MIR8077 (microRNA 8077) - Rat Genome Database

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Gene: MIR8077 (microRNA 8077) Homo sapiens
Analyze
Symbol: MIR8077
Name: microRNA 8077
RGD ID: 8550331
HGNC Page HGNC:50266
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-8077
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,351,131 - 42,351,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,351,131 - 42,351,205 (+)EnsemblGRCh38hg38GRCh38
GRCh371942,855,283 - 42,855,357 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map19q13.2NCBI
HuRef1939,285,426 - 39,285,500 (+)NCBIHuRef
CHM1_11942,856,944 - 42,857,018 (+)NCBICHM1_1
T2T-CHM13v2.01945,170,516 - 45,170,590 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References
Additional References at PubMed
PMID:16381832   PMID:23612084  


Genomics

Variants

.
Variants in MIR8077
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19q13.12-13.2(chr19:37319377-42738688)x3 copy number gain See cases [RCV000050636] Chr19:37319377..42738688 [GRCh38]
Chr19:37810279..43242840 [GRCh37]
Chr19:42502119..47934680 [NCBI36]
Chr19:19q13.12-13.2		 pathogenic
GRCh38/hg38 19q13.2-13.31(chr19:41930894-43141456)x1 copy number loss See cases [RCV000053975] Chr19:41930894..43141456 [GRCh38]
Chr19:42514712..43645608 [GRCh37]
Chr19:47126886..48337448 [NCBI36]
Chr19:19q13.2-13.31		 pathogenic
Single allele duplication Schizophrenia [RCV000754211] Chr19:41608672..44315856 [GRCh38]
Chr19:19q13.2-13.31		 likely pathogenic
NM_001271938.2(MEGF8):c.2737-20T>A single nucleotide variant MEGF8-related Carpenter syndrome [RCV002585626] Chr19:42351196 [GRCh38]
Chr19:42855348 [GRCh37]
Chr19:19q13.2		 likely benign
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:16142
Count of gene targets:7752
Count of transcripts:14088
Interacting mature miRNAs:hsa-miR-8077
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue appendage
High
Medium
Low 6 8 2 7 13 4 7 2 7 3 8
Below cutoff 4 7 1 2 8 10 13 1 2 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000618566
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1942,351,131 - 42,351,205 (+)Ensembl
RefSeq Acc Id: NR_107044
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381942,351,131 - 42,351,205 (+)NCBI
HuRef1939,285,426 - 39,285,500 (+)NCBI
CHM1_11942,856,944 - 42,857,018 (+)NCBI
T2T-CHM13v2.01945,170,516 - 45,170,590 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR8077 COSMIC
Ensembl Genes ENSG00000277533 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000618566 ENTREZGENE
GTEx ENSG00000277533 GTEx
HGNC ID HGNC:50266 ENTREZGENE
Human Proteome Map MIR8077 Human Proteome Map
miRBase MI0025913 ENTREZGENE
NCBI Gene MIR8077 ENTREZGENE
RNAcentral URS000075A1A7 RNACentral
  URS000075D913 RNACentral