MIR761 (microRNA 761) - Rat Genome Database

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Gene: MIR761 (microRNA 761) Homo sapiens
Analyze
Symbol: MIR761
Name: microRNA 761
RGD ID: 3497320
HGNC Page HGNC:37305
Description: Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-761
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38151,836,344 - 51,836,402 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl151,836,344 - 51,836,402 (-)EnsemblGRCh38hg38GRCh38
GRCh37152,302,016 - 52,302,074 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera150,588,633 - 50,588,691 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef150,418,735 - 50,418,793 (-)NCBIHuRef
CHM1_1152,419,340 - 52,419,398 (-)NCBICHM1_1
T2T-CHM13v2.0151,716,720 - 51,716,778 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
RISC complex  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16954537   PMID:18215311   PMID:26563371   PMID:26845057   PMID:28054302   PMID:29191657   PMID:29605301   PMID:30556873   PMID:30782261   PMID:31298329   PMID:31545237  
PMID:32196629   PMID:32772311   PMID:32897512   PMID:33035586   PMID:34515320   PMID:34922544   PMID:35030964   PMID:35321026   PMID:36056285   PMID:36278814   PMID:37258120  


Genomics

Comparative Map Data
MIR761
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38151,836,344 - 51,836,402 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl151,836,344 - 51,836,402 (-)EnsemblGRCh38hg38GRCh38
GRCh37152,302,016 - 52,302,074 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera150,588,633 - 50,588,691 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef150,418,735 - 50,418,793 (-)NCBIHuRef
CHM1_1152,419,340 - 52,419,398 (-)NCBICHM1_1
T2T-CHM13v2.0151,716,720 - 51,716,778 (-)NCBIT2T-CHM13v2.0
Mir761
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394108,874,852 - 108,874,927 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4108,874,852 - 108,874,927 (+)EnsemblGRCm39 Ensembl
GRCm384109,017,655 - 109,017,730 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,017,655 - 109,017,730 (+)EnsemblGRCm38mm10GRCm38
MGSCv374108,690,260 - 108,690,335 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Cytogenetic Map4C7NCBI
cM Map450.77NCBI
Mir761
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85129,005,205 - 129,005,280 (+)NCBIGRCr8
mRatBN7.25123,776,534 - 123,776,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5123,776,534 - 123,776,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5126,392,699 - 126,392,774 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,115,783 - 128,115,858 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,167,058 - 128,167,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,651,867 - 128,651,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,651,867 - 128,651,942 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05132,492,895 - 132,492,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5122,507,589 - 122,507,664 (+)NCBICelera
Cytogenetic Map5q34NCBI
MIR761
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1159,455,388 - 9,455,457 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl159,455,388 - 9,455,457 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,607,226 - 9,607,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0159,579,830 - 9,579,899 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl159,579,830 - 9,579,899 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1159,390,530 - 9,390,599 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0159,479,483 - 9,479,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,497,812 - 9,497,881 (+)NCBIUU_Cfam_GSD_1.0


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p32.3(chr1:51814691-51941708)x3 copy number gain See cases [RCV000135260] Chr1:51814691..51941708 [GRCh38]
Chr1:52280363..52407380 [GRCh37]
Chr1:52052951..52179968 [NCBI36]
Chr1:1p32.3		 likely benign
GRCh38/hg38 1p32.3-31.3(chr1:50222546-61618373)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|See cases [RCV000051819] Chr1:50222546..61618373 [GRCh38]
Chr1:50688218..62084045 [GRCh37]
Chr1:50460805..61856633 [NCBI36]
Chr1:1p32.3-31.3		 pathogenic
GRCh38/hg38 1p33-32.3(chr1:50441439-50959811)x2 copy number loss Orofacial cleft 13 [RCV002488680] Chr1:50441439..50959811 [GRCh38]
Chr1:1p33-32.3		 association
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3		 likely pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:40319
Count of gene targets:14453
Count of transcripts:32648
Interacting mature miRNAs:hsa-miR-761
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system integumental system nervous system renal system reproductive system adipose tissue
High
Medium
Low 1 2 3 1 3 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000390787
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl151,836,344 - 51,836,402 (-)Ensembl
RefSeq Acc Id: NR_031580
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38151,836,344 - 51,836,402 (-)NCBI
GRCh37152,302,016 - 52,302,074 (-)RGD
Celera150,588,633 - 50,588,691 (-)RGD
HuRef150,418,735 - 50,418,793 (-)ENTREZGENE
CHM1_1152,419,340 - 52,419,398 (-)NCBI
T2T-CHM13v2.0151,716,720 - 51,716,778 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:37305 AgrOrtholog
COSMIC MIR761 COSMIC
Ensembl Genes ENSG00000283899 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000390787 ENTREZGENE
GTEx ENSG00000283899 GTEx
HGNC ID HGNC:37305 ENTREZGENE
Human Proteome Map MIR761 Human Proteome Map
miRBase MI0003941 ENTREZGENE
NCBI Gene 100313892 ENTREZGENE
PharmGKB PA165751804 PharmGKB
RNAcentral URS000075A6C8 RNACentral
  URS000075F0EC RNACentral