MIR3681 (microRNA 3681) - Rat Genome Database

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Gene: MIR3681 (microRNA 3681) Homo sapiens
Analyze
Symbol: MIR3681
Name: microRNA 3681
RGD ID: 4888787
HGNC Page HGNC:38994
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38212,199,130 - 12,199,201 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl212,199,130 - 12,199,201 (+)EnsemblGRCh38hg38GRCh38
GRCh37212,339,256 - 12,339,327 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map2p24.3NCBI
HuRef212,189,025 - 12,189,096 (+)NCBIHuRef
CHM1_1212,268,670 - 12,268,741 (+)NCBICHM1_1
T2T-CHM13v2.0212,228,004 - 12,228,075 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
schizophrenia  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References
Additional References at PubMed
PMID:16381832   PMID:20459673   PMID:32655015   PMID:33378013   PMID:34802389   PMID:34850664  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p25.3-23.2(chr2:30341-28419664)x3 copy number gain See cases [RCV000135398] Chr2:30341..28419664 [GRCh38]
Chr2:30341..28642531 [GRCh37]
Chr2:20341..28496035 [NCBI36]
Chr2:2p25.3-23.2		 pathogenic
GRCh38/hg38 2p25.3-23.3(chr2:17019-26318846)x3 copy number gain See cases [RCV000137344] Chr2:17019..26318846 [GRCh38]
Chr2:17019..26541714 [GRCh37]
Chr2:7019..26395218 [NCBI36]
Chr2:2p25.3-23.3		 pathogenic
GRCh38/hg38 2p25.3-24.1(chr2:1664615-23664142)x3 copy number gain See cases [RCV000137913] Chr2:1664615..23664142 [GRCh38]
Chr2:1668387..23887012 [GRCh37]
Chr2:1647394..23740517 [NCBI36]
Chr2:2p25.3-24.1		 pathogenic|likely pathogenic
GRCh38/hg38 2p25.3-24.1(chr2:17019-20001056)x3 copy number gain See cases [RCV000141226] Chr2:17019..20001056 [GRCh38]
Chr2:17019..20200817 [GRCh37]
Chr2:7019..20064298 [NCBI36]
Chr2:2p25.3-24.1		 pathogenic
GRCh38/hg38 2p25.3-23.3(chr2:12770-25039694)x3 copy number gain See cases [RCV000141877] Chr2:12770..25039694 [GRCh38]
Chr2:12770..25262563 [GRCh37]
Chr2:2770..25116067 [NCBI36]
Chr2:2p25.3-23.3		 pathogenic
GRCh38/hg38 2p25.3-22.3(chr2:12770-33711509)x3 copy number gain See cases [RCV000141829] Chr2:12770..33711509 [GRCh38]
Chr2:12770..33936576 [GRCh37]
Chr2:2770..33790080 [NCBI36]
Chr2:2p25.3-22.3		 pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p25.1-24.3(chr2:10790663-14417134)x3 copy number gain See cases [RCV000142512] Chr2:10790663..14417134 [GRCh38]
Chr2:10930789..14557258 [GRCh37]
Chr2:10848240..14474709 [NCBI36]
Chr2:2p25.1-24.3		 pathogenic
GRCh38/hg38 2p25.3-21(chr2:236816-45983232)x3 copy number gain See cases [RCV000143682] Chr2:236816..45983232 [GRCh38]
Chr2:236816..46210371 [GRCh37]
Chr2:226816..46063875 [NCBI36]
Chr2:2p25.3-21		 pathogenic
GRCh38/hg38 2p25.3-24.3(chr2:30141-14494040)x3 copy number gain See cases [RCV000052928] Chr2:30141..14494040 [GRCh38]
Chr2:30141..14634164 [GRCh37]
Chr2:20141..14551615 [NCBI36]
Chr2:2p25.3-24.3		 pathogenic
GRCh38/hg38 2p25.3-23.1(chr2:30141-31766749)x3 copy number gain See cases [RCV000052929] Chr2:30141..31766749 [GRCh38]
Chr2:30141..31991818 [GRCh37]
Chr2:20141..31845322 [NCBI36]
Chr2:2p25.3-23.1		 pathogenic
GRCh38/hg38 2p25.3-24.3(chr2:30342-14866951)x3 copy number gain See cases [RCV000052931] Chr2:30342..14866951 [GRCh38]
Chr2:30342..15007075 [GRCh37]
Chr2:20342..14924526 [NCBI36]
Chr2:2p25.3-24.3		 pathogenic
GRCh38/hg38 2p25.3-16.1(chr2:66097-55570637)x3 copy number gain See cases [RCV000052933] Chr2:66097..55570637 [GRCh38]
Chr2:66097..55797773 [GRCh37]
Chr2:56097..55651277 [NCBI36]
Chr2:2p25.3-16.1		 pathogenic
GRCh38/hg38 2p25.1-24.3(chr2:10216779-13474790)x3 copy number gain See cases [RCV000052627] Chr2:10216779..13474790 [GRCh38]
Chr2:10356905..13614915 [GRCh37]
Chr2:10274356..13532366 [NCBI36]
Chr2:2p25.1-24.3		 uncertain significance
GRCh38/hg38 2p25.2-24.3(chr2:6531172-16103799)x1 copy number loss See cases [RCV000053978] Chr2:6531172..16103799 [GRCh38]
Chr2:6671304..16243921 [GRCh37]
Chr2:6588755..16161372 [NCBI36]
Chr2:2p25.2-24.3		 pathogenic
NC_000002.12:g.(?_11177745)_(16113827_?)del deletion Schizophrenia [RCV000754225] Chr2:11177745..16113827 [GRCh38]
Chr2:2p25.1-24.3		 likely pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:28410
Count of gene targets:10568
Count of transcripts:20952
Interacting mature miRNAs:hsa-miR-3681-3p, hsa-miR-3681-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium 1
Low 4 1 2 44 4 8 3 8 3 3
Below cutoff 1 4 3 2 6 1 1 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000580089
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl212,199,130 - 12,199,201 (+)Ensembl
RefSeq Acc Id: NR_037452
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38212,199,130 - 12,199,201 (+)NCBI
GRCh37212,339,256 - 12,339,327 (+)ENTREZGENE
HuRef212,189,025 - 12,189,096 (+)ENTREZGENE
CHM1_1212,268,670 - 12,268,741 (+)NCBI
T2T-CHM13v2.0212,228,004 - 12,228,075 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR3681 COSMIC
Ensembl Genes ENSG00000264089 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000580089 ENTREZGENE
GTEx ENSG00000264089 GTEx
HGNC ID HGNC:38994 ENTREZGENE
Human Proteome Map MIR3681 Human Proteome Map
miRBase MI0016082 ENTREZGENE
NCBI Gene 100500884 ENTREZGENE
RNAcentral URS000075B2FC RNACentral
  URS000075CD8F RNACentral
  URS000075E1C5 RNACentral