Duox1 (dual oxidase 1) - Rat Genome Database

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Gene: Duox1 (dual oxidase 1) Chinchilla lanigera
Analyze
Symbol: Duox1
Name: dual oxidase 1
RGD ID: 8868369
Description: INVOLVED IN cuticle development (ortholog); cytokine-mediated signaling pathway (ortholog); hydrogen peroxide biosynthetic process (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATED WITH AGAT deficiency (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN cell leading edge (ortholog); cell surface (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,229,199 - 8,255,003 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,228,754 - 8,256,575 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Duox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,229,199 - 8,255,003 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,228,754 - 8,256,575 (-)NCBIChiLan1.0ChiLan1.0
DUOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,129,994 - 45,165,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1545,129,933 - 45,165,576 (+)EnsemblGRCh38hg38GRCh38
GRCh371545,422,192 - 45,457,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,209,484 - 43,245,066 (+)NCBINCBI36Build 36hg18NCBI36
Build 341543,209,483 - 43,245,066NCBI
Celera1522,313,628 - 22,349,058 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,246,405 - 22,281,983 (+)NCBIHuRef
CHM1_11545,540,525 - 45,576,452 (+)NCBICHM1_1
T2T-CHM13v2.01542,938,016 - 42,973,584 (+)NCBIT2T-CHM13v2.0
Duox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,143,525 - 122,178,454 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,146,153 - 122,178,453 (+)EnsemblGRCm39 Ensembl
GRCm382122,313,010 - 122,347,972 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,315,672 - 122,347,972 (+)EnsemblGRCm38mm10GRCm38
MGSCv372122,141,408 - 122,173,708 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362122,005,116 - 122,039,413 (+)NCBIMGSCv36mm8
MGSCv362123,286,960 - 123,321,338 (+)NCBIMGSCv36mm8
Celera2123,465,585 - 123,497,811 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.63NCBI
Duox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,714,125 - 129,749,186 (+)NCBIGRCr8
mRatBN7.23109,260,526 - 109,295,588 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,262,397 - 109,295,563 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,936,198 - 112,969,389 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,531,719 - 121,564,910 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,192,095 - 119,225,286 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,251,794 - 114,286,827 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,253,637 - 114,286,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,791,108 - 120,826,222 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,095,250 - 109,128,415 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13109,000,832 - 109,033,988 (+)NCBI
Celera3108,160,238 - 108,192,976 (+)NCBICelera
Cytogenetic Map3q35NCBI
DUOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,370,156 - 34,405,770 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,548,314 - 38,585,332 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01524,077,557 - 24,113,206 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,432,792 - 42,466,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,431,595 - 42,467,943 (+)Ensemblpanpan1.1panPan2
DUOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,556,024 - 11,588,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,556,024 - 11,588,202 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,612,190 - 11,644,063 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03011,692,796 - 11,724,747 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3011,692,815 - 11,724,746 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13011,599,266 - 11,631,208 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,721,544 - 11,753,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03011,841,362 - 11,873,559 (+)NCBIUU_Cfam_GSD_1.0
Duox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,998,522 - 90,032,014 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,848,472 - 7,879,390 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364717,848,472 - 7,881,417 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,572,492 - 126,603,082 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,572,533 - 126,603,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,171,519 - 141,206,750 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,038,093 - 38,073,993 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2638,038,771 - 38,072,023 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048102,986,753 - 103,021,591 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Duox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,081,245 - 14,107,104 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,080,670 - 14,107,532 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017407   ⟹   ENSCLAP00000017238
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554098,229,199 - 8,255,003 (-)Ensembl
RefSeq Acc Id: XM_005377149   ⟹   XP_005377206
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554098,228,754 - 8,256,575 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013510312   ⟹   XP_013365766
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554098,228,754 - 8,255,773 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013510313   ⟹   XP_013365767
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554098,228,754 - 8,256,575 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005377206 (Get FASTA)   NCBI Sequence Viewer  
  XP_013365766 (Get FASTA)   NCBI Sequence Viewer  
  XP_013365767 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017238
  ENSCLAP00000017238.1
Reference Protein Sequences
RefSeq Acc Id: XP_005377206   ⟸   XM_005377149
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VLB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013365767   ⟸   XM_013510313
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VLB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013365766   ⟸   XM_013510312
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VLB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000017238   ⟸   ENSCLAT00000017407
Protein Domains
EF-hand   FAD-binding FR-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011832 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017407 ENTREZGENE
  ENSCLAT00000017407.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  Translation factors UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  FAD-bd_8 UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/TrEMBL
  Fe3_Rdtase_TM_dom UniProtKB/TrEMBL
  Fe_red_NAD-bd_6 UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/TrEMBL
NCBI Gene Duox1 ENTREZGENE
PANTHER NADPH OXIDASE UniProtKB/TrEMBL
  PTHR11972:SF75 UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/TrEMBL
  EF-hand_1 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
  FAD_binding_8 UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/TrEMBL
  NAD_binding_6 UniProtKB/TrEMBL
PRINTS RECOVERIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  FAD_FR UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF48113 UniProtKB/TrEMBL
  SSF52343 UniProtKB/TrEMBL
  SSF63380 UniProtKB/TrEMBL
UniProt A0A8C2VLB6 ENTREZGENE, UniProtKB/TrEMBL