MIR4446 (microRNA 4446) - Rat Genome Database

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Gene: MIR4446 (microRNA 4446) Homo sapiens
Analyze
Symbol: MIR4446
Name: microRNA 4446
RGD ID: 5133861
HGNC Page HGNC:41700
Description: Located in extracellular space.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-4446
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383113,594,876 - 113,594,942 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3113,594,876 - 113,594,942 (+)EnsemblGRCh38hg38GRCh38
GRCh373113,313,723 - 113,313,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3q13.2NCBI
HuRef3110,688,648 - 110,688,714 (+)NCBIHuRef
CHM1_13113,277,115 - 113,277,181 (+)NCBICHM1_1
T2T-CHM13v2.03116,316,036 - 116,316,102 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
chromium(6+)  (EXP)
paraquat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:16381832   PMID:20733160   PMID:21037258   PMID:21199797   PMID:22454130   PMID:23535732   PMID:26646931   PMID:34550352  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q11.1-13.31(chr3:93819623-116887056)x1 copy number loss See cases [RCV000135320] Chr3:93819623..116887056 [GRCh38]
Chr3:93538467..116605903 [GRCh37]
Chr3:95021157..118088593 [NCBI36]
Chr3:3q11.1-13.31		 pathogenic
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29		 pathogenic
GRCh38/hg38 3q13.2-13.31(chr3:112465096-115774102)x1 copy number loss See cases [RCV000135592] Chr3:112465096..115774102 [GRCh38]
Chr3:112183943..115492949 [GRCh37]
Chr3:113666633..116975639 [NCBI36]
Chr3:3q13.2-13.31		 likely pathogenic
GRCh38/hg38 3q11.2-13.31(chr3:97795369-115663349)x1 copy number loss See cases [RCV000138186] Chr3:97795369..115663349 [GRCh38]
Chr3:97514213..115382196 [GRCh37]
Chr3:98996903..116864886 [NCBI36]
Chr3:3q11.2-13.31		 pathogenic|uncertain significance
GRCh38/hg38 3q13.2-13.31(chr3:112465094-115774111)x1 copy number loss See cases [RCV000138434] Chr3:112465094..115774111 [GRCh38]
Chr3:112183941..115492958 [GRCh37]
Chr3:113666631..116975648 [NCBI36]
Chr3:3q13.2-13.31		 pathogenic
GRCh38/hg38 3q13.2-21.3(chr3:112620977-128734134)x1 copy number loss See cases [RCV000139033] Chr3:112620977..128734134 [GRCh38]
Chr3:112339824..128452977 [GRCh37]
Chr3:113822514..129935667 [NCBI36]
Chr3:3q13.2-21.3		 pathogenic
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24		 pathogenic
GRCh38/hg38 3q13.2-13.31(chr3:112425234-115795585)x1 copy number loss See cases [RCV000142219] Chr3:112425234..115795585 [GRCh38]
Chr3:112144081..115514432 [GRCh37]
Chr3:113626771..116997122 [NCBI36]
Chr3:3q13.2-13.31		 pathogenic
GRCh38/hg38 3q13.2-13.33(chr3:112520553-120031022)x1 copy number loss See cases [RCV000142725] Chr3:112520553..120031022 [GRCh38]
Chr3:112239400..119749869 [GRCh37]
Chr3:113722090..121232559 [NCBI36]
Chr3:3q13.2-13.33		 pathogenic
GRCh38/hg38 3q13.11-13.31(chr3:104621220-116093884)x3 copy number gain See cases [RCV000051722] Chr3:104621220..116093884 [GRCh38]
Chr3:104340064..115812731 [GRCh37]
Chr3:105822754..117295421 [NCBI36]
Chr3:3q13.11-13.31		 pathogenic
GRCh38/hg38 3q11.1-21.1(chr3:93886671-123216683)x1 copy number loss See cases [RCV000051543] Chr3:93886671..123216683 [GRCh38]
Chr3:93605515..122935530 [GRCh37]
Chr3:95088205..124418220 [NCBI36]
Chr3:3q11.1-21.1		 pathogenic
GRCh38/hg38 3q13.13-13.31(chr3:108242572-116169331)x1 copy number loss See cases [RCV000051544] Chr3:108242572..116169331 [GRCh38]
Chr3:107961419..115888178 [GRCh37]
Chr3:109444109..117370868 [NCBI36]
Chr3:3q13.13-13.31		 pathogenic
GRCh38/hg38 3q13.2-13.31(chr3:112479482-115774102)x1 copy number loss See cases [RCV000051545] Chr3:112479482..115774102 [GRCh38]
Chr3:112198329..115492949 [GRCh37]
Chr3:113681019..116975639 [NCBI36]
Chr3:3q13.2-13.31		 pathogenic
GRCh38/hg38 3q13.2-13.31(chr3:112168829-117393356)x1 copy number loss See cases [RCV000050766] Chr3:112168829..117393356 [GRCh38]
Chr3:111887676..117112203 [GRCh37]
Chr3:113370366..118594893 [NCBI36]
Chr3:3q13.2-13.31		 pathogenic
GRCh38/hg38 3q11.1-21.2(chr3:93979547-124774010)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003327614] Chr3:93979547..124774010 [GRCh38]
Chr3:3q11.1-21.2		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:91721
Count of gene targets:24070
Count of transcripts:65816
Interacting mature miRNAs:hsa-miR-4446-3p, hsa-miR-4446-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium 3 33
Low 36 8 9 5 219 6 4 5 10 10 17 16 2 2
Below cutoff 10 2 13 1 2 3 2 1 2 6 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000578505
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3113,594,876 - 113,594,942 (+)Ensembl
RefSeq Acc Id: NR_039648
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383113,594,876 - 113,594,942 (+)NCBI
GRCh373113,313,723 - 113,313,789 (+)ENTREZGENE
HuRef3110,688,648 - 110,688,714 (+)ENTREZGENE
CHM1_13113,277,115 - 113,277,181 (+)NCBI
T2T-CHM13v2.03116,316,036 - 116,316,102 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4446 COSMIC
Ensembl Genes ENSG00000265253 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000578505 ENTREZGENE
GTEx ENSG00000265253 GTEx
HGNC ID HGNC:41700 ENTREZGENE
Human Proteome Map MIR4446 Human Proteome Map
miRBase MI0016789 ENTREZGENE
NCBI Gene 100616476 ENTREZGENE
RNAcentral URS000000EF0B RNACentral
  URS00001BDD9A RNACentral
  URS000075A805 RNACentral