Pkp1 (plakophilin 1) - Rat Genome Database

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Gene: Pkp1 (plakophilin 1) Chinchilla lanigera
Analyze
Symbol: Pkp1
Name: plakophilin 1
RGD ID: 9018760
Description: ENCODES a protein that exhibits lamin binding (ortholog); INVOLVED IN intermediate filament bundle assembly (ortholog); negative regulation of mRNA catabolic process (ortholog); positive regulation of gene expression (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); Ectodermal Dysplasia-Skin Fragility Syndrome (ortholog); familial adult myoclonic epilepsy 5 (ortholog); FOUND IN cornified envelope (ortholog); desmosome (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); plakophilin-1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,419,856 - 37,465,655 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540637,420,019 - 37,465,588 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Pkp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,419,856 - 37,465,655 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540637,420,019 - 37,465,588 (+)NCBIChiLan1.0ChiLan1.0
PKP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,283,506 - 201,332,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,283,452 - 201,332,993 (+)EnsemblGRCh38hg38GRCh38
GRCh371201,252,634 - 201,302,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,519,203 - 199,568,740 (+)NCBINCBI36Build 36hg18NCBI36
Celera1174,376,403 - 174,425,974 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,418,808 - 172,468,387 (+)NCBIHuRef
CHM1_11202,674,744 - 202,724,331 (+)NCBICHM1_1
T2T-CHM13v2.01200,541,289 - 200,590,813 (+)NCBIT2T-CHM13v2.0
Pkp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,799,132 - 135,846,945 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,799,133 - 135,846,945 (-)EnsemblGRCm39 Ensembl
GRCm381135,871,394 - 135,919,207 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,871,395 - 135,919,207 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,767,972 - 137,815,601 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,687,806 - 137,735,435 (-)NCBIMGSCv36mm8
Celera1138,506,279 - 138,553,622 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.35NCBI
Pkp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,861,340 - 49,909,162 (-)NCBIGRCr8
mRatBN7.21347,309,607 - 47,357,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,309,614 - 47,357,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,917,668 - 49,965,528 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,205,725 - 51,253,592 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,468,998 - 48,517,003 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,705,174 - 52,753,089 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,705,174 - 52,752,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,753,232 - 57,800,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,910,028 - 48,958,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,924,070 - 48,973,030 (-)NCBI
Celera1347,626,371 - 47,674,244 (-)NCBICelera
Cytogenetic Map13q13NCBI
PKP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2148,049,593 - 48,099,255 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1148,013,571 - 48,063,272 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01176,881,154 - 176,930,814 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11181,182,829 - 181,232,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1181,182,829 - 181,232,347 (+)Ensemblpanpan1.1panPan2
PKP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.171,921,143 - 1,966,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl71,921,143 - 1,967,703 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,602,267 - 1,648,044 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.071,559,536 - 1,605,354 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl71,559,536 - 1,605,354 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.171,547,384 - 1,593,191 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,655,145 - 1,700,910 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,679,800 - 1,725,628 (-)NCBIUU_Cfam_GSD_1.0
Pkp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,855,210 - 73,903,643 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365673,089,881 - 3,138,331 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365673,089,902 - 3,138,252 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1023,689,380 - 23,735,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11023,689,394 - 23,735,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,237,387 - 28,276,472 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PKP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12528,083,358 - 28,129,356 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2528,081,983 - 28,128,173 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,880,279 - 28,925,618 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pkp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248079,372,099 - 9,419,067 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248079,374,206 - 9,419,075 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000018242   ⟹   ENSCLAP00000018064
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540637,419,856 - 37,465,655 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000018243   ⟹   ENSCLAP00000018065
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540637,419,856 - 37,465,655 (+)Ensembl
RefSeq Acc Id: XM_005375169   ⟹   XP_005375226
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540637,420,019 - 37,465,588 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005375226 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018064.1
  ENSCLAP00000018065
  ENSCLAP00000018065.1
Reference Protein Sequences
RefSeq Acc Id: XP_005375226   ⟸   XM_005375169
- UniProtKB: A0A8C2YRJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000018065   ⟸   ENSCLAT00000018243
RefSeq Acc Id: ENSCLAP00000018064   ⟸   ENSCLAT00000018242


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012392 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018242.1 UniProtKB/TrEMBL
  ENSCLAT00000018243 ENTREZGENE
  ENSCLAT00000018243.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Plakophilin/d_Catenin UniProtKB/TrEMBL
NCBI Gene Pkp1 ENTREZGENE
PANTHER PTHR10372 UniProtKB/TrEMBL
  PTHR10372:SF3 UniProtKB/TrEMBL
Pfam Arm UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/TrEMBL
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A8C2YRJ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Pkp1  plakophilin 1    plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)  Symbol and/or name change 5135510 APPROVED