MIR4691 (microRNA 4691) - Rat Genome Database

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Gene: MIR4691 (microRNA 4691) Homo sapiens
Analyze
Symbol: MIR4691
Name: microRNA 4691
RGD ID: 5134055
HGNC Page HGNC:41796
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-4691
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,033,897 - 68,033,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,033,897 - 68,033,981 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,801,364 - 67,801,448 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11q13.2NCBI
HuRef1164,136,711 - 64,136,795 (+)NCBIHuRef
CHM1_11167,685,131 - 67,685,215 (+)NCBICHM1_1
T2T-CHM13v2.01168,037,549 - 68,037,633 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21199797   PMID:34328265  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002496.3(NDUFS8):c.79C>T (p.Leu27Phe) single nucleotide variant Malignant melanoma [RCV000069640] Chr11:68032306 [GRCh38]
Chr11:67799773 [GRCh37]
Chr11:67556349 [NCBI36]
Chr11:11q13.2		 not provided
GRCh38/hg38 11q13.2-13.3(chr11:67217264-69448598)x1 copy number loss See cases [RCV000135609] Chr11:67217264..69448598 [GRCh38]
Chr11:66984735..69263366 [GRCh37]
Chr11:66741311..68972547 [NCBI36]
Chr11:11q13.2-13.3		 likely pathogenic
GRCh38/hg38 11q13.2-13.4(chr11:68031693-71593495)x1 copy number loss See cases [RCV000142138] Chr11:68031693..71593495 [GRCh38]
Chr11:67799160..71304541 [GRCh37]
Chr11:67555736..70982189 [NCBI36]
Chr11:11q13.2-13.4		 likely pathogenic
GRCh38/hg38 11q13.2(chr11:67446153-68679073)x1 copy number loss See cases [RCV000052683] Chr11:67446153..68679073 [GRCh38]
Chr11:67213624..68446541 [GRCh37]
Chr11:66970200..68203117 [NCBI36]
Chr11:11q13.2		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:62159
Count of gene targets:19502
Count of transcripts:46470
Interacting mature miRNAs:hsa-miR-4691-3p, hsa-miR-4691-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000583764
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1168,033,897 - 68,033,981 (+)Ensembl
RefSeq Acc Id: NR_039840
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381168,033,897 - 68,033,981 (+)NCBI
GRCh371167,801,364 - 67,801,448 (+)ENTREZGENE
HuRef1164,136,711 - 64,136,795 (+)ENTREZGENE
CHM1_11167,685,131 - 67,685,215 (+)NCBI
T2T-CHM13v2.01168,037,549 - 68,037,633 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4691 COSMIC
Ensembl Genes ENSG00000284435 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000583764 ENTREZGENE
GTEx ENSG00000284435 GTEx
HGNC ID HGNC:41796 ENTREZGENE
Human Proteome Map MIR4691 Human Proteome Map
miRBase MI0017324 ENTREZGENE
NCBI Gene 100616403 ENTREZGENE
RNAcentral URS00001067D1 RNACentral
  URS000012F9EC RNACentral
  URS000075C981 RNACentral