Imported Disease Annotations - MGITerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hermansky-Pudlak syndrome | | ISS | Rabggta (Mus musculus) | 13592920 | | MouseDO | | |
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Imported Disease Annotations - MGITerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hermansky-Pudlak syndrome | | ISS | Rabggta (Mus musculus) | 13592920 | | MouseDO | | |
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# | Reference Title | Reference Citation |
1. | cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. | Armstrong SA, etal., J Biol Chem 1993 Jun 5;268(16):12221-9. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. | Guo Z, etal., Angew Chem Int Ed Engl. 2008;47(20):3747-50. doi: 10.1002/anie.200705795. |
4. | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. | Guo Z, etal., EMBO J. 2008 Sep 17;27(18):2444-56. doi: 10.1038/emboj.2008.164. Epub 2008 Aug 28. |
5. | Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1). | Lubelwana Hafver T, etal., Proteomics. 2017 Sep;17(17-18). doi: 10.1002/pmic.201600417. |
6. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
7. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
8. | Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. | Pylypenko O, etal., Mol Cell. 2003 Feb;11(2):483-94. |
9. | GOA pipeline | RGD automated data pipeline |
10. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
11. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
PMID:10737774 | PMID:10745007 | PMID:12477932 | PMID:15489334 | PMID:23114750 | PMID:30053369 |
Rabggta (Rattus norvegicus - Norway rat) |
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RABGGTA (Homo sapiens - human) |
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Rabggta (Mus musculus - house mouse) |
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RABGGTA (Pan paniscus - bonobo/pygmy chimpanzee) |
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RABGGTA (Canis lupus familiaris - dog) |
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Rabggta (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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RABGGTA (Sus scrofa - pig) |
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RABGGTA (Chlorocebus sabaeus - green monkey) |
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Rabggta (Heterocephalus glaber - naked mole-rat) |
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Variants in Rabggta
44 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
BI278294 |
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AI071807 |
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AI410860 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 35 | 47 | 32 | 19 | 32 | 3 | 74 | 34 | 36 | 11 | ||
Low | 8 | 10 | 9 | 9 | 8 | 8 | 1 | 5 | 8 | ||||
Below cutoff |
RefSeq Acc Id: | ENSRNOT00000048455 ⟹ ENSRNOP00000049261 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000099074 ⟹ ENSRNOP00000077243 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000108610 ⟹ ENSRNOP00000091502 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_031654 ⟹ NP_113842 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006252009 ⟹ XP_006252071 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006252010 ⟹ XP_006252072 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NP_113842 ⟸ NM_031654 |
- UniProtKB: | Q08602 (UniProtKB/Swiss-Prot), A6KH43 (UniProtKB/TrEMBL), A0A8I6GJ12 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006252072 ⟸ XM_006252010 |
- Peptide Label: | isoform X1 |
- UniProtKB: | Q08602 (UniProtKB/Swiss-Prot), A6KH43 (UniProtKB/TrEMBL), A0A8I6GJ12 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006252071 ⟸ XM_006252009 |
- Peptide Label: | isoform X1 |
- UniProtKB: | Q08602 (UniProtKB/Swiss-Prot), A6KH43 (UniProtKB/TrEMBL), A0A8I6GJ12 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000049261 ⟸ ENSRNOT00000048455 |
RefSeq Acc Id: | ENSRNOP00000077243 ⟸ ENSRNOT00000099074 |
RefSeq Acc Id: | ENSRNOP00000091502 ⟸ ENSRNOT00000108610 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q08602-F1-model_v2 | AlphaFold | Q08602 | 1-567 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13699686 | ||||||||
Promoter ID: | EPDNEW_R10209 | ||||||||
Type: | initiation region | ||||||||
Name: | Rabggta_1 | ||||||||
Description: | Rab geranylgeranyltransferase, alpha subunit | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:621697 | AgrOrtholog |
BioCyc Gene | G2FUF-13695 | BioCyc |
Ensembl Genes | ENSRNOG00000030483 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000048455.5 | UniProtKB/TrEMBL |
ENSRNOT00000099074.1 | UniProtKB/TrEMBL | |
ENSRNOT00000108610.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 3.80.10.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Protein prenylyltransferase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Rab geranylgeranyltransferase alpha-subunit, insert domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:7301723 | IMAGE-MGC_LOAD |
InterPro | Leu-rich_rpt | UniProtKB/TrEMBL |
LRR_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Prenyl_trans_a | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RabGGT_asu_insert-dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RabGGT_asu_insert-domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:58983 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MGC_CLONE | MGC:105396 | IMAGE-MGC_LOAD |
NCBI Gene | 58983 | ENTREZGENE |
PANTHER | PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR11129:SF2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | LRR_1 | UniProtKB/TrEMBL |
PPTA | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RabGGT_insert | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Rabggta | PhenoGen |
PROSITE | PFTA | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000030483 | RatGTEx |
Superfamily-SCOP | L domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Outer arm dynein light chain 1 | UniProtKB/TrEMBL | |
Protein prenylyltransferase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF49594 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A8I5ZK93_RAT | UniProtKB/TrEMBL |
A0A8I6GJ12 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8L2QNR5_RAT | UniProtKB/TrEMBL | |
A6KH42_RAT | UniProtKB/TrEMBL | |
A6KH43 | ENTREZGENE, UniProtKB/TrEMBL | |
PGTA_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2018-05-04 | Rabggta | Rab geranylgeranyltransferase subunit alpha | Rabggta | Rab geranylgeranyltransferase, alpha subunit | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-09-24 | Rabggta | Rab geranylgeranyltransferase, alpha subunit | Rabggta | Rab geranylgeranyl transferase, a subunit | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2004-12-14 | Rabggta | Rab geranylgeranyl transferase, a subunit | Symbol and Name status set to approved | 1299863 | APPROVED | ||
2002-08-07 | Rabggta | Rab geranylgeranyl transferase, a subunit | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_physical_interaction | combines with beta subunit Rabggtb to form Component B of the Rab geranylgeranyl transferase, which combines with an additional Component A for enzyme activity | 69952 |