Fcho2 (FCH and mu domain containing endocytic adaptor 2) - Rat Genome Database

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Gene: Fcho2 (FCH and mu domain containing endocytic adaptor 2) Chinchilla lanigera
Analyze
Symbol: Fcho2
Name: FCH and mu domain containing endocytic adaptor 2
RGD ID: 8942238
Description: ENCODES a protein that exhibits identical protein binding (ortholog); phosphatidylinositol binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); clathrin-dependent endocytosis (ortholog); membrane invagination (ortholog); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN clathrin-coated pit (ortholog); clathrin-coated vesicle (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-BAR domain only protein 2; FCH domain only 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542527,506,660 - 27,632,983 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542527,506,645 - 27,632,983 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Fcho2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542527,506,660 - 27,632,983 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542527,506,645 - 27,632,983 (-)NCBIChiLan1.0ChiLan1.0
FCHO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38572,956,041 - 73,090,522 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl572,956,041 - 73,090,522 (+)EnsemblGRCh38hg38GRCh38
GRCh37572,251,868 - 72,386,349 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36572,287,655 - 72,422,105 (+)NCBINCBI36Build 36hg18NCBI36
Celera568,147,183 - 68,281,688 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef567,457,697 - 67,591,999 (+)NCBIHuRef
CHM1_1571,684,573 - 71,818,938 (+)NCBICHM1_1
T2T-CHM13v2.0573,437,124 - 73,571,849 (+)NCBIT2T-CHM13v2.0
Fcho2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391398,859,914 - 98,953,085 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1398,859,911 - 98,951,957 (-)EnsemblGRCm39 Ensembl
GRCm381398,723,406 - 98,816,577 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1398,723,403 - 98,815,449 (-)EnsemblGRCm38mm10GRCm38
MGSCv371399,493,361 - 99,585,404 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361399,823,567 - 99,915,303 (-)NCBIMGSCv36mm8
Celera13102,384,562 - 102,476,173 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.16NCBI
Fcho2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8231,813,356 - 31,916,471 (-)NCBIGRCr8
mRatBN7.2230,079,143 - 30,181,639 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,080,962 - 30,181,241 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,142,108 - 37,242,707 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0235,236,463 - 35,337,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0230,049,355 - 30,149,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0228,927,918 - 29,029,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl228,926,107 - 29,029,176 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,110,537 - 48,211,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4229,349,477 - 29,451,434 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera226,114,535 - 26,214,094 (-)NCBICelera
Cytogenetic Map2q12NCBI
FCHO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2442,224,615 - 42,363,411 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1540,378,249 - 40,519,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0542,223,201 - 42,361,317 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1542,822,190 - 42,958,619 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl542,824,621 - 42,958,565 (-)Ensemblpanpan1.1panPan2
FCHO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1255,905,497 - 56,011,395 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl255,905,520 - 56,009,131 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha252,856,825 - 52,977,919 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0256,405,588 - 56,526,744 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl256,405,494 - 56,526,744 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,465,325 - 53,587,071 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0254,233,789 - 54,354,882 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0255,124,469 - 55,245,831 (+)NCBIUU_Cfam_GSD_1.0
Fcho2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213187,276,731 - 187,403,801 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365493,455,172 - 3,565,558 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365493,455,172 - 3,565,507 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCHO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl282,101,343 - 82,248,821 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1282,101,283 - 82,248,410 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2283,869,528 - 83,956,906 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FCHO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1467,289,172 - 67,430,622 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl467,301,984 - 67,428,194 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604916,057,428 - 16,198,003 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcho2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249052,029,808 - 2,140,721 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249052,027,709 - 2,139,312 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000014108   ⟹   ENSCLAP00000013952
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542527,506,660 - 27,632,983 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000014109   ⟹   ENSCLAP00000013953
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542527,507,753 - 27,615,069 (-)Ensembl
RefSeq Acc Id: XM_005386078   ⟹   XP_005386135
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542527,506,645 - 27,632,983 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005386135 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000013952
  ENSCLAP00000013952.1
  ENSCLAP00000013953.1
Reference Protein Sequences
RefSeq Acc Id: XP_005386135   ⟸   XM_005386078
- UniProtKB: A0A8C2VFN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000013952   ⟸   ENSCLAT00000014108
RefSeq Acc Id: ENSCLAP00000013953   ⟸   ENSCLAT00000014109
Protein Domains
F-BAR   MHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009654 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014108 ENTREZGENE
  ENSCLAT00000014108.1 UniProtKB/TrEMBL
  ENSCLAT00000014109.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  Mu homology domain, subdomain B UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH_dom UniProtKB/TrEMBL
  FCHo2 UniProtKB/TrEMBL
  MHD UniProtKB/TrEMBL
  Muniscin_C UniProtKB/TrEMBL
NCBI Gene Fcho2 ENTREZGENE
PANTHER PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 UniProtKB/TrEMBL
  PTHR23065:SF8 UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  muHD UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/TrEMBL
  MHD UniProtKB/TrEMBL
SMART FCH UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
UniProt A0A8C2VFN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VIV6_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-23 Fcho2  FCH and mu domain containing endocytic adaptor 2  Fcho2  FCH domain only 2  Symbol and/or name change 5135510 APPROVED