MIR4729 (microRNA 4729) - Rat Genome Database

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Gene: MIR4729 (microRNA 4729) Homo sapiens
Analyze
Symbol: MIR4729
Name: microRNA 4729
RGD ID: 5134161
HGNC Page HGNC:41585
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,366,083 - 59,366,154 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1759,366,083 - 59,366,154 (+)EnsemblGRCh38hg38GRCh38
GRCh371757,443,444 - 57,443,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q22NCBI
HuRef1752,802,536 - 52,802,607 (+)NCBIHuRef
CHM1_11757,508,832 - 57,508,903 (+)NCBICHM1_1
T2T-CHM13v2.01760,234,221 - 60,234,292 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21199797  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh38/hg38 17q22-23.1(chr17:59151820-59547491)x3 copy number gain See cases [RCV000136959] Chr17:59151820..59547491 [GRCh38]
Chr17:57229181..57624852 [GRCh37]
Chr17:54583963..54979634 [NCBI36]
Chr17:17q22-23.1		 benign
GRCh38/hg38 17q22-23.1(chr17:57418806-59735464)x1 copy number loss See cases [RCV000140211] Chr17:57418806..59735464 [GRCh38]
Chr17:55496167..57812825 [GRCh37]
Chr17:52851166..55167607 [NCBI36]
Chr17:17q22-23.1		 pathogenic
GRCh38/hg38 17q22-23.1(chr17:59151705-59547602)x3 copy number gain See cases [RCV000139556] Chr17:59151705..59547602 [GRCh38]
Chr17:57229066..57624963 [GRCh37]
Chr17:54583848..54979745 [NCBI36]
Chr17:17q22-23.1		 likely benign
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:24293
Count of gene targets:9244
Count of transcripts:17839
Interacting mature miRNAs:hsa-miR-4729
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1 3 9 1
Low 30 19 44 35 119 36 32 12 29 50 51 29 1 7 1
Below cutoff 16 2 4 13 7 11 8 8 9 14 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000584140
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1759,366,083 - 59,366,154 (+)Ensembl
RefSeq Acc Id: NR_039882
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,366,083 - 59,366,154 (+)NCBI
GRCh371757,443,444 - 57,443,515 (+)ENTREZGENE
HuRef1752,802,536 - 52,802,607 (+)ENTREZGENE
CHM1_11757,508,832 - 57,508,903 (+)NCBI
T2T-CHM13v2.01760,234,221 - 60,234,292 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4729 COSMIC
Ensembl Genes ENSG00000263857 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000584140 ENTREZGENE
GTEx ENSG00000263857 GTEx
HGNC ID HGNC:41585 ENTREZGENE
Human Proteome Map MIR4729 Human Proteome Map
miRBase MI0017366 ENTREZGENE
NCBI Gene 100616204 ENTREZGENE
RNAcentral URS000024F41A RNACentral
  URS000075B85E RNACentral