Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | 1,1-dichloroethene | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of CLSTN1 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of CLSTN1 mRNA | CTD | PMID:22206623 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | 17beta-estradiol | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of CLSTN1 mRNA | CTD | PMID:16514628 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CLSTN1 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CLSTN1 mRNA | CTD | PMID:33387578 | 2-methylcholine | affects expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of CLSTN1 mRNA | CTD | PMID:21179406 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Clstn1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of CLSTN1 mRNA | CTD | PMID:20188158 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | CLSTN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CLSTN1 mRNA | CTD | PMID:28628672 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of CLSTN1 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Clstn1 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of CLSTN1 exon | CTD | PMID:33297965 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of CLSTN1 mRNA | CTD | PMID:31881176 | afimoxifene | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | afimoxifene results in decreased expression of CLSTN1 mRNA | CTD | PMID:16514628 | aflatoxin B1 | increases expression | ISO | Clstn1 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of CLSTN1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | CLSTN1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of CLSTN1 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | decreases methylation | ISO | CLSTN1 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of CLSTN1 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of CLSTN1 mRNA | CTD | PMID:33167477 | arsenous acid | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of CLSTN1 mRNA | CTD | PMID:22521957 | azoxystrobin | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | azoxystrobin results in decreased expression of CLSTN1 mRNA | CTD | PMID:33512557 | benzo[a]pyrene | increases expression | ISO | Clstn1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CLSTN1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | CLSTN1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CLSTN1 promoter | CTD | PMID:27901495 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of CLSTN1 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CLSTN1 mRNA | CTD | PMID:30816183 and PMID:34947998 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in decreased methylation of CLSTN1 gene | CTD | PMID:28505145 | bisphenol F | multiple interactions | ISO | CLSTN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CLSTN1 mRNA | CTD | PMID:28628672 | butan-1-ol | multiple interactions | ISO | CLSTN1 (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CLSTN1 mRNA | CTD | PMID:29432896 | caffeine | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | captan | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | Captan results in decreased expression of CLSTN1 mRNA | CTD | PMID:31558096 | carbon nanotube | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of CLSTN1 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | CLSTN1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CLSTN1 gene] | CTD | PMID:28238834 | chloropicrin | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | chloropicrin results in decreased expression of CLSTN1 mRNA | CTD | PMID:28476498 | choline | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLSTN1 mRNA | CTD | PMID:20938992 | ciguatoxin CTX1B | affects expression | ISO | Clstn1 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of CLSTN1 mRNA | CTD | PMID:18353800 | cobalt dichloride | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of CLSTN1 mRNA | CTD | PMID:19320972 | crocidolite asbestos | increases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of CLSTN1 protein | CTD | PMID:29553831 | cyclosporin A | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CLSTN1 mRNA | CTD | PMID:25562108 | dexamethasone | multiple interactions | ISO | CLSTN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CLSTN1 mRNA | CTD | PMID:28628672 | diarsenic trioxide | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of CLSTN1 mRNA | CTD | PMID:22521957 | dibutyl phthalate | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of CLSTN1 mRNA | CTD | PMID:21266533 | dioxygen | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CLSTN1 mRNA | CTD | PMID:30529165 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of CLSTN1 mRNA | CTD | PMID:29391264 | epoxiconazole | increases expression | ISO | Clstn1 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of CLSTN1 mRNA | CTD | PMID:35436446 | ethanol | affects expression | ISO | Clstn1 (Mus musculus) | 6480464 | Ethanol affects the expression of CLSTN1 mRNA | CTD | PMID:30319688 | ethanol | affects splicing | ISO | Clstn1 (Mus musculus) | 6480464 | Ethanol affects the splicing of CLSTN1 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLSTN1 mRNA | CTD | PMID:20938992 | folpet | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | folpet results in decreased expression of CLSTN1 mRNA | CTD | PMID:31558096 | fulvestrant | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | fulvestrant results in decreased expression of CLSTN1 mRNA | CTD | PMID:16514628 | genistein | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Genistein] results in decreased methylation of CLSTN1 gene | CTD | PMID:28505145 | indometacin | multiple interactions | ISO | CLSTN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CLSTN1 mRNA | CTD | PMID:28628672 | inulin | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of CLSTN1 mRNA | CTD | PMID:36331819 | L-methionine | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLSTN1 mRNA | CTD | PMID:20938992 | lead(0) | affects splicing | ISO | CLSTN1 (Homo sapiens) | 6480464 | Lead affects the splicing of CLSTN1 mRNA | CTD | PMID:28903495 | lead(0) | affects expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Lead affects the expression of CLSTN1 mRNA | CTD | PMID:28903495 | methotrexate | affects response to substance | ISO | CLSTN1 (Homo sapiens) | 6480464 | CLSTN1 protein affects the susceptibility to Methotrexate | CTD | PMID:16217747 | nicotine | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of CLSTN1 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of CLSTN1 mRNA | CTD | PMID:34911549 | paracetamol | increases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of CLSTN1 mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CLSTN1 mRNA | CTD | PMID:33387578 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of CLSTN1 mRNA | CTD | PMID:32680482 | PCB138 | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Clstn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of CLSTN1 mRNA | CTD | PMID:36331819 | picoxystrobin | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | picoxystrobin results in decreased expression of CLSTN1 mRNA | CTD | PMID:33512557 | pirinixic acid | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of CLSTN1 mRNA | CTD | PMID:17426115 | pyrimidifen | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | pyrimidifen results in decreased expression of CLSTN1 mRNA | CTD | PMID:33512557 | raloxifene | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Raloxifene Hydrochloride results in decreased expression of CLSTN1 mRNA | CTD | PMID:16514628 | rotenone | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of CLSTN1 mRNA | CTD | PMID:33512557 | silicon dioxide | affects secretion | ISO | CLSTN1 (Homo sapiens) | 6480464 | Silicon Dioxide analog affects the secretion of CLSTN1 protein | CTD | PMID:25895662 | sodium arsenite | increases expression | ISO | Clstn1 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of CLSTN1 mRNA | CTD | PMID:36209798 | tert-butyl hydroperoxide | decreases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of CLSTN1 mRNA | CTD | PMID:15336504 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of CLSTN1 mRNA | CTD | PMID:25729387 | triptonide | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | triptonide results in decreased expression of CLSTN1 mRNA | CTD | PMID:33045310 | tunicamycin | decreases expression | ISO | Clstn1 (Mus musculus) | 6480464 | Tunicamycin results in decreased expression of CLSTN1 mRNA | CTD | PMID:17127020 | urethane | increases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Urethane results in increased expression of CLSTN1 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | CLSTN1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of CLSTN1 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | CLSTN1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of CLSTN1 mRNA | CTD | PMID:23179753 more ... | |