Chp1 (calcineurin like EF-hand protein 1)

Gene: Chp1 (calcineurin like EF-hand protein 1) Chinchilla lanigera

Analyze

Symbol:

Chp1

Name:

calcineurin like EF-hand protein 1

RGD ID:

8991411

Description:

ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); kinase binding (ortholog); INVOLVED IN cytoplasmic microtubule organization (ortholog); membrane docking (ortholog); membrane fusion (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); Spastic Ataxia 9, Autosomal Recessive (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); Golgi membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

calcineurin B homologous protein 1; calcineurin-like EF-hand protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	8,090,034 - 8,132,870 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	8,090,034 - 8,131,605 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

Spastic Ataxia 9, Autosomal Recessive (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoplasmic microtubule organization (ISO)

membrane docking (ISO)

membrane fusion (ISO)

membrane organization (ISO)

microtubule bundle formation (ISO)

negative regulation of calcineurin-NFAT signaling cascade (ISO)

negative regulation of protein autophosphorylation (ISO)

negative regulation of protein import into nucleus (ISO)

negative regulation of protein phosphorylation (ISO)

negative regulation of protein ubiquitination (ISO)

positive regulation of phospholipid biosynthetic process (ISO)

positive regulation of protein glycosylation (ISO)

positive regulation of protein transport (ISO)

protein complex oligomerization (ISO)

protein export from nucleus (ISO)

protein stabilization (ISO)

regulation of intracellular pH (ISO)

vesicle fusion (ISO)

vesicle targeting (ISO)

Cellular Component

cytoplasm (ISO)

endoplasmic reticulum (ISO)

Golgi membrane (ISO)

membrane raft (ISO)

microtubule cytoskeleton (ISO)

nucleus (ISO)

plasma membrane (ISO)

transport vesicle (ISO)

transporter complex (ISO)

Molecular Function

calcium ion binding (ISO)

calcium-dependent protein binding (ISO)

kinase binding (ISO)

microtubule binding (ISO)

protein binding (ISO)

sodium:proton antiporter activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Chp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	8,090,034 - 8,132,870 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	8,090,034 - 8,131,605 (+)	NCBI	ChiLan1.0	ChiLan1.0

CHP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	41,231,268 - 41,281,887 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	41,230,839 - 41,281,887 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	41,523,466 - 41,574,085 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	39,310,729 - 39,361,377 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	39,310,728 - 39,361,373	NCBI
Celera	15	18,291,415 - 18,342,063 (+)	NCBI		Celera
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	18,371,799 - 18,422,604 (+)	NCBI		HuRef
CHM1_1	15	41,641,426 - 41,692,297 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	39,037,454 - 39,088,066 (+)	NCBI		T2T-CHM13v2.0

Chp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	119,378,172 - 119,417,505 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	119,378,178 - 119,417,508 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	119,547,707 - 119,587,024 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	119,547,697 - 119,587,027 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	119,373,443 - 119,412,760 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	119,239,155 - 119,278,461 (+)	NCBI		MGSCv36	mm8
Celera	2	120,700,969 - 120,740,985 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.97	NCBI

Chp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,989,800 - 127,025,071 (+)	NCBI		GRCr8
mRatBN7.2	3	106,536,009 - 106,571,255 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	106,536,004 - 106,571,251 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	110,213,376 - 110,248,697 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	118,808,913 - 118,844,244 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	116,469,312 - 116,504,631 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	111,354,506 - 111,389,998 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,354,506 - 111,389,989 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	117,902,988 - 117,938,480 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	106,066,389 - 106,101,635 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	105,962,816 - 105,998,059 (+)	NCBI
Celera	3	105,447,792 - 105,483,065 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

CHP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	30,472,900 - 30,523,533 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	34,624,238 - 34,674,873 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	20,172,874 - 20,223,382 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	38,418,815 - 38,466,925 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	38,418,815 - 38,467,681 (+)	Ensembl	panpan1.1		panPan2

CHP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	8,304,939 - 8,352,833 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	8,305,007 - 8,350,904 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	8,363,447 - 8,409,616 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	8,438,344 - 8,484,537 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	8,438,397 - 8,486,280 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	8,359,874 - 8,408,027 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	8,467,375 - 8,515,299 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	8,598,734 - 8,645,069 (+)	NCBI		UU_Cfam_GSD_1.0

Chp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	86,763,916 - 86,812,248 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	4,611,252 - 4,660,359 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	4,611,980 - 4,660,320 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	130,073,928 - 130,112,751 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	130,073,919 - 130,112,461 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	145,221,139 - 145,259,701 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	41,734,698 - 41,785,273 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	41,733,063 - 41,785,586 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	99,207,184 - 99,258,544 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	8,431,996 - 8,474,458 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	8,431,999 - 8,474,458 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013512484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01017028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01017029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01017030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01017031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01003296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000014450 ⟹ ENSCLAP00000014292

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955416	8,090,034 - 8,132,870 (+)	Ensembl

RefSeq Acc Id:

XM_013512484 ⟹ XP_013367938

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955416	8,090,034 - 8,131,605 (+)	NCBI

Sequence:

show sequence

CAAGAAACGCTCCCTTCTCGCTGCTTGACCCCTGGTTCTTTCTTCCCTCTGTCCCTCCCTACTG
CCGCCGTTGCTTCAGGAGCTGCCGCTCCCGGAGGAGCTCCCGGCACGGTAATGGGGTCTCGGGC
CTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGT
CAGATCACTCGCCTCTACAGCCGATTCACCAGCCTGGACAAAGGAGAGAACGGGACTCTCAGCC
GGGAAGATTTCCAGAGGATTCCAGAGCTTGCCATCAACCCACTGGGGGACCGGATCATCAATGC
CTTCTTTCCAGAGGGAGAGGACCAGGTGAATTTCCGTGGATTCATGAGAACTTTGGCTCATTTC
CGACCCATTGAGGATAATGAAAAGAGCAAAGATGTGAATGGACCAGAACCACTCAACAGCAGAA
GCAACAAACTGCATTTTGCTTTCCGGCTGTACGATCTGGATAAAGATGACAAGATCTCCCGTGA
TGAGCTGTTACAGGTGCTACGCATGATGGTTGGCGTGAACATCTCAGATGAGCAGCTGGGCAGC
ATTGCAGACAGGACCATCCAGGAGGCTGACCAGGACGGTGACAGTGCCATATCTTTCACAGAGT
TTGTTAAGGTTTTGGAGAAGGTGGATGTAGAACAGAAAATGAGCATCCGGTTTCTTCACTAAAG
GACACAGACCAGACTATTCCTTGCTGTCTAGTATTTAAGAACTGGAACTTCAAGAGTCCTCCTG
TCCACCTGCCCCACCTTCACCCCAGCGCTCCCCTTCTCCCGAAGTCCCACTGCTGTTGCATGAT
GACCCCAAGTGTCTGCCCAGCCAGACCCGCCTTGTGTGTAAACCTGCCTTACGGAAGGGAACTC
CCAGTGTCTCTCTGCTCGGTAGCTGCCCACCACCTCTTTCTCAGCACCGCCTTTCCCTCTTCTG
CTGTGAAACGTCTCAATCCATCCAGCCTGAGAAGGTGAGGGGGCCTCACGCTCAGAGTGGCCCG
CACAGCTCTCGCTGGGTGGAGATGTGGCCGTGCGGCCTTCCCTGCAGCGAGGTTCCAGCATTCT
GTGTCCTTGTGTGCATCCTTGGCTTTCTGTTTCCCTGTCTCCCAGCCTGCCTTTCAGCCTCCCG
GCTTTGTACGGATCCTCACAGTTCCCCCTCTTCTACCTGGCACCCCACGCTATGCCTGTTAATC
TCTTTCTGACTTGGCAGGATGGTTCAGTGGTCTGGTGGTTTTTATCTACCTTCCCTCTGAAATG
GGTCTCTGGGATGCTGCCTTCTAGGGGCTTTCAGGAACCAACACTTCTTTTGTAAGAATGTGAC
CCTCTCTTGTCGCTTGCACTGTTCTGTCATCAAAGGGCTTCTGGGTAGAAAGTTCCCTGAAAGG
TCACTTTGGTGGCTTGTCCAGGTCGCTCTACCTCTGGCTTCTGATTCTCAGCTTACGAACCAAC
ACAGCTCTGGTGAGTGTCGTGCTGAGTATTCAGAAAGTAGTCATAGTTCCGCAGATCTGCTTAG
CTTTGGGTCACCGTCACCACCAGAACGGCTGTGCAGACAGTTGCTGGGACCGCCTCACGGCTCT
TTGATCCACAAAACAAGGCACCTGGCACCTCCCCACTCATACCGCGGCATGGCATATGCGGCGG
TGTGACGACACTGGAAGGTTTCTCCCTTCACATTTCCAAGTAGAGCGACTAGTGTCACGGAAGT
GCCTAACTTATCCCAGGCCAAGAGAATTAAGGATCAGCTTCAGTGTCCTGAAGTTCCGCGCAAA
ATTCTTCATGAATTTTACACTTGGCAAGTTGTTAATGCGGAAGCCATAGTCAGCTCCTACTACA
GCCCAAAGCATTGAGTGTATTGTCTTAGCTGCCTGGTTACGTGACCTTCCTGGCTCCTATCTAG
ACCATTGCTAATCCCTTGGGGACAAGGGGTCCGGCACTAGTGGCATTTAGGTCATCGAGAGTGA
GCCAGGGCAACTTCTCTGCCAAAGCCAGCTTAGACCCATCGGGCCGTGGCCGTCTTTTCTTGTG
AGTCCCTTCATCCATACATCTGCCCTTGGCTGACTTTCTGTGCCTGGCTGCTTGCTTGTTGCCC
TTGCTCTCCAAGGTGTGCAAACAACTCTTTAGGGGAGGAACTTCTAAAAAAATACCAGTGCAAA
GGGCTGGACAAAGGTAGGGAACAGGAGTGGCCAGGCTGGACGGCGTAAGTATAAATGCATGGGG
AACTCTTCATGAGGTATCAGTCTGGCTTCATGATCAAAGTGAAGTAATAGAATTATAGAAAAGG
GAAGAACTGTCTAATAGTGGCCTGTTAGAGAGGAGTCTGGAGCTCCTTGGTTTGCATATTTAAA
GTTCCTAAGATTATGGCTTTTCCCCTCTTTGGCTGTAGAGCAAACTGTTTTAATCCACAGTTGT
GCCTTACTGTCCCATTAAAACTGTATTGTTCAATTCGTCAATAAATACTTGTGGTTAAAACAAA
A

hide sequence

Protein Sequences


Protein RefSeqs	XP_013367938	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000014292
	ENSCLAP00000014292.1

RefSeq Acc Id:	XP_013367938 ⟸ XM_013512484
- UniProtKB:	A0A8C2VE90 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGD RIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDD KISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIR FLH hide sequence

RefSeq Acc Id:

ENSCLAP00000014292 ⟸ ENSCLAT00000014450

Protein Domains

EF-hand

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000009852	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000014450	ENTREZGENE
	ENSCLAT00000014450.1	UniProtKB/TrEMBL
Gene3D-CATH	EF-hand	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
NCBI Gene	Chp1	ENTREZGENE
PANTHER	CALCINEURIN B HOMOLOGOUS PROTEIN 1	UniProtKB/TrEMBL
	EG:114D9.1 PROTEIN-RELATED	UniProtKB/TrEMBL
Pfam	EF-hand_7	UniProtKB/TrEMBL
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A0A8C2VE90	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Chp1	calcineurin like EF-hand protein 1		calcineurin-like EF-hand protein 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM