MIR3188 (microRNA 3188) - Rat Genome Database

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Gene: MIR3188 (microRNA 3188) Homo sapiens
Analyze
Symbol: MIR3188
Name: microRNA 3188
RGD ID: 4109079
HGNC Page HGNC:38226
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-3188
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,282,077 - 18,282,161 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,282,077 - 18,282,161 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,392,887 - 18,392,971 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1918,294,628 - 18,294,712 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,956,597 - 17,956,681 (+)NCBIHuRef
CHM1_11918,393,133 - 18,393,217 (+)NCBICHM1_1
T2T-CHM13v2.01918,416,177 - 18,416,261 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:21037258   PMID:27095304   PMID:28560951   PMID:29442044   PMID:30961650   PMID:31274844   PMID:33533580   PMID:33805769   PMID:34704819   PMID:38565755  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19p13.12-12(chr19:15133594-24193591)x3 copy number gain See cases [RCV000136696] Chr19:15133594..24193591 [GRCh38]
Chr19:15244405..24376393 [GRCh37]
Chr19:15105405..24168233 [NCBI36]
Chr19:19p13.12-12		 pathogenic|likely pathogenic
GRCh38/hg38 19p13.11(chr19:18133970-18424117)x1 copy number loss See cases [RCV000142944] Chr19:18133970..18424117 [GRCh38]
Chr19:18244780..18534927 [GRCh37]
Chr19:18105780..18395927 [NCBI36]
Chr19:19p13.11		 uncertain significance
GRCh38/hg38 19p13.11-q13.11(chr19:17176767-34924150)x3 copy number gain See cases [RCV000050635] Chr19:17176767..34924150 [GRCh38]
Chr19:17287576..35415054 [GRCh37]
Chr19:17148576..40106894 [NCBI36]
Chr19:19p13.11-q13.11		 pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3 copy number gain See cases [RCV000052912] Chr19:13974677..27839676 [GRCh38]
Chr19:14085489..28330584 [GRCh37]
Chr19:13946489..33022424 [NCBI36]
Chr19:19p13.12-q11		 pathogenic
GRCh38/hg38 19p13.11(chr19:17922234-18463153)x1 copy number loss See cases [RCV000053946] Chr19:17922234..18463153 [GRCh38]
Chr19:18033043..18573963 [GRCh37]
Chr19:17894043..18434963 [NCBI36]
Chr19:19p13.11		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
RPLP1hsa-miR-3188Mirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:27373
Count of gene targets:11451
Count of transcripts:22358
Interacting mature miRNAs:hsa-miR-3188
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
PMC155158P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371918,391,850 - 18,391,930UniSTSGRCh37
Build 361918,252,850 - 18,252,930RGDNCBI36
Celera1918,293,591 - 18,293,671RGD
Cytogenetic Map19p13.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 1 1 2 4
Low 160 131 178 22 223 20 230 78 247 64 242 225 7 30 120 3
Below cutoff 123 128 70 15 85 6 134 102 257 23 97 53 9 47 87

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000583494
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1918,282,077 - 18,282,161 (+)Ensembl
RefSeq Acc Id: NR_036155
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381918,282,077 - 18,282,161 (+)NCBI
GRCh371918,392,887 - 18,392,971 (+)RGD
Celera1918,294,628 - 18,294,712 (+)RGD
HuRef1917,956,597 - 17,956,681 (+)RGD
CHM1_11918,393,133 - 18,393,217 (+)NCBI
T2T-CHM13v2.01918,416,177 - 18,416,261 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR3188 COSMIC
Ensembl Genes ENSG00000267959 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000583494 ENTREZGENE
GTEx ENSG00000267959 GTEx
HGNC ID HGNC:38226 ENTREZGENE
Human Proteome Map MIR3188 Human Proteome Map
miRBase MI0014232 ENTREZGENE
NCBI Gene 100422833 ENTREZGENE
PharmGKB PA165393757 PharmGKB
RNAcentral URS000049704B RNACentral
  URS000075E5AE RNACentral