OVCH1-AS1 (OVCH1 antisense RNA 1) - Rat Genome Database

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Gene: OVCH1-AS1 (OVCH1 antisense RNA 1) Homo sapiens
Analyze
Symbol: OVCH1-AS1
Name: OVCH1 antisense RNA 1
RGD ID: 7244714
HGNC Page HGNC:44484
Description: INTERACTS WITH Aflatoxin B2 alpha
Type: ncrna (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381229,389,294 - 29,487,324 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1229,389,289 - 29,487,488 (+)EnsemblGRCh38hg38GRCh38
GRCh371229,542,227 - 29,640,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12p11.22NCBI
HuRef1229,311,198 - 29,408,532 (+)NCBIHuRef
CHM1_11229,507,814 - 29,605,463 (+)NCBICHM1_1
T2T-CHM13v2.01229,261,819 - 29,359,454 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (HEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:10737800   PMID:37817005  


Genomics

Variants

.
Variants in OVCH1-AS1
43 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p12.1-11.1(chr12:25263833-34064528)x1 copy number loss See cases [RCV000133858] Chr12:25263833..34064528 [GRCh38]
Chr12:25416767..34217463 [GRCh37]
Chr12:25308034..34108730 [NCBI36]
Chr12:12p12.1-11.1		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p11.22(chr12:28942339-29418625)x3 copy number gain See cases [RCV000141623] Chr12:28942339..29418625 [GRCh38]
Chr12:29095272..29571558 [GRCh37]
Chr12:28986539..29462825 [NCBI36]
Chr12:12p11.22		 uncertain significance
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p12.1-11.21(chr12:21771052-32222232)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052783]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052783]|See cases [RCV000052783] Chr12:21771052..32222232 [GRCh38]
Chr12:21923986..32375166 [GRCh37]
Chr12:21815253..32266433 [NCBI36]
Chr12:12p12.1-11.21		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
NM_001353179.2(OVCH1):c.2498C>A (p.Ala833Asp) single nucleotide variant not specified [RCV004324376] Chr12:29455293 [GRCh38]
Chr12:29608226 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1318C>T (p.Leu440Phe) single nucleotide variant not specified [RCV004288462] Chr12:29477374 [GRCh38]
Chr12:29630307 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1317G>T (p.Glu439Asp) single nucleotide variant not specified [RCV004288461] Chr12:29477375 [GRCh38]
Chr12:29630308 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1229A>G (p.Lys410Arg) single nucleotide variant not specified [RCV004298167] Chr12:29477463 [GRCh38]
Chr12:29630396 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.965A>G (p.Glu322Gly) single nucleotide variant not specified [RCV004309616] Chr12:29486276 [GRCh38]
Chr12:29639209 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2141T>G (p.Val714Gly) single nucleotide variant not specified [RCV004325660] Chr12:29464596 [GRCh38]
Chr12:29617529 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.3205G>C (p.Val1069Leu) single nucleotide variant not specified [RCV004164638] Chr12:29443418 [GRCh38]
Chr12:29596351 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2053A>G (p.Ile685Val) single nucleotide variant not specified [RCV004097517] Chr12:29464684 [GRCh38]
Chr12:29617617 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1426C>T (p.Pro476Ser) single nucleotide variant not specified [RCV004218712] Chr12:29477158 [GRCh38]
Chr12:29630091 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2317C>T (p.Pro773Ser) single nucleotide variant not specified [RCV004108993] Chr12:29461922 [GRCh38]
Chr12:29614855 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1631C>T (p.Thr544Met) single nucleotide variant not specified [RCV004079147] Chr12:29475135 [GRCh38]
Chr12:29628068 [GRCh37]
Chr12:12p11.22		 likely benign
NM_001353179.2(OVCH1):c.1450T>A (p.Phe484Ile) single nucleotide variant not specified [RCV004118900] Chr12:29477134 [GRCh38]
Chr12:29630067 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2299A>G (p.Thr767Ala) single nucleotide variant not specified [RCV004199296] Chr12:29461940 [GRCh38]
Chr12:29614873 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.3161T>C (p.Ile1054Thr) single nucleotide variant not specified [RCV004169667] Chr12:29443462 [GRCh38]
Chr12:29596395 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1942G>A (p.Ala648Thr) single nucleotide variant not specified [RCV004203163] Chr12:29471821 [GRCh38]
Chr12:29624754 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1154A>G (p.Lys385Arg) single nucleotide variant not specified [RCV004238129] Chr12:29478894 [GRCh38]
Chr12:29631827 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2135A>G (p.Asn712Ser) single nucleotide variant not specified [RCV004182691] Chr12:29464602 [GRCh38]
Chr12:29617535 [GRCh37]
Chr12:12p11.22		 likely benign
NM_001353179.2(OVCH1):c.2717T>C (p.Leu906Pro) single nucleotide variant not specified [RCV004076073] Chr12:29451488 [GRCh38]
Chr12:29604421 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2876G>A (p.Arg959Lys) single nucleotide variant not specified [RCV004177833] Chr12:29445388 [GRCh38]
Chr12:29598321 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1748A>G (p.Asn583Ser) single nucleotide variant not specified [RCV004089857] Chr12:29473061 [GRCh38]
Chr12:29625994 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.3154C>T (p.His1052Tyr) single nucleotide variant not specified [RCV004110067] Chr12:29443469 [GRCh38]
Chr12:29596402 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1877G>A (p.Gly626Asp) single nucleotide variant not specified [RCV004229322] Chr12:29471886 [GRCh38]
Chr12:29624819 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2371A>G (p.Lys791Glu) single nucleotide variant not specified [RCV004162819] Chr12:29461868 [GRCh38]
Chr12:29614801 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.978C>A (p.Ser326Arg) single nucleotide variant not specified [RCV004175226] Chr12:29486263 [GRCh38]
Chr12:29639196 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2540A>G (p.Asn847Ser) single nucleotide variant not specified [RCV004208364] Chr12:29455251 [GRCh38]
Chr12:29608184 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.3224G>A (p.Arg1075His) single nucleotide variant not specified [RCV004114444] Chr12:29443399 [GRCh38]
Chr12:29596332 [GRCh37]
Chr12:12p11.22		 likely benign
NM_001353179.2(OVCH1):c.2603C>G (p.Pro868Arg) single nucleotide variant not specified [RCV004123172] Chr12:29454873 [GRCh38]
Chr12:29607806 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1214-64A>G single nucleotide variant not specified [RCV004195348] Chr12:29477542 [GRCh38]
Chr12:29630475 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1610T>C (p.Ile537Thr) single nucleotide variant not specified [RCV004085061] Chr12:29475156 [GRCh38]
Chr12:29628089 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1289A>T (p.Asp430Val) single nucleotide variant not specified [RCV004221084] Chr12:29477403 [GRCh38]
Chr12:29630336 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2716C>G (p.Leu906Val) single nucleotide variant not specified [RCV004264626] Chr12:29451489 [GRCh38]
Chr12:29604422 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2216G>A (p.Gly739Glu) single nucleotide variant not specified [RCV004270731] Chr12:29464521 [GRCh38]
Chr12:29617454 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1146C>A (p.Asp382Glu) single nucleotide variant not specified [RCV004267907] Chr12:29478902 [GRCh38]
Chr12:29631835 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1762G>A (p.Val588Ile) single nucleotide variant not specified [RCV004256097] Chr12:29473047 [GRCh38]
Chr12:29625980 [GRCh37]
Chr12:12p11.22		 likely benign
NM_001353179.2(OVCH1):c.3041T>C (p.Leu1014Ser) single nucleotide variant not specified [RCV004250595] Chr12:29444226 [GRCh38]
Chr12:29597159 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.3185C>T (p.Pro1062Leu) single nucleotide variant not specified [RCV004259175] Chr12:29443438 [GRCh38]
Chr12:29596371 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1841A>T (p.Glu614Val) single nucleotide variant not specified [RCV004351548] Chr12:29471922 [GRCh38]
Chr12:29624855 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1804A>G (p.Ser602Gly) single nucleotide variant not specified [RCV004348570] Chr12:29471959 [GRCh38]
Chr12:29624892 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1792A>G (p.Ile598Val) single nucleotide variant not specified [RCV004344036] Chr12:29471971 [GRCh38]
Chr12:29624904 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1703C>T (p.Ser568Leu) single nucleotide variant not specified [RCV004504829] Chr12:29475063 [GRCh38]
Chr12:29627996 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2690G>A (p.Arg897Gln) single nucleotide variant not specified [RCV004504831] Chr12:29451515 [GRCh38]
Chr12:29604448 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.3038A>C (p.His1013Pro) single nucleotide variant not specified [RCV004504832] Chr12:29444229 [GRCh38]
Chr12:29597162 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.2092T>A (p.Ser698Thr) single nucleotide variant not specified [RCV004504830] Chr12:29464645 [GRCh38]
Chr12:29617578 [GRCh37]
Chr12:12p11.22		 uncertain significance
R1098T single nucleotide variant not specified [RCV004504835] Chr12:29433785 [GRCh38]
Chr12:29586718 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.1198A>G (p.Ser400Gly) single nucleotide variant not specified [RCV004504827] Chr12:29478850 [GRCh38]
Chr12:29631783 [GRCh37]
Chr12:12p11.22		 uncertain significance
NM_001353179.2(OVCH1):c.3106C>T (p.His1036Tyr) single nucleotide variant not specified [RCV004504834] Chr12:29444161 [GRCh38]
Chr12:29597094 [GRCh37]
Chr12:12p11.22		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:327
Interacting mature miRNAs:348
Transcripts:ENST00000549411, ENST00000550906, ENST00000551108
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 16 1 2 73
Low 85 461 283 21 376 17 361 59 69 73 407 351 5 251 135
Below cutoff 1470 1907 1078 351 969 251 2420 1374 2106 209 519 900 104 787 1572 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000549411
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1229,425,925 - 29,487,488 (+)Ensembl
RefSeq Acc Id: ENST00000550906
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1229,389,637 - 29,464,930 (+)Ensembl
RefSeq Acc Id: ENST00000551108
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1229,389,294 - 29,487,473 (+)Ensembl
RefSeq Acc Id: ENST00000641955
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1229,389,289 - 29,394,817 (+)Ensembl
RefSeq Acc Id: ENST00000701302
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1229,389,642 - 29,487,473 (+)Ensembl
RefSeq Acc Id: NR_073170
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,389,294 - 29,464,930 (+)NCBI
GRCh371229,542,227 - 29,640,257 (+)NCBI
HuRef1229,311,198 - 29,408,532 (+)NCBI
CHM1_11229,507,814 - 29,583,069 (+)NCBI
T2T-CHM13v2.01229,261,819 - 29,337,063 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073171
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,389,294 - 29,464,930 (+)NCBI
GRCh371229,542,227 - 29,640,257 (+)NCBI
HuRef1229,311,198 - 29,408,532 (+)NCBI
CHM1_11229,507,814 - 29,583,069 (+)NCBI
T2T-CHM13v2.01229,261,819 - 29,337,063 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073172
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,389,294 - 29,487,324 (+)NCBI
GRCh371229,542,227 - 29,640,257 (+)NCBI
HuRef1229,311,198 - 29,408,532 (+)NCBI
CHM1_11229,507,814 - 29,605,463 (+)NCBI
T2T-CHM13v2.01229,261,819 - 29,359,454 (+)NCBI
Sequence:
Promoters
RGD ID:15096599
Promoter ID:EPDNEWNC_H1425
Type:multiple initiation site
Name:OVCH1-AS1_1
Description:OVCH1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44484]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,389,295 - 29,389,355EPDNEWNC

Additional Information

Database Acc Id Source(s)
COSMIC OVCH1-AS1 COSMIC
Ensembl Genes ENSG00000257599 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000551108 ENTREZGENE
GTEx ENSG00000257599 GTEx
HGNC ID HGNC:44484 ENTREZGENE
Human Proteome Map OVCH1-AS1 Human Proteome Map
NCBI Gene OVCH1-AS1 ENTREZGENE
RNAcentral URS000075A407 RNACentral
  URS000075D789 RNACentral
  URS000075E73F RNACentral