MIR6165 (microRNA 6165) - Rat Genome Database

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Pathways
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Gene: MIR6165 (microRNA 6165) Homo sapiens
Analyze
Symbol: MIR6165
Name: microRNA 6165
RGD ID: 8551010
HGNC Page HGNC:50197
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6165
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,510,817 - 49,510,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,510,817 - 49,510,900 (+)EnsemblGRCh38hg38GRCh38
GRCh371747,588,179 - 47,588,262 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q21.33NCBI
HuRef1742,953,165 - 42,953,248 (+)NCBIHuRef
CHM1_11747,653,347 - 47,653,430 (+)NCBICHM1_1
T2T-CHM13v2.01750,373,836 - 50,373,919 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22558167   PMID:28956260   PMID:31702994   PMID:35199365  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh38/hg38 17q21.33(chr17:49361155-50269440)x1 copy number loss See cases [RCV000139901] Chr17:49361155..50269440 [GRCh38]
Chr17:47438517..48346801 [GRCh37]
Chr17:44793516..45701800 [NCBI36]
Chr17:17q21.33		 pathogenic
GRCh38/hg38 17q21.32-21.33(chr17:48450628-49552921)x3 copy number gain See cases [RCV000143451] Chr17:48450628..49552921 [GRCh38]
Chr17:46527990..47630283 [GRCh37]
Chr17:43882989..44985282 [NCBI36]
Chr17:17q21.32-21.33		 uncertain significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q21.32-21.33(chr17:48520885-49511208)x1 copy number loss See cases [RCV000053431] Chr17:48520885..49511208 [GRCh38]
Chr17:46598247..47588570 [GRCh37]
Chr17:43953246..44943569 [NCBI36]
Chr17:17q21.32-21.33		 pathogenic
GRCh38/hg38 17q21.32-22(chr17:49137864-52147810)x1 copy number loss See cases [RCV000053432] Chr17:49137864..52147810 [GRCh38]
Chr17:47215226..50225170 [GRCh37]
Chr17:44570225..47580169 [NCBI36]
Chr17:17q21.32-22		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:31518
Count of gene targets:12458
Count of transcripts:25661
Interacting mature miRNAs:hsa-miR-6165
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1 1 3 1
Low 112 149 108 13 64 4 731 88 546 13 134 122 11 98 581
Below cutoff 94 147 74 32 49 10 160 88 107 6 63 37 22 91 79

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000614803
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1749,510,817 - 49,510,900 (+)Ensembl
RefSeq Acc Id: NR_106751
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,510,817 - 49,510,900 (+)NCBI
HuRef1742,953,165 - 42,953,248 (+)NCBI
CHM1_11747,653,347 - 47,653,430 (+)NCBI
T2T-CHM13v2.01750,373,836 - 50,373,919 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR6165 COSMIC
Ensembl Genes ENSG00000277478 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000614803 ENTREZGENE
GTEx ENSG00000277478 GTEx
HGNC ID HGNC:50197 ENTREZGENE
Human Proteome Map MIR6165 Human Proteome Map
miRBase MI0021472 ENTREZGENE
NCBI Gene MIR6165 ENTREZGENE
RNAcentral URS0000298172 RNACentral
  URS000075BB89 RNACentral