MZF1-AS1 (MZF1 antisense RNA 1) - Rat Genome Database

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Gene: MZF1-AS1 (MZF1 antisense RNA 1) Homo sapiens
Analyze
Symbol: MZF1-AS1
Name: MZF1 antisense RNA 1
RGD ID: 9479263
HGNC Page HGNC:51271
Description: INTERACTS WITH acrylamide; aristolochic acid A; chlorpyrifos
Type: ncrna (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381958,559,186 - 58,574,797 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1958,559,125 - 58,574,797 (+)EnsemblGRCh38hg38GRCh38
GRCh371959,070,553 - 59,086,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361963,765,117 - 63,776,781 (+)NCBINCBI36Build 36hg18NCBI36
Celera1956,113,771 - 56,128,903 (+)NCBICelera
Cytogenetic Map19q13.43NCBI
HuRef1955,380,761 - 55,396,367 (+)NCBIHuRef
CHM1_11959,064,382 - 59,079,994 (+)NCBICHM1_1
T2T-CHM13v2.01961,656,863 - 61,672,475 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12477932   PMID:16344560  


Genomics

Variants

.
Variants in MZF1-AS1
39 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.43(chr19:58548841-58581203)x3 copy number gain See cases [RCV000133726] Chr19:58548841..58581203 [GRCh38]
Chr19:59060208..59092570 [GRCh37]
Chr19:63752020..63784382 [NCBI36]
Chr19:19q13.43		 benign
GRCh38/hg38 19q13.41-13.43(chr19:52612432-58581203)x3 copy number gain See cases [RCV000134174] Chr19:52612432..58581203 [GRCh38]
Chr19:53115685..59092570 [GRCh37]
Chr19:57807497..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:52955056-58581203)x3 copy number gain See cases [RCV000134139] Chr19:52955056..58581203 [GRCh38]
Chr19:53458309..59092570 [GRCh37]
Chr19:58150121..63784382 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.43(chr19:58407283-58581129)x1 copy number loss See cases [RCV000135198] Chr19:58407283..58581129 [GRCh38]
Chr19:58918650..59092496 [GRCh37]
Chr19:63610462..63784308 [NCBI36]
Chr19:19q13.43		 likely benign
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.43(chr19:56363208-58581203)x3 copy number gain See cases [RCV000052927] Chr19:56363208..58581203 [GRCh38]
Chr19:56874577..59092570 [GRCh37]
Chr19:61566389..63784382 [NCBI36]
Chr19:19q13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
NM_198055.2(MZF1):c.2051C>A (p.Pro684His) single nucleotide variant not specified [RCV004317360] Chr19:58562226 [GRCh38]
Chr19:59073593 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.471A>C (p.Glu157Asp) single nucleotide variant not specified [RCV004296382] Chr19:58570453 [GRCh38]
Chr19:59081820 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1708G>T (p.Ala570Ser) single nucleotide variant not specified [RCV004310586] Chr19:58562569 [GRCh38]
Chr19:59073936 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.789A>G (p.Leu263=) single nucleotide variant not provided [RCV000968400] Chr19:58563488 [GRCh38]
Chr19:59074855 [GRCh37]
Chr19:19q13.43		 benign
NM_198055.2(MZF1):c.1907A>T (p.Gln636Leu) single nucleotide variant not specified [RCV004286353] Chr19:58562370 [GRCh38]
Chr19:59073737 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1427C>T (p.Pro476Leu) single nucleotide variant not specified [RCV004301690] Chr19:58562850 [GRCh38]
Chr19:59074217 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.875T>G (p.Ile292Ser) single nucleotide variant not provided [RCV000891254] Chr19:58563402 [GRCh38]
Chr19:59074769 [GRCh37]
Chr19:19q13.43		 benign
NM_198055.2(MZF1):c.1064G>A (p.Gly355Asp) single nucleotide variant not specified [RCV004293352] Chr19:58563213 [GRCh38]
Chr19:59074580 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1540G>C (p.Gly514Arg) single nucleotide variant not specified [RCV004208522] Chr19:58562737 [GRCh38]
Chr19:59074104 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1037C>T (p.Pro346Leu) single nucleotide variant not specified [RCV004233817] Chr19:58563240 [GRCh38]
Chr19:59074607 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1007G>A (p.Arg336His) single nucleotide variant not specified [RCV004215030] Chr19:58563270 [GRCh38]
Chr19:59074637 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1243G>A (p.Gly415Ser) single nucleotide variant not specified [RCV004150026] Chr19:58563034 [GRCh38]
Chr19:59074401 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1730C>A (p.Ala577Asp) single nucleotide variant not specified [RCV004218696] Chr19:58562547 [GRCh38]
Chr19:59073914 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1932G>T (p.Gln644His) single nucleotide variant not specified [RCV004170401] Chr19:58562345 [GRCh38]
Chr19:59073712 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.914T>C (p.Leu305Pro) single nucleotide variant not specified [RCV004136876] Chr19:58563363 [GRCh38]
Chr19:59074730 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1504G>A (p.Glu502Lys) single nucleotide variant not specified [RCV004125060] Chr19:58562773 [GRCh38]
Chr19:59074140 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1511A>T (p.Gln504Leu) single nucleotide variant not specified [RCV004081938] Chr19:58562766 [GRCh38]
Chr19:59074133 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1028G>T (p.Arg343Leu) single nucleotide variant not specified [RCV004153221] Chr19:58563249 [GRCh38]
Chr19:59074616 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.803C>A (p.Ala268Glu) single nucleotide variant not specified [RCV004089515] Chr19:58563474 [GRCh38]
Chr19:59074841 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.790G>C (p.Gly264Arg) single nucleotide variant not specified [RCV004174632] Chr19:58563487 [GRCh38]
Chr19:59074854 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.2188G>C (p.Val730Leu) single nucleotide variant not specified [RCV004229113] Chr19:58562089 [GRCh38]
Chr19:59073456 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.942A>C (p.Glu314Asp) single nucleotide variant not specified [RCV004203521] Chr19:58563335 [GRCh38]
Chr19:59074702 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.290C>T (p.Pro97Leu) single nucleotide variant not specified [RCV004107058] Chr19:58571100 [GRCh38]
Chr19:59082467 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.338A>G (p.Glu113Gly) single nucleotide variant not specified [RCV004101962] Chr19:58571052 [GRCh38]
Chr19:59082419 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1243G>C (p.Gly415Arg) single nucleotide variant not specified [RCV004179070] Chr19:58563034 [GRCh38]
Chr19:59074401 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1303A>G (p.Thr435Ala) single nucleotide variant not specified [RCV004217077] Chr19:58562974 [GRCh38]
Chr19:59074341 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.920T>C (p.Leu307Pro) single nucleotide variant not specified [RCV004201478] Chr19:58563357 [GRCh38]
Chr19:59074724 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1678C>T (p.Arg560Trp) single nucleotide variant not specified [RCV004148766] Chr19:58562599 [GRCh38]
Chr19:59073966 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1344C>G (p.Ser448Arg) single nucleotide variant not specified [RCV004279357] Chr19:58562933 [GRCh38]
Chr19:59074300 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.2149C>G (p.Arg717Gly) single nucleotide variant not specified [RCV004254291] Chr19:58562128 [GRCh38]
Chr19:59073495 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.812G>T (p.Gly271Val) single nucleotide variant not specified [RCV004352604] Chr19:58563465 [GRCh38]
Chr19:59074832 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1333T>A (p.Cys445Ser) single nucleotide variant not specified [RCV004355398] Chr19:58562944 [GRCh38]
Chr19:59074311 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1614G>T (p.Glu538Asp) single nucleotide variant not specified [RCV004346309] Chr19:58562663 [GRCh38]
Chr19:59074030 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.323G>C (p.Arg108Pro) single nucleotide variant not specified [RCV004348458] Chr19:58571067 [GRCh38]
Chr19:59082434 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1455T>G (p.Phe485Leu) single nucleotide variant not specified [RCV004341363] Chr19:58562822 [GRCh38]
Chr19:59074189 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1976G>A (p.Gly659Asp) single nucleotide variant not specified [RCV004343171] Chr19:58562301 [GRCh38]
Chr19:59073668 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1615C>T (p.Arg539Trp) single nucleotide variant not specified [RCV004346310] Chr19:58562662 [GRCh38]
Chr19:59074029 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1584G>A (p.Leu528=) single nucleotide variant not provided [RCV003407146] Chr19:58562693 [GRCh38]
Chr19:59074060 [GRCh37]
Chr19:19q13.43		 likely benign
NM_198055.2(MZF1):c.1436C>T (p.Pro479Leu) single nucleotide variant not specified [RCV004460717] Chr19:58562841 [GRCh38]
Chr19:59074208 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1685T>C (p.Ile562Thr) single nucleotide variant not specified [RCV004460743] Chr19:58562592 [GRCh38]
Chr19:59073959 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1031G>A (p.Gly344Asp) single nucleotide variant not specified [RCV004460673] Chr19:58563246 [GRCh38]
Chr19:59074613 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1162G>C (p.Glu388Gln) single nucleotide variant not specified [RCV004460686] Chr19:58563115 [GRCh38]
Chr19:59074482 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1272C>G (p.Ser424Arg) single nucleotide variant not specified [RCV004460704] Chr19:58563005 [GRCh38]
Chr19:59074372 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1450C>T (p.Pro484Ser) single nucleotide variant not specified [RCV004460719] Chr19:58562827 [GRCh38]
Chr19:59074194 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.115G>A (p.Gly39Ser) single nucleotide variant not specified [RCV004460683] Chr19:58571275 [GRCh38]
Chr19:59082642 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1484C>T (p.Ala495Val) single nucleotide variant not specified [RCV004460723] Chr19:58562793 [GRCh38]
Chr19:59074160 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1787C>G (p.Pro596Arg) single nucleotide variant not specified [RCV004460748] Chr19:58562490 [GRCh38]
Chr19:59073857 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.2109C>A (p.His703Gln) single nucleotide variant not specified [RCV004460759] Chr19:58562168 [GRCh38]
Chr19:59073535 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.388C>T (p.Arg130Trp) single nucleotide variant not specified [RCV004460780] Chr19:58571002 [GRCh38]
Chr19:59082369 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.11C>T (p.Ala4Val) single nucleotide variant not specified [RCV004460689] Chr19:58571379 [GRCh38]
Chr19:59082746 [GRCh37]
Chr19:19q13.43		 uncertain significance
NM_198055.2(MZF1):c.1523C>A (p.Thr508Lys) single nucleotide variant not specified [RCV004460730] Chr19:58562754 [GRCh38]
Chr19:59074121 [GRCh37]
Chr19:19q13.43		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:961
Count of miRNA genes:627
Interacting mature miRNAs:709
Transcripts:ENST00000593642, ENST00000600534, ENST00000600726
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 12 15 3 19 3 5 5 15 1 23 36 1
Low 2409 2383 1674 593 1450 435 4246 2012 3569 406 1421 1564 169 1192 2698 4
Below cutoff 11 599 34 26 476 26 104 176 124 10 4 8 12 90

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000593642
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1958,559,129 - 58,570,584 (+)Ensembl
RefSeq Acc Id: ENST00000600534
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1958,559,225 - 58,574,797 (+)Ensembl
RefSeq Acc Id: ENST00000600726
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1958,559,186 - 58,571,029 (+)Ensembl
RefSeq Acc Id: ENST00000653470
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1958,559,209 - 58,573,114 (+)Ensembl
RefSeq Acc Id: ENST00000661912
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1958,559,160 - 58,560,279 (+)Ensembl
RefSeq Acc Id: ENST00000692455
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1958,559,125 - 58,560,357 (+)Ensembl
RefSeq Acc Id: ENST00000692537
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1958,559,151 - 58,560,357 (+)Ensembl
RefSeq Acc Id: NR_027334
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381958,559,186 - 58,574,797 (+)NCBI
HuRef1955,380,761 - 55,396,367 (+)NCBI
CHM1_11959,064,382 - 59,079,994 (+)NCBI
T2T-CHM13v2.01961,656,863 - 61,672,475 (+)NCBI
Sequence:
Promoters
RGD ID:15097253
Promoter ID:EPDNEWNC_H2085
Type:initiation region
Name:MZF1-AS1_1
Description:MZF1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51271]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381958,559,154 - 58,559,214EPDNEWNC

Additional Information

Database Acc Id Source(s)
COSMIC MZF1-AS1 COSMIC
Ensembl Genes ENSG00000267858 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000600534 ENTREZGENE
GTEx ENSG00000267858 GTEx
HGNC ID HGNC:51271 ENTREZGENE
Human Proteome Map MZF1-AS1 Human Proteome Map
NCBI Gene MZF1-AS1 ENTREZGENE
RNAcentral URS000075B500 RNACentral