MIR6779 (microRNA 6779) - Rat Genome Database

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Pathways
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Gene: MIR6779 (microRNA 6779) Homo sapiens
Analyze
Symbol: MIR6779
Name: microRNA 6779
RGD ID: 8551384
HGNC Page HGNC:50148
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6779
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381738,914,979 - 38,915,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1738,914,979 - 38,915,042 (+)EnsemblGRCh38hg38GRCh38
GRCh371737,071,232 - 37,071,295 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q12NCBI
HuRef1732,866,424 - 32,866,487 (+)NCBIHuRef
CHM1_11737,306,531 - 37,306,594 (+)NCBICHM1_1
T2T-CHM13v2.01739,778,055 - 39,778,118 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:101801
Count of gene targets:26019
Count of transcripts:70594
Interacting mature miRNAs:hsa-miR-6779-3p, hsa-miR-6779-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1
Low 48 20 14 6 80 7 39 16 38 22 36 79 6 7 20 1
Below cutoff 21 7 5 3 28 4 14 23 26 10 6 15 5

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000617283
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1738,914,979 - 38,915,042 (+)Ensembl
RefSeq Acc Id: NR_106837
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381738,914,979 - 38,915,042 (+)NCBI
HuRef1732,866,424 - 32,866,487 (+)NCBI
CHM1_11737,306,531 - 37,306,594 (+)NCBI
T2T-CHM13v2.01739,778,055 - 39,778,118 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR6779 COSMIC
Ensembl Genes ENSG00000277057 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000617283 ENTREZGENE
GTEx ENSG00000277057 GTEx
HGNC ID HGNC:50148 ENTREZGENE
Human Proteome Map MIR6779 Human Proteome Map
miRBase MI0022624 ENTREZGENE
NCBI Gene MIR6779 ENTREZGENE
RNAcentral URS000075A236 RNACentral
  URS000075B933 RNACentral
  URS000075D7CB RNACentral