Rabggta (Rab geranylgeranyltransferase subunit alpha) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Rabggta (Rab geranylgeranyltransferase subunit alpha) Rattus norvegicus
Analyze
Symbol: Rabggta
Name: Rab geranylgeranyltransferase subunit alpha
RGD ID: 621697
Description: Enables Rab geranylgeranyltransferase activity and small GTPase binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: geranylgeranyl transferase type II subunit alpha; geranylgeranyl transferase type-2 subunit alpha; rab geranyl-geranyltransferase subunit alpha; Rab geranylgeranyl transferase, a subunit; Rab geranylgeranyltransferase alpha; Rab geranylgeranyltransferase, alpha subunit; rab GG transferase alpha; rab GGTase alpha
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,176,268 - 33,183,320 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,176,099 - 33,183,271 (-)EnsemblGRCr8
mRatBN7.21529,206,328 - 29,213,398 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,206,157 - 29,213,348 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,052,659 - 31,059,003 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,199,884 - 32,206,228 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,442,218 - 30,448,562 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1531,876,183 - 31,882,527 (-)NCBI
Lyon_Normotensive1531,580,936 - 31,587,280 (-)NCBI
Lyon_Hypertensive1531,687,416 - 31,693,760 (-)NCBI
F344_StmMcwi1530,874,147 - 30,880,491 (-)NCBI
Rnor_6.01534,393,419 - 34,400,466 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,393,233 - 34,400,449 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01538,283,389 - 38,290,429 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,862,275 - 33,868,619 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,783,370 - 28,789,714 (-)NCBICelera
RGSC_v3.11533,877,146 - 33,883,992 (-)NCBI
Cytogenetic Map15p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. Armstrong SA, etal., J Biol Chem 1993 Jun 5;268(16):12221-9.
2. Structure-guided development of selective RabGGTase inhibitors. Bon RS, etal., Angew Chem Int Ed Engl. 2011 May 16;50(21):4957-61. doi: 10.1002/anie.201101210. Epub 2011 Apr 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Guo Z, etal., Angew Chem Int Ed Engl. 2008;47(20):3747-50. doi: 10.1002/anie.200705795.
5. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. Guo Z, etal., EMBO J. 2008 Sep 17;27(18):2444-56. doi: 10.1038/emboj.2008.164. Epub 2008 Aug 28.
6. Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1). Lubelwana Hafver T, etal., Proteomics. 2017 Sep;17(17-18). doi: 10.1002/pmic.201600417.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Pylypenko O, etal., Mol Cell. 2003 Feb;11(2):483-94.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Development of selective, potent RabGGTase inhibitors. Stigter EA, etal., J Med Chem. 2012 Oct 11;55(19):8330-40. doi: 10.1021/jm300624s. Epub 2012 Oct 3.
14. Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. Tan KT, etal., J Med Chem. 2009 Dec 24;52(24):8025-37. doi: 10.1021/jm901117d.
Additional References at PubMed
PMID:10737774   PMID:10745007   PMID:12477932   PMID:15489334   PMID:23114750   PMID:30053369  


Genomics

Comparative Map Data
Rabggta
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,176,268 - 33,183,320 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,176,099 - 33,183,271 (-)EnsemblGRCr8
mRatBN7.21529,206,328 - 29,213,398 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,206,157 - 29,213,348 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,052,659 - 31,059,003 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,199,884 - 32,206,228 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,442,218 - 30,448,562 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1531,876,183 - 31,882,527 (-)NCBI
Lyon_Normotensive1531,580,936 - 31,587,280 (-)NCBI
Lyon_Hypertensive1531,687,416 - 31,693,760 (-)NCBI
F344_StmMcwi1530,874,147 - 30,880,491 (-)NCBI
Rnor_6.01534,393,419 - 34,400,466 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,393,233 - 34,400,449 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01538,283,389 - 38,290,429 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,862,275 - 33,868,619 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,783,370 - 28,789,714 (-)NCBICelera
RGSC_v3.11533,877,146 - 33,883,992 (-)NCBI
Cytogenetic Map15p13NCBI
RABGGTA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,265,538 - 24,271,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,265,468 - 24,271,620 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371424,734,744 - 24,740,833 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,804,584 - 23,810,643 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341423,804,585 - 23,810,643NCBI
Celera144,599,360 - 4,605,419 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,849,901 - 4,855,990 (-)NCBIHuRef
CHM1_11424,733,345 - 24,739,434 (-)NCBICHM1_1
T2T-CHM13v2.01418,463,884 - 18,469,973 (-)NCBIT2T-CHM13v2.0
Rabggta
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,953,321 - 55,959,720 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,952,101 - 55,959,743 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381455,715,864 - 55,722,263 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,715,416 - 55,722,263 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371456,334,714 - 56,341,013 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361454,669,948 - 54,676,247 (-)NCBIMGSCv36mm8
Celera1453,520,890 - 53,527,189 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
RABGGTA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,620,464 - 25,627,815 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,836,956 - 24,843,040 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,041,694 - 5,047,775 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,165,254 - 23,171,339 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,163,034 - 23,171,311 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
RABGGTA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,244,731 - 4,250,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,244,781 - 4,250,744 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha84,166,409 - 4,172,506 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.084,355,507 - 4,361,606 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,355,513 - 4,361,532 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,045,886 - 4,051,978 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,107,715 - 4,113,807 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,370,053 - 4,376,415 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rabggta
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1589,455,544 - 89,461,447 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440864036,099,444 - 36,105,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722283,544 - 290,429 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936722283,682 - 289,548 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RABGGTA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,021,755 - 75,028,875 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1775,021,716 - 75,028,229 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,292,566 - 80,298,870 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RABGGTA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap124514,228 - 520,326 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603612,933,353 - 12,939,556 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1241,248,637 - 1,254,937 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,248,393 - 1,266,254 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Rabggta
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248208,230,560 - 8,236,843 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248208,230,893 - 8,236,843 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl222,152,884 - 22,159,107 (-)Ensembl
Rabggta
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11269,286,459 - 69,294,100 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Rabggta
63 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:49
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000048455
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
BI278294  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,206,773 - 29,206,932 (+)MAPPERmRatBN7.2
Rnor_6.01534,393,865 - 34,394,023NCBIRnor6.0
Rnor_5.01538,283,841 - 38,283,999UniSTSRnor5.0
RGSC_v3.41533,862,062 - 33,862,220UniSTSRGSC3.4
Celera1528,783,157 - 28,783,315UniSTS
RH 3.4 Map15214.1UniSTS
Cytogenetic Map15p13UniSTS
AI071807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,206,412 - 29,206,630 (+)MAPPERmRatBN7.2
Rnor_6.01534,393,504 - 34,393,721NCBIRnor6.0
Rnor_5.01538,283,480 - 38,283,697UniSTSRnor5.0
RGSC_v3.41533,861,701 - 33,861,918UniSTSRGSC3.4
Celera1528,782,796 - 28,783,013UniSTS
RH 3.4 Map15260.81UniSTS
Cytogenetic Map15p13UniSTS
AI410860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,207,004 - 29,207,142 (+)MAPPERmRatBN7.2
Rnor_6.01534,394,096 - 34,394,233NCBIRnor6.0
Rnor_5.01538,284,072 - 38,284,209UniSTSRnor5.0
RGSC_v3.41533,862,293 - 33,862,430UniSTSRGSC3.4
Celera1528,783,388 - 28,783,525UniSTS
RH 3.4 Map15260.61UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
274 156 730 1591 4054 1010 1726 133 873 483 855 156 5380 2585 449 3967 38 1389 741 908 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000048455   ⟹   ENSRNOP00000049261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,176,099 - 33,182,759 (-)Ensembl
mRatBN7.2 Ensembl1529,206,157 - 29,213,348 (-)Ensembl
Rnor_6.0 Ensembl1534,393,233 - 34,400,449 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099074   ⟹   ENSRNOP00000077243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,176,927 - 33,183,271 (-)Ensembl
mRatBN7.2 Ensembl1529,206,324 - 29,213,302 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108610   ⟹   ENSRNOP00000091502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,176,927 - 33,183,271 (-)Ensembl
mRatBN7.2 Ensembl1529,206,157 - 29,213,284 (-)Ensembl
RefSeq Acc Id: NM_031654   ⟹   NP_113842
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,176,927 - 33,183,271 (-)NCBI
mRatBN7.21529,206,987 - 29,213,331 (-)NCBI
Dahl_SR_JrHsd1531,876,183 - 31,882,527 (-)NCBI
Lyon_Normotensive1531,580,936 - 31,587,280 (-)NCBI
Lyon_Hypertensive1531,687,416 - 31,693,760 (-)NCBI
F344_StmMcwi1530,874,147 - 30,880,491 (-)NCBI
Rnor_6.01534,394,078 - 34,400,422 (-)NCBI
Rnor_5.01538,283,389 - 38,290,429 (-)NCBI
RGSC_v3.41533,862,275 - 33,868,619 (-)RGD
Celera1528,783,370 - 28,789,714 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252009   ⟹   XP_006252071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,176,268 - 33,183,288 (-)NCBI
mRatBN7.21529,206,328 - 29,213,302 (-)NCBI
Rnor_6.01534,393,419 - 34,400,381 (-)NCBI
Rnor_5.01538,283,389 - 38,290,429 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252010   ⟹   XP_006252072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,176,268 - 33,183,320 (-)NCBI
mRatBN7.21529,206,328 - 29,213,398 (-)NCBI
Rnor_6.01534,393,419 - 34,400,466 (-)NCBI
Rnor_5.01538,283,389 - 38,290,429 (-)NCBI
Sequence:
RefSeq Acc Id: NP_113842   ⟸   NM_031654
- UniProtKB: Q08602 (UniProtKB/Swiss-Prot),   A0A8L2QNR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252072   ⟸   XM_006252010
- Peptide Label: isoform X1
- UniProtKB: Q08602 (UniProtKB/Swiss-Prot),   A0A8L2QNR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252071   ⟸   XM_006252009
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000049261   ⟸   ENSRNOT00000048455
Ensembl Acc Id: ENSRNOP00000077243   ⟸   ENSRNOT00000099074
Ensembl Acc Id: ENSRNOP00000091502   ⟸   ENSRNOT00000108610
Protein Domains
Rab geranylgeranyltransferase alpha subunit insert-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08602-F1-model_v2 AlphaFold Q08602 1-567 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699686
Promoter ID:EPDNEW_R10209
Type:initiation region
Name:Rabggta_1
Description:Rab geranylgeranyltransferase, alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,400,443 - 34,400,503EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621697 AgrOrtholog
BioCyc Gene G2FUF-13695 BioCyc
Ensembl Genes ENSRNOG00000030483 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048455 ENTREZGENE
  ENSRNOT00000108610 ENTREZGENE
  ENSRNOT00000108610.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
  Protein prenylyltransferase UniProtKB/Swiss-Prot
  Rab geranylgeranyltransferase alpha-subunit, insert domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7301723 IMAGE-MGC_LOAD
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  Prenyl_trans_a UniProtKB/Swiss-Prot
  RabGGT_asu_insert-dom_sf UniProtKB/Swiss-Prot
  RabGGT_asu_insert-domain UniProtKB/Swiss-Prot
KEGG Report rno:58983 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105396 IMAGE-MGC_LOAD
NCBI Gene 58983 ENTREZGENE
PANTHER PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT UniProtKB/Swiss-Prot
  PTHR11129:SF2 UniProtKB/Swiss-Prot
Pfam LRR_1 UniProtKB/Swiss-Prot
  PPTA UniProtKB/Swiss-Prot
  RabGGT_insert UniProtKB/Swiss-Prot
PhenoGen Rabggta PhenoGen
PROSITE PFTA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030483 RatGTEx
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  Protein prenylyltransferase UniProtKB/Swiss-Prot
  SSF49594 UniProtKB/Swiss-Prot
UniProt A0A8I5ZK93_RAT UniProtKB/TrEMBL
  A0A8I6GJ12_RAT UniProtKB/TrEMBL
  A0A8L2QNR5 ENTREZGENE, UniProtKB/TrEMBL
  PGTA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-04 Rabggta  Rab geranylgeranyltransferase subunit alpha  Rabggta  Rab geranylgeranyltransferase, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Rabggta  Rab geranylgeranyltransferase, alpha subunit  Rabggta  Rab geranylgeranyl transferase, a subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Rabggta  Rab geranylgeranyl transferase, a subunit      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rabggta  Rab geranylgeranyl transferase, a subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction combines with beta subunit Rabggtb to form Component B of the Rab geranylgeranyl transferase, which combines with an additional Component A for enzyme activity 69952