Macf1 (microtubule actin crosslinking factor 1) - Rat Genome Database

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Gene: Macf1 (microtubule actin crosslinking factor 1) Chinchilla lanigera
Analyze
Symbol: Macf1
Name: microtubule actin crosslinking factor 1
RGD ID: 8996004
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); ATP hydrolysis activity (ortholog); INVOLVED IN cell migration (ortholog); establishment or maintenance of cell polarity (ortholog); Golgi to plasma membrane protein transport (ortholog); ASSOCIATED WITH cerebellar hypoplasia (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); Developmental Disabilities (ortholog); FOUND IN actin cytoskeleton (ortholog); cell junction (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Kiaa0754; KIAA0754 ortholog; microtubule-actin cross-linking factor 1; microtubule-actin crosslinking factor 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545216,798,911 - 17,024,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545216,684,784 - 17,025,940 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Macf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545216,798,911 - 17,024,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545216,684,784 - 17,025,940 (+)NCBIChiLan1.0ChiLan1.0
MACF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38139,084,167 - 39,487,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl139,081,316 - 39,487,177 (+)EnsemblGRCh38hg38GRCh38
GRCh37139,549,839 - 39,952,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36139,319,705 - 39,725,376 (+)NCBINCBI36Build 36hg18NCBI36
Build 34139,465,902 - 39,621,882NCBI
Celera137,828,167 - 38,234,164 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef137,669,045 - 38,071,866 (+)NCBIHuRef
CHM1_1139,665,458 - 40,068,698 (+)NCBICHM1_1
T2T-CHM13v2.0138,951,565 - 39,355,064 (+)NCBIT2T-CHM13v2.0
Macf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394123,243,386 - 123,581,594 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4123,243,426 - 123,581,331 (-)EnsemblGRCm39 Ensembl
GRCm384123,349,633 - 123,687,802 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4123,349,633 - 123,684,360 (-)EnsemblGRCm38mm10GRCm38
MGSCv374123,026,959 - 123,361,603 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364122,851,896 - 123,186,492 (-)NCBIMGSCv36mm8
Celera4121,682,320 - 122,018,135 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.42NCBI
Macf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,908,829 - 141,234,127 (-)NCBIGRCr8
mRatBN7.25135,623,734 - 135,949,097 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,623,742 - 135,945,905 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5138,329,667 - 138,655,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05140,099,629 - 140,425,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05140,106,778 - 140,432,405 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05141,039,455 - 141,363,524 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5141,039,468 - 141,363,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05144,829,588 - 145,151,477 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45142,659,726 - 142,986,873 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15142,667,739 - 142,701,960 (-)NCBI
Celera5134,162,059 - 134,482,913 (-)NCBICelera
Cytogenetic Map5q36NCBI
MACF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21187,340,369 - 187,743,318 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11186,478,005 - 186,880,950 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0138,369,021 - 38,771,911 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1139,820,066 - 40,097,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl139,820,394 - 40,096,558 (+)Ensemblpanpan1.1panPan2
MACF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1153,361,887 - 3,703,891 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl153,362,867 - 3,573,325 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha153,601,727 - 3,942,472 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0153,482,603 - 3,548,295 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1153,352,416 - 3,693,488 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0153,419,561 - 3,761,243 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0153,435,346 - 3,776,614 (-)NCBIUU_Cfam_GSD_1.0
Macf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505855,228,978 - 55,576,554 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647421,178,791 - 21,400,147 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647421,053,755 - 21,401,336 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MACF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl695,153,005 - 95,301,618 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1694,960,385 - 95,318,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2688,111,268 - 88,403,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MACF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12093,413,111 - 93,814,388 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603323,023,831 - 23,431,976 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Macf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476421,782,162 - 22,014,676 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476421,663,516 - 22,015,866 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013519481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013519482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01044525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01044536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBBH01092673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCE01174433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCLAT00000016265   ⟹   ENSCLAP00000016101
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545216,798,911 - 17,024,732 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000016266   ⟹   ENSCLAP00000016102
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545216,832,734 - 17,024,732 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000016267   ⟹   ENSCLAP00000016103
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545216,862,742 - 17,024,732 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000016268   ⟹   ENSCLAP00000016104
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545216,886,265 - 17,024,732 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000016269   ⟹   ENSCLAP00000016105
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545216,999,645 - 17,024,732 (+)Ensembl
RefSeq Acc Id: XM_013519481   ⟹   XP_013374935
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545216,684,784 - 17,025,940 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013519482   ⟹   XP_013374936
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545216,950,335 - 17,025,940 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013374935 (Get FASTA)   NCBI Sequence Viewer  
  XP_013374936 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000016101
  ENSCLAP00000016101.1
  ENSCLAP00000016102.1
  ENSCLAP00000016103.1
  ENSCLAP00000016104.1
  ENSCLAP00000016105.1
Reference Protein Sequences
RefSeq Acc Id: XP_013374935   ⟸   XM_013519481
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VQ61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013374936   ⟸   XM_013519482
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000016102   ⟸   ENSCLAT00000016266
RefSeq Acc Id: ENSCLAP00000016101   ⟸   ENSCLAT00000016265
RefSeq Acc Id: ENSCLAP00000016104   ⟸   ENSCLAT00000016268
RefSeq Acc Id: ENSCLAP00000016103   ⟸   ENSCLAT00000016267
RefSeq Acc Id: ENSCLAP00000016105   ⟸   ENSCLAT00000016269
Protein Domains
Calponin-homology (CH)   EF-hand   GAR   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011083 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000016265 ENTREZGENE
  ENSCLAT00000016265.1 UniProtKB/TrEMBL
  ENSCLAT00000016266.1 UniProtKB/TrEMBL
  ENSCLAT00000016267.1 UniProtKB/TrEMBL
  ENSCLAT00000016268.1 UniProtKB/TrEMBL
  ENSCLAT00000016269.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.1060 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  3.30.920.20 UniProtKB/TrEMBL
  3.90.1290.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  Desmoplakin_SH3 UniProtKB/TrEMBL
  Desmoplakin_Spectrin-like UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  GAR_dom UniProtKB/TrEMBL
  GAR_dom_sf UniProtKB/TrEMBL
  PCN-like_spectrin-like_rpt UniProtKB/TrEMBL
  Plakin UniProtKB/TrEMBL
  Plakin_repeat_sf UniProtKB/TrEMBL
  Plectin_repeat UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
NCBI Gene Macf1 ENTREZGENE
PANTHER EPIPLAKIN UniProtKB/TrEMBL
  MICROTUBULE-ACTIN CROSS-LINKING FACTOR 1, ISOFORMS 1/2/3/5 UniProtKB/TrEMBL
  PTHR23169 UniProtKB/TrEMBL
  SHORT STOP, ISOFORM H UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  GAS2 UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  Plectin UniProtKB/TrEMBL
  SH3_10 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
  Spectrin_3 UniProtKB/TrEMBL
  Spectrin_4 UniProtKB/TrEMBL
  Spectrin_like UniProtKB/TrEMBL
  SR_plectin_7 UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  GAR UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART DELLA UniProtKB/TrEMBL
  EFh UniProtKB/TrEMBL
  GAS2 UniProtKB/TrEMBL
  PLEC UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/TrEMBL
  SSF143575 UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
  SSF75399 UniProtKB/TrEMBL
UniProt A0A8C2VIF6_CHILA UniProtKB/TrEMBL
  A0A8C2VIG3_CHILA UniProtKB/TrEMBL
  A0A8C2VKN4_CHILA UniProtKB/TrEMBL
  A0A8C2VNX0_CHILA UniProtKB/TrEMBL
  A0A8C2VQ61 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 Macf1  microtubule actin crosslinking factor 1    microtubule-actin crosslinking factor 1  Symbol and/or name change 5135510 APPROVED
2017-11-21 Macf1  microtubule-actin crosslinking factor 1  Kiaa0754  KIAA0754 ortholog  Data merged from RGD:9043074 737654 PROVISIONAL