P2ry12 (purinergic receptor P2Y12) - Rat Genome Database

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Gene: P2ry12 (purinergic receptor P2Y12) Chinchilla lanigera
Analyze
Symbol: P2ry12
Name: purinergic receptor P2Y12
RGD ID: 8745275
Description: ENCODES a protein that exhibits G protein-coupled adenosine receptor activity (ortholog); G protein-coupled ADP receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); calcium ion transmembrane transport (ortholog); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ticlopidine pharmacodynamics pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Lung Injury (ortholog); arteriosclerosis (ortholog); FOUND IN basal plasma membrane (ortholog); caveola (ortholog); cell body membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: P2Y purinoceptor 12; purinergic receptor P2Y, G-protein coupled, 12
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554482,442,368 - 2,488,567 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554482,442,368 - 2,488,567 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
calcium ion transmembrane transport  (ISO)
calcium-mediated signaling  (ISO)
cell projection organization  (ISO)
cellular response to ATP  (ISO)
cellular response to organic cyclic compound  (ISO)
cerebral cortex radial glia-guided migration  (ISO)
establishment of localization in cell  (ISO)
G protein-coupled adenosine receptor signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glial cell migration  (ISO)
lamellipodium assembly  (ISO)
monoatomic ion transport  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of norepinephrine secretion  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
platelet activation  (ISO)
platelet aggregation  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of integrin activation by cell surface receptor linked signal transduction  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of monoatomic ion transport  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of ruffle assembly  (ISO)
potassium ion transmembrane transport  (ISO)
regulation of calcium ion transport  (ISO)
regulation of chemotaxis  (ISO)
regulation of microglial cell migration  (ISO)
response to axon injury  (ISO)
substrate-dependent cell migration, cell extension  (ISO)
visual system development  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
P2ry12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554482,442,368 - 2,488,567 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554482,442,368 - 2,488,567 (-)NCBIChiLan1.0ChiLan1.0
P2RY12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383151,336,843 - 151,384,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3151,336,843 - 151,384,753 (-)EnsemblGRCh38hg38GRCh38
GRCh373151,054,631 - 151,102,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363152,538,066 - 152,585,234 (-)NCBINCBI36Build 36hg18NCBI36
Build 343152,538,073 - 152,541,283NCBI
Celera3149,468,086 - 149,515,254 (-)NCBICelera
Cytogenetic Map3q25.1NCBI
HuRef3148,427,988 - 148,475,876 (-)NCBIHuRef
CHM1_13151,017,744 - 151,065,720 (-)NCBICHM1_1
T2T-CHM13v2.03154,087,845 - 154,135,691 (-)NCBIT2T-CHM13v2.0
P2ry12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39359,123,692 - 59,170,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl359,123,693 - 59,170,292 (-)EnsemblGRCm39 Ensembl
GRCm38359,216,271 - 59,262,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl359,216,272 - 59,262,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv37359,020,193 - 59,066,753 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36359,304,201 - 59,350,751 (-)NCBIMGSCv36mm8
Celera358,903,452 - 58,949,752 (-)NCBICelera
Cytogenetic Map3DNCBI
cM Map329.01NCBI
P2ry12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,631,487 - 145,673,194 (-)NCBIGRCr8
mRatBN7.22143,481,468 - 143,523,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2143,481,430 - 143,523,361 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2150,121,752 - 150,124,700 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02148,234,328 - 148,237,278 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02142,866,741 - 142,869,691 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02149,440,807 - 149,482,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2149,441,598 - 149,444,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02168,873,062 - 168,914,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,611,035 - 148,613,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12148,560,997 - 148,563,948 (-)NCBI
Celera2137,906,910 - 137,909,860 (-)NCBICelera
Cytogenetic Map2q26NCBI
P2RY12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22149,235,279 - 149,282,898 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13149,240,013 - 149,287,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03148,364,151 - 148,412,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13155,934,333 - 155,981,818 (-)NCBIpanpan1.1PanPan1.1panPan2
P2RY12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12345,908,574 - 45,954,675 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2345,909,485 - 45,910,526 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2345,774,299 - 45,775,340 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02346,535,240 - 46,581,332 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2346,535,243 - 46,581,291 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12346,125,167 - 46,126,208 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02346,177,435 - 46,178,476 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02346,454,355 - 46,455,396 (-)NCBIUU_Cfam_GSD_1.0
P2ry12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560290,143,659 - 90,185,986 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367581,581,897 - 1,592,222 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367581,581,828 - 1,624,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1391,521,817 - 91,572,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11391,522,754 - 91,572,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21399,604,550 - 99,654,172 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11539,315,140 - 39,361,614 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1539,359,612 - 39,360,637 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604112,130,267 - 12,177,497 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473028,772,525 - 28,782,431 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473028,771,020 - 28,819,179 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000003320   ⟹   ENSCLAP00000003255
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554482,442,368 - 2,488,567 (-)Ensembl
RefSeq Acc Id: XM_005393019   ⟹   XP_005393076
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554482,442,368 - 2,488,567 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005393020   ⟹   XP_005393077
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554482,442,368 - 2,453,107 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005393076 (Get FASTA)   NCBI Sequence Viewer  
  XP_005393077 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000003255
  ENSCLAP00000003255.1
Reference Protein Sequences
RefSeq Acc Id: XP_005393076   ⟸   XM_005393019
- UniProtKB: A0A8C2URI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005393077   ⟸   XM_005393020
- UniProtKB: A0A8C2URI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000003255   ⟸   ENSCLAT00000003320
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002335 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000003320 ENTREZGENE
  ENSCLAT00000003320.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  P2Y12_rcpt UniProtKB/TrEMBL
NCBI Gene P2ry12 ENTREZGENE
PANTHER P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR24233:SF0 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  P2Y12PRNCPTR UniProtKB/TrEMBL
  P2YPURNOCPTR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C2URI8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 P2ry12  purinergic receptor P2Y12    purinergic receptor P2Y, G-protein coupled, 12  Symbol and/or name change 5135510 APPROVED