MIR4511 (microRNA 4511) - Rat Genome Database

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Gene: MIR4511 (microRNA 4511) Homo sapiens
Analyze
Symbol: MIR4511
Name: microRNA 4511
RGD ID: 5133918
HGNC Page HGNC:41589
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-4511
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381565,719,246 - 65,719,332 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1565,719,246 - 65,719,332 (-)EnsemblGRCh38hg38GRCh38
GRCh371566,011,584 - 66,011,670 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map15q22.31NCBI
HuRef1542,836,346 - 42,836,432 (-)NCBIHuRef
CHM1_11566,129,538 - 66,129,624 (-)NCBICHM1_1
T2T-CHM13v2.01563,528,642 - 63,528,728 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:21037258   PMID:21785231  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh38/hg38 15q22.31(chr15:64448836-65975439)x3 copy number gain See cases [RCV000052344] Chr15:64448836..65975439 [GRCh38]
Chr15:64741035..66267777 [GRCh37]
Chr15:62528088..64054831 [NCBI36]
Chr15:15q22.31		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:18024
Count of gene targets:7399
Count of transcripts:14089
Interacting mature miRNAs:hsa-miR-4511
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1
Low 13 12 38 16 135 15 14 13 23 25 33 45 1 6 5
Below cutoff 16 18 13 2 30 3 23 15 31 9 19 21 6 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000582784
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1565,719,246 - 65,719,332 (-)Ensembl
RefSeq Acc Id: NR_039736
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381565,719,246 - 65,719,332 (-)NCBI
GRCh371566,011,584 - 66,011,670 (-)ENTREZGENE
HuRef1542,836,346 - 42,836,432 (-)ENTREZGENE
CHM1_11566,129,538 - 66,129,624 (-)NCBI
T2T-CHM13v2.01563,528,642 - 63,528,728 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4511 COSMIC
Ensembl Genes ENSG00000264737 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000582784 ENTREZGENE
GTEx ENSG00000264737 GTEx
HGNC ID HGNC:41589 ENTREZGENE
Human Proteome Map MIR4511 Human Proteome Map
miRBase MI0016877 ENTREZGENE
NCBI Gene 100616379 ENTREZGENE
RNAcentral URS000075A281 RNACentral
  URS000075E8E6 RNACentral