LOC107399302 (Apex1 promoter region) - Rat Genome Database

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Gene: LOC107399302 (Apex1 promoter region) Mus musculus
Analyze
Symbol: LOC107399302
Name: Apex1 promoter region
RGD ID: 39128339
Description: This region represents the promoter of the Apex1 (apurinic/apyrimidinic endodeoxyribonuclease 1) gene. Unlike the orthologous human region, this promoter may not have strong bi-directional activity for the adjacent Osgep (O-sialoglycoprotein endopeptidase) gene. Sp1 transcription factor and CCAAT/enhancer binding proteins bind to recognition elements in this region; expression of this gene during the S phase of the cell cycle may require binding by Sp1 to a specific sequence downstream of the transcription start site. This locus also includes a B cell regulatory element that was identified by FAIRE-seq (formaldehyde-assisted isolation of regulatory elements sequencing), and which was validated as an enhancer by STARR-seq (self-transcribing active regulatory region sequencing) in lipopolysaccharide-activated mouse splenic B cells. [provided by RefSeq, Oct 2023]
Type: biological-region
RefSeq Status: REVIEWED
Previously known as: Rr366657
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,162,126 - 51,162,598 (+)NCBIGRCm39GRCm39mm39
GRCm381450,924,669 - 50,925,141 (+)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map14C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:7533013   PMID:7782087   PMID:9506886   PMID:11555653   PMID:17938202   PMID:18715144   PMID:31873292   PMID:31873293  


Genomics

Comparative Map Data
LOC107399302
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,162,126 - 51,162,598 (+)NCBIGRCm39GRCm39mm39
GRCm381450,924,669 - 50,925,141 (+)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map14C3NCBI
LOC107372315
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,451,644 - 20,455,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371420,919,803 - 20,923,495 (+)NCBIGRCh37GRCh37hg19GRCh37
T2T-CHM13v2.01414,648,545 - 14,652,392 (+)NCBIT2T-CHM13v2.0

Variants

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Variants in LOC107399302
18 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse


Expression


Sequence



Additional Information

Database Acc Id Source(s)
NCBI Gene LOC107399302 ENTREZGENE
PhenoGen LOC107399302 PhenoGen