Mir103a2 (microRNA 103a-2) - Rat Genome Database

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Gene: Mir103a2 (microRNA 103a-2) Rattus norvegicus
Analyze
Symbol: Mir103a2
Name: microRNA 103a-2
RGD ID: 7489028
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in miRNA-mediated gene silencing by inhibition of translation; negative regulation of peptidyl-threonine phosphorylation; and negative regulation of potassium ion import across plasma membrane. Predicted to act upstream of or within several processes, including cellular response to cytokine stimulus; positive regulation of adipose tissue development; and positive regulation of transcription by RNA polymerase II. Orthologous to human MIR103A2 (microRNA 103a-2); INTERACTS WITH atrazine; bisphenol A; paracetamol.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 103-2; Mir103-2; rno-mir-103-2
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,963,227 - 138,963,312 (+)NCBIGRCr8
mRatBN7.23118,510,194 - 118,510,279 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,510,194 - 118,510,279 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3122,404,503 - 122,404,588 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,003,723 - 131,003,808 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,660,610 - 128,660,695 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,833,671 - 123,833,756 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,833,671 - 123,833,756 (+)EnsemblRnor6.0rn6Rnor6.0
Celera3117,318,107 - 117,318,192 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:16381832   PMID:16766679   PMID:17604727   PMID:19188425   PMID:20223197   PMID:20403161   PMID:20439489   PMID:20548288   PMID:24205035   PMID:26038570   PMID:26164754  
PMID:31650542   PMID:33583602   PMID:34888746   PMID:34923106   PMID:35617312  


Genomics

Comparative Map Data
Mir103a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,963,227 - 138,963,312 (+)NCBIGRCr8
mRatBN7.23118,510,194 - 118,510,279 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,510,194 - 118,510,279 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3122,404,503 - 122,404,588 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,003,723 - 131,003,808 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,660,610 - 128,660,695 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,833,671 - 123,833,756 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,833,671 - 123,833,756 (+)EnsemblRnor6.0rn6Rnor6.0
Celera3117,318,107 - 117,318,192 (+)NCBICelera
Cytogenetic Map3q36NCBI
MIR103A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,917,494 - 3,917,571 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,917,494 - 3,917,571 (+)EnsemblGRCh38hg38GRCh38
GRCh37203,898,141 - 3,898,218 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,846,140 - 3,846,217 (+)NCBINCBI36Build 36hg18NCBI36
Celera203,960,014 - 3,960,091 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,846,794 - 3,846,871 (+)NCBIHuRef
CHM1_1203,898,136 - 3,898,213 (+)NCBICHM1_1
T2T-CHM13v2.0203,948,404 - 3,948,481 (+)NCBIT2T-CHM13v2.0
Mir103-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,129,972 - 131,130,057 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,129,972 - 131,130,057 (+)EnsemblGRCm39 Ensembl
GRCm382131,288,052 - 131,288,137 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,288,052 - 131,288,137 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,113,788 - 131,113,873 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera2132,514,231 - 132,514,316 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.31NCBI
MIR103-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,468,354 - 17,468,430 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,468,355 - 17,468,434 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,298,078 - 17,298,154 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02417,886,699 - 17,886,775 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12417,481,690 - 17,481,766 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,594,068 - 17,594,144 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,920,861 - 17,920,937 (-)NCBIUU_Cfam_GSD_1.0
MIR103-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,808,836 - 31,808,920 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11731,808,837 - 31,808,916 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,149,787 - 36,149,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:6476
Count of gene targets:4642
Count of transcripts:5002
Interacting mature miRNAs:rno-miR-103-2-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 11 4 3
Low 15 19 10 5 10 7 7 56 20 22 6 7
Below cutoff 8 2 2 2 10 2 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000053619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3118,510,194 - 118,510,279 (+)Ensembl
Rnor_6.0 Ensembl3123,833,671 - 123,833,756 (+)Ensembl
RefSeq Acc Id: NR_031860
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,963,227 - 138,963,312 (+)NCBI
mRatBN7.23118,510,194 - 118,510,279 (+)NCBI
Rnor_6.03123,833,671 - 123,833,756 (+)NCBI
Celera3117,318,107 - 117,318,192 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7489028 AgrOrtholog
BioCyc Gene G2FUF-47814 BioCyc
Ensembl Genes ENSRNOG00000035496 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053619 ENTREZGENE
miRBase MI0000887 ENTREZGENE
NCBI Gene Mir103-2 ENTREZGENE
PhenoGen Mir103a2 PhenoGen
RatGTEx ENSRNOG00000035496 RatGTEx
RNAcentral URS0000476BE1 RNACentral
  URS000075AC7F RNACentral
  URS000075E6B2 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 Mir103a2  microRNA 103a-2  Mir103-2  microRNA 103-2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-04-09 Mir103-2  microRNA 103-2  Mir103-2  microRNA mir-103-2  Name updated 61478 APPROVED
2013-12-10 Mir103-2  microRNA mir-103-2      Symbol and Name status set to provisional 70820 PROVISIONAL