HTR5A-AS1 (HTR5A antisense RNA 1) - Rat Genome Database

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Gene: HTR5A-AS1 (HTR5A antisense RNA 1) Homo sapiens
Analyze
Symbol: HTR5A-AS1
Name: HTR5A antisense RNA 1
RGD ID: 7248157
HGNC Page HGNC:48956
Description: ASSOCIATED WITH Autism; autistic disorder; Prostate cancer; INTERACTS WITH permethrin; rotenone
Type: ncrna (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Previously known as: HTR5AOS
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,067,067 - 155,071,557 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7155,067,034 - 155,072,450 (-)EnsemblGRCh38hg38GRCh38
GRCh377154,858,777 - 154,863,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367154,489,710 - 154,494,200 (-)NCBINCBI36Build 36hg18NCBI36
Celera7149,276,249 - 149,280,737 (-)NCBICelera
Cytogenetic Map7q36.2NCBI
HuRef7148,591,181 - 148,595,671 (-)NCBIHuRef
CHM1_17154,867,170 - 154,871,656 (-)NCBICHM1_1
T2T-CHM13v2.07156,242,667 - 156,247,155 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27154,087,103 - 154,091,591 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
permethrin  (EXP)
rotenone  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Autism  (IAGP)
Prostate cancer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in HTR5A-AS1
12 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_024012.4(HTR5A):c.79G>C (p.Asp27His) single nucleotide variant Malignant tumor of prostate [RCV000149304] Chr7:155070978 [GRCh38]
Chr7:154862688 [GRCh37]
Chr7:7q36.2
uncertain significance
NM_024012.3(HTR5A):c.117C>T (p.Phe39=) single nucleotide variant Malignant melanoma [RCV000067792] Chr7:155071016 [GRCh38]
Chr7:154862726 [GRCh37]
Chr7:154493659 [NCBI36]
Chr7:7q36.2
not provided
NM_024012.3(HTR5A):c.264G>A (p.Leu88=) single nucleotide variant Malignant melanoma [RCV000067793] Chr7:155071163 [GRCh38]
Chr7:154862873 [GRCh37]
Chr7:154493806 [NCBI36]
Chr7:7q36.2
not provided
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q36.2-36.3(chr7:153908499-159325876)x1 copy number loss See cases [RCV000135826] Chr7:153908499..159325876 [GRCh38]
Chr7:153605584..159118566 [GRCh37]
Chr7:153236517..158811327 [NCBI36]
Chr7:7q36.2-36.3
pathogenic
GRCh38/hg38 7q36.1-36.3(chr7:151378879-158923762)x1 copy number loss See cases [RCV000136125] Chr7:151378879..158923762 [GRCh38]
Chr7:151075965..158716453 [GRCh37]
Chr7:150706898..158409214 [NCBI36]
Chr7:7q36.1-36.3
pathogenic|benign
GRCh38/hg38 7q36.2-36.3(chr7:152860576-159325876)x1 copy number loss See cases [RCV000136143] Chr7:152860576..159325876 [GRCh38]
Chr7:152557661..159118566 [GRCh37]
Chr7:152188594..158811327 [NCBI36]
Chr7:7q36.2-36.3
pathogenic
GRCh38/hg38 7q36.2-36.3(chr7:154939710-159325876)x1 copy number loss See cases [RCV000136593] Chr7:154939710..159325876 [GRCh38]
Chr7:154731420..159118566 [GRCh37]
Chr7:154362353..158811327 [NCBI36]
Chr7:7q36.2-36.3
pathogenic
GRCh38/hg38 7q36.1-36.3(chr7:150486071-159335865)x1 copy number loss See cases [RCV000136089] Chr7:150486071..159335865 [GRCh38]
Chr7:150183159..159128555 [GRCh37]
Chr7:149814092..158821316 [NCBI36]
Chr7:7q36.1-36.3
pathogenic
GRCh38/hg38 7q36.2-36.3(chr7:152807205-159325876)x1 copy number loss See cases [RCV000136940] Chr7:152807205..159325876 [GRCh38]
Chr7:152504290..159118566 [GRCh37]
Chr7:152135223..158811327 [NCBI36]
Chr7:7q36.2-36.3
pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q36.1-36.3(chr7:151104277-159325876)x3 copy number gain See cases [RCV000136683] Chr7:151104277..159325876 [GRCh38]
Chr7:150801364..159118566 [GRCh37]
Chr7:150432297..158811327 [NCBI36]
Chr7:7q36.1-36.3
pathogenic
GRCh38/hg38 7q36.1-36.3(chr7:150802801-159335866)x1 copy number loss See cases [RCV000137465] Chr7:150802801..159335866 [GRCh38]
Chr7:150499889..159128556 [GRCh37]
Chr7:150130822..158821317 [NCBI36]
Chr7:7q36.1-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:141960861-159335866)x1 copy number loss See cases [RCV000137256] Chr7:141960861..159335866 [GRCh38]
Chr7:142528609..159128556 [GRCh37]
Chr7:141307130..158821317 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:145436544-159331441)x1 copy number loss See cases [RCV000137338] Chr7:145436544..159331441 [GRCh38]
Chr7:145133637..159124131 [GRCh37]
Chr7:144764570..158816892 [NCBI36]
Chr7:7q35-36.3
pathogenic|likely pathogenic
GRCh38/hg38 7q35-36.3(chr7:145250254-159335866)x1 copy number loss See cases [RCV000138005] Chr7:145250254..159335866 [GRCh38]
Chr7:144947347..159128556 [GRCh37]
Chr7:144578280..158821317 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:134666829-158591882)x1 copy number loss See cases [RCV000138120] Chr7:134666829..158591882 [GRCh38]
Chr7:134351581..158384574 [GRCh37]
Chr7:134002121..158077335 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:146047157-157522158)x1 copy number loss See cases [RCV000137781] Chr7:146047157..157522158 [GRCh38]
Chr7:145744250..157314852 [GRCh37]
Chr7:145375183..157007613 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132444095-159335866)x3 copy number gain See cases [RCV000139654] Chr7:132444095..159335866 [GRCh38]
Chr7:132128854..159128556 [GRCh37]
Chr7:131779394..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q36.1-36.3(chr7:152428852-159335865)x3 copy number gain See cases [RCV000139725] Chr7:152428852..159335865 [GRCh38]
Chr7:152125937..159128555 [GRCh37]
Chr7:151756870..158821316 [NCBI36]
Chr7:7q36.1-36.3
pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131228764-159335866)x3 copy number gain See cases [RCV000142802] Chr7:131228764..159335866 [GRCh38]
Chr7:130913523..159128556 [GRCh37]
Chr7:130564063..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q36.1-36.3(chr7:150260297-159325876)x1 copy number loss See cases [RCV000142592] Chr7:150260297..159325876 [GRCh38]
Chr7:149957386..159118566 [GRCh37]
Chr7:149588319..158811327 [NCBI36]
Chr7:7q36.1-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131171478-159327017)x3 copy number gain See cases [RCV000143754] Chr7:131171478..159327017 [GRCh38]
Chr7:130856237..159119707 [GRCh37]
Chr7:130506777..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132438072-159327017)x3 copy number gain See cases [RCV000143707] Chr7:132438072..159327017 [GRCh38]
Chr7:132122831..159119707 [GRCh37]
Chr7:131773371..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:147144002-159327017)x1 copy number loss See cases [RCV000143503] Chr7:147144002..159327017 [GRCh38]
Chr7:146841094..159119707 [GRCh37]
Chr7:146472027..158812468 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7q36.2-36.3(chr7:155007022-159135526)x1 copy number loss See cases [RCV000050856] Chr7:155007022..159135526 [GRCh38]
Chr7:154798732..158928217 [GRCh37]
Chr7:154429665..158620978 [NCBI36]
Chr7:7q36.2-36.3
pathogenic
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132850196-159325876)x3 copy number gain See cases [RCV000051101] Chr7:132850196..159325876 [GRCh38]
Chr7:132534956..159118566 [GRCh37]
Chr7:132185496..158811327 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:147250465-159325876)x1 copy number loss See cases [RCV000051108] Chr7:147250465..159325876 [GRCh38]
Chr7:146947557..159118566 [GRCh37]
Chr7:146578490..158811327 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:136309982-159307523)x3 copy number gain See cases [RCV000053576] Chr7:136309982..159307523 [GRCh38]
Chr7:135994730..159100212 [GRCh37]
Chr7:135645270..158792973 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:142021716-159325876)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|See cases [RCV000053577] Chr7:142021716..159325876 [GRCh38]
Chr7:142528609..159118566 [GRCh37]
Chr7:141367985..158811327 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:139365967-159282531)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|See cases [RCV000054175] Chr7:139365967..159282531 [GRCh38]
Chr7:139050713..159075220 [GRCh37]
Chr7:138701253..158767981 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:140754198-159307523)x1 copy number loss See cases [RCV000054176] Chr7:140754198..159307523 [GRCh38]
Chr7:140453998..159100212 [GRCh37]
Chr7:140100467..158792973 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:142358524-159282531)x1 copy number loss See cases [RCV000054177] Chr7:142358524..159282531 [GRCh38]
Chr7:142528609..159075220 [GRCh37]
Chr7:141726947..158767981 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:143884559-159282390)x1 copy number loss See cases [RCV000054178] Chr7:143884559..159282390 [GRCh38]
Chr7:143581652..159075079 [GRCh37]
Chr7:143212585..158767840 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7q35-36.3(chr7:145699944-159296617)x1 copy number loss See cases [RCV000054188] Chr7:145699944..159296617 [GRCh38]
Chr7:145397037..159089306 [GRCh37]
Chr7:145027970..158782067 [NCBI36]
Chr7:7q35-36.3
pathogenic
GRCh38/hg38 7q36.1-36.3(chr7:152332476-159296617)x1 copy number loss See cases [RCV000054190] Chr7:152332476..159296617 [GRCh38]
Chr7:152029561..159089306 [GRCh37]
Chr7:151660494..158782067 [NCBI36]
Chr7:7q36.1-36.3
pathogenic
GRCh38/hg38 7q36.2-36.3(chr7:152918472-159307523)x1 copy number loss See cases [RCV000054191] Chr7:152918472..159307523 [GRCh38]
Chr7:152615557..159100212 [GRCh37]
Chr7:152246490..158792973 [NCBI36]
Chr7:7q36.2-36.3
pathogenic
GRCh38/hg38 7q36.2-36.3(chr7:152920128-159332714)x1 copy number loss See cases [RCV000054192] Chr7:152920128..159332714 [GRCh38]
Chr7:152617213..159125404 [GRCh37]
Chr7:152248146..158818165 [NCBI36]
Chr7:7q36.2-36.3
pathogenic
GRCh38/hg38 7q36.2-36.3(chr7:153833092-159282531)x1 copy number loss See cases [RCV000054193] Chr7:153833092..159282531 [GRCh38]
Chr7:153530177..159075220 [GRCh37]
Chr7:153161110..158767981 [NCBI36]
Chr7:7q36.2-36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:137463392-159345973)x3 copy number gain Neurodevelopmental disorder [RCV003327609] Chr7:137463392..159345973 [GRCh38]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:138620939-159233475)x3 copy number gain Neurodevelopmental disorder [RCV003327610] Chr7:138620939..159233475 [GRCh38]
Chr7:7q34-36.3
likely pathogenic
NC_000007.14:g.(?_152454659)_(158705768_?)del deletion Autism [RCV000754327] Chr7:152454659..158705768 [GRCh38]
Chr7:7q36.1-36.3
likely pathogenic
NM_024012.4(HTR5A):c.300C>T (p.His100=) single nucleotide variant not provided [RCV000965063] Chr7:155071199 [GRCh38]
Chr7:154862909 [GRCh37]
Chr7:7q36.2
benign
NM_024012.4(HTR5A):c.621C>T (p.Gly207=) single nucleotide variant not provided [RCV000969537] Chr7:155071520 [GRCh38]
Chr7:154863230 [GRCh37]
Chr7:7q36.2
benign
NM_024012.4(HTR5A):c.567C>T (p.Ser189=) single nucleotide variant not provided [RCV000880331] Chr7:155071466 [GRCh38]
Chr7:154863176 [GRCh37]
Chr7:7q36.2
benign
NM_024012.4(HTR5A):c.121G>A (p.Val41Met) single nucleotide variant not specified [RCV004187030] Chr7:155071020 [GRCh38]
Chr7:154862730 [GRCh37]
Chr7:7q36.2
uncertain significance
NM_024012.4(HTR5A):c.484A>G (p.Ile162Val) single nucleotide variant not specified [RCV004093206] Chr7:155071383 [GRCh38]
Chr7:154863093 [GRCh37]
Chr7:7q36.2
uncertain significance
NM_024012.4(HTR5A):c.205C>G (p.Arg69Gly) single nucleotide variant not specified [RCV004153549] Chr7:155071104 [GRCh38]
Chr7:154862814 [GRCh37]
Chr7:7q36.2
uncertain significance
NM_024012.4(HTR5A):c.181G>T (p.Val61Leu) single nucleotide variant not specified [RCV004250815] Chr7:155071080 [GRCh38]
Chr7:154862790 [GRCh37]
Chr7:7q36.2
uncertain significance
NM_024012.4(HTR5A):c.398C>T (p.Thr133Met) single nucleotide variant not specified [RCV004328818] Chr7:155071297 [GRCh38]
Chr7:154863007 [GRCh37]
Chr7:7q36.2
uncertain significance
GRCh38/hg38 7q36.2-36.3(chr7:154446117-159206757)x1 copy number loss Holoprosencephaly 3 [RCV003327714] Chr7:154446117..159206757 [GRCh38]
Chr7:7q36.2-36.3
pathogenic
NM_024012.4(HTR5A):c.110C>T (p.Ser37Leu) single nucleotide variant not specified [RCV004335750] Chr7:155071009 [GRCh38]
Chr7:154862719 [GRCh37]
Chr7:7q36.2
uncertain significance
NM_024012.4(HTR5A):c.68G>C (p.Ser23Thr) single nucleotide variant not specified [RCV004397421] Chr7:155070967 [GRCh38]
Chr7:154862677 [GRCh37]
Chr7:7q36.2
uncertain significance
NM_024012.4(HTR5A):c.190A>G (p.Thr64Ala) single nucleotide variant not specified [RCV004397419] Chr7:155071089 [GRCh38]
Chr7:154862799 [GRCh37]
Chr7:7q36.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1211
Count of miRNA genes:752
Interacting mature miRNAs:853
Transcripts:ENST00000395731, ENST00000493904, ENST00000543018
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1 942 3
Low 10 1 5 1 5 1398 3 5 8 1 3
Below cutoff 389 332 420 60 193 47 528 259 685 42 228 264 13 122 361

Sequence


RefSeq Acc Id: ENST00000395731
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7155,067,067 - 155,071,557 (-)Ensembl
RefSeq Acc Id: ENST00000493904
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7155,068,619 - 155,071,584 (-)Ensembl
RefSeq Acc Id: ENST00000655797
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7155,067,086 - 155,071,704 (-)Ensembl
RefSeq Acc Id: ENST00000671665
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7155,067,034 - 155,072,450 (-)Ensembl
RefSeq Acc Id: NR_038945
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387155,067,067 - 155,071,557 (-)NCBI
GRCh377154,858,777 - 154,863,267 (-)NCBI
HuRef7148,591,181 - 148,595,671 (-)NCBI
CHM1_17154,867,170 - 154,871,656 (-)NCBI
T2T-CHM13v2.07156,242,667 - 156,247,155 (-)NCBI
CRA_TCAGchr7v27154,087,103 - 154,091,591 (-)NCBI
Sequence:
Protein Sequences
GenBank Protein BAH13932 (Get FASTA)   NCBI Sequence Viewer  

Promoters
RGD ID:15096193
Promoter ID:EPDNEWNC_H1012
Type:initiation region
Name:HTR5A-AS1_1
Description:HTR5A antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:48956]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387155,071,560 - 155,071,620EPDNEWNC

Additional Information

Database Acc Id Source(s)
COSMIC HTR5A-AS1 COSMIC
Ensembl Genes ENSG00000220575 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000395731 ENTREZGENE
GTEx ENSG00000220575 GTEx
HGNC ID HGNC:48956 ENTREZGENE
Human Proteome Map HTR5A-AS1 Human Proteome Map
NCBI Gene HTR5A-AS1 ENTREZGENE
RNAcentral URS000075D18F RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-10-07 HTR5A-AS1  HTR5A antisense RNA 1  HTR5AOS  HTR5A opposite strand  Symbol and/or name change 5135510 APPROVED
2014-04-15 HTR5AOS  HTR5A opposite strand  HTR5A-AS1  HTR5A antisense RNA 1  Symbol and/or name change 5135510 APPROVED