Or10s1 (olfactory receptor family 10 subfamily S member 1) - Rat Genome Database

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Gene: Or10s1 (olfactory receptor family 10 subfamily S member 1) Rattus norvegicus
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Symbol: Or10s1
Name: olfactory receptor family 10 subfamily S member 1
RGD ID: 1333299
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be active in plasma membrane. Orthologous to human OR10S1 (olfactory receptor family 10 subfamily S member 1); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1337; olfactory receptor gene Olr1337; olfactory receptor Olr1337; Olr1337; ratchr8-42975013-42975966_ORF
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8849,274,175 - 49,275,225 (+)NCBIGRCr8
mRatBN7.2840,377,018 - 40,378,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl840,377,103 - 40,378,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx845,861,309 - 45,862,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0844,145,361 - 44,146,314 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0842,007,501 - 42,008,454 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0843,872,728 - 43,873,681 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl843,872,728 - 43,873,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0861,647,010 - 61,647,963 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4842,966,247 - 42,967,200 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1842,975,012 - 42,975,966 (+)NCBI
Celera840,001,975 - 40,002,928 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10s1Ratchromosome 11 partial duplication syndrome  ISOOR10S1 (Homo sapiens)8554872ClinVar Annotator: match by term: Distal trisomy 11qClinVarPMID:25741868
Or10s1RatDwarfism  ISOOR10S1 (Homo sapiens)8554872ClinVar Annotator: match by term: Short statureClinVarPMID:32581362
Or10s1Ratholoprosencephaly 11  ISOOR10S1 (Homo sapiens)8554872ClinVar Annotator: match by term: Holoprosencephaly 11ClinVarPMID:28492532
Or10s1Ratschizophrenia  ISOOR10S1 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311

1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10s1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOOr10s1 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Or10s1Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOOr10s1 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Or10s1Rat2,2',5,5'-tetrachlorobiphenyl affects expressionEXP 64804642 more ...CTDPMID:23829299
Or10s1Rat2-palmitoylglycerol increases expressionISOOR10S1 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of OR10S1 mRNACTDPMID:37199045
Or10s1Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of OR10S1 mRNACTDPMID:24780913
Or10s1Ratbenzo[a]pyrene increases methylationISOOR10S1 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of OR10S1 exon and Benzo(a)pyrene results in increased methylation of OR10S1 promoterCTDPMID:27901495
Or10s1Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of OR10S1 mRNACTDPMID:25181051
Or10s1Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of OR10S1 geneCTDPMID:28505145
Or10s1RatCGP 52608 multiple interactionsISOOR10S1 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to OR10S1 gene]CTDPMID:28238834
Or10s1RatPCB138 multiple interactionsISOOr10s1 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Or10s1RatPCB138 decreases expressionEXP 64804642 more ...CTDPMID:23829299
Or10s1Ratsodium arsenite decreases expressionISOOR10S1 (Homo sapiens)6480464sodium arsenite results in decreased expression of OR10S1 mRNACTDPMID:34032870

1 to 12 of 12 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10s1Ratdetection of chemical stimulus involved in sensory perception of smell involved_inIBAMGI:106182 and PANTHER:PTN0028180001600115GO_REF:0000033GO_CentralGO_REF:0000033
Or10s1Ratdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or10s1RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or10s1RatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or10s1Ratsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or10s1Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10s1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or10s1Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or10s1Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or10s1Ratplasma membrane is_active_inIBAMGI:106648 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or10s1Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10s1RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or10s1Ratolfactory receptor activity enablesIBAMGI:106182 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or10s1Ratolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or10s1Ratolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or10s1Rattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Or10s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8849,274,175 - 49,275,225 (+)NCBIGRCr8
mRatBN7.2840,377,018 - 40,378,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl840,377,103 - 40,378,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx845,861,309 - 45,862,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0844,145,361 - 44,146,314 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0842,007,501 - 42,008,454 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0843,872,728 - 43,873,681 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl843,872,728 - 43,873,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0861,647,010 - 61,647,963 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4842,966,247 - 42,967,200 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1842,975,012 - 42,975,966 (+)NCBI
Celera840,001,975 - 40,002,928 (+)NCBICelera
Cytogenetic Map8q22NCBI
OR10S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811123,976,661 - 123,977,781 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11123,976,661 - 123,977,781 (-)EnsemblGRCh38hg38GRCh38
GRCh3711123,847,368 - 123,848,488 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611123,352,613 - 123,353,608 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411123,352,612 - 123,353,608NCBI
Celera11121,006,598 - 121,007,593 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11119,788,191 - 119,789,186 (-)NCBIHuRef
CHM1_111123,733,565 - 123,734,560 (-)NCBICHM1_1
T2T-CHM13v2.011124,005,286 - 124,006,406 (-)NCBIT2T-CHM13v2.0
Or10s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39939,985,593 - 39,986,558 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl939,985,125 - 39,990,700 (+)EnsemblGRCm39 Ensembl
GRCm38940,074,297 - 40,075,262 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,073,829 - 40,079,404 (+)EnsemblGRCm38mm10GRCm38
MGSCv37939,881,882 - 39,882,847 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36939,824,868 - 39,825,833 (+)NCBIMGSCv36mm8
Celera937,313,177 - 37,314,142 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.36NCBI
LOC100970443
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29124,673,549 - 124,674,514 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111125,778,019 - 125,778,984 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011118,805,119 - 118,806,084 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111122,722,014 - 122,722,979 (-)NCBIpanpan1.1PanPan1.1panPan2
OR10S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1510,509,352 - 10,510,380 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl510,509,385 - 10,510,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha510,565,627 - 10,566,655 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0510,458,618 - 10,459,646 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl510,458,651 - 10,459,646 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1510,525,522 - 10,526,550 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0510,494,179 - 10,495,207 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0510,539,927 - 10,540,955 (+)NCBIUU_Cfam_GSD_1.0
LOC101964472
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947105,451,074 - 105,452,063 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365428,372,483 - 8,373,478 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365428,372,483 - 8,373,472 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100512247
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl950,909,148 - 50,910,113 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1950,909,148 - 50,910,125 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2956,139,991 - 56,140,986 (-)NCBISscrofa10.2Sscrofa10.2susScr3

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Variants in Or10s1
6 total Variants

1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat

1 to 10 of 54 rows



ectoderm
endocrine system
nervous system
reproductive system
2 1 2 7



Ensembl Acc Id: ENSRNOT00000079702   ⟹   ENSRNOP00000069537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl840,377,103 - 40,378,068 (+)Ensembl
Rnor_6.0 Ensembl843,872,728 - 43,873,681 (+)Ensembl
RefSeq Acc Id: NM_001000480   ⟹   NP_001000480
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,274,272 - 49,275,225 (+)NCBI
mRatBN7.2840,377,115 - 40,378,068 (+)NCBI
Rnor_6.0843,872,728 - 43,873,681 (+)NCBI
Rnor_5.0861,647,010 - 61,647,963 (-)NCBI
RGSC_v3.4842,966,247 - 42,967,200 (+)RGD
Celera840,001,975 - 40,002,928 (+)RGD
Sequence:
RefSeq Acc Id: XM_039081028   ⟹   XP_038936956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,274,175 - 49,275,225 (+)NCBI
mRatBN7.2840,377,018 - 40,378,068 (+)NCBI
Protein RefSeqs NP_001000480 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936956 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95216 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069537
  ENSRNOP00000069537.2
RefSeq Acc Id: NP_001000480   ⟸   NM_001000480
- UniProtKB: A0A0G2JVM1 (UniProtKB/TrEMBL),   A6J3P3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069537   ⟸   ENSRNOT00000079702
RefSeq Acc Id: XP_038936956   ⟸   XM_039081028
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVM1 (UniProtKB/TrEMBL),   A6J3P3 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVM1-F1-model_v2 AlphaFold A0A0G2JVM1 1-317 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 19 of 19 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-30853 BioCyc
Ensembl Genes ENSRNOG00000058978 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079702 ENTREZGENE
  ENSRNOT00000079702.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
NCBI Gene 300637 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or10s1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058978 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0G2JVM1 ENTREZGENE, UniProtKB/TrEMBL
  A6J3P3 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or10s1  olfactory receptor family 10 subfamily S member 1  Olr1337  olfactory receptor 1337  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1337  olfactory receptor 1337   Olr1337_predicted  olfactory receptor 1337 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1337_predicted  olfactory receptor 1337 (predicted)      Symbol and Name status set to approved 70820 APPROVED