MIR6831 (microRNA 6831) - Rat Genome Database

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Gene: MIR6831 (microRNA 6831) Homo sapiens
Analyze
Symbol: MIR6831
Name: microRNA 6831
RGD ID: 8550603
HGNC Page HGNC:49936
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6831
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385140,563,671 - 140,563,751 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5140,563,671 - 140,563,751 (-)EnsemblGRCh38hg38GRCh38
GRCh375139,943,256 - 139,943,336 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map5q31.3NCBI
HuRef5135,088,593 - 135,088,673 (-)NCBIHuRef
CHM1_15139,376,504 - 139,376,584 (-)NCBICHM1_1
T2T-CHM13v2.05141,089,102 - 141,089,182 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q31.2-31.3(chr5:137836682-140696361)x3 copy number gain See cases [RCV000134725] Chr5:137836682..140696361 [GRCh38]
Chr5:137172371..140075946 [GRCh37]
Chr5:137200270..140056130 [NCBI36]
Chr5:5q31.2-31.3		 pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q31.2-31.3(chr5:138942857-144605017)x3 copy number gain See cases [RCV000142806] Chr5:138942857..144605017 [GRCh38]
Chr5:138278546..143984580 [GRCh37]
Chr5:138306445..143964773 [NCBI36]
Chr5:5q31.2-31.3		 uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q31.2-32(chr5:138871137-145812309)x1 copy number loss See cases [RCV000052142] Chr5:138871137..145812309 [GRCh38]
Chr5:138206826..145191872 [GRCh37]
Chr5:138234725..145172065 [NCBI36]
Chr5:5q31.2-32		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:17922
Count of gene targets:7332
Count of transcripts:12833
Interacting mature miRNAs:hsa-miR-6831-3p, hsa-miR-6831-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 113 326 147 9 48 504 77 334 7 209 156 9 141 378
Below cutoff 97 167 77 23 44 8 236 125 228 7 82 43 15 81 166

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000617240
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5140,563,671 - 140,563,751 (-)Ensembl
RefSeq Acc Id: NR_106889
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385140,563,671 - 140,563,751 (-)NCBI
HuRef5135,088,593 - 135,088,673 (-)NCBI
CHM1_15139,376,504 - 139,376,584 (-)NCBI
T2T-CHM13v2.05141,089,102 - 141,089,182 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR6831 COSMIC
Ensembl Genes ENSG00000283717 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000617240 ENTREZGENE
GTEx ENSG00000283717 GTEx
HGNC ID HGNC:49936 ENTREZGENE
Human Proteome Map MIR6831 Human Proteome Map
miRBase MI0022676 ENTREZGENE
NCBI Gene MIR6831 ENTREZGENE
RNAcentral URS000075A9CE RNACentral
  URS000075DA8F RNACentral
  URS000075E08F RNACentral