Sucla2 (succinate-CoA ligase ADP-forming subunit beta)

Gene: Sucla2 (succinate-CoA ligase ADP-forming subunit beta) Chinchilla lanigera

Analyze

Symbol:

Sucla2

Name:

succinate-CoA ligase ADP-forming subunit beta (Ensembl:succinate-CoA ligase ADP-forming beta subunit)

RGD ID:

8832322

Description:

ENCODES a protein that exhibits succinate-CoA ligase (ADP-forming) activity (ortholog); INVOLVED IN succinate metabolic process (ortholog); succinyl-CoA metabolic process (ortholog); tricarboxylic acid cycle (ortholog); PARTICIPATES IN citric acid cycle pathway; ASSOCIATED WITH chromosome 13q14 deletion syndrome (ortholog); Developmental Disabilities (ortholog); genetic disease (ortholog); FOUND IN mitochondrion (ortholog); succinate-CoA ligase complex (ADP-forming) (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

succinate-CoA ligase ADP-forming beta subunit; succinate-CoA ligase, ADP-forming, beta subunit; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	1,676,362 - 1,737,489 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955431	1,678,720 - 1,737,234 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 13q14 deletion syndrome (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

intellectual disability (ISO)

mitochondrial DNA depletion syndrome (ISO)

mitochondrial DNA depletion syndrome 5 (ISO)

obesity (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

succinate metabolic process (ISO)

succinyl-CoA metabolic process (ISO)

tricarboxylic acid cycle (ISO)

Cellular Component

mitochondrion (ISO)

succinate-CoA ligase complex (ADP-forming) (ISO)

Molecular Function

protein binding (ISO)

succinate-CoA ligase (ADP-forming) activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

citric acid cycle pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Sucla2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	1,676,362 - 1,737,489 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955431	1,678,720 - 1,737,234 (-)	NCBI	ChiLan1.0	ChiLan1.0

SUCLA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	47,942,656 - 48,001,273 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	47,745,736 - 48,037,968 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	48,516,791 - 48,575,409 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	47,414,792 - 47,473,463 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	47,414,792 - 47,473,463	NCBI
Celera	13	29,571,546 - 29,630,199 (-)	NCBI		Celera
Cytogenetic Map	13	q14.2	NCBI
HuRef	13	29,309,155 - 29,368,411 (-)	NCBI		HuRef
CHM1_1	13	48,484,523 - 48,543,193 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	47,163,055 - 47,221,676 (-)	NCBI		T2T-CHM13v2.0

Sucla2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	73,790,226 - 73,833,584 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	73,762,759 - 73,833,582 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	73,552,786 - 73,596,144 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	73,525,319 - 73,596,142 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	73,952,593 - 73,995,949 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	72,286,941 - 72,330,297 (+)	NCBI		MGSCv36	mm8
Celera	14	71,073,111 - 71,117,384 (+)	NCBI		Celera
Cytogenetic Map	14	D3	NCBI
cM Map	14	39.06	NCBI

Sucla2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	55,161,894 - 55,215,031 (+)	NCBI		GRCr8
mRatBN7.2	15	48,752,356 - 48,805,495 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	48,752,312 - 48,805,138 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	52,895,875 - 52,948,688 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	54,007,458 - 54,060,266 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	50,851,011 - 50,904,131 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	55,461,695 - 55,516,954 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	55,461,695 - 55,516,952 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	59,183,906 - 59,238,472 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	54,214,262 - 54,267,830 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	54,229,991 - 54,283,608 (+)	NCBI
Celera	15	48,400,643 - 48,453,857 (+)	NCBI		Celera
Cytogenetic Map	15	q11	NCBI

SUCLA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	49,394,622 - 49,453,897 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	48,045,845 - 48,104,812 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	29,095,062 - 29,189,618 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	47,797,472 - 47,856,138 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	47,797,472 - 47,856,138 (-)	Ensembl	panpan1.1		panPan2

SUCLA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	3,440,908 - 3,478,683 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	3,440,923 - 3,478,683 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	3,467,376 - 3,511,078 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	3,553,012 - 3,596,821 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	3,552,645 - 3,748,277 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	3,337,746 - 3,381,115 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	3,400,838 - 3,444,516 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	3,405,868 - 3,449,226 (+)	NCBI		UU_Cfam_GSD_1.0

Sucla2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	157,829,100 - 157,871,665 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936565	1,313,150 - 1,355,693 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936565	1,313,150 - 1,355,693 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SUCLA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	19,616,495 - 19,670,662 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	19,616,415 - 19,670,667 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	20,069,114 - 20,123,461 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SUCLA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	25,889,687 - 25,951,641 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666057	18,008,281 - 18,072,322 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sucla2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624748	6,848,804 - 6,923,478 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624748	6,848,785 - 6,923,831 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005387550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01029913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01029914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01029915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01005588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000010886 ⟹ ENSCLAP00000010753

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955431	1,676,362 - 1,737,489 (-)	Ensembl

RefSeq Acc Id:

XM_005387550 ⟹ XP_005387607

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955431	1,678,720 - 1,737,234 (-)	NCBI

Sequence:

show sequence

CGCCGCACTCCGCGTCGCTCTTCTGCGCCTGCGCGAGGCGCCGAGGGGACGGGTCGGACTCAGG
AATGGCGGCCTCCGTGTTCTATAGCCGGTTGTTGGCCGCGGCCACCCTTAGGAGCCACCTGCCC
CGGACGGCGCTGCGGGCCGCCGCCCAGGTTCTGGGAAATTCTGGATTGTTTAATAATCATGGAC
TCCAAGTACAGCAGCAACAGCAAAGAAATCTCTCACTACATGAATATATGAGTATGGAATTGTT
GCAAGAAGCTGGTGTCTCAATTCCCAAAGGTTATGTGGCAAAGTCAGCAGATGAAGCTTATGCA
ATTGCCAAAAAATTAGGTTCAAAAGATGTTGTGATAAAGGCACAGGTTTTAGCTGGTGGTAGAG
GAAAAGGAACATTTGAAAGTGGCCTGAAAGGAGGAGTGAAGATAGTTTTCTCTCCAGAAGAAGC
AAAAGCTGTTTCTTCACAGATGATTGGGAAAAAGTTGTTTACCAAGCAAACTGGAGAAAAGGGC
AGAATATGCAATCAAGTTTTGATTTGTGAGAGAAAATACCCCAGGAGAGAATACTACTTTGCAA
TAACAATGGAAAGGTCATTTCACGGTCCTGTATTAATAGGAAGTTCACAAGGTGGTGTTAATAT
CGAAGATGTTGCTGCTGAAACTCCTGATGCCATAGTTAAAGAACCTGTTGATATTGTAGAAGGC
ATCAAAAAGGAACAAGCTGTCCGGCTAGCACAGAAGATGGGATTTCCACCTAATATTGTGGATT
CTGCGGCAGAAAACATGGTCAAGCTTTATAACCTTTTTCTGAAATATGATGCAACCATGGTAGA
AATAAATCCAATGGTAGAAGATTCAGATGGAGCTGTGCTTTGTATGGATGCAAAGATCAATTTT
GATTCAAATTCAGCCTATCGCCAAAAGAAAATCTTTGATCTTCAGGACTGGACCCAAGAAGATG
AAAGGGACAGAGAAGCAGCTAAGGCAGATCTCAACTACATTGGCCTTGACGGAAATATAGGCTG
TCTAGTAAATGGTGCTGGTTTGGCTATGGCCACAATGGATATAATAAAACTTCATGGAGGGACA
CCAGCCAACTTCCTTGATGTTGGTGGTGGTGCCACGGTTCATCAAGTAACAGAAGCATTTAAGC
TTATCACTTCAGATAAAAAGGTACTGGCTATTCTGGTCAACATTTTTGGAGGAATCATGCGATG
TGATGTTATTGCACAGGGTATAGTCATGGCAGTGAAAGACTTGGAAATTAAAATACCTGTTGTG
GTACGGTTACAAGGTACACGAGTTGATGATGCCAAGGCACTGATAGCAGACAGTGGGCTTAAAA
TTCTTGCTTGTGATGACTTGGATGAAGCTGCTAGAATGGTTGTAAAGCTCTCTGAAATAGTGAC
CTTAGCCAAGCAAGCCCATGTAGATGTGAAATTTCAGTTGCCAATCTGATCTGAGAACCCAGTG
GATGGCTGAAGGTGTTAAATGTGCTGTAATCTTTGAAAATACTGTGTTCTGTATTGTTCTTTTT
CTTTTTAGTGTGTGGAGATTTTGTCATATAGGTACACAGACCTTTAAAAGCGTTTGGTCTGCAT
TTAATTCTGTTATTCAGAACCATCTGTATAAAGAACGTATACTGCAGGCATCTAGTTTCTTATT
TGCGTCCATCTTTTTTGCTTCTCCTGCAATGTCACTTACAATATCCCTGTTTTTTATTGTTGGA
TACAAAGTTCTTCATTGATAAGATTCCTATAAATAAAATAAATATGAAGATAAAGCTTTATTCT
TTAGTATTAAAATATATTATATCTAATAACTAGTCTCATTAGTAGAGCAGTGTATTAAAACAAT
GTTTTATATAAGAAGTGTTTATCCTCAGTACCAAATACCTAATAAATGTATCCGTCACTATTTA
TAGACAGCACTTTTCAAACACTCCTCAGAATGTTCTTTTTAAGTGAAGTAACTTGCTAATTGTT
TGAATGAGTGTTGTTTTAATCATTGTACAACCCTGATAACTGCAAGTCTTCATGATTCTGTGGT
ATTAAGAAACACCTATAGGTTTATATTAAGTTAATAAGGACTTGGAAGACAAAATTGAAAATGT
CAATGTAAGTTAATAAAAATTTACCAATGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005387607	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000010753
	ENSCLAP00000010753.1

RefSeq Acc Id:

XP_005387607 ⟸ XM_005387550

- UniProtKB:

A0A8C2YN26 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAASVFYSRLLAAATLRSHLPRTALRAAAQVLGNSGLFNNHGLQVQQQQQRNLSLHEYMSMELL
QEAGVSIPKGYVAKSADEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEA
KAVSSQMIGKKLFTKQTGEKGRICNQVLICERKYPRREYYFAITMERSFHGPVLIGSSQGGVNI
EDVAAETPDAIVKEPVDIVEGIKKEQAVRLAQKMGFPPNIVDSAAENMVKLYNLFLKYDATMVE
INPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDREAAKADLNYIGLDGNIGC
LVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRC
DVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVT
LAKQAHVDVKFQLPI

hide sequence

RefSeq Acc Id:

ENSCLAP00000010753 ⟸ ENSCLAT00000010886

Protein Domains

ATP-grasp

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007422	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000010886	ENTREZGENE
	ENSCLAT00000010886.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1490.20	UniProtKB/TrEMBL
	3.40.50.261	UniProtKB/TrEMBL
	ATP-grasp fold, B domain	UniProtKB/TrEMBL
InterPro	ATP-grasp	UniProtKB/TrEMBL
	ATP-grasp_succ-CoA_synth-type	UniProtKB/TrEMBL
	ATP_grasp_subdomain_1	UniProtKB/TrEMBL
	CoA_ligase	UniProtKB/TrEMBL
	Succ-CoA_synthase_bsu_CS	UniProtKB/TrEMBL
	Succ_CoA_betaA_euk	UniProtKB/TrEMBL
	Succ_CoA_synthase_bsu	UniProtKB/TrEMBL
	Succinyl-CoA_synth-like	UniProtKB/TrEMBL
NCBI Gene	Sucla2	ENTREZGENE
PANTHER	PTHR11815	UniProtKB/TrEMBL
	SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	ATP-grasp_2	UniProtKB/TrEMBL
	Ligase_CoA	UniProtKB/TrEMBL
PIRSF	SucCS_beta	UniProtKB/TrEMBL
PROSITE	ATP_GRASP	UniProtKB/TrEMBL
	SUCCINYL_COA_LIG_3	UniProtKB/TrEMBL
Superfamily-SCOP	Glutathione synthetase ATP-binding domain-like	UniProtKB/TrEMBL
	SSF52210	UniProtKB/TrEMBL
UniProt	A0A8C2YN26	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-09-07	Sucla2	succinate-CoA ligase ADP-forming subunit beta	Sucla2	succinate-CoA ligase ADP-forming beta subunit	Symbol and/or name change	5135510	APPROVED
2016-08-03	Sucla2	succinate-CoA ligase ADP-forming beta subunit		succinate-CoA ligase, ADP-forming, beta subunit	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations