Rgl2 (ral guanine nucleotide dissociation stimulator like 2) - Rat Genome Database

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Gene: Rgl2 (ral guanine nucleotide dissociation stimulator like 2) Chinchilla lanigera
Analyze
Symbol: Rgl2
Name: ral guanine nucleotide dissociation stimulator like 2
RGD ID: 8967189
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN negative regulation of cardiac muscle cell apoptotic process (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); regulation of Ral protein signal transduction (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 5 (ortholog); proteasome-associated autoinflammatory syndrome 1 (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ral guanine nucleotide dissociation stimulator-like 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,851,005 - 1,856,720 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,851,005 - 1,857,567 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rgl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,851,005 - 1,856,720 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,851,005 - 1,857,567 (-)NCBIChiLan1.0ChiLan1.0
RGL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,291,654 - 33,301,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,291,654 - 33,298,942 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,259,431 - 33,266,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,367,414 - 33,374,716 (-)NCBINCBI36Build 36hg18NCBI36
Build 34633,367,415 - 33,374,716NCBI
Celera634,813,789 - 34,821,534 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef633,001,065 - 33,008,799 (-)NCBIHuRef
CHM1_1633,261,371 - 33,269,102 (-)NCBICHM1_1
T2T-CHM13v2.0633,113,016 - 33,120,834 (-)NCBIT2T-CHM13v2.0
Rgl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,148,813 - 34,156,661 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,148,517 - 34,156,661 (+)EnsemblGRCm39 Ensembl
GRCm381733,929,514 - 33,937,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,929,543 - 33,937,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,066,839 - 34,074,632 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,540,348 - 33,548,141 (+)NCBIMGSCv36mm8
Celera1736,682,808 - 36,690,599 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Ralgdsl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,950,379 - 4,958,315 (-)NCBIGRCr8
mRatBN7.2204,948,495 - 4,956,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,948,497 - 4,969,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,671,867 - 5,679,650 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,033,612 - 5,041,395 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,514,408 - 5,522,140 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,458,509 - 5,466,853 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,458,509 - 5,466,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,517,121 - 7,524,877 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,100,260 - 5,108,016 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,100,488 - 5,109,200 (-)NCBI
Celera206,532,606 - 6,540,362 (-)NCBICelera
Cytogenetic Map20p12NCBI
RGL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,769,559 - 47,777,456 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,641,226 - 43,648,923 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,863,954 - 32,871,684 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,978,024 - 33,985,749 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,978,024 - 33,985,749 (-)Ensemblpanpan1.1panPan2
RGL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,731,366 - 2,739,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,731,983 - 2,739,032 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,812,550 - 2,820,074 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,063,045 - 3,070,569 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,063,050 - 3,070,550 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,730,271 - 2,737,794 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,811,759 - 2,819,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,886,472 - 2,893,996 (-)NCBIUU_Cfam_GSD_1.0
Rgl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,384,992 - 38,392,961 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,566,925 - 25,577,066 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,566,714 - 25,574,667 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,655,743 - 29,662,375 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,655,530 - 29,662,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,159,294 - 34,167,044 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,777,719 - 38,785,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,778,859 - 38,785,984 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,126,279 - 33,133,987 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,522,258 - 23,529,766 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,522,277 - 23,530,541 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000014325   ⟹   ENSCLAP00000014167
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554371,851,005 - 1,856,720 (-)Ensembl
RefSeq Acc Id: XM_005389484   ⟹   XP_005389541
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554371,851,005 - 1,857,567 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005389541 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000014167
  ENSCLAP00000014167.1
Reference Protein Sequences
RefSeq Acc Id: XP_005389541   ⟸   XM_005389484
- UniProtKB: A0A8C2VKG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000014167   ⟸   ENSCLAT00000014325
Protein Domains
N-terminal Ras-GEF   Ras-associating   Ras-GEF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009780 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014325 ENTREZGENE
  ENSCLAT00000014325.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro RA_dom UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Rgl2 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2 UniProtKB/TrEMBL
Pfam PF00788 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PROSITE PS50200 UniProtKB/TrEMBL
  RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  SM00314 UniProtKB/TrEMBL
Superfamily-SCOP SSF48366 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8C2VKG2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Rgl2  ral guanine nucleotide dissociation stimulator like 2    ral guanine nucleotide dissociation stimulator-like 2  Symbol and/or name change 5135510 APPROVED