Cimip5 (ciliary microtubule inner protein 5) - Rat Genome Database

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Gene: Cimip5 (ciliary microtubule inner protein 5) Rattus norvegicus
Analyze
Symbol: Cimip5 (Ensembl: C6h2orf50)
Name: ciliary microtubule inner protein 5 (Ensembl:similar to human chromosome 2 open reading frame 50)
RGD ID: 1582838
Description: Predicted to be located in cilium. Orthologous to human CIMIP5 (ciliary microtubule inner protein 5); INTERACTS WITH bisphenol A; 4-hydroxyphenyl retinamide (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C6h2orf50; hypothetical protein LOC690276; LOC690276; similar to human chromosome 2 open reading frame 50; uncharacterized protein C2orf50 homolog; uncharacterized protein LOC690276
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,520,575 - 45,525,810 (-)NCBIGRCr8
mRatBN7.2639,792,416 - 39,797,072 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,790,913 - 39,797,090 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx640,123,403 - 40,129,555 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,438,112 - 40,444,264 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0639,871,401 - 39,877,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,306,788 - 42,313,322 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,306,788 - 42,312,935 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0652,026,112 - 52,032,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4640,692,672 - 40,698,799 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera639,098,911 - 39,105,046 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cimip5Rat4-hydroxyphenyl retinamide increases expressionISOCimip5 (Mus musculus)6480464Fenretinide results in increased expression of CIMIP5 mRNACTDPMID:28973697
Cimip5Ratbenzo[a]pyrene decreases methylationISOCIMIP5 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of CIMIP5 3' UTR and Benzo(a)pyrene results in decreased methylation of CIMIP5 exonCTDPMID:27901495
Cimip5Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of CIMIP5 mRNACTDPMID:25181051
Cimip5Ratfolic acid increases expressionISOCIMIP5 (Homo sapiens)6480464Folic Acid results in increased expression of CIMIP5 mRNACTDPMID:21867686
Cimip5Ratvalproic acid increases methylationISOCIMIP5 (Homo sapiens)6480464Valproic Acid results in increased methylation of CIMIP5 geneCTDPMID:29154799


Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cimip5Ratcilium located_inISOCIMIP5 (Homo sapiens)1624291 PMID:38538594RGDPMID:38538594
Cimip5Ratcilium located_inIEAUniProtKB:Q96LR7 and ensembl:ENSP000003709971600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cimip5Ratprotein binding enablesISOCIMIP5 (Homo sapiens)1624291UniProtKB:O15217 more ...RGDPMID:25416956 and PMID:32296183


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Cimip5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,520,575 - 45,525,810 (-)NCBIGRCr8
mRatBN7.2639,792,416 - 39,797,072 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,790,913 - 39,797,090 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx640,123,403 - 40,129,555 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,438,112 - 40,444,264 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0639,871,401 - 39,877,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,306,788 - 42,313,322 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,306,788 - 42,312,935 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0652,026,112 - 52,032,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4640,692,672 - 40,698,799 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera639,098,911 - 39,105,046 (-)NCBICelera
Cytogenetic Map6q16NCBI
CIMIP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38211,133,128 - 11,154,576 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl211,133,128 - 11,151,317 (+)EnsemblGRCh38hg38GRCh38
GRCh37211,273,254 - 11,291,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36211,190,630 - 11,203,603 (+)NCBINCBI36Build 36hg18NCBI36
Celera211,188,994 - 11,202,728 (+)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef211,123,012 - 11,136,737 (+)NCBIHuRef
CHM1_1211,202,785 - 11,216,519 (+)NCBICHM1_1
T2T-CHM13v2.0211,162,478 - 11,183,718 (+)NCBIT2T-CHM13v2.0
Cimip5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391217,054,958 - 17,061,759 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1217,053,320 - 17,061,728 (-)EnsemblGRCm39 Ensembl
GRCm381217,004,958 - 17,011,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1217,003,319 - 17,011,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv371217,011,764 - 17,018,533 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361217,031,070 - 17,079,436 (-)NCBIMGSCv36mm8
Celera1217,328,730 - 17,372,814 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map128.04NCBI
Cimip5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554875,843,411 - 5,847,738 (+)NCBIChiLan1.0ChiLan1.0
CIMIP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212115,371,785 - 115,393,592 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A115,375,754 - 115,397,563 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A11,122,309 - 11,143,343 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A11,272,390 - 11,286,375 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A11,272,390 - 11,286,375 (+)Ensemblpanpan1.1panPan2
C17H2orf50
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,898,117 - 7,906,038 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,898,070 - 7,905,270 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,830,014 - 7,838,143 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0178,000,947 - 8,009,095 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl178,000,670 - 8,008,286 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,886,187 - 7,894,315 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,889,300 - 7,897,594 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,909,392 - 7,917,685 (+)NCBIUU_Cfam_GSD_1.0
Cimip5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629252,359,603 - 52,369,327 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365327,114,921 - 7,121,405 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365327,115,070 - 7,121,433 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIMIP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.13125,520,922 - 125,526,031 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23134,183,959 - 134,193,660 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CIMIP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11496,475,769 - 96,489,392 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1496,479,073 - 96,488,991 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604515,792,719 - 15,804,261 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cimip5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,600,267 - 4,602,927 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,597,333 - 4,602,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Cimip5
21 total Variants

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:57
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000033550
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63432335751121479Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat

1 to 10 of 34 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 49 113 76 75 44 25 44 6 197 94 93 45 54 31



Ensembl Acc Id: ENSRNOT00000033550   ⟹   ENSRNOP00000030116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl639,790,913 - 39,797,090 (-)Ensembl
Rnor_6.0 Ensembl642,306,788 - 42,312,915 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081004   ⟹   ENSRNOP00000071438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl642,308,738 - 42,312,935 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096580   ⟹   ENSRNOP00000096787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl639,791,848 - 39,797,040 (-)Ensembl
RefSeq Acc Id: NM_001415120   ⟹   NP_001402049
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,521,154 - 45,525,810 (-)NCBI
mRatBN7.2639,792,416 - 39,797,072 (-)NCBI
RefSeq Acc Id: XM_063262519   ⟹   XP_063118589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,520,575 - 45,525,803 (-)NCBI
Protein RefSeqs NP_001402049 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118589 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03144 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030116
  ENSRNOP00000030116.4
  ENSRNOP00000096787
  ENSRNOP00000096787.1
Ensembl Acc Id: ENSRNOP00000030116   ⟸   ENSRNOT00000033550
Ensembl Acc Id: ENSRNOP00000071438   ⟸   ENSRNOT00000081004
Ensembl Acc Id: ENSRNOP00000096787   ⟸   ENSRNOT00000096580
RefSeq Acc Id: NP_001402049   ⟸   NM_001415120
- UniProtKB: D4A5F3 (UniProtKB/TrEMBL),   A6HAU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118589   ⟸   XM_063262519
- Peptide Label: isoform X1
- UniProtKB: D4A5F3 (UniProtKB/TrEMBL),   A0A8I6ATY8 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-D4A5F3-F1-model_v2 AlphaFold D4A5F3 1-148 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694510
Promoter ID:EPDNEW_R5031
Type:multiple initiation site
Name:LOC690276_1
Description:hypothetical protein LOC690276
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0642,312,947 - 42,313,007EPDNEW


1 to 16 of 16 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38060 BioCyc
Ensembl Genes ENSRNOG00000024338 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033550 ENTREZGENE
  ENSRNOT00000033550.5 UniProtKB/TrEMBL
  ENSRNOT00000096580 ENTREZGENE
  ENSRNOT00000096580.1 UniProtKB/TrEMBL
InterPro Uncharacterised_C20orf85 UniProtKB/TrEMBL
NCBI Gene 690276 ENTREZGENE
PANTHER CHROMOSOME 20 ORF85 FAMILY MEMBER UniProtKB/TrEMBL
  RIKEN CDNA 2410004P03 GENE UniProtKB/TrEMBL
Pfam LLC1 UniProtKB/TrEMBL
PhenoGen Cimip5 PhenoGen
RatGTEx ENSRNOG00000024338 RatGTEx
UniProt A0A8I6ATY8 ENTREZGENE, UniProtKB/TrEMBL
  A6HAU0 ENTREZGENE, UniProtKB/TrEMBL
  D4A5F3 ENTREZGENE, UniProtKB/TrEMBL
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-11-01 Cimip5  ciliary microtubule inner protein 5  C6h2orf50  similar to human chromosome 2 open reading frame 50  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-07-21 C6h2orf50  similar to human chromosome 2 open reading frame 50  LOC690276  hypothetical protein LOC690276  Name and Symbol changed 629549 APPROVED
2008-01-09 LOC690276  hypothetical protein LOC690276  LOC686463  hypothetical protein LOC686463  Data merged from RGD:1597621 1643240 APPROVED
2006-11-20 LOC686463  hypothetical protein LOC686463      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690276  hypothetical protein LOC690276      Symbol and Name status set to provisional 70820 PROVISIONAL