MIR6886 (microRNA 6886) - Rat Genome Database

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Gene: MIR6886 (microRNA 6886) Homo sapiens
Analyze
Symbol: MIR6886
Name: microRNA 6886
RGD ID: 8551252
HGNC Page HGNC:50121
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6886
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,113,474 - 11,113,534 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,113,474 - 11,113,534 (+)EnsemblGRCh38hg38GRCh38
GRCh371911,224,150 - 11,224,210 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map19p13.2NCBI
HuRef1910,800,495 - 10,800,555 (+)NCBIHuRef
CHM1_11911,225,405 - 11,225,465 (+)NCBICHM1_1
T2T-CHM13v2.01911,240,483 - 11,240,543 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

Variants

.
Variants in MIR6886
22 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NC_000019.10:g.(?_11110632)_(11117018_?)del deletion Hypercholesterolemia, familial, 1 [RCV000543243] Chr19:11110632..11117018 [GRCh38]
Chr19:19p13.2		 pathogenic
FH Osaka 2 deletion Hypercholesterolemia, familial, 1 [RCV000003914] Chr19:11110330..11121805 [GRCh38]
Chr19:11221006..11232481 [GRCh37]
Chr19:19p13.2		 pathogenic|other
GRCh38/hg38 19p13.2(chr19:9735443-11228001)x1 copy number loss See cases [RCV000135403] Chr19:9735443..11228001 [GRCh38]
Chr19:9846119..11338677 [GRCh37]
Chr19:9707119..11199677 [NCBI36]
Chr19:19p13.2		 pathogenic
GRCh38/hg38 19p13.2-13.13(chr19:10319474-13777860)x1 copy number loss See cases [RCV000141568] Chr19:10319474..13777860 [GRCh38]
Chr19:10430150..13888674 [GRCh37]
Chr19:10291150..13749674 [NCBI36]
Chr19:19p13.2-13.13		 pathogenic
GRCh38/hg38 19p13.2-13.13(chr19:8831147-13331227)x3 copy number gain See cases [RCV000052908] Chr19:8831147..13331227 [GRCh38]
Chr19:8941823..13442041 [GRCh37]
Chr19:8802823..13303041 [NCBI36]
Chr19:19p13.2-13.13		 likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:10315258-14048994)x3 copy number gain See cases [RCV000052909] Chr19:10315258..14048994 [GRCh38]
Chr19:10425934..14159806 [GRCh37]
Chr19:10286934..14020806 [NCBI36]
Chr19:19p13.2-13.12		 pathogenic
NM_000527.5(LDLR):c.1359-1G>A single nucleotide variant Cardiovascular phenotype [RCV002381462]|Familial hypercholesterolemia [RCV000775066]|Homozygous familial hypercholesterolemia [RCV000844728]|Hypercholesterolemia [RCV002051685]|Hypercholesterolemia, familial, 1 [RCV000172962]|not provided [RCV001579677] Chr19:11113534 [GRCh38]
Chr19:11224210 [GRCh37]
Chr19:19p13.2		 pathogenic|likely pathogenic|conflicting interpretations of pathogenicity
NM_000527.5(LDLR):c.1359-30C>T single nucleotide variant Cardiovascular phenotype [RCV002379067]|Familial hypercholesterolemia [RCV001183729]|Hypercholesterolemia, familial, 1 [RCV000237169]|not provided [RCV001729480]|not specified [RCV001726071] Chr19:11113505 [GRCh38]
Chr19:11224181 [GRCh37]
Chr19:19p13.2		 benign|likely benign
NM_000527.5(LDLR):c.1359-4T>C single nucleotide variant Hypercholesterolemia, familial, 1 [RCV000237177] Chr19:11113531 [GRCh38]
Chr19:11224207 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-29G>A single nucleotide variant Familial hypercholesterolemia [RCV001526180]|Hypercholesterolemia, familial, 1 [RCV000237721] Chr19:11113506 [GRCh38]
Chr19:11224182 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-3C>T single nucleotide variant Familial hypercholesterolemia [RCV001182460]|Hypercholesterolemia, familial, 1 [RCV000237778] Chr19:11113532 [GRCh38]
Chr19:11224208 [GRCh37]
Chr19:19p13.2		 likely benign|conflicting interpretations of pathogenicity
NM_000527.5(LDLR):c.1359-31_1359-23delinsCGGCT indel Cardiovascular phenotype [RCV002379066]|Familial hypercholesterolemia [RCV001525939]|Hypercholesterolemia, familial, 1 [RCV000238072] Chr19:11113504..11113512 [GRCh38]
Chr19:11224180..11224188 [GRCh37]
Chr19:19p13.2		 pathogenic|likely pathogenic|conflicting interpretations of pathogenicity|uncertain significance
NM_000527.5(LDLR):c.1359-5C>G single nucleotide variant Familial hypercholesterolemia [RCV001052016]|Hypercholesterolemia, familial, 1 [RCV000238316]|not provided [RCV001568174]|not specified [RCV000844742] Chr19:11113530 [GRCh38]
Chr19:11224206 [GRCh37]
Chr19:19p13.2		 pathogenic|likely pathogenic|conflicting interpretations of pathogenicity|uncertain significance
NM_000527.5(LDLR):c.1359-1G>C single nucleotide variant Familial hypercholesterolemia [RCV002519848]|Hypercholesterolemia, familial, 1 [RCV000238326] Chr19:11113534 [GRCh38]
Chr19:11224210 [GRCh37]
Chr19:19p13.2		 pathogenic|likely pathogenic|conflicting interpretations of pathogenicity
NM_000527.5(LDLR):c.1359-13C>T single nucleotide variant Cardiovascular phenotype [RCV002379077]|Familial hypercholesterolemia [RCV002055043]|not specified [RCV000246480] Chr19:11113522 [GRCh38]
Chr19:11224198 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.4(LDLR):c.1186+700_2141-545del deletion Hypercholesterolemia, familial, 1 [RCV000237394] Chr19:11112339..11122629 [GRCh38]
Chr19:11223015..11233305 [GRCh37]
Chr19:19p13.2		 pathogenic
c.941-2966_*2583+4485del deletion Hypercholesterolemia, familial, 1 [RCV000237449] Chr19:11107686..11138384 [GRCh38]
Chr19:11218362..11249060 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_000527.4(LDLR):c.190+984_1846-1160del deletion Hypercholesterolemia, familial, 1 [RCV000237471] Chr19:11101329..11118932 [GRCh38]
Chr19:11212005..11229608 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_000527.4(LDLR):c.1187-169_2312-790del deletion Hypercholesterolemia, familial, 1 [RCV000238023] Chr19:11113109..11127218 [GRCh38]
Chr19:11223785..11237894 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_000527.5(LDLR):c.1197_2205del (p.Ala399_Tyr400insTer) deletion Hypercholesterolemia, familial, 1 [RCV000238376] Chr19:11113287..11123237 [GRCh38]
Chr19:11223963..11233913 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_000527.5(LDLR):c.695-67_1586+371del deletion Hypercholesterolemia, familial, 1 [RCV000238414] Chr19:11106494..11114129 [GRCh38]
Chr19:11217170..11224805 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_000527.5(LDLR):c.1358+32C>T single nucleotide variant Familial hypercholesterolemia [RCV001080540]|Hypercholesterolemia, familial, 1 [RCV000467166] Chr19:11113481 [GRCh38]
Chr19:11224157 [GRCh37]
Chr19:19p13.2		 benign
NC_000019.10:g.(?_11113278)_(11133830_?)del deletion Hypercholesterolemia, familial, 1 [RCV000469198] Chr19:11113278..11133830 [GRCh38]
Chr19:11223954..11244506 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_000527.5(LDLR):c.1359-6C>T single nucleotide variant Familial hypercholesterolemia [RCV001189132]|Hypercholesterolemia, familial, 1 [RCV000497075]|not provided [RCV001575765] Chr19:11113529 [GRCh38]
Chr19:11224205 [GRCh37]
Chr19:19p13.2		 likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_000527.5(LDLR):c.1359-27T>G single nucleotide variant Hypercholesterolemia, familial, 1 [RCV000509487] Chr19:11113508 [GRCh38]
Chr19:11224184 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_000527.5(LDLR):c.1359-31G>A single nucleotide variant Familial hypercholesterolemia [RCV001525354]|Hypercholesterolemia, familial, 1 [RCV000508786] Chr19:11113504 [GRCh38]
Chr19:11224180 [GRCh37]
Chr19:19p13.2		 benign|likely benign
NM_000527.5(LDLR):c.1359-25A>G single nucleotide variant Hypercholesterolemia, familial, 1 [RCV000495872] Chr19:11113510 [GRCh38]
Chr19:11224186 [GRCh37]
Chr19:19p13.2		 pathogenic
NC_000019.10:g.(?_11111494)_(11113782_?)del deletion Familial hypercholesterolemia [RCV001388217]|Hypercholesterolemia, familial, 1 [RCV000631383] Chr19:11111494..11113782 [GRCh38]
Chr19:11222170..11224458 [GRCh37]
Chr19:19p13.2		 pathogenic
NC_000019.10:g.(?_11113272)_(11120528_?)del deletion Familial hypercholesterolemia [RCV001388219]|Hypercholesterolemia, familial, 1 [RCV000707861] Chr19:11113272..11120528 [GRCh38]
Chr19:11223948..11231204 [GRCh37]
Chr19:19p13.2		 pathogenic
NC_000019.9:g.(?_11223934)_(11227694_?)dup duplication Hypercholesterolemia, familial, 1 [RCV000708143] Chr19:11113258..11117018 [GRCh38]
Chr19:11223934..11227694 [GRCh37]
Chr19:19p13.2		 pathogenic
NC_000019.10:g.(?_11100213)_(11117013_?)del deletion Familial hypercholesterolemia [RCV000820590] Chr19:11100213..11117013 [GRCh38]
Chr19:11210889..11227689 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_000527.5(LDLR):c.1357_1359-37del deletion Familial hypercholesterolemia [RCV000810973] Chr19:11113446..11113496 [GRCh38]
Chr19:11224122..11224172 [GRCh37]
Chr19:19p13.2		 likely pathogenic
NC_000019.10:g.(?_11111504)_(11117013_?)del deletion Familial hypercholesterolemia [RCV000794137] Chr19:11111504..11117013 [GRCh38]
Chr19:11222180..11227689 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_000527.5(LDLR):c.1359-10C>T single nucleotide variant Familial hypercholesterolemia [RCV001189131]|Hypercholesterolemia, familial, 1 [RCV004010343] Chr19:11113525 [GRCh38]
Chr19:11224201 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-14T>G single nucleotide variant Familial hypercholesterolemia [RCV001188732] Chr19:11113521 [GRCh38]
Chr19:11224197 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-26G>A single nucleotide variant Familial hypercholesterolemia [RCV001181950] Chr19:11113509 [GRCh38]
Chr19:11224185 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-5C>T single nucleotide variant Familial hypercholesterolemia [RCV002170350] Chr19:11113530 [GRCh38]
Chr19:11224206 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-13C>A single nucleotide variant Familial hypercholesterolemia [RCV003740710] Chr19:11113522 [GRCh38]
Chr19:11224198 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-20C>T single nucleotide variant Familial hypercholesterolemia [RCV003742323] Chr19:11113515 [GRCh38]
Chr19:11224191 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-14del deletion Familial hypercholesterolemia [RCV003582114] Chr19:11113521 [GRCh38]
Chr19:11224197 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_000527.5(LDLR):c.1359-30C>A single nucleotide variant Familial hypercholesterolemia [RCV003582111] Chr19:11113505 [GRCh38]
Chr19:11224181 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_000527.5(LDLR):c.1359-6C>A single nucleotide variant Familial hypercholesterolemia [RCV003740960] Chr19:11113529 [GRCh38]
Chr19:11224205 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-26_1359-23del deletion Familial hypercholesterolemia [RCV003582113]|Hypercholesterolemia, familial, 1 [RCV004011486] Chr19:11113509..11113512 [GRCh38]
Chr19:11224185..11224188 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_000527.5(LDLR):c.1359-29G>C single nucleotide variant Familial hypercholesterolemia [RCV003582112]|Hypercholesterolemia, familial, 1 [RCV004011485] Chr19:11113506 [GRCh38]
Chr19:11224182 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-28C>A single nucleotide variant Hypercholesterolemia, familial, 1 [RCV004008060] Chr19:11113507 [GRCh38]
Chr19:11224183 [GRCh37]
Chr19:19p13.2		 likely benign
NM_000527.5(LDLR):c.1359-27_1359-3dup duplication Hypercholesterolemia, familial, 1 [RCV004012072] Chr19:11113506..11113507 [GRCh38]
Chr19:11224182..11224183 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_000527.5(LDLR):c.1359-10_1359-8del microsatellite Hypercholesterolemia, familial, 1 [RCV004016036] Chr19:11113520..11113522 [GRCh38]
Chr19:11224196..11224198 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_000527.5(LDLR):c.1359-30C>G single nucleotide variant Hypercholesterolemia, familial, 1 [RCV004013476] Chr19:11113505 [GRCh38]
Chr19:11224181 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_000527.5(LDLR):c.1359-31G>C single nucleotide variant Hypercholesterolemia, familial, 1 [RCV004013477] Chr19:11113504 [GRCh38]
Chr19:11224180 [GRCh37]
Chr19:19p13.2		 likely benign
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:46741
Count of gene targets:16828
Count of transcripts:38664
Interacting mature miRNAs:hsa-miR-6886-3p, hsa-miR-6886-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 23 8 9 2 5 25 12 18 8 8 2 4 18
Below cutoff 6 5 2 1 1 1 5 4 11 4 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000619864
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,113,474 - 11,113,534 (+)Ensembl
RefSeq Acc Id: NR_106946
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,113,474 - 11,113,534 (+)NCBI
HuRef1910,800,495 - 10,800,555 (+)NCBI
CHM1_11911,225,405 - 11,225,465 (+)NCBI
T2T-CHM13v2.01911,240,483 - 11,240,543 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR6886 COSMIC
Ensembl Genes ENSG00000284553 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000619864 ENTREZGENE
GTEx ENSG00000284553 GTEx
HGNC ID HGNC:50121 ENTREZGENE
Human Proteome Map MIR6886 Human Proteome Map
miRBase MI0022733 ENTREZGENE
NCBI Gene MIR6886 ENTREZGENE
RNAcentral URS000075A1D9 RNACentral
  URS000075D6A4 RNACentral
  URS000075EF90 RNACentral