Mbd4 (methyl-CpG binding domain 4, DNA glycosylase)

Gene: Mbd4 (methyl-CpG binding domain 4, DNA glycosylase) Chinchilla lanigera

Analyze

Symbol:

Mbd4

Name:

methyl-CpG binding domain 4, DNA glycosylase

RGD ID:

8986223

Description:

ENCODES a protein that exhibits DNA binding (ortholog); pyrimidine-specific mismatch base pair DNA N-glycosylase activity (ortholog); INVOLVED IN DNA damage response (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); mitotic G2 DNA damage checkpoint signaling (ortholog); PARTICIPATES IN altered DNA modification pathway; DNA modification pathway; ASSOCIATED WITH alkaptonuria (ortholog); autistic disorder (ortholog); colorectal carcinoma (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nuclear speck (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

methyl-CpG binding domain 4 DNA glycosylase; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	17,858,937 - 17,869,262 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	17,858,656 - 17,868,111 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alkaptonuria (ISO)

autistic disorder (ISO)

colorectal carcinoma (ISO)

Colorectal Neoplasms (ISO)

cranioectodermal dysplasia 1 (ISO)

esophagus squamous cell carcinoma (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

immunodeficiency 21 (ISO)

Intestinal Neoplasms (ISO)

lung cancer (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

rheumatoid arthritis (ISO)

Tumor Predisposition Syndrome 2 (ISO)

uveal melanoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (ISO)

mitotic G2 DNA damage checkpoint signaling (ISO)

response to estradiol (ISO)

response to radiation (ISO)

Cellular Component

chromatin (ISO)

cytoplasm (ISO)

nuclear speck (ISO)

nucleus (ISO)

Molecular Function

DNA binding (ISO)

protein binding (ISO)

pyrimidine-specific mismatch base pair DNA N-glycosylase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered DNA modification pathway (ISO)

DNA modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Mbd4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	17,858,937 - 17,869,262 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	17,858,656 - 17,868,111 (+)	NCBI	ChiLan1.0	ChiLan1.0

MBD4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	129,430,947 - 129,439,948 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	129,430,947 - 129,440,179 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	129,149,790 - 129,158,791 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	130,632,483 - 130,641,542 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	130,632,490 - 130,641,550	NCBI
Celera	3	127,576,629 - 127,585,688 (-)	NCBI		Celera
Cytogenetic Map	3	q21.3	NCBI
HuRef	3	126,533,265 - 126,542,500 (-)	NCBI		HuRef
CHM1_1	3	129,112,922 - 129,122,157 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	132,175,773 - 132,184,774 (-)	NCBI		T2T-CHM13v2.0

Mbd4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	115,817,658 - 115,830,361 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	115,817,658 - 115,830,332 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	115,840,697 - 115,853,400 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	115,840,697 - 115,853,371 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	115,790,715 - 115,803,359 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	115,808,047 - 115,819,340 (-)	NCBI		MGSCv36	mm8
Celera	6	117,677,344 - 117,690,709 (-)	NCBI		Celera
Cytogenetic Map	6	E3	NCBI
cM Map	6	53.72	NCBI

Mbd4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	150,565,646 - 150,577,433 (-)	NCBI		GRCr8
mRatBN7.2	4	148,893,049 - 148,904,833 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	148,894,280 - 148,904,982 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	4	147,744,673 - 147,756,462 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	147,746,186 - 147,756,294 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	211,028,384 - 211,040,158 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	151,972,272 - 151,981,633 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	137,783,059 - 137,794,850 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

MBD4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	127,363,949 - 127,372,866 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	127,368,337 - 127,377,271 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	126,489,125 - 126,498,034 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	133,842,156 - 133,851,450 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	133,839,643 - 133,851,450 (-)	Ensembl	panpan1.1		panPan2

MBD4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	5,716,162 - 5,725,068 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	5,716,239 - 5,724,881 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	5,753,617 - 5,762,527 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	5,745,974 - 5,754,885 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	5,745,978 - 5,754,919 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	5,461,788 - 5,470,699 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	5,814,748 - 5,823,669 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	5,790,467 - 5,799,355 (+)	NCBI		UU_Cfam_GSD_1.0

MBD4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	68,816,679 - 68,828,580 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	68,816,677 - 68,828,559 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MBD4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	51,616,840 - 51,626,232 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	51,616,803 - 51,626,224 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	114,838,792 - 114,848,231 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mbd4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624872	451,118 - 462,509 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624872	453,303 - 462,661 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005387086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005387087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01028868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01252939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000013154 ⟹ ENSCLAP00000013004

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955429	17,858,937 - 17,869,262 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000013155 ⟹ ENSCLAP00000013005

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955429	17,861,836 - 17,867,830 (+)	Ensembl

RefSeq Acc Id:

XM_005387086 ⟹ XP_005387143

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955429	17,858,675 - 17,868,111 (+)	NCBI

Sequence:

show sequence

AGGCGCTAAGGAGCAAACGCGCCCAGCGAACGGGAGCCCAGAAGGCCAAAGCGCAATTCCGACG
TGCTTGATTGGTCAGGAAGAGGCGCTGCCTCTGTCCTCCCGCTGCTGCGGCCGGACCCCGCCGG
AGGCCGCCTTTTGCATGGCGAGGCCGAGCCCCGGGGGCGGCGGAGAGGTCCCGTCCGAGCGCCG
AGCCTCAGCGCCGCTGCGTGACCTCTGTGAGGAAGATGTCGGTACAAGTGTGGGAAAAGATGAA
AAACAAATGGTGACAAGTGGAAGCAGAGAGTGTAATGCTCTGCTACAGGAACCCATTGCTTCCA
CTCAGTGTGCTGTTGCTGCAGTGACAGAATGTCACAAGCCTGTCCTCTGTGGATGGGAGAGGAT
TGTGAAGCAAAGGTTATCTGGGAAAACAGCAGGAAGATTTGATGTGTATTTTATCAGCCCACAG
GGACTGAAGTTCAGATCTAAAAGTTCAGTTGCTAATTATCTTCGCAAAAATGGAGACACAGCTC
TGCAGCCAGAAGATTTTGATTTTACTGTTCTTTCTAAAAGGAACATCAAGTCAAGATGTAAGGG
CCCCAGCGTGCCCGCTCTGACAGACCAACAGCAAAACAACACTAACATTTCAAGCCGGAACCTC
CGGACTCGAAGCAGGCGGAAAACAGATGTTTCTCCTCTACCAAATAGCACTTCAGAGTTGCAAG
ATAGCAGAGGACCATCTAACCTTGATTCCTTCCATGTGCTTTTGAGAGAAGAAGAGAATGTTAA
TGACGTTAGCTCTGGGAAGGTTAGGAAATTCAAGGGAAAAGTGACTGTTTTGAAAGGAATTCGA
ATTAAGAAAACCAAAAAACAGTGCAGCAATCGTCTTTCAGATTCTGCCCAAACTAATGCAAAAA
GAGAATCTGTGTTTAATAAAGCAGAGGCTGAAAGGGCATCTGTTTCACAAGGAAGTCAACTTGA
TAGAACTTTCTGCGTTTCTAATGACACCACAACCCACGGTACCTTCCATGTGACCGAGGAGGAA
AAGAGCCTCATAAAAGAAAAGTCATTGCACCCAGGATCAGATTTTCATTTTGAACAAATAACAT
CTGGTATCACAAACAAATCATGTCCAACCACAGAAGGGGAACCCAAGAAGTATGAGGAGACCGT
TTTAGAATCAGAGGAAATCAGAACAAAAGTAGAAGATGCGGAAAGAAAGGAACATTTGCATACT
GACATTTTGCAGTGTGGCTCTGAAGTGGACAACAGCTGCTCACAAAGCAGGAAAGACTTGACTT
CTGAGAAAATGCATCCAGAGGACAGCAACCCTCAGACACACACAGAAAAGCGGAAGACAAGCCA
GTACTTCACCAGCAAGTACAACAGAGGAGCTCTTAGCCCTCCTCGACGCAAAGCCTTTAAGAAG
TGGACCCCGCCTCGGTCACCTTTTAATCTCATCCAGGAGACGCTGTTCCATGACCCGTGGAAGC
TCCTCATCGCGACAATATTTCTCAACCGGACCTCAGGTAAGATGGCGATCCCTGTGCTGTGGGA
GTTCCTGGAGAAGTACCCCTCGGCGGAGGTGGCCAGAGCTGCAGACTGGAGAGATGTGTCCGAA
TTGCTGAAACCCATTGGCCTCTACGAGCTCCGAGCCAAAACCATTATCAAGTTTTCAGATGAGT
ACCTGACCAAGCAGTGGAAGTACCCGATCGAGCTTCATGGAATCGGCAAATACGGCAACGACTC
TTACCGCATTTTTTGCGTCAATGAGTGGAAGCAGGTGCACCCTGAAGACCACAAGCTGAACAAG
TACCACGACTGGCTTTGGGAAAACCATGAAAAGCTGAGTCTGTCCTGAAGCCTTTGCCGCCCCA
GACTCTTCATTTTGTGCTTTGCTTTTTTTTTCCCCTGTGCTTTGCGTCTTGGTTTCTATGAGCT
CCATGGAGCAAACCAGCCGCCTTCCCCCTGAGTCAGGTGTGAGGCTGGTGGCCGGGGAGTACTT
CCTCAGCTCGTGTGCCCATGGTGCTGTGTTACTGAAGGCAGTAGAAGATTCTTTGAAATTTAAA
CAACAGTTCTAAAAATGTACATGACTTTTCTGATACTGAAATGGATGTAAAGGTAAAAGGCTTT
TCTAAACTA

hide sequence

RefSeq Acc Id:

XM_005387087 ⟹ XP_005387144

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955429	17,858,656 - 17,868,111 (+)	NCBI

Sequence:

show sequence

CGCACGTCCAAAAGGGAGAAGGCGCTAAGGAGCAAACGCGCCCAGCGAACGGGAGCCCAGAAGG
CCAAAGCGCAATTCCGACGTGCTTGATTGGCGCTGCCTCTGTCCTCCCGCTGCTGCGGCCGGAC
CCCGCCGGAGGCCGCCTTTTGCATGGCGAGGCCGAGCCCCGGGGGCGGCGGAGAGGTCCCGTCC
GAGCGCCGAGCCTCAGCGCCGCTGCGTGACCTCTGTGAGGAAGATGTCGGTACAAGTGTGGGAA
AAGATGAAAAACAAATGGTGACAAGTGGAAGCAGAGAGTGTAATGCTCTGCTACAGGAACCCAT
TGCTTCCACTCAGTGTGCTGTTGCTGCAGTGACAGAATGTCACAAGCCTGTCCTCTGTGGATGG
GAGAGGATTGTGAAGCAAAGGTTATCTGGGAAAACAGCAGGAAGATTTGATGTGTATTTTATCA
GCCCACAGGGACTGAAGTTCAGATCTAAAAGTTCAGTTGCTAATTATCTTCGCAAAAATGGAGA
CACAGCTCTGCAGCCAGAAGATTTTGATTTTACTGTTCTTTCTAAAAGGAACATCAAGTCAAGA
TGTAAGGGCCCCAGCGTGCCCGCTCTGACAGACCAACAGCAAAACAACACTAACATTTCAAGCC
GGAACCTCCGGACTCGAAGCAGGCGGAAAACAGATGTTTCTCCTCTACCAAATAGCACTTCAGA
GTTGCAAGATAGCAGAGGACCATCTAACCTTGATTCCTTCCATGTGCTTTTGAGAGAAGAAGAG
AATGTTAATGACGTTAGCTCTGGGAAGGTTAGGAAATTCAAGGGAAAAGTGACTGTTTTGAAAG
GAATTCGAATTAAGAAAACCAAAAAACAGTGCAGCAATCGTCTTTCAGATTCTGCCCAAACTAA
TGCAAAAAGAGAATCTGTGTTTAATAAAGCAGAGGCTGAAAGGGCATCTGTTTCACAAGGAAGT
CAACTTGATAGAACTTTCTGCGTTTCTAATGACACCACAACCCACGGTACCTTCCATGTGACCG
AGGAGGAAAAGAGCCTCATAAAAGAAAAGTCATTGCACCCAGGATCAGATTTTCATTTTGAACA
AATAACATCTGGTATCACAAACAAATCATGTCCAACCACAGAAGGGGAACCCAAGAAGTATGAG
GAGACCGTTTTAGAATCAGAGGAAATCAGAACAAAAGTAGAAGATGCGGAAAGAAAGGAACATT
TGCATACTGACATTTTGCAGTGTGGCTCTGAAGTGGACAACAGCTGCTCACAAAGCAGGAAAGA
CTTGACTTCTGAGAAAATGCATCCAGAGGACAGCAACCCTCAGACACACACAGAAAAGCGGAAG
ACAAGCCAGTACTTCACCAGCAAGTACAACAGAGGAGCTCTTAGCCCTCCTCGACGCAAAGCCT
TTAAGAAGTGGACCCCGCCTCGGTCACCTTTTAATCTCATCCAGGAGACGCTGTTCCATGACCC
GTGGAAGCTCCTCATCGCGACAATATTTCTCAACCGGACCTCAGGTAAGATGGCGATCCCTGTG
CTGTGGGAGTTCCTGGAGAAGTACCCCTCGGCGGAGGTGGCCAGAGCTGCAGACTGGAGAGATG
TGTCCGAATTGCTGAAACCCATTGGCCTCTACGAGCTCCGAGCCAAAACCATTATCAAGTTTTC
AGATGAGTACCTGACCAAGCAGTGGAAGTACCCGATCGAGCTTCATGGAATCGGCAAATACGGC
AACGACTCTTACCGCATTTTTTGCGTCAATGAGTGGAAGCAGGTGCACCCTGAAGACCACAAGC
TGAACAAGTACCACGACTGGCTTTGGGAAAACCATGAAAAGCTGAGTCTGTCCTGAAGCCTTTG
CCGCCCCAGACTCTTCATTTTGTGCTTTGCTTTTTTTTTCCCCTGTGCTTTGCGTCTTGGTTTC
TATGAGCTCCATGGAGCAAACCAGCCGCCTTCCCCCTGAGTCAGGTGTGAGGCTGGTGGCCGGG
GAGTACTTCCTCAGCTCGTGTGCCCATGGTGCTGTGTTACTGAAGGCAGTAGAAGATTCTTTGA
AATTTAAACAACAGTTCTAAAAATGTACATGACTTTTCTGATACTGAAATGGATGTAAAGGTAA
AAGGCTTTTCTAAACTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005387143	(Get FASTA)	NCBI Sequence Viewer
	XP_005387144	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000013004
	ENSCLAP00000013004.1
	ENSCLAP00000013005.1

RefSeq Acc Id:

XP_005387144 ⟸ XM_005387087

- UniProtKB:

A0A8C2VDG3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARPSPGGGGEVPSERRASAPLRDLCEEDVGTSVGKDEKQMVTSGSRECNALLQEPIASTQCAV
AAVTECHKPVLCGWERIVKQRLSGKTAGRFDVYFISPQGLKFRSKSSVANYLRKNGDTALQPED
FDFTVLSKRNIKSRCKGPSVPALTDQQQNNTNISSRNLRTRSRRKTDVSPLPNSTSELQDSRGP
SNLDSFHVLLREEENVNDVSSGKVRKFKGKVTVLKGIRIKKTKKQCSNRLSDSAQTNAKRESVF
NKAEAERASVSQGSQLDRTFCVSNDTTTHGTFHVTEEEKSLIKEKSLHPGSDFHFEQITSGITN
KSCPTTEGEPKKYEETVLESEEIRTKVEDAERKEHLHTDILQCGSEVDNSCSQSRKDLTSEKMH
PEDSNPQTHTEKRKTSQYFTSKYNRGALSPPRRKAFKKWTPPRSPFNLIQETLFHDPWKLLIAT
IFLNRTSGKMAIPVLWEFLEKYPSAEVARAADWRDVSELLKPIGLYELRAKTIIKFSDEYLTKQ
WKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS

hide sequence

RefSeq Acc Id:

XP_005387143 ⟸ XM_005387086

- UniProtKB:

A0A8C2VDG3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARPSPGGGGEVPSERRASAPLRDLCEEDVGTSVGKDEKQMVTSGSRECNALLQEPIASTQCAV
AAVTECHKPVLCGWERIVKQRLSGKTAGRFDVYFISPQGLKFRSKSSVANYLRKNGDTALQPED
FDFTVLSKRNIKSRCKGPSVPALTDQQQNNTNISSRNLRTRSRRKTDVSPLPNSTSELQDSRGP
SNLDSFHVLLREEENVNDVSSGKVRKFKGKVTVLKGIRIKKTKKQCSNRLSDSAQTNAKRESVF
NKAEAERASVSQGSQLDRTFCVSNDTTTHGTFHVTEEEKSLIKEKSLHPGSDFHFEQITSGITN
KSCPTTEGEPKKYEETVLESEEIRTKVEDAERKEHLHTDILQCGSEVDNSCSQSRKDLTSEKMH
PEDSNPQTHTEKRKTSQYFTSKYNRGALSPPRRKAFKKWTPPRSPFNLIQETLFHDPWKLLIAT
IFLNRTSGKMAIPVLWEFLEKYPSAEVARAADWRDVSELLKPIGLYELRAKTIIKFSDEYLTKQ
WKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS

hide sequence

RefSeq Acc Id:

ENSCLAP00000013004 ⟸ ENSCLAT00000013154

RefSeq Acc Id:

ENSCLAP00000013005 ⟸ ENSCLAT00000013155

Protein Domains

HhH-GPD MBD

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008974	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000013154	ENTREZGENE
	ENSCLAT00000013154.1	UniProtKB/TrEMBL
	ENSCLAT00000013155.1	UniProtKB/TrEMBL
InterPro	DNA-bd_dom_sf	UniProtKB/TrEMBL
	DNA_glycosylase	UniProtKB/TrEMBL
	HhH-GPD_domain	UniProtKB/TrEMBL
	MBD4	UniProtKB/TrEMBL
	MeCP2/MBD4	UniProtKB/TrEMBL
	Methyl_CpG_DNA-bd	UniProtKB/TrEMBL
NCBI Gene	Mbd4	ENTREZGENE
PANTHER	METHYL-CPG-BINDING DOMAIN PROTEIN 4	UniProtKB/TrEMBL
	PTHR15074	UniProtKB/TrEMBL
Pfam	HhH-GPD	UniProtKB/TrEMBL
	MBD	UniProtKB/TrEMBL
PIRSF	Methyl_CpG_bd_MBD4	UniProtKB/TrEMBL
PROSITE	MBD	UniProtKB/TrEMBL
SMART	MBD	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48150	UniProtKB/TrEMBL
	SSF54171	UniProtKB/TrEMBL
UniProt	A0A8C2VDG3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2VGJ0_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Mbd4	methyl-CpG binding domain 4, DNA glycosylase		methyl-CpG binding domain 4 DNA glycosylase	Symbol and/or name change	5135510	APPROVED
2015-08-25	Mbd4	methyl-CpG binding domain 4 DNA glycosylase		methyl-CpG binding domain protein 4	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations