Pde4c (phosphodiesterase 4C) - Rat Genome Database

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Pathways
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Gene: Pde4c (phosphodiesterase 4C) Rattus norvegicus
Analyze
Symbol: Pde4c
Name: phosphodiesterase 4C
RGD ID: 727918
Description: Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cilium. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE4C (phosphodiesterase 4C); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3',5'-cyclic-AMP phosphodiesterase 4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; cAMP-specific 3,5-cyclic phosphodiesterase 4C; cAMP-specific 35-cyclic phosphodiesterase 4C; cAMP-specific phosphodiesterase 4C; Dpde1; MGC188426; phosphodiesterase 4C, cAMP specific; phosphodiesterase 4C, cAMP-specific; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,724,703 - 18,745,528 (-)NCBIGRCr8
mRatBN7.21618,690,727 - 18,711,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,691,700 - 18,710,640 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,734,078 - 18,752,085 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,866,751 - 19,884,992 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,787,025 - 18,805,032 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,442,305 - 20,466,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,462,609 - 20,466,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,442,609 - 20,460,959 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,298,910 - 20,318,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,197,277 - 19,215,627 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,197,497 - 19,200,188 (-)NCBI
Celera1618,883,915 - 18,902,144 (-)NCBICelera
Celera1618,903,793 - 18,907,574 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (ISO,ISS)
cytosol  (IBA,IEA)
membrane  (IEA)
nucleus  (IBA,IEA)
perinuclear region of cytoplasm  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. Acin-Perez R, etal., J Biol Chem. 2011 Sep 2;286(35):30423-32. doi: 10.1074/jbc.M111.266379. Epub 2011 Jul 1.
2. Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. Bolger GB, etal., Gene 1994 Nov 18;149(2):237-44.
3. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. Swinnen JV, etal., Proc Natl Acad Sci U S A 1989 Jul;86(14):5325-9.
12. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Waddleton D, etal., Biochem Pharmacol. 2008 Oct 1;76(7):884-93. Epub 2008 Jul 26.
Additional References at PubMed
PMID:12477932   PMID:21670265   PMID:22664934  


Genomics

Comparative Map Data
Pde4c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,724,703 - 18,745,528 (-)NCBIGRCr8
mRatBN7.21618,690,727 - 18,711,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,691,700 - 18,710,640 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,734,078 - 18,752,085 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,866,751 - 19,884,992 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,787,025 - 18,805,032 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,442,305 - 20,466,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,462,609 - 20,466,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,442,609 - 20,460,959 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,298,910 - 20,318,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,197,277 - 19,215,627 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,197,497 - 19,200,188 (-)NCBI
Celera1618,883,915 - 18,902,144 (-)NCBICelera
Celera1618,903,793 - 18,907,574 (-)NCBICelera
Cytogenetic Map16p14NCBI
PDE4C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,207,965 - 18,255,362 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,207,965 - 18,248,200 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,318,775 - 18,359,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,179,771 - 18,220,010 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,181,514 - 18,205,015NCBI
Celera1918,220,510 - 18,260,722 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,882,418 - 17,922,774 (-)NCBIHuRef
CHM1_11918,318,324 - 18,358,516 (-)NCBICHM1_1
T2T-CHM13v2.01918,342,065 - 18,389,460 (-)NCBIT2T-CHM13v2.0
Pde4c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,176,485 - 71,203,835 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,176,369 - 71,203,835 (+)EnsemblGRCm39 Ensembl
GRCm38870,723,835 - 70,751,186 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,723,720 - 70,751,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,247,963 - 73,275,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,653,053 - 73,680,175 (+)NCBIMGSCv36mm8
Celera873,280,734 - 73,312,488 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Pde4c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,200,486 - 3,218,618 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,199,534 - 3,218,013 (+)NCBIChiLan1.0ChiLan1.0
PDE4C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,061,872 - 23,090,878 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,070,976 - 22,099,221 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,683,455 - 17,709,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,663,378 - 18,686,194 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,663,378 - 18,686,194 (-)Ensemblpanpan1.1panPan2
PDE4C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,767,187 - 44,792,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,742,161 - 44,791,053 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,689,267 - 44,706,455 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,261,030 - 45,278,277 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,261,110 - 45,278,493 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,498,073 - 44,515,446 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,908,785 - 44,925,897 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,184,206 - 45,201,379 (+)NCBIUU_Cfam_GSD_1.0
Pde4c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,425,746 - 203,437,639 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,977,933 - 2,984,831 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,962,671 - 2,984,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE4C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,578,261 - 59,598,396 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,567,644 - 59,598,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,129,446 - 59,137,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE4C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,684,622 - 16,707,412 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660742,669,399 - 2,693,322 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde4c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,538,265 - 1,554,744 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,539,934 - 1,551,001 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pde4c
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:449
Count of miRNA genes:242
Interacting mature miRNAs:279
Transcripts:ENSRNOT00000026457, ENSRNOT00000066168
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
RH69933  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,702,670 - 18,703,175 (+)MAPPERmRatBN7.2
Rnor_6.01620,453,580 - 20,454,084NCBIRnor6.0
Rnor_5.01620,310,648 - 20,311,152UniSTSRnor5.0
RGSC_v3.41619,208,248 - 19,208,752UniSTSRGSC3.4
Celera1618,894,886 - 18,895,390UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 1 43 6 5
Low 3 26 70 52 28 52 8 11 38 25 50 15 8
Below cutoff 12 41 30 6 30 41 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026457   ⟹   ENSRNOP00000026457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,691,700 - 18,710,640 (-)Ensembl
Rnor_6.0 Ensembl1620,442,609 - 20,460,959 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000066168   ⟹   ENSRNOP00000061615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,711,703 - 18,714,161 (-)Ensembl
Rnor_6.0 Ensembl1620,462,609 - 20,466,351 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097187   ⟹   ENSRNOP00000085862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,711,703 - 18,715,496 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113780   ⟹   ENSRNOP00000096064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,691,834 - 18,698,721 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114545   ⟹   ENSRNOP00000091339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,711,703 - 18,715,496 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114874   ⟹   ENSRNOP00000079655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,711,703 - 18,714,109 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116505   ⟹   ENSRNOP00000083315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,691,834 - 18,710,640 (-)Ensembl
RefSeq Acc Id: NM_001276765   ⟹   NP_001263694
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,725,676 - 18,744,026 (-)NCBI
mRatBN7.21618,691,700 - 18,710,051 (-)NCBI
Rnor_6.01620,442,609 - 20,460,959 (-)NCBI
Rnor_5.01620,298,910 - 20,318,430 (-)NCBI
Celera1618,883,915 - 18,902,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252868   ⟹   XP_006252930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,724,703 - 18,745,528 (-)NCBI
mRatBN7.21618,690,727 - 18,711,555 (-)NCBI
Rnor_6.01620,442,305 - 20,461,554 (-)NCBI
Rnor_5.01620,298,910 - 20,318,430 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252869   ⟹   XP_006252931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,724,703 - 18,737,990 (-)NCBI
mRatBN7.21618,690,727 - 18,704,017 (-)NCBI
Rnor_6.01620,442,305 - 20,449,803 (-)NCBI
Rnor_5.01620,298,910 - 20,318,430 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063275157   ⟹   XP_063131227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,724,703 - 18,730,645 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001263694   ⟸   NM_001276765
- UniProtKB: G3V8J8 (UniProtKB/TrEMBL),   A6KA07 (UniProtKB/TrEMBL),   A6KA06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252930   ⟸   XM_006252868
- Peptide Label: isoform X1
- UniProtKB: G3V8J8 (UniProtKB/TrEMBL),   A6KA07 (UniProtKB/TrEMBL),   A6KA06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252931   ⟸   XM_006252869
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AN21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026457   ⟸   ENSRNOT00000026457
RefSeq Acc Id: ENSRNOP00000061615   ⟸   ENSRNOT00000066168
RefSeq Acc Id: ENSRNOP00000079655   ⟸   ENSRNOT00000114874
RefSeq Acc Id: ENSRNOP00000096064   ⟸   ENSRNOT00000113780
RefSeq Acc Id: ENSRNOP00000091339   ⟸   ENSRNOT00000114545
RefSeq Acc Id: ENSRNOP00000085862   ⟸   ENSRNOT00000097187
RefSeq Acc Id: ENSRNOP00000083315   ⟸   ENSRNOT00000116505
RefSeq Acc Id: XP_063131227   ⟸   XM_063275157
- Peptide Label: isoform X3
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14644-F1-model_v2 AlphaFold P14644 1-536 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700036
Promoter ID:EPDNEW_R10541
Type:multiple initiation site
Name:Pde4c_1
Description:phosphodiesterase 4C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,466,344 - 20,466,404EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727918 AgrOrtholog
BioCyc Gene G2FUF-11804 BioCyc
Ensembl Genes ENSRNOG00000019518 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000043249 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026457 ENTREZGENE
  ENSRNOT00000026457.7 UniProtKB/TrEMBL
  ENSRNOT00000066168.2 UniProtKB/TrEMBL
  ENSRNOT00000097187.1 UniProtKB/TrEMBL
  ENSRNOT00000113780.1 UniProtKB/TrEMBL
  ENSRNOT00000114874.1 UniProtKB/TrEMBL
  ENSRNOT00000116505 ENTREZGENE
  ENSRNOT00000116505.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7931953 IMAGE-MGC_LOAD
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDE4_UCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290646 UniProtKB/TrEMBL
MGC_CLONE MGC:188426 IMAGE-MGC_LOAD
NCBI Gene 290646 ENTREZGENE
PANTHER CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDE4_UCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pde4c PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019518 RatGTEx
  ENSRNOG00000043249 RatGTEx
SMART HDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZNT7_RAT UniProtKB/TrEMBL
  A0A8I5ZZS2_RAT UniProtKB/TrEMBL
  A0A8I6A4J3_RAT UniProtKB/TrEMBL
  A0A8I6AN21 ENTREZGENE, UniProtKB/TrEMBL
  A6KA06 ENTREZGENE, UniProtKB/TrEMBL
  A6KA07 ENTREZGENE, UniProtKB/TrEMBL
  F7FIG6_RAT UniProtKB/TrEMBL
  G3V8J8 ENTREZGENE, UniProtKB/TrEMBL
  P14644 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pde4c  phosphodiesterase 4C  Pde4c  phosphodiesterase 4C, cAMP-specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Pde4c  phosphodiesterase 4C, cAMP-specific  Pde4c  phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Pde4c  phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)  Pde4c  phosphodiesterase 4C, cAMP specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Pde4c  phosphodiesterase 4C, cAMP specific  Dpde1  phosphodiesterase 4C, cAMP-specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Serpinf1  phosphodiesterase 4C, cAMP-specific  Dpde1  cAMP-specific 3,5-cyclic phosphodiesterase 4C  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED