STEAP2-AS1 (STEAP2 antisense RNA 1) - Rat Genome Database

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Gene: STEAP2-AS1 (STEAP2 antisense RNA 1) Homo sapiens
Analyze
Symbol: STEAP2-AS1
Name: STEAP2 antisense RNA 1
RGD ID: 6481305
HGNC Page HGNC:40820
Description:
Type: ncrna (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38789,882,353 - 90,211,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl789,882,353 - 90,211,635 (-)EnsemblGRCh38hg38GRCh38
GRCh37789,511,667 - 89,840,949 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map7q21.13NCBI
HuRef784,122,438 - 84,451,042 (-)NCBIHuRef
CHM1_1789,441,698 - 89,770,915 (-)NCBICHM1_1
T2T-CHM13v2.0791,133,216 - 91,459,940 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:9847074   PMID:23870195   PMID:25130324   PMID:33991537  


Genomics

Variants

.
Variants in STEAP2-AS1
39 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NR_110029.2(STEAP2-AS1):n.425-22205G>T single nucleotide variant Lung cancer [RCV000106631] Chr7:89904760 [GRCh38]
Chr7:89534074 [GRCh37]
Chr7:7q21.13		 uncertain significance
NR_110029.2(STEAP2-AS1):n.425-129032G>C single nucleotide variant Lung cancer [RCV000106632] Chr7:90011587 [GRCh38]
Chr7:89640901 [GRCh37]
Chr7:7q21.13		 uncertain significance
NR_110029.2(STEAP2-AS1):n.425-149086C>A single nucleotide variant Lung cancer [RCV000106633] Chr7:90031641 [GRCh38]
Chr7:89660955 [GRCh37]
Chr7:7q21.13		 uncertain significance
NR_110029.2(STEAP2-AS1):n.424+156343A>C single nucleotide variant Lung cancer [RCV000106634] Chr7:90053508 [GRCh38]
Chr7:89682822 [GRCh37]
Chr7:7q21.13		 uncertain significance
NR_110029.2(STEAP2-AS1):n.424+105198G>T single nucleotide variant Lung cancer [RCV000106636] Chr7:90104653 [GRCh38]
Chr7:89733967 [GRCh37]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:88563550-90066568)x3 copy number gain See cases [RCV000133730] Chr7:88563550..90066568 [GRCh38]
Chr7:88192865..89695882 [GRCh37]
Chr7:88030801..89533818 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:89941939-90066509)x1 copy number loss See cases [RCV000134336] Chr7:89941939..90066509 [GRCh38]
Chr7:89571253..89695823 [GRCh37]
Chr7:89409189..89533759 [NCBI36]
Chr7:7q21.13		 benign
GRCh38/hg38 7q21.13(chr7:88563521-90066533)x3 copy number gain See cases [RCV000134131] Chr7:88563521..90066533 [GRCh38]
Chr7:88192836..89695847 [GRCh37]
Chr7:88030772..89533783 [NCBI36]
Chr7:7q21.13		 conflicting data from submitters
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.13(chr7:88763658-90066533)x3 copy number gain See cases [RCV000136066] Chr7:88763658..90066533 [GRCh38]
Chr7:88392972..89695847 [GRCh37]
Chr7:88230908..89533783 [NCBI36]
Chr7:7q21.13		 likely benign
GRCh38/hg38 7q21.13(chr7:88520043-90253333)x3 copy number gain See cases [RCV000137631] Chr7:88520043..90253333 [GRCh38]
Chr7:88149358..89882647 [GRCh37]
Chr7:87987294..89720583 [NCBI36]
Chr7:7q21.13		 likely benign|conflicting data from submitters
GRCh38/hg38 7q21.13(chr7:89880753-90888838)x3 copy number gain See cases [RCV000137233] Chr7:89880753..90888838 [GRCh38]
Chr7:89510067..90518153 [GRCh37]
Chr7:89348003..90356089 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:88724612-90253333)x3 copy number gain See cases [RCV000137297] Chr7:88724612..90253333 [GRCh38]
Chr7:88353926..89882647 [GRCh37]
Chr7:88191862..89720583 [NCBI36]
Chr7:7q21.13		 likely benign|conflicting data from submitters
GRCh38/hg38 7q21.13(chr7:88520043-90261496)x3 copy number gain See cases [RCV000137996] Chr7:88520043..90261496 [GRCh38]
Chr7:88149358..89890810 [GRCh37]
Chr7:87987294..89728746 [NCBI36]
Chr7:7q21.13		 likely benign
GRCh38/hg38 7q21.13(chr7:89467226-90255387)x3 copy number gain See cases [RCV000139935] Chr7:89467226..90255387 [GRCh38]
Chr7:89096540..89884701 [GRCh37]
Chr7:88934476..89722637 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.12-21.2(chr7:87379476-91731873)x1 copy number loss See cases [RCV000139869] Chr7:87379476..91731873 [GRCh38]
Chr7:87008792..91361188 [GRCh37]
Chr7:86846728..91199124 [NCBI36]
Chr7:7q21.12-21.2		 likely pathogenic|uncertain significance
GRCh38/hg38 7q21.13(chr7:89490493-90170632)x3 copy number gain See cases [RCV000142449] Chr7:89490493..90170632 [GRCh38]
Chr7:89119807..89799946 [GRCh37]
Chr7:88957743..89637882 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:89886335-90747262)x3 copy number gain See cases [RCV000142041] Chr7:89886335..90747262 [GRCh38]
Chr7:89515649..90376577 [GRCh37]
Chr7:89353585..90214513 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:88685497-90170632)x3 copy number gain See cases [RCV000142599] Chr7:88685497..90170632 [GRCh38]
Chr7:88314811..89799946 [GRCh37]
Chr7:88152747..89637882 [NCBI36]
Chr7:7q21.13		 pathogenic
GRCh38/hg38 7q21.11-21.3(chr7:84002634-95228883)x1 copy number loss See cases [RCV000143271] Chr7:84002634..95228883 [GRCh38]
Chr7:83631950..94858195 [GRCh37]
Chr7:83469886..94696131 [NCBI36]
Chr7:7q21.11-21.3		 pathogenic
GRCh38/hg38 7q21.13(chr7:88724612-90261496)x3 copy number gain See cases [RCV000143201] Chr7:88724612..90261496 [GRCh38]
Chr7:88353926..89890810 [GRCh37]
Chr7:88191862..89728746 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:88517003-90256109)x3 copy number gain See cases [RCV000143134] Chr7:88517003..90256109 [GRCh38]
Chr7:88146318..89885423 [GRCh37]
Chr7:87984254..89723359 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:88517003-90255387)x3 copy number gain See cases [RCV000143155] Chr7:88517003..90255387 [GRCh38]
Chr7:88146318..89884701 [GRCh37]
Chr7:87984254..89722637 [NCBI36]
Chr7:7q21.13		 uncertain significance|conflicting data from submitters
GRCh38/hg38 7q21.13(chr7:88563550-90170632)x3 copy number gain See cases [RCV000148087] Chr7:88563550..90170632 [GRCh38]
Chr7:88192865..89799946 [GRCh37]
Chr7:88030801..89637882 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:88563550-90170632)x3 copy number gain See cases [RCV000050715] Chr7:88563550..90170632 [GRCh38]
Chr7:88192865..89799946 [GRCh37]
Chr7:88030801..89637882 [NCBI36]
Chr7:7q21.13		 conflicting interpretations of pathogenicity|uncertain significance|conflicting data from submitters
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.13(chr7:88520043-90241919)x3 copy number gain See cases [RCV000053468] Chr7:88520043..90241919 [GRCh38]
Chr7:88149358..89871233 [GRCh37]
Chr7:87987294..89709169 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:88521030-90256023)x3 copy number gain See cases [RCV000053469] Chr7:88521030..90256023 [GRCh38]
Chr7:88150345..89885337 [GRCh37]
Chr7:87988281..89723273 [NCBI36]
Chr7:7q21.13		 uncertain significance
GRCh38/hg38 7q21.13(chr7:88685297-90170773)x3 copy number gain See cases [RCV000053495] Chr7:88685297..90170773 [GRCh38]
Chr7:88314611..89800087 [GRCh37]
Chr7:88152547..89638023 [NCBI36]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.166G>C (p.Asp56His) single nucleotide variant not specified [RCV004314997] Chr7:90160886 [GRCh38]
Chr7:89790200 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.804C>T (p.His268=) single nucleotide variant STEAP1-related condition [RCV003925925]|not provided [RCV000950162] Chr7:90164518 [GRCh38]
Chr7:89793832 [GRCh37]
Chr7:7q21.13		 benign
GRCh38/hg38 7q21.13(chr7:89998146-90352986) copy number gain Diaphragmatic hernia [RCV001823081] Chr7:89998146..90352986 [GRCh38]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.839T>C (p.Ile280Thr) single nucleotide variant not specified [RCV004111983] Chr7:90164553 [GRCh38]
Chr7:89793867 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.319T>C (p.Tyr107His) single nucleotide variant not specified [RCV004151254] Chr7:90161039 [GRCh38]
Chr7:89790353 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.541T>A (p.Ser181Thr) single nucleotide variant not specified [RCV004203503] Chr7:90161261 [GRCh38]
Chr7:89790575 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.76G>A (p.Asp26Asn) single nucleotide variant not specified [RCV004204606] Chr7:90159864 [GRCh38]
Chr7:89789178 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.517G>A (p.Val173Ile) single nucleotide variant not specified [RCV004072666] Chr7:90161237 [GRCh38]
Chr7:89790551 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.413T>C (p.Ile138Thr) single nucleotide variant not specified [RCV004193568] Chr7:90161133 [GRCh38]
Chr7:89790447 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.187C>G (p.His63Asp) single nucleotide variant not specified [RCV004172455] Chr7:90160907 [GRCh38]
Chr7:89790221 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.823A>T (p.Asn275Tyr) single nucleotide variant not specified [RCV004261938] Chr7:90164537 [GRCh38]
Chr7:89793851 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.557G>A (p.Arg186Gln) single nucleotide variant not specified [RCV004254048] Chr7:90161277 [GRCh38]
Chr7:89790591 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.817G>A (p.Ala273Thr) single nucleotide variant not specified [RCV004258112] Chr7:90164531 [GRCh38]
Chr7:89793845 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.772G>A (p.Gly258Arg) single nucleotide variant not specified [RCV004264726] Chr7:90164486 [GRCh38]
Chr7:89793800 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.908T>C (p.Ile303Thr) single nucleotide variant not specified [RCV004264038] Chr7:90164622 [GRCh38]
Chr7:89793936 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.508T>C (p.Phe170Leu) single nucleotide variant not specified [RCV004365145] Chr7:90161228 [GRCh38]
Chr7:89790542 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.107G>A (p.Ser36Asn) single nucleotide variant not specified [RCV004342411] Chr7:90160827 [GRCh38]
Chr7:89790141 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.410C>A (p.Ala137Glu) single nucleotide variant not specified [RCV004352407] Chr7:90161130 [GRCh38]
Chr7:89790444 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.965A>G (p.His322Arg) single nucleotide variant not specified [RCV004346145] Chr7:90164679 [GRCh38]
Chr7:89793993 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.406G>C (p.Ala136Pro) single nucleotide variant not specified [RCV004465554] Chr7:90161126 [GRCh38]
Chr7:89790440 [GRCh37]
Chr7:7q21.13		 uncertain significance
NM_012449.3(STEAP1):c.550A>G (p.Met184Val) single nucleotide variant not specified [RCV004465556] Chr7:90161270 [GRCh38]
Chr7:89790584 [GRCh37]
Chr7:7q21.13		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:139
Interacting mature miRNAs:141
Transcripts:ENST00000433534, ENST00000478318
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 229 138 190 67 27 31 238 160 291 53 511 246 37 106 204
Below cutoff 1235 1058 1011 366 295 265 1732 643 2161 234 647 794 109 688 1087

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000433534
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl790,209,270 - 90,211,635 (-)Ensembl
RefSeq Acc Id: ENST00000478318
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl789,882,353 - 90,211,635 (-)Ensembl
RefSeq Acc Id: NR_110029
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38789,882,353 - 90,211,635 (-)NCBI
HuRef784,122,438 - 84,451,042 (-)NCBI
CHM1_1789,441,698 - 89,770,915 (-)NCBI
T2T-CHM13v2.0791,133,216 - 91,459,940 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC STEAP2-AS1 COSMIC
Ensembl Genes ENSG00000227646 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000478318 ENTREZGENE
GTEx ENSG00000227646 GTEx
HGNC ID HGNC:40820 ENTREZGENE
Human Proteome Map STEAP2-AS1 Human Proteome Map
NCBI Gene STEAP2-AS1 ENTREZGENE
RNAcentral URS000075AF5F RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-21 STEAP2-AS1  STEAP2 antisense RNA 1  STEAP2-AS1  STEAP2 antisense RNA 1 (non-protein coding)  Symbol and/or name change 5135510 APPROVED