MIR544B (microRNA 544b) - Rat Genome Database

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Gene: MIR544B (microRNA 544b) Homo sapiens
Analyze
Symbol: MIR544B
Name: microRNA 544b
RGD ID: 4109043
HGNC Page HGNC:38361
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383124,732,439 - 124,732,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3124,732,439 - 124,732,516 (+)EnsemblGRCh38hg38GRCh38
GRCh373124,451,286 - 124,451,363 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera3122,858,457 - 122,858,534 (+)NCBICelera
Cytogenetic Map3q21.2NCBI
HuRef3121,825,555 - 121,825,632 (+)NCBIHuRef
CHM1_13124,414,269 - 124,414,346 (+)NCBICHM1_1
T2T-CHM13v2.03127,458,250 - 127,458,327 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
chromium(6+)  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:32127022   PMID:33221764  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29		 pathogenic
GRCh38/hg38 3q13.2-21.3(chr3:112620977-128734134)x1 copy number loss See cases [RCV000139033] Chr3:112620977..128734134 [GRCh38]
Chr3:112339824..128452977 [GRCh37]
Chr3:113822514..129935667 [NCBI36]
Chr3:3q13.2-21.3		 pathogenic
GRCh38/hg38 3q13.33-21.3(chr3:121925147-126782249)x1 copy number loss See cases [RCV000140814] Chr3:121925147..126782249 [GRCh38]
Chr3:121643994..126501092 [GRCh37]
Chr3:123126684..127983782 [NCBI36]
Chr3:3q13.33-21.3		 pathogenic
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24		 pathogenic
GRCh38/hg38 3q13.32-21.3(chr3:118673898-126540730)x1 copy number loss See cases [RCV000143695] Chr3:118673898..126540730 [GRCh38]
Chr3:118392745..126259573 [GRCh37]
Chr3:119875435..127742263 [NCBI36]
Chr3:3q13.32-21.3		 pathogenic
GRCh38/hg38 3q13.32-21.2(chr3:119117166-125920734)x1 copy number loss See cases [RCV000051546] Chr3:119117166..125920734 [GRCh38]
Chr3:118836013..125639577 [GRCh37]
Chr3:120318703..127122267 [NCBI36]
Chr3:3q13.32-21.2		 pathogenic
GRCh38/hg38 3q13.33-21.2(chr3:121644209-125676353)x1 copy number loss See cases [RCV000051569] Chr3:121644209..125676353 [GRCh38]
Chr3:121363056..125395197 [GRCh37]
Chr3:122845746..126877887 [NCBI36]
Chr3:3q13.33-21.2		 pathogenic
GRCh38/hg38 3q11.1-21.2(chr3:93979547-124774010)x1 copy number loss Chromosome 3q13.31 deletion syndrome [RCV003327614] Chr3:93979547..124774010 [GRCh38]
Chr3:3q11.1-21.2		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:28872
Count of gene targets:11769
Count of transcripts:23383
Interacting mature miRNAs:hsa-miR-544b
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 4 1 9 1 2 3 2
Low 106 16 135 98 327 99 154 49 98 95 170 194 6 3 14 3
Below cutoff 7 4 8 4 3 1 13 9 11 10 7 11 3 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000582372
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3124,732,439 - 124,732,516 (+)Ensembl
RefSeq Acc Id: NR_036088
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383124,732,439 - 124,732,516 (+)NCBI
GRCh373124,451,286 - 124,451,363 (+)RGD
Celera3122,858,457 - 122,858,534 (+)RGD
HuRef3121,825,555 - 121,825,632 (+)ENTREZGENE
CHM1_13124,414,269 - 124,414,346 (+)NCBI
T2T-CHM13v2.03127,458,250 - 127,458,327 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR544B COSMIC
Ensembl Genes ENSG00000265981 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000582372 ENTREZGENE
GTEx ENSG00000265981 GTEx
HGNC ID HGNC:38361 ENTREZGENE
Human Proteome Map MIR544B Human Proteome Map
miRBase MI0014159 ENTREZGENE
NCBI Gene 100422864 ENTREZGENE
PharmGKB PA165697843 PharmGKB
RNAcentral URS00000EE7F0 RNACentral
  URS000075E1F0 RNACentral