PET117 (PET117 cytochrome c oxidase chaperone) - Rat Genome Database

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Gene: PET117 (PET117 cytochrome c oxidase chaperone) Homo sapiens
Analyze
Symbol: PET117
Name: PET117 cytochrome c oxidase chaperone
RGD ID: 5688594
HGNC Page HGNC:40045
Description: Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Implicated in mitochondrial complex IV deficiency nuclear type 19.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alternative protein CSRP2BP; CSRP2BP; cytochrome c oxidase assembly factor-like; MC4DN19; PET117 homolog; protein PET117 homolog, mitochondrial
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: PET117P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382018,137,863 - 18,143,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2018,137,863 - 18,143,169 (+)EnsemblGRCh38hg38GRCh38
GRCh372018,118,507 - 18,123,813 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera2018,193,220 - 18,198,534 (+)NCBICelera
Cytogenetic Map20p11.23NCBI
HuRef2018,081,311 - 18,086,626 (+)NCBIHuRef
CHM1_12018,118,254 - 18,123,806 (+)NCBICHM1_1
T2T-CHM13v2.02018,188,733 - 18,194,026 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IDA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12975309   PMID:21873635   PMID:22356826   PMID:28199844   PMID:28386624   PMID:30232004   PMID:34373451  


Genomics

Comparative Map Data
PET117
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382018,137,863 - 18,143,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2018,137,863 - 18,143,169 (+)EnsemblGRCh38hg38GRCh38
GRCh372018,118,507 - 18,123,813 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera2018,193,220 - 18,198,534 (+)NCBICelera
Cytogenetic Map20p11.23NCBI
HuRef2018,081,311 - 18,086,626 (+)NCBIHuRef
CHM1_12018,118,254 - 18,123,806 (+)NCBICHM1_1
T2T-CHM13v2.02018,188,733 - 18,194,026 (+)NCBIT2T-CHM13v2.0
Pet117
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392144,210,903 - 144,215,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2144,210,916 - 144,215,641 (+)EnsemblGRCm39 Ensembl
GRCm382144,368,983 - 144,373,337 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2144,368,996 - 144,373,721 (+)EnsemblGRCm38mm10GRCm38
MGSCv372144,194,719 - 144,199,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera2145,557,111 - 145,561,480 (+)NCBICelera
Cytogenetic Map2G1NCBI
cM Map271.01NCBI
Pet117
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83152,187,473 - 152,195,173 (+)NCBIGRCr8
Pet117
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541526,868,451 - 26,871,832 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541526,868,442 - 26,871,832 (+)NCBIChiLan1.0ChiLan1.0
LOC103784797
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22119,031,979 - 19,037,160 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12019,028,832 - 19,036,300 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02018,102,060 - 18,107,357 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12018,078,074 - 18,091,102 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2018,078,074 - 18,083,346 (+)Ensemblpanpan1.1panPan2
LOC100688040
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1244,968,462 - 4,971,802 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl244,933,573 - 4,971,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha244,899,008 - 4,902,345 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0245,376,249 - 5,379,580 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl245,340,853 - 5,379,563 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1244,975,871 - 4,979,194 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0245,083,019 - 5,086,327 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0245,359,413 - 5,362,759 (-)NCBIUU_Cfam_GSD_1.0
LOC106144621
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640153,600,113 - 153,604,176 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364852,031,175 - 2,035,517 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364852,031,175 - 2,035,517 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PET117
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1726,480,898 - 26,485,325 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11726,479,411 - 26,485,552 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21729,969,317 - 29,973,593 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103214828
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1247,203,572 - 47,208,914 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660781,929,523 - 1,942,671 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pet117
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474119,039,732 - 19,043,788 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474119,039,725 - 19,043,820 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PET117
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20p13-11.21(chr20:89939-25697564)x3 copy number gain See cases [RCV000051227] Chr20:89939..25697564 [GRCh38]
Chr20:70580..25678200 [GRCh37]
Chr20:18580..25626200 [NCBI36]
Chr20:20p13-11.21
pathogenic
GRCh38/hg38 20p13-11.23(chr20:89939-19146279)x3 copy number gain See cases [RCV000051041] Chr20:89939..19146279 [GRCh38]
Chr20:70580..19126923 [GRCh37]
Chr20:18580..19074923 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh38/hg38 20p12.2-q12(chr20:9811433-39316956)x3 copy number gain See cases [RCV000052999] Chr20:9811433..39316956 [GRCh38]
Chr20:9792081..37945599 [GRCh37]
Chr20:9740081..37379013 [NCBI36]
Chr20:20p12.2-q12
pathogenic
GRCh38/hg38 20p13-11.23(chr20:89939-19071495)x3 copy number gain See cases [RCV000052995] Chr20:89939..19071495 [GRCh38]
Chr20:70580..19052139 [GRCh37]
Chr20:18580..19000139 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh38/hg38 20p13-11.22(chr20:89939-21787252)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|See cases [RCV000052996] Chr20:89939..21787252 [GRCh38]
Chr20:70580..21767890 [GRCh37]
Chr20:18580..21715890 [NCBI36]
Chr20:20p13-11.22
pathogenic
GRCh38/hg38 20p13-q11.1(chr20:80106-30227427)x3 copy number gain See cases [RCV000133996] Chr20:80106..30227427 [GRCh38]
Chr20:60747..29462103 [GRCh37]
Chr20:8747..28075764 [NCBI36]
Chr20:20p13-q11.1
pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20p12.1-11.22(chr20:17772771-21426789)x1 copy number loss See cases [RCV000135439] Chr20:17772771..21426789 [GRCh38]
Chr20:17753416..21407427 [GRCh37]
Chr20:17701416..21355427 [NCBI36]
Chr20:20p12.1-11.22
pathogenic
GRCh38/hg38 20p13-11.1(chr20:80927-26324843)x3 copy number gain See cases [RCV000142017] Chr20:80927..26324843 [GRCh38]
Chr20:61568..26305479 [GRCh37]
Chr20:9568..26253479 [NCBI36]
Chr20:20p13-11.1
pathogenic
GRCh38/hg38 20p13-11.23(chr20:80928-18688031)x3 copy number gain See cases [RCV000143426] Chr20:80928..18688031 [GRCh38]
Chr20:61569..18668675 [GRCh37]
Chr20:9569..18616675 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh37/hg19 20p13-11.1(chr20:80198-26075841)x3 copy number gain See cases [RCV000239954] Chr20:80198..26075841 [GRCh37]
Chr20:20p13-11.1
pathogenic
GRCh37/hg19 20p12.1-q11.21(chr20:17705775-31600738)x3 copy number gain See cases [RCV000240436] Chr20:17705775..31600738 [GRCh37]
Chr20:20p12.1-q11.21
pathogenic
GRCh37/hg19 20p13-q11.21(chr20:80198-26208081)x3 copy number gain not provided [RCV000487461] Chr20:80198..26208081 [GRCh37]
Chr20:20p13-q11.21
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
Single allele duplication not provided [RCV000677978] Chr20:17705775..31600738 [GRCh37]
Chr20:20p12.1-q11.21
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p12.3-11.22(chr20:8571696-22088650)x1 copy number loss not provided [RCV001007080] Chr20:8571696..22088650 [GRCh37]
Chr20:20p12.3-11.22
pathogenic
NM_001164811.2(PET117):c.157C>G (p.Arg53Gly) single nucleotide variant not provided [RCV000900182] Chr20:18142268 [GRCh38]
Chr20:18122912 [GRCh37]
Chr20:20p11.23
benign
GRCh37/hg19 20p12.2-11.23(chr20:11716825-19331055) copy number gain not provided [RCV000767743] Chr20:11716825..19331055 [GRCh37]
Chr20:20p12.2-11.23
pathogenic
GRCh37/hg19 20p13-11.1(chr20:61568-26305479)x3 copy number gain not provided [RCV001007068] Chr20:61568..26305479 [GRCh37]
Chr20:20p13-11.1
pathogenic
NM_001164811.2(PET117):c.172C>T (p.Gln58Ter) single nucleotide variant Mitochondrial complex 4 deficiency, nuclear type 19 [RCV001260985] Chr20:18142283 [GRCh38]
Chr20:18122927 [GRCh37]
Chr20:20p11.23
pathogenic|likely pathogenic
GRCh37/hg19 20p12.2-11.23(chr20:11702911-19179706)x3 copy number gain not provided [RCV001795841] Chr20:11702911..19179706 [GRCh37]
Chr20:20p12.2-11.23
uncertain significance
NC_000020.10:g.(?_17587682)_(18168103_?)del deletion not provided [RCV003122983] Chr20:17587682..18168103 [GRCh37]
Chr20:20p12.1-11.23
pathogenic
NM_001164811.2(PET117):c.139C>T (p.Arg47Trp) single nucleotide variant not specified [RCV004191694] Chr20:18142250 [GRCh38]
Chr20:18122894 [GRCh37]
Chr20:20p11.23
uncertain significance
NM_001164811.2(PET117):c.157C>T (p.Arg53Cys) single nucleotide variant not specified [RCV004206409] Chr20:18142268 [GRCh38]
Chr20:18122912 [GRCh37]
Chr20:20p11.23
uncertain significance
NM_001164811.2(PET117):c.208G>A (p.Glu70Lys) single nucleotide variant not specified [RCV004272110] Chr20:18142319 [GRCh38]
Chr20:18122963 [GRCh37]
Chr20:20p11.23
uncertain significance
NM_001164811.2(PET117):c.31C>T (p.Leu11Phe) single nucleotide variant not specified [RCV004277169] Chr20:18137986 [GRCh38]
Chr20:18118630 [GRCh37]
Chr20:20p11.23
uncertain significance
GRCh38/hg38 20p13-11.21(chr20:87153-23635465)x3 copy number gain Renal agenesis [RCV003327640] Chr20:87153..23635465 [GRCh38]
Chr20:20p13-11.21
pathogenic
NM_001164811.2(PET117):c.104G>C (p.Arg35Pro) single nucleotide variant not specified [RCV004360202] Chr20:18142215 [GRCh38]
Chr20:18122859 [GRCh37]
Chr20:20p11.23
uncertain significance
NM_001164811.2(PET117):c.63C>T (p.Ala21=) single nucleotide variant not provided [RCV003431265] Chr20:18138018 [GRCh38]
Chr20:18118662 [GRCh37]
Chr20:20p11.23
likely benign
NM_001392073.1(KAT14):c.253C>T (p.Pro85Ser) single nucleotide variant not provided [RCV003431266] Chr20:18142913 [GRCh38]
Chr20:18123557 [GRCh37]
Chr20:20p11.23
uncertain significance
NC_000020.10:g.16400000_24400000del deletion Hyperinsulinemic hypoglycemia, familial, 1 [RCV003992661] Chr20:16400000..24400000 [GRCh37]
Chr20:20p12.1-11.21
pathogenic
NM_001164811.2(PET117):c.6T>C (p.Ser2=) single nucleotide variant PET117-related condition [RCV003917331] Chr20:18137961 [GRCh38]
Chr20:18118605 [GRCh37]
Chr20:20p11.23
likely benign
GRCh37/hg19 20p13-11.21(chr20:68351-23860313)x3 copy number gain not provided [RCV003885495] Chr20:68351..23860313 [GRCh37]
Chr20:20p13-11.21
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:160
Interacting mature miRNAs:162
Transcripts:ENST00000432901
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-N40959  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372018,123,451 - 18,123,631UniSTSGRCh37
Build 362018,071,451 - 18,071,631RGDNCBI36
Celera2018,198,172 - 18,198,352RGD
Cytogenetic Map20p11.23UniSTS
HuRef2018,086,264 - 18,086,444UniSTS
GeneMap99-GB4 RH Map2088.57UniSTS
D20S1140  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372018,117,857 - 18,117,998UniSTSGRCh37
Build 362018,065,857 - 18,065,998RGDNCBI36
Celera2018,192,578 - 18,192,719RGD
Cytogenetic Map20p11.23UniSTS
HuRef2018,080,666 - 18,080,810UniSTS
Marshfield Genetic Map2039.25UniSTS
deCODE Assembly Map2045.76UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 566 85 538 70 260 68 475 278 971 158 400 516 18 1 35 139 5 1
Low 1873 2702 1188 554 1498 397 3882 1908 2763 260 1060 1097 156 1169 2649 1 1
Below cutoff 193 181 10 1

Sequence


RefSeq Acc Id: ENST00000432901   ⟹   ENSP00000397881
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2018,137,863 - 18,143,169 (+)Ensembl
RefSeq Acc Id: NM_001164811   ⟹   NP_001158283
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382018,137,863 - 18,143,169 (+)NCBI
GRCh372018,118,499 - 18,169,016 (+)NCBI
HuRef2018,081,311 - 18,086,626 (+)ENTREZGENE
CHM1_12018,118,254 - 18,123,806 (+)NCBI
T2T-CHM13v2.02018,188,733 - 18,194,026 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001158283 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ89029 (Get FASTA)   NCBI Sequence Viewer  
  CAI93430 (Get FASTA)   NCBI Sequence Viewer  
  CCO13715 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000397881
  ENSP00000397881.2
GenBank Protein Q6UWS5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001158283   ⟸   NM_001164811
- Peptide Label: precursor
- UniProtKB: Q6UWS5 (UniProtKB/Swiss-Prot),   L0R6F6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000397881   ⟸   ENST00000432901

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6UWS5-F1-model_v2 AlphaFold Q6UWS5 1-81 view protein structure

Promoters
RGD ID:13206447
Promoter ID:EPDNEW_H26803
Type:initiation region
Name:PET117_1
Description:PET117 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382018,137,873 - 18,137,933EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:40045 AgrOrtholog
COSMIC PET117 COSMIC
Ensembl Genes ENSG00000232838 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000432901 ENTREZGENE
  ENST00000432901.4 UniProtKB/Swiss-Prot
GTEx ENSG00000232838 GTEx
HGNC ID HGNC:40045 ENTREZGENE
Human Proteome Map PET117 Human Proteome Map
InterPro Pet117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:100303755 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene PET117 ENTREZGENE
OMIM 614771 OMIM
PANTHER PROTEIN PET117 HOMOLOG, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28163 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PET117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA166049064 PharmGKB
UniProt L0R6F6 ENTREZGENE, UniProtKB/TrEMBL
  PT117_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-19 PET117  PET117 cytochrome c oxidase chaperone    PET117 homolog  Symbol and/or name change 5135510 APPROVED
2015-07-14 PET117  PET117 homolog    PET117 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED