MIR6840 (microRNA 6840) - Rat Genome Database

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Gene: MIR6840 (microRNA 6840) Homo sapiens
Analyze
Symbol: MIR6840
Name: microRNA 6840
RGD ID: 8551389
HGNC Page HGNC:50138
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6840
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,356,651 - 100,356,721 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,356,651 - 100,356,721 (+)EnsemblGRCh38hg38GRCh38
GRCh37799,954,274 - 99,954,344 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map7q22.1NCBI
HuRef794,587,551 - 94,587,621 (+)NCBIHuRef
CHM1_1799,884,849 - 99,884,919 (+)NCBICHM1_1
T2T-CHM13v2.07101,596,730 - 101,596,800 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1		 pathogenic|uncertain significance
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99932610-102473188)x3 copy number gain See cases [RCV000138109] Chr7:99932610..102473188 [GRCh38]
Chr7:99530233..102113635 [GRCh37]
Chr7:99368169..101900640 [NCBI36]
Chr7:7q22.1		 uncertain significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1		 pathogenic
GRCh38/hg38 7q22.1(chr7:99219420-100902269)x1 copy number loss See cases [RCV000054154] Chr7:99219420..100902269 [GRCh38]
Chr7:98817043..100499889 [GRCh37]
Chr7:98654979..100337825 [NCBI36]
Chr7:7q22.1		 pathogenic
GRCh38/hg38 7q22.1(chr7:98454022-100723798)x1 copy number loss Multiple congenital anomalies/dysmorphic syndrome [RCV003327701] Chr7:98454022..100723798 [GRCh38]
Chr7:7q22.1		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:69613
Count of gene targets:19621
Count of transcripts:49962
Interacting mature miRNAs:hsa-miR-6840-3p, hsa-miR-6840-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000611937
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7100,356,651 - 100,356,721 (+)Ensembl
RefSeq Acc Id: NR_106899
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387100,356,651 - 100,356,721 (+)NCBI
HuRef794,587,551 - 94,587,621 (+)NCBI
CHM1_1799,884,849 - 99,884,919 (+)NCBI
T2T-CHM13v2.07101,596,730 - 101,596,800 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR6840 COSMIC
Ensembl Genes ENSG00000284012 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000611937 ENTREZGENE
GTEx ENSG00000284012 GTEx
HGNC ID HGNC:50138 ENTREZGENE
Human Proteome Map MIR6840 Human Proteome Map
miRBase MI0022686 ENTREZGENE
NCBI Gene MIR6840 ENTREZGENE
RNAcentral URS000075B995 RNACentral
  URS000075C1B6 RNACentral
  URS000075C594 RNACentral