Dkk2 (dickkopf WNT signaling pathway inhibitor 2) - Rat Genome Database

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Pathways
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Gene: Dkk2 (dickkopf WNT signaling pathway inhibitor 2) Chinchilla lanigera
Analyze
Symbol: Dkk2
Name: dickkopf WNT signaling pathway inhibitor 2
RGD ID: 8973886
Description: ENCODES a protein that exhibits co-receptor binding (ortholog); INVOLVED IN negative regulation of canonical Wnt signaling pathway (ortholog); negative regulation of Wnt signaling pathway (ortholog); positive regulation of canonical Wnt signaling pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dickkopf-related protein 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554962,489,373 - 2,578,639 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554962,489,373 - 2,578,310 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dkk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554962,489,373 - 2,578,639 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554962,489,373 - 2,578,310 (+)NCBIChiLan1.0ChiLan1.0
DKK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384106,921,802 - 107,036,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4106,921,802 - 107,283,806 (-)EnsemblGRCh38hg38GRCh38
GRCh374107,842,959 - 107,957,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364108,062,408 - 108,176,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 344108,200,564 - 108,315,057NCBI
Celera4105,142,017 - 105,256,526 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4103,577,892 - 103,692,398 (-)NCBIHuRef
CHM1_14107,819,993 - 107,934,463 (-)NCBICHM1_1
T2T-CHM13v2.04110,226,876 - 110,341,391 (-)NCBIT2T-CHM13v2.0
Dkk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393131,791,027 - 131,886,065 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3131,791,053 - 131,886,065 (+)EnsemblGRCm39 Ensembl
GRCm383132,085,266 - 132,180,304 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3132,085,292 - 132,180,304 (+)EnsemblGRCm38mm10GRCm38
MGSCv373131,748,256 - 131,843,268 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363132,022,607 - 132,117,610 (+)NCBIMGSCv36mm8
Celera3138,511,569 - 138,606,576 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map361.32NCBI
Dkk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82223,242,375 - 223,334,249 (+)NCBIGRCr8
mRatBN7.22220,568,338 - 220,660,225 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2220,568,338 - 220,660,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2228,216,913 - 228,308,598 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02226,116,586 - 226,208,267 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,974,246 - 221,065,929 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02237,148,918 - 237,240,883 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2237,148,941 - 237,241,350 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02255,689,579 - 255,781,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42229,542,203 - 229,634,156 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12229,529,344 - 229,619,963 (+)NCBI
Celera2212,811,245 - 212,902,656 (+)NCBICelera
Cytogenetic Map2q43NCBI
DKK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23105,015,174 - 105,130,173 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14105,316,460 - 105,431,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0499,428,210 - 99,542,884 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14110,002,933 - 110,117,159 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4110,001,499 - 110,117,326 (-)Ensemblpanpan1.1panPan2
DKK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13227,548,877 - 27,647,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3227,550,833 - 27,713,838 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3214,380,145 - 14,478,884 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03227,778,999 - 27,877,746 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3227,779,000 - 27,877,708 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13227,773,574 - 27,872,045 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03227,516,644 - 27,615,395 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03212,241,851 - 12,340,868 (+)NCBIUU_Cfam_GSD_1.0
Dkk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530113,467,767 - 13,563,668 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936814184,832 - 282,633 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936814184,625 - 280,945 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8114,862,247 - 114,974,304 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18114,862,056 - 114,974,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28123,169,059 - 123,280,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1754,875,611 - 54,982,310 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl754,875,627 - 54,982,300 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603733,521,289 - 33,628,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dkk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248302,093,797 - 2,186,754 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248302,093,481 - 2,186,497 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000004116   ⟹   ENSCLAP00000004035
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554962,489,373 - 2,578,639 (+)Ensembl
RefSeq Acc Id: XM_005406215   ⟹   XP_005406272
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554962,489,373 - 2,578,310 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005406272 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000004035
  ENSCLAP00000004035.1
Reference Protein Sequences
RefSeq Acc Id: XP_005406272   ⟸   XM_005406215
- UniProtKB: A0A8C2UTF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000004035   ⟸   ENSCLAT00000004116
Protein Domains
Dickkopf N-terminal cysteine-rich   Dickkopf-related protein 1/2/4 C-terminal subdomain


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002881 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004116 ENTREZGENE
  ENSCLAT00000004116.1 UniProtKB/TrEMBL
Gene3D-CATH Lipase, subunit A UniProtKB/TrEMBL
InterPro Dickkopf_N UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom1 UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom2 UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
  Dkk2_Cys1 UniProtKB/TrEMBL
  Dkk2_Cys2 UniProtKB/TrEMBL
NCBI Gene Dkk2 ENTREZGENE
PANTHER DICKKOPF-RELATED PROTEIN 2 UniProtKB/TrEMBL
  PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom1 UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom2 UniProtKB/TrEMBL
UniProt A0A8C2UTF0 ENTREZGENE, UniProtKB/TrEMBL