MIR3132 (microRNA 3132) - Rat Genome Database

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Gene: MIR3132 (microRNA 3132) Homo sapiens
Analyze
Symbol: MIR3132
Name: microRNA 3132
RGD ID: 4108860
HGNC Page HGNC:38373
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,549,073 - 219,549,147 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,549,073 - 219,549,147 (-)EnsemblGRCh38hg38GRCh38
GRCh372220,413,795 - 220,413,869 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera2214,183,758 - 214,183,832 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2212,266,825 - 212,266,899 (-)NCBIHuRef
CHM1_12220,419,616 - 220,419,690 (-)NCBICHM1_1
T2T-CHM13v2.02220,033,772 - 220,033,846 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:20300190  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q34-37.3(chr2:210579676-242126245)x3 copy number gain See cases [RCV000135934] Chr2:210579676..242126245 [GRCh38]
Chr2:211444400..243059659 [GRCh37]
Chr2:211152645..242717069 [NCBI36]
Chr2:2q34-37.3		 pathogenic
GRCh38/hg38 2q35(chr2:219081620-219758878)x3 copy number gain See cases [RCV000138093] Chr2:219081620..219758878 [GRCh38]
Chr2:219946342..220623600 [GRCh37]
Chr2:219654586..220331844 [NCBI36]
Chr2:2q35		 uncertain significance
GRCh38/hg38 2q31.3-36.2(chr2:180513793-224302848)x3 copy number gain See cases [RCV000139446] Chr2:180513793..224302848 [GRCh38]
Chr2:181378520..225167565 [GRCh37]
Chr2:181086765..224875809 [NCBI36]
Chr2:2q31.3-36.2		 pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:189436149-241841232)x3 copy number gain See cases [RCV000142307] Chr2:189436149..241841232 [GRCh38]
Chr2:190300875..242783384 [GRCh37]
Chr2:190009120..242432057 [NCBI36]
Chr2:2q32.2-37.3		 pathogenic
GRCh38/hg38 2q35-37.3(chr2:218101759-242126245)x3 copy number gain See cases [RCV000143216] Chr2:218101759..242126245 [GRCh38]
Chr2:218966482..243059659 [GRCh37]
Chr2:218674727..242717069 [NCBI36]
Chr2:2q35-37.3		 pathogenic
GRCh38/hg38 2q32.3-37.3(chr2:194898783-236473913)x3 copy number gain See cases [RCV000051119] Chr2:194898783..236473913 [GRCh38]
Chr2:195763507..237382556 [GRCh37]
Chr2:195471752..237047295 [NCBI36]
Chr2:2q32.3-37.3		 pathogenic
GRCh38/hg38 2q35-36.3(chr2:219081620-225430308)x1 copy number loss See cases [RCV000052634] Chr2:219081620..225430308 [GRCh38]
Chr2:219946342..226295024 [GRCh37]
Chr2:219654586..226003268 [NCBI36]
Chr2:2q35-36.3		 pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:188818195-242065208)x3 copy number gain See cases [RCV000052958] Chr2:188818195..242065208 [GRCh38]
Chr2:189682921..243007359 [GRCh37]
Chr2:189391166..242656032 [NCBI36]
Chr2:2q32.2-37.3		 pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:190310736-241892770)x3 copy number gain See cases [RCV000052959] Chr2:190310736..241892770 [GRCh38]
Chr2:191175462..242834921 [GRCh37]
Chr2:190883707..242483594 [NCBI36]
Chr2:2q32.2-37.3		 pathogenic
GRCh38/hg38 2q32.3-37.3(chr2:193122313-241074980)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]|See cases [RCV000052960] Chr2:193122313..241074980 [GRCh38]
Chr2:193987039..242014395 [GRCh37]
Chr2:193695284..241663068 [NCBI36]
Chr2:2q32.3-37.3		 pathogenic
GRCh38/hg38 2q34-36.3(chr2:212614422-227121230)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052964]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052964]|See cases [RCV000052964] Chr2:212614422..227121230 [GRCh38]
Chr2:213479146..227985946 [GRCh37]
Chr2:213187391..227694190 [NCBI36]
Chr2:2q34-36.3		 pathogenic
GRCh38/hg38 2q35-36.3(chr2:219547204-228287942)x4 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052965]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052965]|See cases [RCV000052965] Chr2:219547204..228287942 [GRCh38]
Chr2:220411926..229152658 [GRCh37]
Chr2:220120170..228860902 [NCBI36]
Chr2:2q35-36.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:32148
Count of gene targets:12267
Count of transcripts:24389
Interacting mature miRNAs:hsa-miR-3132
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
ECD02441  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,414,503 - 220,415,332UniSTSGRCh37
Build 362220,122,747 - 220,123,576RGDNCBI36
Celera2214,184,466 - 214,185,295RGD
Cytogenetic Map2q35UniSTS
HuRef2212,267,533 - 212,268,362UniSTS
ECD03460  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,413,644 - 220,414,438UniSTSGRCh37
Build 362220,121,888 - 220,122,682RGDNCBI36
Celera2214,183,607 - 214,184,401RGD
Cytogenetic Map2q35UniSTS
HuRef2212,266,674 - 212,267,468UniSTS
REN53315  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,413,304 - 220,413,537UniSTSGRCh37
Build 362220,121,548 - 220,121,781RGDNCBI36
Celera2214,183,267 - 214,183,500RGD
Cytogenetic Map2q35UniSTS
HuRef2212,266,334 - 212,266,567UniSTS
REN53316  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,413,503 - 220,413,741UniSTSGRCh37
Build 362220,121,747 - 220,121,985RGDNCBI36
Celera2214,183,466 - 214,183,704RGD
Cytogenetic Map2q35UniSTS
HuRef2212,266,533 - 212,266,771UniSTS
REN53317  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,413,710 - 220,413,948UniSTSGRCh37
Build 362220,121,954 - 220,122,192RGDNCBI36
Celera2214,183,673 - 214,183,911RGD
Cytogenetic Map2q35UniSTS
HuRef2212,266,740 - 212,266,978UniSTS
REN53318  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,413,924 - 220,414,182UniSTSGRCh37
Build 362220,122,168 - 220,122,426RGDNCBI36
Celera2214,183,887 - 214,184,145RGD
Cytogenetic Map2q35UniSTS
HuRef2212,266,954 - 212,267,212UniSTS
REN53319  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,414,178 - 220,414,433UniSTSGRCh37
Build 362220,122,422 - 220,122,677RGDNCBI36
Celera2214,184,141 - 214,184,396RGD
Cytogenetic Map2q35UniSTS
HuRef2212,267,208 - 212,267,463UniSTS
REN53320  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,414,432 - 220,414,676UniSTSGRCh37
Build 362220,122,676 - 220,122,920RGDNCBI36
Celera2214,184,395 - 214,184,639RGD
Cytogenetic Map2q35UniSTS
HuRef2212,267,462 - 212,267,706UniSTS
REN53321  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,414,586 - 220,414,829UniSTSGRCh37
Build 362220,122,830 - 220,123,073RGDNCBI36
Celera2214,184,549 - 214,184,792RGD
Cytogenetic Map2q35UniSTS
HuRef2212,267,616 - 212,267,859UniSTS
REN53322  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,414,808 - 220,415,057UniSTSGRCh37
Build 362220,123,052 - 220,123,301RGDNCBI36
Celera2214,184,771 - 214,185,020RGD
Cytogenetic Map2q35UniSTS
HuRef2212,267,838 - 212,268,087UniSTS
REN53323  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,415,051 - 220,415,295UniSTSGRCh37
Build 362220,123,295 - 220,123,539RGDNCBI36
Celera2214,185,014 - 214,185,258RGD
Cytogenetic Map2q35UniSTS
HuRef2212,268,081 - 212,268,325UniSTS
REN53324  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,415,275 - 220,415,524UniSTSGRCh37
Build 362220,123,519 - 220,123,768RGDNCBI36
Celera2214,185,238 - 214,185,487RGD
Cytogenetic Map2q35UniSTS
HuRef2212,268,305 - 212,268,554UniSTS
REN53325  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372220,415,450 - 220,415,688UniSTSGRCh37
Build 362220,123,694 - 220,123,932RGDNCBI36
Celera2214,185,413 - 214,185,651RGD
Cytogenetic Map2q35UniSTS
HuRef2212,268,480 - 212,268,718UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 1 1 1 3 1 2 1 4 3 1
Low 77 47 66 38 31 39 172 84 132 64 178 133 4 10 38 1
Below cutoff 38 46 9 2 18 2 50 66 33 8 28 14 1 9 43 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000581997
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2219,549,073 - 219,549,147 (-)Ensembl
RefSeq Acc Id: NR_036082
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382219,549,073 - 219,549,147 (-)NCBI
GRCh372220,413,795 - 220,413,869 (-)RGD
Celera2214,183,758 - 214,183,832 (-)RGD
HuRef2212,266,825 - 212,266,899 (-)ENTREZGENE
CHM1_12220,419,616 - 220,419,690 (-)NCBI
T2T-CHM13v2.02220,033,772 - 220,033,846 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR3132 COSMIC
Ensembl Genes ENSG00000265252 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000581997 ENTREZGENE
GTEx ENSG00000265252 GTEx
HGNC ID HGNC:38373 ENTREZGENE
Human Proteome Map MIR3132 Human Proteome Map
miRBase MI0014152 ENTREZGENE
NCBI Gene 100423039 ENTREZGENE
PharmGKB PA165696814 PharmGKB
RNAcentral URS000053C4D7 RNACentral
  URS000075E739 RNACentral