Thap3 (THAP domain containing 3) - Rat Genome Database

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Gene: Thap3 (THAP domain containing 3) Rattus norvegicus
Analyze
Symbol: Thap3
Name: THAP domain containing 3
RGD ID: 1308109
Description: Predicted to enable DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Orthologous to human THAP3 (THAP domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362667; RGD1308109; similar to hypothetical protein FLJ10477; THAP domain containing, apoptosis associated protein 3; THAP domain-containing protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85167,771,209 - 167,776,878 (-)NCBIGRCr8
mRatBN7.25162,488,480 - 162,494,149 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,488,480 - 162,494,149 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,191,560 - 165,197,234 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,012,417 - 167,018,082 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05166,974,616 - 166,980,281 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,155,239 - 169,160,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,155,239 - 169,160,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,713,824 - 172,719,572 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,209,740 - 169,215,409 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,219,927 - 169,225,739 (-)NCBI
Celera5160,721,273 - 160,726,942 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Thap3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85167,771,209 - 167,776,878 (-)NCBIGRCr8
mRatBN7.25162,488,480 - 162,494,149 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,488,480 - 162,494,149 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,191,560 - 165,197,234 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,012,417 - 167,018,082 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05166,974,616 - 166,980,281 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,155,239 - 169,160,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,155,239 - 169,160,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,713,824 - 172,719,572 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,209,740 - 169,215,409 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15169,219,927 - 169,225,739 (-)NCBI
Celera5160,721,273 - 160,726,942 (-)NCBICelera
Cytogenetic Map5q36NCBI
THAP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,624,868 - 6,635,595 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16,624,868 - 6,635,586 (+)EnsemblGRCh38hg38GRCh38
GRCh3716,684,928 - 6,695,655 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,607,839 - 6,618,232 (+)NCBINCBI36Build 36hg18NCBI36
Build 3416,619,517 - 6,629,911NCBI
Celera15,799,113 - 5,809,502 (+)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,832,415 - 5,843,109 (+)NCBIHuRef
CHM1_116,673,648 - 6,684,364 (+)NCBICHM1_1
T2T-CHM13v2.016,150,532 - 6,161,259 (+)NCBIT2T-CHM13v2.0
Thap3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,067,095 - 152,073,443 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,067,096 - 152,073,454 (-)EnsemblGRCm39 Ensembl
GRCm384151,982,638 - 151,988,986 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4151,982,639 - 151,988,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv374151,356,747 - 151,363,095 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364150,826,439 - 150,832,797 (-)NCBIMGSCv36mm8
Celera4154,267,662 - 154,273,960 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map482.8NCBI
Thap3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554866,012,557 - 6,018,101 (-)NCBIChiLan1.0ChiLan1.0
THAP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21221,591,323 - 221,600,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,233,520 - 220,242,792 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v015,388,841 - 5,397,607 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.116,644,481 - 6,649,302 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16,644,481 - 6,649,823 (+)Ensemblpanpan1.1panPan2
THAP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,443,010 - 60,449,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,443,059 - 60,449,302 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha560,452,505 - 60,459,021 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,658,899 - 60,665,424 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,658,940 - 60,665,173 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,658,197 - 60,664,718 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,524,405 - 60,530,932 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,926,834 - 60,933,357 (+)NCBIUU_Cfam_GSD_1.0
Thap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,889,071 - 30,893,603 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366231,374,351 - 1,378,393 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366231,374,309 - 1,378,841 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THAP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,455,277 - 67,463,399 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,452,272 - 67,463,400 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,380,039 - 62,387,114 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THAP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,112,772 - 125,121,578 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,114,104 - 125,120,955 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,157,382 - 29,165,046 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thap3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248184,906,385 - 4,912,544 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248184,905,070 - 4,913,095 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thap3
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:138
Interacting mature miRNAs:166
Transcripts:ENSRNOT00000055487
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
RH130518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,488,513 - 162,488,701 (+)MAPPERmRatBN7.2
Rnor_6.05169,155,273 - 169,155,460NCBIRnor6.0
Rnor_5.05172,713,858 - 172,714,045UniSTSRnor5.0
RGSC_v3.45169,209,774 - 169,209,961UniSTSRGSC3.4
Celera5160,721,307 - 160,721,494UniSTS
RH 3.4 Map51140.1UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 35 28 13 19 13 8 11 74 35 34 11 8
Low 1 8 29 28 28 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055487   ⟹   ENSRNOP00000052352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,488,480 - 162,494,149 (-)Ensembl
Rnor_6.0 Ensembl5169,155,239 - 169,160,987 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109515   ⟹   ENSRNOP00000097984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,488,896 - 162,494,149 (-)Ensembl
RefSeq Acc Id: NM_001108695   ⟹   NP_001102165
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85167,771,209 - 167,776,878 (-)NCBI
mRatBN7.25162,488,480 - 162,494,149 (-)NCBI
Rnor_6.05169,155,239 - 169,160,987 (-)NCBI
Rnor_5.05172,713,824 - 172,719,572 (-)NCBI
RGSC_v3.45169,209,740 - 169,215,409 (-)RGD
Celera5160,721,273 - 160,726,942 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102165 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI59428 (Get FASTA)   NCBI Sequence Viewer  
  EDL81209 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052352
  ENSRNOP00000052352.2
  ENSRNOP00000097984.1
Reference Protein Sequences
RefSeq Acc Id: NP_001102165   ⟸   NM_001108695
- UniProtKB: B0K027 (UniProtKB/TrEMBL),   A6IUF8 (UniProtKB/TrEMBL),   A0A8I6GMS0 (UniProtKB/TrEMBL),   F7FBA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052352   ⟸   ENSRNOT00000055487
RefSeq Acc Id: ENSRNOP00000097984   ⟸   ENSRNOT00000109515
Protein Domains
THAP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0K027-F1-model_v2 AlphaFold B0K027 1-220 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694293
Promoter ID:EPDNEW_R4816
Type:initiation region
Name:Thap3_1
Description:THAP domain containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05169,160,912 - 169,160,972EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308109 AgrOrtholog
BioCyc Gene G2FUF-39031 BioCyc
Ensembl Genes ENSRNOG00000026840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055487 ENTREZGENE
  ENSRNOT00000055487.3 UniProtKB/TrEMBL
  ENSRNOT00000109515.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9088591 IMAGE-MGC_LOAD
InterPro THAP3 UniProtKB/TrEMBL
  Znf_C2CH UniProtKB/TrEMBL
KEGG Report rno:362667 UniProtKB/TrEMBL
MGC_CLONE MGC:188747 IMAGE-MGC_LOAD
NCBI Gene 362667 ENTREZGENE
PANTHER PTHR47120 UniProtKB/TrEMBL
  THAP DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
Pfam THAP UniProtKB/TrEMBL
PhenoGen Thap3 PhenoGen
PROSITE ZF_THAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026840 RatGTEx
SMART DM3 UniProtKB/TrEMBL
  THAP UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A8I6GMS0 ENTREZGENE, UniProtKB/TrEMBL
  A6IUF8 ENTREZGENE, UniProtKB/TrEMBL
  B0K027 ENTREZGENE
  F7FBA5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B0K027 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-23 Thap3  THAP domain containing 3  Thap3  THAP domain containing, apoptosis associated protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Thap3  THAP domain containing, apoptosis associated protein 3   Thap3_predicted  THAP domain containing, apoptosis associated protein 3 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Thap3_predicted  THAP domain containing, apoptosis associated protein 3 (predicted)  RGD1308109_predicted  similar to hypothetical protein FLJ10477 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308109_predicted  similar to hypothetical protein FLJ10477 (predicted)  LOC362667_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362667_predicted  similar to hypothetical protein FLJ10477 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL