Lpcat1 (lysophosphatidylcholine acyltransferase 1)

Gene: Lpcat1 (lysophosphatidylcholine acyltransferase 1) Chinchilla lanigera

Analyze

Symbol:

Lpcat1

Name:

lysophosphatidylcholine acyltransferase 1

RGD ID:

9005016

Description:

ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (ortholog); 1-acylglycerophosphocholine O-acyltransferase activity (ortholog); 1-alkylglycerophosphocholine O-acetyltransferase activity (ortholog); INVOLVED IN negative regulation of phosphatidylcholine biosynthetic process (ortholog); phosphatidylcholine acyl-chain remodeling (ortholog); phosphatidylcholine biosynthetic process (ortholog); ASSOCIATED WITH autosomal dominant dyskeratosis congenita 2 (ortholog); dopamine transporter deficiency syndrome (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi apparatus (ortholog); lipid droplet (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955504	758,881 - 791,996 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955504	760,941 - 791,996 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 2 (ISO)

dopamine transporter deficiency syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of phosphatidylcholine biosynthetic process (ISO)

phosphatidylcholine acyl-chain remodeling (ISO)

phosphatidylcholine biosynthetic process (ISO)

phospholipid biosynthetic process (ISO)

positive regulation of protein catabolic process (ISO)

protein catabolic process (ISO)

retina development in camera-type eye (ISO)

surfactant homeostasis (ISO)

Cellular Component

endoplasmic reticulum (ISO)

Golgi apparatus (ISO)

lipid droplet (ISO)

membrane (ISO)

Molecular Function

1-acylglycerol-3-phosphate O-acyltransferase activity (ISO)

1-acylglycerophosphocholine O-acyltransferase activity (ISO)

1-alkylglycerophosphocholine O-acetyltransferase activity (ISO)

1-alkylglycerophosphocholine O-acyltransferase activity (ISO)

plasmalogen synthase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Lpcat1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955504	758,881 - 791,996 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955504	760,941 - 791,996 (-)	NCBI	ChiLan1.0	ChiLan1.0

LPCAT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	1,461,427 - 1,523,960 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	1,456,480 - 1,523,962 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	1,461,542 - 1,524,075 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	1,514,542 - 1,577,076 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	1,499,585 - 1,562,101 (-)	NCBI		Celera
Cytogenetic Map	5	p15.33	NCBI
HuRef	5	1,442,770 - 1,505,328 (-)	NCBI		HuRef
CHM1_1	5	1,461,370 - 1,523,947 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	1,373,271 - 1,435,654 (-)	NCBI		T2T-CHM13v2.0

Lpcat1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	73,615,332 - 73,664,539 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	73,615,316 - 73,664,541 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	73,467,231 - 73,516,420 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	73,467,197 - 73,516,422 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	73,604,831 - 73,651,986 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	73,933,228 - 73,982,413 (+)	NCBI		MGSCv36	mm8
Celera	13	75,795,573 - 75,842,729 (+)	NCBI		Celera
Cytogenetic Map	13	C1	NCBI
cM Map	13	39.97	NCBI

Lpcat1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	31,594,621 - 31,644,946 (-)	NCBI		GRCr8
mRatBN7.2	1	29,766,070 - 29,816,401 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	29,766,071 - 29,816,401 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	29,567,204 - 29,617,533 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	35,567,047 - 35,617,376 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	29,767,829 - 29,818,157 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	32,379,431 - 32,429,917 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	32,379,432 - 32,429,917 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	33,802,632 - 33,853,118 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	30,573,254 - 30,624,147 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	30,576,204 - 30,627,092 (-)	NCBI
Celera	1	28,412,898 - 28,463,109 (-)	NCBI		Celera
Cytogenetic Map	1	p11	NCBI

LPCAT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	1,732,113 - 1,797,068 (-)	NCBI		NHGRI_mPanPan1-v2
PanPan1.1 Ensembl	5	1,503,853 - 1,544,741 (-)	Ensembl	panpan1.1		panPan2

LPCAT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	11,162,715 - 11,195,380 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	11,164,615 - 11,193,681 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	15,658,942 - 15,705,323 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	11,049,553 - 11,095,789 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	11,049,271 - 11,095,790 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	11,100,715 - 11,147,111 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	11,079,852 - 11,126,208 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	11,290,686 - 11,337,070 (+)	NCBI		UU_Cfam_GSD_1.0

Lpcat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	244,130,919 - 244,184,633 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936815	292,200 - 344,413 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936815	281,664 - 345,915 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LPCAT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	79,134,465 - 79,173,772 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	79,134,396 - 79,173,775 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	85,797,427 - 85,837,645 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LPCAT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	1,273,542 - 1,333,840 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	1,275,769 - 1,333,801 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	35,841,315 - 35,902,916 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lpcat1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	730,472 - 764,430 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624751	732,364 - 764,421 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013505909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01064829	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01033177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01208884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000011122 ⟹ ENSCLAP00000010987

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955504	758,881 - 791,996 (-)	Ensembl

RefSeq Acc Id:

XM_013505909 ⟹ XP_013361363

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955504	760,941 - 791,996 (-)	NCBI

Sequence:

show sequence

CCGCGCCTGCGCATCCCGCGCACCGCGCATCCCGGCGGCCGCGCATCCCGCTGCCCGCCGCTCC
CGCGCCGGCCGCCCCGCTCAGCTCCGGTCCGCCCGCGTGCTCCTCCTCCTCCCCGCGGCACCAT
GAGGCTGCGGGGCCGCGGGCCGCGCGCCTTCCCCGCTTGCAGCTCAGGGGCGGGCGGCACGCGG
CGGCTGGCGCCCCCCGGGCGGAACCCGTTCGTGCACGAGCTGCGCCTCGGCGCCCTGCAGAAGC
TCCAGGTGGCCTTCATGACGCTCACGCTGTTCCCCATCCGGCTCCTGCTCGCTGCCTTCATGAT
GCTGCTGGCCTGGCCCTTGGCGCTCGTGGCCTCGCTGGGACCTGCCGAGAAGGAGCCCGAGCAG
CCCCCAGCGCTGTGGCGGAGGCTGGTGGACATCCTGCTCAAGGCCATCATGCGTGCCATGTGGT
TCGCCGGCGGCTTCCACCACGTGGCCGTGAAGGGGCGGCAAGCGCTGCCCAGTGAGGCCGCCAT
CCTCACGCTGGCCCCACACTCGTCCTACTTTGACGCCATCCCTGTCACCATGACCATGTCCTCC
ATTGTAATGAAGGCGGAGAGCAGAGACATCCCAATCTGGGGAACCCTGATCCGGTACATACGGC
CGGTGTTCGTGTCCCGGTCCGACCAGGACTCGCGCCGAAGAACCGTGGAGGAGATCAAGAGACG
GGCGCAGTCGGGCGGAAAGTGGCCGCAGATAATGATTTTCCCAGAAGGAACCTGTACCAACAGG
ACCTGCCTAATTACCTTCAAGCCAGGTGCGTTCATCCCCGGAGTCCCTGTGCAGCCTGTGGTGC
TTCGATACCCAAACAGGCTGGACACCATCACATGGACGTGGCAGGGCCCTGGCGCGTTGGAGAT
CCTGTGGCTCACGCTGTGCCAGTTGCACAATCGGGTGGAGATCGAGTTTCTGCCCGTGTACCGC
CCATCCGCCGAGGAGCGCAGGGACCCCGCGCTGTTCGCAGCCAACGTGCGGCGCGTCATGGCCG
AGGCCCTGGGTGTTTCTGTGACTGACTACACGTTTGAAGACTGCCAGCTCGCGCTGGCGGGGGG
ACAGCTGCGCCTCCCGCCCGACTCCTGCCTGCTGGAGTTCGCCAGGCTGGTGCGAGGCCTCGGG
CTGAGGCCGGAAAAGCTTGAAAAGGACCTGGACAAGTACTCAGAGAGGGCGACGGGGAAGCGGG
GCGAGAAGGTCGGCCTGGCGGAGTTCTCGGCGTACCTGCAGGTGCCGCACTCGGACGTGCTGGA
GGACATGTTCGCGCTCTTCGACGAGGGCGGCTGTGGTGAAGTGGACCTGCGGGAGTATGTGGTG
GCCCTGTCGGTTGTGTGCCGGCCGTCCCAGACCCTGGACACCATCCAGCTGGCGTTCAAGATGT
ACGGGGCGCCGGGGGATGGGAGCATCCAGGAGGACCACCTCGCCCGCATCCTCAGGGCCGCCCT
GGGCGTGGCAGAGCTGTCTGTCACAGACCTGTTCCGGGCCATCGACCAGGAGGAGAAGGGGAGA
ATCTCATTCGCCGACTTTCAGAGGTTCACAGAGCTGTACCCCGACTTCGCCGAGGAGTACCTGT
ACCCCGAGCAGCGGCCCTTCCACGGCTGTGCCCAGACGCCGCCCACGCTGACCCCCAACGGCTT
CTGTACCGACTTTAGCCCCGAGAGCTCAGACTTGGACAAGCCACCCTGTAAGAAACTGGACTAG
GGCTCGTGGACCCGAGGACCAGGCCCCTCCCACAGCCGCCAACTCCATACAACCAGGAGCCCAG
TCCCCAGGGACCTCCGTCTTGCGCCTGAGGGCTTCGGGCTGAGTTCCGGGAGACCCAGGCCCTG
TGCAGTGCTTCTCCGTGAAGAGTCTGAGCTCAGAGTGTGTGGGGAGCCGGGCCTCGGGACGCGG
GCCGGGGCCGGGTGGGCGCCAAGCACACCCTTGCTCCACACGGAGAGTCCGGTCTGAGTTCCTG
CCATCCCCTCCTGAAGCCCCATCCTGTCTGGTCAAGCTGAGGTCACCTGCGCTCTGAGCCAGCG
CGGCCTCTGCCACCTCGGTCATACTCGGGGTCACCTGCGCTGTGAGCCAGTGGGGCCTCCGCCT
CCTTGGGGTCACAACACAGAGGCACCACCATCTGGTTTTTAAACATTTCTATATTTGCGCGCGA
GCTCATGCGTATTTTATAACTTCATTTAGGTACTTCAGAAGATATTCAGCATTTTTTTAGGAAA
AGAGGAAATGTTTTTTCTACTTCATTGTTCCTGTTGAGCTCGGAGGTCATTTATTTGTTGGCCC
TTCCCTGACAGACTCTGAGGCGGTCTCGGGCACGGCCATACATGCCCAGCCGGTGCCCCCTGCA
CCCGGCCCCAAGGTGCCTCTGGTCTCCATCCTTTTGGAATCCCCTCTTTTTTATAACTTTACCA
TTTTGGTGGTTCTGTTTCAGCACAACAAGATCTACTTCACTGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013361363	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000010987
	ENSCLAP00000010987.1

RefSeq Acc Id:

XP_013361363 ⟸ XM_013505909

- UniProtKB:

A0A8C2V8S7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRLRGRGPRAFPACSSGAGGTRRLAPPGRNPFVHELRLGALQKLQVAFMTLTLFPIRLLLAAFM
MLLAWPLALVASLGPAEKEPEQPPALWRRLVDILLKAIMRAMWFAGGFHHVAVKGRQALPSEAA
ILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIRYIRPVFVSRSDQDSRRRTVEEIKR
RAQSGGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGVPVQPVVLRYPNRLDTITWTWQGPGALE
ILWLTLCQLHNRVEIEFLPVYRPSAEERRDPALFAANVRRVMAEALGVSVTDYTFEDCQLALAG
GQLRLPPDSCLLEFARLVRGLGLRPEKLEKDLDKYSERATGKRGEKVGLAEFSAYLQVPHSDVL
EDMFALFDEGGCGEVDLREYVVALSVVCRPSQTLDTIQLAFKMYGAPGDGSIQEDHLARILRAA
LGVAELSVTDLFRAIDQEEKGRISFADFQRFTELYPDFAEEYLYPEQRPFHGCAQTPPTLTPNG
FCTDFSPESSDLDKPPCKKLD

hide sequence

RefSeq Acc Id:

ENSCLAP00000010987 ⟸ ENSCLAT00000011122

Protein Domains

EF-hand

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007581	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000011122	ENTREZGENE
	ENSCLAT00000011122.1	UniProtKB/TrEMBL
Gene3D-CATH	EF-hand	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	LPCAT1-like	UniProtKB/TrEMBL
	Plipid/glycerol_acylTrfase	UniProtKB/TrEMBL
NCBI Gene	Lpcat1	ENTREZGENE
PANTHER	LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 1	UniProtKB/TrEMBL
	PHOSPHOLIPID ACYLTRANSFERASE	UniProtKB/TrEMBL
Pfam	Acyltransferase	UniProtKB/TrEMBL
	EF-hand_7	UniProtKB/TrEMBL
PROSITE	EF_HAND_2	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
	PlsC	UniProtKB/TrEMBL
Superfamily-SCOP	Glycerol-3-phosphate (1)-acyltransferase	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
UniProt	A0A8C2V8S7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar