acid cholesteryl ester hydrolase; Chole; Chole2; CHOLEST; cholesterol esterase (pancreatic); Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25; cholesteryl esterase; LAL; Lip1; lipase A; lipase A, lysosomal acid; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase 1; lysosomal acid lipase A; lysosomal acid lipase/cholesteryl ester hydrolase; pancreatic cholesterol esterase; RATCHOLEST; sterol esterase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Lipam1Hyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,437,524 - 241,470,936 (-)NCBIGRCr8
mRatBN7.21232,024,351 - 232,057,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,024,356 - 232,057,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1240,414,292 - 240,447,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,337,140 - 247,370,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,175,338 - 240,208,560 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,816,536 - 252,959,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,816,527 - 252,849,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01260,038,180 - 260,091,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,466,493 - 238,500,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,630,381 - 238,664,124 (-)NCBI
Celera1229,136,934 - 229,170,119 (-)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbamate ester  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
haloperidol  (ISO)
hydrogen cyanide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
linalool  (ISO)
LY294002  (ISO)
lycopene  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Morroniside  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
progesterone  (EXP)
Propiverine  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiadiazoles  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (IEA,ISO)
adaptive thermogenesis  (IEA,ISO)
adipose tissue development  (IEA,ISO)
ATP biosynthetic process  (IEA,ISO)
blood vessel endothelial cell differentiation  (IEA,ISO)
bone marrow development  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (ISO)
cell proliferation in bone marrow  (IEA,ISO)
cellular lipid biosynthetic process  (IEA,ISO)
cellular lipid metabolic process  (ISO)
cholesterol biosynthetic process  (IEA,ISO)
cholesterol efflux  (IEA,ISO)
cholesterol metabolic process  (ISO)
cholesterol storage  (IEA,ISO)
cholesterol transport  (ISO)
common myeloid progenitor cell proliferation  (IEA,ISO)
defecation  (IEA,ISO)
determination of adult lifespan  (IEA,ISO)
endocytosis  (IEA,ISO)
endosome to lysosome transport  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
energy homeostasis  (ISO)
epithelial cell proliferation  (ISO)
fat cell proliferation  (IEA,ISO)
fatty acid metabolic process  (IDA,IEA,ISO)
gene expression  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
glycolytic process  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IEA,ISO)
hemopoiesis  (ISO)
homeostasis of number of cells  (ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
inflammatory response  (ISO)
lipid catabolic process  (IEA)
lipid homeostasis  (IEA,ISO)
lipid import into cell  (IEA,ISO)
lipid metabolic process  (ISO)
lipid storage  (ISO)
lipoprotein catabolic process  (IEA,ISO)
liver development  (ISO)
liver morphogenesis  (IEA,ISO)
lung development  (IEA,ISO)
lysosome organization  (IEA,ISO)
macrophage homeostasis  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
mitotic cell cycle  (IEA,ISO)
multicellular organismal-level chemical homeostasis  (IEA,ISO)
multicellular organismal-level homeostasis  (ISO)
myeloid cell apoptotic process  (IEA,ISO)
myeloid cell differentiation  (IEA,ISO)
neutral lipid metabolic process  (ISO)
positive regulation of T cell receptor signaling pathway  (IEA,ISO)
programmed cell death  (ISO)
reactive oxygen species biosynthetic process  (IEA,ISO)
regulation of membrane potential  (ISO)
regulation of mitochondrial membrane potential  (IEA,ISO)
respiratory burst involved in inflammatory response  (IEA,ISO)
response to cold  (IEA,ISO)
response to dietary excess  (IEA,ISO)
response to lipid  (ISO)
response to rapamycin  (IEA,ISO)
response to vitamin A  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
retinoid metabolic process  (ISO)
small GTPase-mediated signal transduction  (IEA,ISO)
spleen development  (IEA,ISO)
sterol metabolic process  (IBA,IDA,IEA,ISO)
T cell apoptotic process  (IEA,ISO)
T cell differentiation  (IEA,ISO)
T cell proliferation  (IEA,ISO)
tissue remodeling  (IEA,ISO)
TOR signaling  (IEA,ISO)
triglyceride metabolic process  (IEA,ISO)
triglyceride-rich lipoprotein particle clearance  (IEA,ISO)
vitamin A metabolic process  (IEA,ISO)

Cellular Component
cytosol  (IEA,ISO)
fibrillar center  (IEA,ISO)
intracellular membrane-bounded organelle  (IBA,IEA,ISO)
lysosome  (IDA,IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Subcellular localization of acid lipase in rat liver. Amanuma K, etal., Biochem Int. 1985 Sep;11(3):349-55.
2. Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease. Anderson RA, etal., Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2718-22.
3. Structure of the rat pancreatic cholesterol esterase gene. Fontaine RN, etal., Biochemistry 1991 Jul 16;30(28):7008-14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cholesteryl ester storage disease and Wolman disease: phenotypic variants of lysosomal acid cholesteryl ester hydrolase deficiency. Hoeg JM, etal., Am J Hum Genet. 1984 Nov;36(6):1190-203.
7. Inhibition of the acid lipase activity by apolipoprotein A-I in the presence of lysosomal proteases. Inoue Y, etal., Biosci Biotechnol Biochem. 1999 May;63(5):937-9.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Changes in the activity of lysosomal enzymes in rat kidneys in the course of acute pancreatitis. Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Cloning of rat lysosomal acid lipase cDNA and identification of the mutation in the rat model of Wolman's disease. Nakagawa H, etal., J Lipid Res 1995 Oct;36(10):2212-8.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1718995   PMID:7204383   PMID:8112342   PMID:9633819   PMID:12477932   PMID:14644759   PMID:15269241   PMID:23376485  


Genomics

Comparative Map Data
Lipa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,437,524 - 241,470,936 (-)NCBIGRCr8
mRatBN7.21232,024,351 - 232,057,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,024,356 - 232,057,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1240,414,292 - 240,447,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,337,140 - 247,370,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,175,338 - 240,208,560 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,816,536 - 252,959,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,816,527 - 252,849,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01260,038,180 - 260,091,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,466,493 - 238,500,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,630,381 - 238,664,124 (-)NCBI
Celera1229,136,934 - 229,170,119 (-)NCBICelera
Cytogenetic Map1q53NCBI
LIPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381089,213,572 - 89,251,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1089,213,569 - 89,414,557 (-)EnsemblGRCh38hg38GRCh38
GRCh371090,973,329 - 91,011,532 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,963,309 - 91,001,640 (-)NCBINCBI36Build 36hg18NCBI36
Build 341090,963,308 - 91,001,640NCBI
Celera1084,720,143 - 84,758,472 (-)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1084,607,788 - 84,646,145 (-)NCBIHuRef
CHM1_11091,255,383 - 91,293,719 (-)NCBICHM1_1
T2T-CHM13v2.01090,097,469 - 90,135,709 (-)NCBIT2T-CHM13v2.0
Lipa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,469,716 - 34,504,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1934,469,718 - 34,504,874 (-)EnsemblGRCm39 Ensembl
GRCm381934,492,316 - 34,527,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,492,318 - 34,527,474 (-)EnsemblGRCm38mm10GRCm38
MGSCv371934,566,806 - 34,601,964 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361934,558,313 - 34,593,419 (-)NCBIMGSCv36mm8
Celera1935,267,889 - 35,303,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.7NCBI
Lipa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554253,718,206 - 3,756,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554253,718,291 - 3,755,942 (+)NCBIChiLan1.0ChiLan1.0
LIPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28101,231,830 - 101,270,354 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110101,237,141 - 101,275,629 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01085,938,240 - 85,976,610 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11089,478,502 - 89,516,580 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,477,082 - 89,516,874 (-)Ensemblpanpan1.1panPan2
LIPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,892,771 - 38,918,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,893,337 - 38,918,436 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,643,855 - 38,671,678 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02640,476,944 - 40,504,767 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2640,476,940 - 40,505,350 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12638,347,241 - 38,375,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02637,910,947 - 37,938,676 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02639,180,692 - 39,208,434 (-)NCBIUU_Cfam_GSD_1.0
LIPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14101,126,257 - 101,193,614 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114101,131,372 - 101,254,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214110,116,088 - 110,152,009 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,639,220 - 82,677,479 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl982,638,621 - 82,677,488 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604843,315,133 - 43,353,408 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lipa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473749,371 - 83,514 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473749,471 - 82,981 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lipa
362 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:146
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000025845
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat

Markers in Region
D3Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map321.9UniSTS
RH 3.4 Map321.9RGD
Cytogenetic Map1q52UniSTS
D3Wox26   No map positions available.
D3Mgh25  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map327.2UniSTS
RH 3.4 Map327.2RGD
Cytogenetic Map1q52UniSTS
RH142813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,024,884 - 232,025,032 (+)MAPPERmRatBN7.2
Rnor_6.01252,817,070 - 252,817,217NCBIRnor6.0
Rnor_5.01260,038,714 - 260,038,861UniSTSRnor5.0
RGSC_v3.41238,467,025 - 238,467,172UniSTSRGSC3.4
Celera1229,137,466 - 229,137,613UniSTS
RH 3.4 Map4490.82UniSTS
Cytogenetic Map1q52UniSTS
RH135375  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,025,259 - 232,025,445 (+)MAPPERmRatBN7.2
Rnor_6.01252,817,445 - 252,817,630NCBIRnor6.0
Rnor_5.01260,039,089 - 260,039,274UniSTSRnor5.0
RGSC_v3.41238,467,400 - 238,467,585UniSTSRGSC3.4
Celera1229,137,841 - 229,138,026UniSTS
Cytogenetic Map1q52UniSTS
RH139563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,024,414 - 232,024,629 (+)MAPPERmRatBN7.2
Rnor_6.01252,816,600 - 252,816,814NCBIRnor6.0
Rnor_5.01260,038,244 - 260,038,458UniSTSRnor5.0
RGSC_v3.41238,466,555 - 238,466,769UniSTSRGSC3.4
Celera1229,136,996 - 229,137,210UniSTS
Cytogenetic Map1q52UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 34 11 8
Low 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025845   ⟹   ENSRNOP00000025845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1232,024,509 - 232,057,619 (-)Ensembl
Rnor_6.0 Ensembl1252,816,538 - 252,849,756 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078279   ⟹   ENSRNOP00000074398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1232,024,356 - 232,057,633 (-)Ensembl
Rnor_6.0 Ensembl1252,816,527 - 252,849,904 (-)Ensembl
RefSeq Acc Id: NM_012732   ⟹   NP_036864
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,437,524 - 241,470,740 (-)NCBI
mRatBN7.21232,024,353 - 232,057,573 (-)NCBI
Rnor_6.01252,816,538 - 252,849,756 (-)NCBI
Rnor_5.01260,038,180 - 260,091,819 (-)NCBI
RGSC_v3.41238,466,493 - 238,500,195 (-)RGD
Celera1229,136,934 - 229,170,119 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231275   ⟹   XP_006231337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,437,524 - 241,470,936 (-)NCBI
mRatBN7.21232,024,351 - 232,057,735 (-)NCBI
Rnor_6.01252,816,536 - 252,849,873 (-)NCBI
Rnor_5.01260,038,180 - 260,091,819 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036864   ⟸   NM_012732
- Peptide Label: precursor
- UniProtKB: Q64194 (UniProtKB/Swiss-Prot),   Q6IMY6 (UniProtKB/TrEMBL),   A0A0G2K7Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231337   ⟸   XM_006231275
- Peptide Label: isoform X1
- UniProtKB: Q64194 (UniProtKB/Swiss-Prot),   Q6IMY6 (UniProtKB/TrEMBL),   A0A0G2K7Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074398   ⟸   ENSRNOT00000078279
RefSeq Acc Id: ENSRNOP00000025845   ⟸   ENSRNOT00000025845
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64194-F1-model_v2 AlphaFold Q64194 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690864
Promoter ID:EPDNEW_R1389
Type:initiation region
Name:Lipa_1
Description:lipase A, lysosomal acid type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01252,849,812 - 252,849,872EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3008 AgrOrtholog
BioCyc Gene G2FUF-55873 BioCyc
BioCyc Pathway PWY-7424 [sterol:steryl ester interconversion (yeast)] BioCyc
BioCyc Pathway Image PWY-7424 BioCyc
Ensembl Genes ENSRNOG00000019077 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025845.5 UniProtKB/TrEMBL
  ENSRNOT00000078279.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099460 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25055 UniProtKB/TrEMBL
MGC_CLONE MGC:91515 IMAGE-MGC_LOAD
NCBI Gene 25055 ENTREZGENE
PANTHER LYSOSOMAL ACID LIPASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LYSOSOMAL ACID LIPASE/CHOLESTERYL ESTER HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lipa PhenoGen
PIRSF Steryl_ester_lip UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019077 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207304
UniProt A0A0G2K7Y6 ENTREZGENE, UniProtKB/TrEMBL
  F7F0N1_RAT UniProtKB/TrEMBL
  LICH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IMY6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Lipa  lipase A, lysosomal acid type  Lipa  lipase A, lysosomal acid  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Lipa  lipase A, lysosomal acid  Lipa  lipase A, lysosomal acid, cholesterol esterase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Lipa  lipase A, lysosomal acid, cholesterol esterase  Lipa  lysosomal acid lipase A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Lipa  lysosomal acid lipase A  Lip1  lysosomal acid lipase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Lip1  lysosomal acid lipase 1      Symbol and Name updated 1299863 APPROVED
2002-06-10 Lipa  lipase A, lysosomal acid      Symbol and Name status set to approved 70586 APPROVED
2001-04-10 Chole  Cholesterol esterase (pancreatic)      Symbol withdrawn, duplicate entry of Lipa (RGD:3008) 61478 WITHDRAWN
2001-04-06 Lipa  Lipase A, lysosomal acid      Name updated to reflect symbol 61478 APPROVED
2001-04-06 Lipa  Cholesterol esterase (pancreatic)      Name inconsistent with current symbol 61478 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_disease mutation in gene causing substitution of 367Ile to Asn, 368Pro to stop codon, and deletion of the C-terminal 29 amino acids results in Wolman's disease 729052
gene_homology 79.9% homology with human lysosomal acid lipase (LAL) 729052