Fstl4 (follistatin like 4) - Rat Genome Database

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Gene: Fstl4 (follistatin like 4) Chinchilla lanigera
Analyze
Symbol: Fstl4
Name: follistatin like 4
RGD ID: 9012440
Description: ENCODES a protein that exhibits brain-derived neurotrophic factor binding (ortholog); INVOLVED IN negative regulation of axon extension (ortholog); negative regulation of brain-derived neurotrophic factor receptor signaling pathway (ortholog); negative regulation of collateral sprouting (ortholog); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN secretory granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: follistatin-like 4; follistatin-related protein 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,522,031 - 4,898,690 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,521,922 - 4,898,697 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fstl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,522,031 - 4,898,690 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,521,922 - 4,898,697 (-)NCBIChiLan1.0ChiLan1.0
FSTL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385133,196,455 - 133,842,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5133,196,455 - 133,612,541 (-)EnsemblGRCh38hg38GRCh38
GRCh375132,532,147 - 132,948,232 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,560,051 - 132,976,122 (-)NCBINCBI36Build 36hg18NCBI36
Celera5128,660,188 - 129,071,771 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,723,604 - 128,135,825 (-)NCBIHuRef
CHM1_15131,965,487 - 132,380,818 (-)NCBICHM1_1
T2T-CHM13v2.05133,716,210 - 134,365,647 (-)NCBIT2T-CHM13v2.0
Fstl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,655,320 - 53,083,277 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,655,461 - 53,079,365 (+)EnsemblGRCm39 Ensembl
GRCm381152,764,489 - 53,192,450 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,764,634 - 53,188,538 (+)EnsemblGRCm38mm10GRCm38
MGSCv371152,578,208 - 53,000,849 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361152,608,129 - 53,030,770 (+)NCBIMGSCv36mm8
Celera1157,342,639 - 57,767,017 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.86NCBI
Fstl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81037,412,288 - 37,845,405 (+)NCBIGRCr8
mRatBN7.21036,911,422 - 37,344,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,911,420 - 37,338,588 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1041,604,194 - 42,031,429 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,094,180 - 41,521,446 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01036,597,935 - 37,025,179 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,104,344 - 38,532,216 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,104,558 - 38,532,196 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,877,767 - 38,314,006 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,190,597 - 38,635,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,196,029 - 38,642,071 (+)NCBI
Celera1036,261,450 - 36,687,189 (+)NCBICelera
Cytogenetic Map10q22NCBI
FSTL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24128,501,372 - 128,911,889 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,640,933 - 127,051,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,606,171 - 129,016,734 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,764,310 - 135,171,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,766,944 - 135,163,711 (-)Ensemblpanpan1.1panPan2
FSTL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,453,982 - 21,850,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,458,678 - 21,856,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1120,263,099 - 20,590,135 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01122,253,158 - 22,646,541 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,250,466 - 22,644,782 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,959,653 - 21,352,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,817,666 - 21,210,744 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01121,460,502 - 21,853,816 (-)NCBIUU_Cfam_GSD_1.0
Fstl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213114,780,303 - 114,998,812 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366471,606,731 - 1,995,738 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366471,783,065 - 1,997,203 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSTL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,488,563 - 136,096,787 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,486,885 - 136,096,939 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22141,008,905 - 141,041,306 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FSTL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,005,475 - 36,423,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2336,011,179 - 36,217,708 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603441,515,669 - 41,933,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fstl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473338,577,921 - 38,947,430 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473338,339,826 - 38,952,595 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000020548   ⟹   ENSCLAP00000020352
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554084,522,031 - 4,898,690 (-)Ensembl
RefSeq Acc Id: XM_005376123   ⟹   XP_005376180
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554084,521,922 - 4,898,697 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013508431   ⟹   XP_013363885
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554084,521,922 - 4,898,697 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005376180 (Get FASTA)   NCBI Sequence Viewer  
  XP_013363885 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000020352
  ENSCLAP00000020352.1
Reference Protein Sequences
RefSeq Acc Id: XP_005376180   ⟸   XM_005376123
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VW06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013363885   ⟸   XM_013508431
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000020352   ⟸   ENSCLAT00000020548
Protein Domains
EF-hand   Ig-like   Kazal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013940 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000020548 ENTREZGENE
  ENSCLAT00000020548.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.30.60.30 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Fstl4 ENTREZGENE
PANTHER FOLLISTATIN-RELATED UniProtKB/TrEMBL
  FOLLISTATIN-RELATED PROTEIN 4 UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/TrEMBL
  Kazal_2 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  KAZAL UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP 3-carboxy-cis,cis-mucoante lactonizing enzyme UniProtKB/TrEMBL
  SSF100895 UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A8C2VW06 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Fstl4  follistatin like 4    follistatin-like 4  Symbol and/or name change 5135510 APPROVED