RASSF9 (Ras association domain family member 9) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: RASSF9 (Ras association domain family member 9) Homo sapiens
Analyze
Symbol: RASSF9
Name: Ras association domain family member 9
RGD ID: 731307
HGNC Page HGNC:15739
Description: Predicted to be involved in intracellular transport. Located in cytosol; endosome; and trans-Golgi network transport vesicle membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: P-CIP1; PAM COOH-terminal interactor protein 1; PAMCI; PCIP1; peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor protein-1; Ras association (RalGDS/AF-6) domain family (N-terminal) member 9; ras association domain-containing protein 9
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381285,800,703 - 85,836,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1285,800,703 - 85,836,409 (-)EnsemblGRCh38hg38GRCh38
GRCh371286,194,481 - 86,230,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361284,722,462 - 84,754,449 (-)NCBINCBI36Build 36hg18NCBI36
Build 341284,700,798 - 84,732,551NCBI
Celera1285,861,052 - 85,893,065 (-)NCBICelera
Cytogenetic Map12q21.31NCBI
HuRef1283,254,816 - 83,286,827 (-)NCBIHuRef
CHM1_11286,163,121 - 86,195,108 (-)NCBICHM1_1
T2T-CHM13v2.01285,781,370 - 85,817,046 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. Chen L, etal., J Biol Chem 1998 Dec 11;273(50):33524-32.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:18272789   PMID:18570454   PMID:21873635   PMID:22658674   PMID:24366813   PMID:25277244   PMID:25496667   PMID:26673895   PMID:27760139   PMID:30132526  
PMID:33051258   PMID:35256949  


Genomics

Comparative Map Data
RASSF9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381285,800,703 - 85,836,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1285,800,703 - 85,836,409 (-)EnsemblGRCh38hg38GRCh38
GRCh371286,194,481 - 86,230,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361284,722,462 - 84,754,449 (-)NCBINCBI36Build 36hg18NCBI36
Build 341284,700,798 - 84,732,551NCBI
Celera1285,861,052 - 85,893,065 (-)NCBICelera
Cytogenetic Map12q21.31NCBI
HuRef1283,254,816 - 83,286,827 (-)NCBIHuRef
CHM1_11286,163,121 - 86,195,108 (-)NCBICHM1_1
T2T-CHM13v2.01285,781,370 - 85,817,046 (-)NCBIT2T-CHM13v2.0
Rassf9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910102,348,083 - 102,385,598 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10102,348,083 - 102,385,597 (+)EnsemblGRCm39 Ensembl
GRCm3810102,512,222 - 102,549,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10102,512,222 - 102,549,736 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710101,974,856 - 102,009,194 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610101,941,910 - 101,976,248 (+)NCBIMGSCv36mm8
Celera10104,446,473 - 104,480,811 (+)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1053.56NCBI
Rassf9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8739,486,257 - 39,518,090 (+)NCBIGRCr8
mRatBN7.2737,599,720 - 37,631,553 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl737,599,720 - 37,635,245 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx739,526,586 - 39,558,388 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0741,729,658 - 41,761,461 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0741,504,624 - 41,536,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0744,146,345 - 44,178,179 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl744,146,237 - 44,181,201 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0744,175,398 - 44,207,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4740,509,837 - 40,541,671 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1740,530,107 - 40,561,942 (+)NCBI
Celera734,562,208 - 34,594,055 (+)NCBICelera
Cytogenetic Map7q21NCBI
Rassf9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540523,677,319 - 23,711,542 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540523,677,319 - 23,711,542 (-)NCBIChiLan1.0ChiLan1.0
RASSF9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21093,854,026 - 93,898,013 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11293,857,294 - 93,894,411 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01283,331,750 - 83,367,348 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11286,574,486 - 86,606,877 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1286,574,635 - 86,575,918 (-)Ensemblpanpan1.1panPan2
RASSF9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11527,304,618 - 27,331,876 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1527,308,088 - 27,309,347 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1527,747,833 - 27,775,420 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01527,917,941 - 27,945,543 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1527,920,198 - 27,945,729 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11527,270,333 - 27,297,925 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01527,311,017 - 27,338,600 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01527,600,327 - 27,627,944 (-)NCBIUU_Cfam_GSD_1.0
Rassf9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494532,938,009 - 32,970,745 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365073,262,493 - 3,297,571 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365073,265,356 - 3,297,495 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASSF9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl596,297,661 - 96,341,750 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1596,296,580 - 96,341,751 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RASSF9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11181,199,766 - 81,233,027 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1181,200,262 - 81,231,842 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037164,098,405 - 164,127,114 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rassf9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248374,975,321 - 5,005,418 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248374,975,582 - 5,005,419 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RASSF9
24 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_005447.3(RASSF9):c.552G>A (p.Glu184=) single nucleotide variant Malignant melanoma [RCV000070238] Chr12:85805458 [GRCh38]
Chr12:86199236 [GRCh37]
Chr12:84723367 [NCBI36]
Chr12:12q21.31		 not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q21.31(chr12:85578345-85815687)x1 copy number loss See cases [RCV000142165] Chr12:85578345..85815687 [GRCh38]
Chr12:85972123..86209465 [GRCh37]
Chr12:84496254..84733596 [NCBI36]
Chr12:12q21.31		 uncertain significance
GRCh38/hg38 12q21.1-22(chr12:73485697-92795805)x1 copy number loss See cases [RCV000143099] Chr12:73485697..92795805 [GRCh38]
Chr12:73879477..93189581 [GRCh37]
Chr12:72165744..91713712 [NCBI36]
Chr12:12q21.1-22		 pathogenic
GRCh38/hg38 12q21.31-21.32(chr12:85722164-86332192)x3 copy number gain See cases [RCV000143492] Chr12:85722164..86332192 [GRCh38]
Chr12:86115942..86725970 [GRCh37]
Chr12:84640073..85250101 [NCBI36]
Chr12:12q21.31-21.32		 likely benign|uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q21.31(chr12:85922052-86231685)x1 copy number loss See cases [RCV000511177] Chr12:85922052..86231685 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.329T>A (p.Met110Lys) single nucleotide variant not specified [RCV004318890] Chr12:85805681 [GRCh38]
Chr12:86199459 [GRCh37]
Chr12:12q21.31		 uncertain significance
GRCh37/hg19 12q21.31-21.32(chr12:86115942-88186381)x1 copy number loss not provided [RCV000683467] Chr12:86115942..88186381 [GRCh37]
Chr12:12q21.31-21.32		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q15-21.33(chr12:69608090-89629345)x1 copy number loss not provided [RCV000737927] Chr12:69608090..89629345 [GRCh37]
Chr12:12q15-21.33		 pathogenic
NM_005447.4(RASSF9):c.606G>C (p.Lys202Asn) single nucleotide variant not specified [RCV004308972] Chr12:85805404 [GRCh38]
Chr12:86199182 [GRCh37]
Chr12:12q21.31		 uncertain significance
GRCh37/hg19 12q21.31-21.32(chr12:82183041-88755577) copy number gain not provided [RCV000767570] Chr12:82183041..88755577 [GRCh37]
Chr12:12q21.31-21.32		 pathogenic
GRCh37/hg19 12q21.31-21.32(chr12:86138213-88183106)x1 copy number loss not provided [RCV000847390] Chr12:86138213..88183106 [GRCh37]
Chr12:12q21.31-21.32		 uncertain significance
GRCh37/hg19 12q21.2-22(chr12:77737623-94330526)x1 copy number loss not provided [RCV000848027] Chr12:77737623..94330526 [GRCh37]
Chr12:12q21.2-22		 pathogenic
NM_005447.4(RASSF9):c.803A>C (p.Gln268Pro) single nucleotide variant not specified [RCV004315778] Chr12:85805207 [GRCh38]
Chr12:86198985 [GRCh37]
Chr12:12q21.31		 uncertain significance
GRCh37/hg19 12q21.31(chr12:86173243-86421728)x3 copy number gain not provided [RCV001006519] Chr12:86173243..86421728 [GRCh37]
Chr12:12q21.31		 uncertain significance
GRCh37/hg19 12q21.31(chr12:86223018-86302962)x1 copy number loss not provided [RCV001259622] Chr12:86223018..86302962 [GRCh37]
Chr12:12q21.31		 likely benign
GRCh37/hg19 12q21.31-21.32(chr12:85812496-86797077)x3 copy number gain not provided [RCV001259625] Chr12:85812496..86797077 [GRCh37]
Chr12:12q21.31-21.32		 uncertain significance
GRCh37/hg19 12q21.31-21.32(chr12:86017618-86786974)x3 copy number gain not provided [RCV001259624] Chr12:86017618..86786974 [GRCh37]
Chr12:12q21.31-21.32		 likely benign
NM_005447.4(RASSF9):c.188C>T (p.Thr63Met) single nucleotide variant not specified [RCV004130550] Chr12:85805822 [GRCh38]
Chr12:86199600 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.658C>T (p.Leu220Phe) single nucleotide variant not specified [RCV004210031] Chr12:85805352 [GRCh38]
Chr12:86199130 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.905C>T (p.Ala302Val) single nucleotide variant not specified [RCV004183869] Chr12:85805105 [GRCh38]
Chr12:86198883 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.961G>A (p.Asp321Asn) single nucleotide variant not specified [RCV004138680] Chr12:85805049 [GRCh38]
Chr12:86198827 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.490A>G (p.Thr164Ala) single nucleotide variant not specified [RCV004111937] Chr12:85805520 [GRCh38]
Chr12:86199298 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.305C>T (p.Ala102Val) single nucleotide variant not specified [RCV004157100] Chr12:85805705 [GRCh38]
Chr12:86199483 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.944T>C (p.Leu315Ser) single nucleotide variant not specified [RCV004177045] Chr12:85805066 [GRCh38]
Chr12:86198844 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.203G>C (p.Arg68Pro) single nucleotide variant Inborn genetic diseases [RCV002805010] Chr12:85805807 [GRCh38]
Chr12:86199585 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.953T>C (p.Val318Ala) single nucleotide variant not specified [RCV004241629] Chr12:85805057 [GRCh38]
Chr12:86198835 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.974G>A (p.Ser325Asn) single nucleotide variant not specified [RCV004245480] Chr12:85805036 [GRCh38]
Chr12:86198814 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.1145C>T (p.Ala382Val) single nucleotide variant not specified [RCV004152165] Chr12:85804865 [GRCh38]
Chr12:86198643 [GRCh37]
Chr12:12q21.31		 likely benign
NM_005447.4(RASSF9):c.96G>C (p.Trp32Cys) single nucleotide variant not specified [RCV004180703] Chr12:85805914 [GRCh38]
Chr12:86199692 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.131C>T (p.Thr44Ile) single nucleotide variant not specified [RCV004214626] Chr12:85805879 [GRCh38]
Chr12:86199657 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.157A>T (p.Ile53Phe) single nucleotide variant not specified [RCV004151052] Chr12:85805853 [GRCh38]
Chr12:86199631 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.29A>G (p.Lys10Arg) single nucleotide variant not specified [RCV004157425] Chr12:85836173 [GRCh38]
Chr12:86229951 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.615A>C (p.Lys205Asn) single nucleotide variant not specified [RCV004144624] Chr12:85805395 [GRCh38]
Chr12:86199173 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.728T>G (p.Val243Gly) single nucleotide variant not specified [RCV004259104] Chr12:85805282 [GRCh38]
Chr12:86199060 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.893_894del (p.Ile298fs) microsatellite Premature coronary artery atherosclerosis [RCV003444013] Chr12:85805116..85805117 [GRCh38]
Chr12:86198894..86198895 [GRCh37]
Chr12:12q21.31		 uncertain significance
GRCh37/hg19 12q21.1-21.33(chr12:74887087-90469800)x1 copy number loss not specified [RCV003986972] Chr12:74887087..90469800 [GRCh37]
Chr12:12q21.1-21.33		 pathogenic
NM_005447.4(RASSF9):c.274C>T (p.Pro92Ser) single nucleotide variant not specified [RCV004440917] Chr12:85805736 [GRCh38]
Chr12:86199514 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.1212T>G (p.Asn404Lys) single nucleotide variant not specified [RCV004438847] Chr12:85804798 [GRCh38]
Chr12:86198576 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.370C>T (p.Pro124Ser) single nucleotide variant not specified [RCV004440918] Chr12:85805640 [GRCh38]
Chr12:86199418 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.615A>T (p.Lys205Asn) single nucleotide variant not specified [RCV004440919] Chr12:85805395 [GRCh38]
Chr12:86199173 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.686A>C (p.Asn229Thr) single nucleotide variant not specified [RCV004440920] Chr12:85805324 [GRCh38]
Chr12:86199102 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.1120G>A (p.Gly374Arg) single nucleotide variant not specified [RCV004438846] Chr12:85804890 [GRCh38]
Chr12:86198668 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.157A>G (p.Ile53Val) single nucleotide variant not specified [RCV004438848] Chr12:85805853 [GRCh38]
Chr12:86199631 [GRCh37]
Chr12:12q21.31		 uncertain significance
NM_005447.4(RASSF9):c.1047G>T (p.Leu349Phe) single nucleotide variant not specified [RCV004438845] Chr12:85804963 [GRCh38]
Chr12:86198741 [GRCh37]
Chr12:12q21.31		 uncertain significance
GRCh37/hg19 12q21.31(chr12:85973023-86204120)x1 copy number loss not provided [RCV000750495] Chr12:85973023..86204120 [GRCh37]
Chr12:12q21.31		 benign
NM_005447.4(RASSF9):c.463G>T (p.Asp155Tyr) single nucleotide variant not specified [RCV004236293] Chr12:85805547 [GRCh38]
Chr12:86199325 [GRCh37]
Chr12:12q21.31		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:71
Interacting mature miRNAs:82
Transcripts:ENST00000361228
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G17641  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371286,208,859 - 86,209,110UniSTSGRCh37
Build 361284,732,990 - 84,733,241RGDNCBI36
Celera1285,871,606 - 85,871,857RGD
Cytogenetic Map12q21.31UniSTS
HuRef1283,265,367 - 83,265,618UniSTS
PAMCI__5820  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371286,198,268 - 86,199,121UniSTSGRCh37
Build 361284,722,399 - 84,723,252RGDNCBI36
Celera1285,860,989 - 85,861,842RGD
HuRef1283,254,753 - 83,255,606UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 6 29 38 14 2 14 55 2 15 33 128 102 30 26
Low 2047 2091 1354 361 500 209 3875 1836 1388 286 1084 1379 163 1 1119 2506 1
Below cutoff 373 443 326 242 665 236 405 348 2223 88 230 120 9 55 256 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000361228   ⟹   ENSP00000354884
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1285,800,703 - 85,836,409 (-)Ensembl
RefSeq Acc Id: NM_005447   ⟹   NP_005438
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381285,800,703 - 85,836,409 (-)NCBI
GRCh371286,198,331 - 86,230,318 (-)RGD
Build 361284,722,462 - 84,754,449 (-)NCBI Archive
Celera1285,861,052 - 85,893,065 (-)RGD
HuRef1283,254,816 - 83,286,827 (-)ENTREZGENE
CHM1_11286,163,121 - 86,195,108 (-)NCBI
T2T-CHM13v2.01285,781,370 - 85,817,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054373833   ⟹   XP_054229808
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01285,781,370 - 85,815,369 (-)NCBI
Protein Sequences
Protein RefSeqs NP_005438 (Get FASTA)   NCBI Sequence Viewer  
  XP_054229808 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD03250 (Get FASTA)   NCBI Sequence Viewer  
  AAH31589 (Get FASTA)   NCBI Sequence Viewer  
  BAG51066 (Get FASTA)   NCBI Sequence Viewer  
  EAW97399 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000354884
  ENSP00000354884.3
GenBank Protein O75901 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_005438   ⟸   NM_005447
- UniProtKB: B3KMQ4 (UniProtKB/Swiss-Prot),   Q8N5U8 (UniProtKB/Swiss-Prot),   O75901 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000354884   ⟸   ENST00000361228
RefSeq Acc Id: XP_054229808   ⟸   XM_054373833
- Peptide Label: isoform X1
Protein Domains
Ras-associating

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O75901-F1-model_v2 AlphaFold O75901 1-435 view protein structure

Promoters
RGD ID:6790428
Promoter ID:HG_KWN:16264
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000361228
Position:
Human AssemblyChrPosition (strand)Source
Build 361284,722,596 - 84,723,096 (-)MPROMDB
RGD ID:6790432
Promoter ID:HG_KWN:16265
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:NM_005447
Position:
Human AssemblyChrPosition (strand)Source
Build 361284,753,971 - 84,754,471 (-)MPROMDB
RGD ID:7224941
Promoter ID:EPDNEW_H18217
Type:initiation region
Name:RASSF9_2
Description:Ras association domain family member 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18218  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381285,836,206 - 85,836,266EPDNEW
RGD ID:7224945
Promoter ID:EPDNEW_H18218
Type:initiation region
Name:RASSF9_1
Description:Ras association domain family member 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18217  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381285,836,547 - 85,836,607EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15739 AgrOrtholog
COSMIC RASSF9 COSMIC
Ensembl Genes ENSG00000198774 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000361228 ENTREZGENE
  ENST00000361228.5 UniProtKB/Swiss-Prot
GTEx ENSG00000198774 GTEx
HGNC ID HGNC:15739 ENTREZGENE
Human Proteome Map RASSF9 Human Proteome Map
InterPro N-RASSF UniProtKB/Swiss-Prot
  RA_dom UniProtKB/Swiss-Prot
  RASSF9_RA UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report hsa:9182 UniProtKB/Swiss-Prot
NCBI Gene 9182 ENTREZGENE
OMIM 610383 OMIM
PANTHER PTHR15286 UniProtKB/Swiss-Prot
  PTHR15286:SF10 UniProtKB/Swiss-Prot
PharmGKB PA162400725 PharmGKB
PROSITE PS50200 UniProtKB/Swiss-Prot
SMART SM00314 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot
UniProt B3KMQ4 ENTREZGENE
  O75901 ENTREZGENE
  Q8N5U8 ENTREZGENE
  RASF9_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B3KMQ4 UniProtKB/Swiss-Prot
  Q8N5U8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 RASSF9  Ras association domain family member 9  RASSF9  Ras association (RalGDS/AF-6) domain family (N-terminal) member 9  Symbol and/or name change 5135510 APPROVED