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Gene: Mep1b (meprin A subunit beta) Rattus norvegicus

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Symbol:

Mep1b

Name:

meprin A subunit beta

RGD ID:

3081

Description:

Enables metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Predicted to be part of meprin A complex. Predicted to be active in extracellular region. Orthologous to human MEP1B (meprin A subunit beta); INTERACTS WITH 17beta-estradiol; 3-chloropropane-1,2-diol; allopurinol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

endopeptidase-2; LOC100911405; LOC102554362; meprin; meprin 1 beta; meprin A beta; meprin A subunit beta-like; meprin B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MEP1B (meprin A subunit beta)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Mep1b (meprin 1 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mep1b (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MEP1B (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MEP1B (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mep1b (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MEP1B (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MEP1B (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mep1b (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mep1b (meprin A subunit beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MEP1B (meprin A subunit beta)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mep1b (meprin 1 beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG15255	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG15254	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG15253	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG5715	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG6974	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6696	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6763	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Semp1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	nas-21	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	mep1b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	12,641,041 - 12,667,759 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	12,641,041 - 12,667,755 (+)	Ensembl				GRCr8
mRatBN7.2	18	12,366,126 - 12,392,840 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	12,365,289 - 12,392,840 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	12,549,574 - 12,575,989 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	13,337,224 - 13,363,645 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	12,608,782 - 12,635,267 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	18	12,924,807 - 12,951,304 (+)	NCBI
Lyon_Normotensive	18	12,527,676 - 12,554,173 (+)	NCBI
Lyon_Hypertensive	18	12,527,081 - 12,553,580 (+)	NCBI
F344_StmMcwi	18	12,543,699 - 12,570,072 (+)	NCBI
Rnor_6.0	18	15,063,159 - 15,090,877 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	15,063,079 - 15,089,988 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	18	14,847,661 - 14,874,235 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	18	12,357,847 - 12,384,551 (+)	NCBI		Celera
RH 3.4 Map	18	131.4	RGD
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

melanoma (ISO)

nonpapillary renal cell carcinoma (ISO)

ovarian serous cystadenocarcinoma (ISO)

sarcoma (ISO)

stomach cancer (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,4-D (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP,ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

allopurinol (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorothalonil (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

D-glucose (ISO)

dextran sulfate (ISO)

diquat (ISO)

doxorubicin (ISO)

enilconazole (ISO)

eugenol (EXP)

fentin chloride (EXP)

flavonoids (EXP)

folic acid (ISO)

fructose (ISO)

furan (EXP)

genistein (EXP)

gentamycin (EXP)

glucose (ISO)

glycidol (ISO)

levonorgestrel (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

perfluorononanoic acid (ISO)

procymidone (ISO)

prothioconazole (ISO)

Prothioconazole-desthio (ISO)

sodium arsenite (ISO)

testosterone (EXP)

testosterone undecanoate (ISO)

Theaflavin 3,3'-digallate (ISO)

titanium dioxide (ISO)

tributylstannane (ISO)

triphenylstannane (EXP)

Triptolide (EXP)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA,NAS)

Cellular Component

extracellular region (IBA,IEA,ISO,ISS)

membrane (IEA,ISO)

meprin A complex (IEA,ISO)

plasma membrane (IEA,ISO,ISS)

Molecular Function

identical protein binding (IEA,ISO)

metalloendopeptidase activity (IBA,IDA,IEA)

metallopeptidase activity (IEA)

protein domain specific binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Probing the active sites and mechanisms of rat metalloproteases meprin A and B.	Bertenshaw GP, etal., Biol Chem 2002 Jul-Aug;383(7-8):1175-83.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes.	Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
5.	Cloning a rat meprin cDNA reveals the enzyme is a heterodimer.	Johnson GD and Hersh LB, J Biol Chem 1992 Jul 5;267(19):13505-12.
6.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:8407940	PMID:8760356	PMID:8939981	PMID:9288916	PMID:12093806	PMID:12399461	PMID:15695509	PMID:18509531	PMID:18786924	PMID:22988105	PMID:23716698	PMID:27180358

Genomics

Comparative Map Data

Mep1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	12,641,041 - 12,667,759 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	12,641,041 - 12,667,755 (+)	Ensembl				GRCr8
mRatBN7.2	18	12,366,126 - 12,392,840 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	12,365,289 - 12,392,840 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	12,549,574 - 12,575,989 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	13,337,224 - 13,363,645 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	12,608,782 - 12,635,267 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	18	12,924,807 - 12,951,304 (+)	NCBI
Lyon_Normotensive	18	12,527,676 - 12,554,173 (+)	NCBI
Lyon_Hypertensive	18	12,527,081 - 12,553,580 (+)	NCBI
F344_StmMcwi	18	12,543,699 - 12,570,072 (+)	NCBI
Rnor_6.0	18	15,063,159 - 15,090,877 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	15,063,079 - 15,089,988 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	18	14,847,661 - 14,874,235 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	18	12,357,847 - 12,384,551 (+)	NCBI		Celera
RH 3.4 Map	18	131.4	RGD
Cytogenetic Map	18	p12	NCBI

MEP1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	32,190,039 - 32,220,404 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	32,185,069 - 32,222,605 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	18	29,770,002 - 29,800,367 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	28,023,985 - 28,054,365 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	28,023,985 - 28,054,362	NCBI
Celera	18	26,576,994 - 26,607,343 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI
HuRef	18	26,626,575 - 26,656,944 (+)	NCBI		HuRef
CHM1_1	18	29,697,554 - 29,727,904 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	32,380,357 - 32,410,718 (+)	NCBI		T2T-CHM13v2.0

Mep1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	21,205,401 - 21,233,256 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	21,194,980 - 21,233,256 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	21,072,344 - 21,100,199 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	21,061,923 - 21,100,199 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	18	21,230,845 - 21,258,700 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	21,215,354 - 21,243,199 (+)	NCBI		MGSCv36	mm8
Celera	18	21,568,002 - 21,595,856 (+)	NCBI		Celera
Cytogenetic Map	18	A2	NCBI
cM Map	18	11.81	NCBI

Mep1b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	19,404,096 - 19,433,044 (+)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955402	19,404,026 - 19,432,724 (+)	NCBI	ChiLan1.0	ChiLan1.0

MEP1B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	49,554,834 - 49,605,537 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	35,247,431 - 35,288,816 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	25,396,288 - 25,427,530 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	28,991,439 - 29,021,928 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	28,991,439 - 29,021,928 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

MEP1B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	57,456,414 - 57,476,238 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	57,456,530 - 57,478,337 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	56,888,238 - 56,911,333 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	57,436,320 - 57,459,609 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	57,436,464 - 57,459,701 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	57,114,830 - 57,136,681 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	57,132,324 - 57,155,413 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	57,429,048 - 57,452,158 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mep1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	13	38,463,930 - 38,497,227 (-)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024404944	53,099,990 - 53,130,877 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936682	1,105,243 - 1,132,404 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936682	1,102,365 - 1,132,404 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MEP1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	116,015,021 - 116,049,791 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	6	116,015,021 - 116,049,796 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	108,695,842 - 108,729,740 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MEP1B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	18	50,777,497 - 50,807,953 (-)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666050	23,072,664 - 23,101,070 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	18	48,519,933 - 48,551,223 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	48,518,403 - 48,550,604 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Mep1b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624770	757,626 - 806,289 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624770	757,711 - 806,330 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	18	47,631,851 - 47,672,628 (-)	Ensembl

Mep1b
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	22,388,035 - 22,415,145 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in Mep1b
252 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	81
Count of miRNA genes:	75
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000074116
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	12219237	26822399	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	7065728	52065728	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	12216684	31644508	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	7065728	52065728	Rat
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	26032889	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	7065728	52065728	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	7065728	52065728	Rat
1331781	Scl28	Serum cholesterol level QTL 28	3.995		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	1	25071266	Rat
6903356	Bp354	Blood pressure QTL 354	4.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	15642423	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
6903347	Bp350	Blood pressure QTL 350	4.4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5460455	42690191	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	12216684	31644508	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	12219237	26822399	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
1641910	Colcr3	Colorectal carcinoma resistance QTL 3	5.02	0.000007	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	1	25022372	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	12219237	26822399	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	12219237	26822399	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	3811902	30809809	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	12219237	26822399	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	12219237	26822399	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34566578	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	12219237	26822399	Rat
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	26032889	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4482648	49482648	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	7065728	52065728	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34566578	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	4307354	49307354	Rat

Markers in Region

RH94561

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	12,392,705 - 12,392,805 (-)	MAPPER	mRatBN7.2
Rnor_6.0	18	15,063,204 - 15,063,303	NCBI	Rnor6.0
Rnor_5.0	18	14,847,706 - 14,847,805	UniSTS	Rnor5.0
Celera	18	12,384,417 - 12,384,516	UniSTS
RH 3.4 Map	18	131.4	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
42	136	66	82	482	171	203	86	104	46	103	12	1631	335	29	445	1141	329	89	82	82

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001433413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_013183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254459	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277124	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M88601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000074116 ⟹ ENSRNOP00000063916

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	12,641,066 - 12,664,637 (+)	Ensembl
mRatBN7.2 Ensembl	18	12,366,151 - 12,389,722 (+)	Ensembl
Rnor_6.0 Ensembl	18	15,063,079 - 15,089,988 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082044

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	18	12,140,400 - 12,146,683 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118375 ⟹ ENSRNOP00000091050

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	12,641,041 - 12,667,755 (+)	Ensembl
mRatBN7.2 Ensembl	18	12,365,289 - 12,392,840 (+)	Ensembl

RefSeq Acc Id:

NM_001433413 ⟹ NP_001420342

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Dahl_SR_JrHsd	18	12,924,807 - 12,951,304 (+)	NCBI
Lyon_Normotensive	18	12,527,676 - 12,554,173 (+)	NCBI
Lyon_Hypertensive	18	12,527,081 - 12,553,580 (+)	NCBI
F344_StmMcwi	18	12,543,699 - 12,570,072 (+)	NCBI

RefSeq Acc Id:

NM_013183 ⟹ NP_037315

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	12,641,041 - 12,667,755 (+)	NCBI
mRatBN7.2	18	12,366,126 - 12,392,840 (+)	NCBI
Dahl_SR_JrHsd	18	12,924,807 - 12,951,304 (+)	NCBI
Lyon_Normotensive	18	12,527,676 - 12,554,173 (+)	NCBI
Lyon_Hypertensive	18	12,527,081 - 12,553,580 (+)	NCBI
F344_StmMcwi	18	12,543,699 - 12,570,072 (+)	NCBI
Rnor_6.0	18	15,063,169 - 15,089,989 (-)	NCBI
Rnor_5.0	18	14,847,661 - 14,874,235 (-)	NCBI
Celera	18	12,357,847 - 12,384,551 (+)	RGD

Sequence:

show sequence

AGCTTGCAACTTTGAAAGCCACAGTATGGATGCCCGGCATTGGCCCTGGTTTCTGGTTTTTGCC
ACATTTCTCCTGGTTTCTGGCTTGCCAGCTCCAGAAAAGTTTGTCAAAGACATAGATGGGGGAA
TCGATCAAGACATATTCGATATCAATGAAGATTTAGGACTGGACCTTTTCGAGGGAGACATCAA
ACTGGAGGCAAGTGGGAGGAATTCCATCATTGGAGACAACTACAGATGGCCACATACCATTCCA
TATGTTCTAGAAGACAGCTTGGAAATGAATGCTAAAGGAGTAATCCTCAATGCGTTCGAGCGCT
ATCGCCTTAAAACGTGCATTGACTTCAAGCCCTGGTCTGGAGAAGAGAACTATATATCAGTGTT
CAAGGGCAGTGGGTGCTGGTCTTCAGTGGGAAACATTCACGCTGGGAAGCAAGAGTTGTCCATC
GGGACAAACTGTGACAGAATAGCAACAGTTCAACATGAGTTCCTCCACGCCCTGGGATTCTGGC
ACGAGCAGTCGCGTGCTGACCGAGATGATTACATCACTATAGTTTGGGACAGGATCTTGTCCGG
CAAGGAACACAATTTCAACATCTACAACGACAGTGTGTCTGATTCCCTGAATGTCCCATACGAC
TACACCTCGGTAATGCACTACAGCAAAACCGCTTTCCAGAATGGGACAGAGTCTACCATCATTA
CGAAAATCTCAGACTTTGAGGATGTGATTGGCCAACGAATGGACTTCAGTGACTATGACCTTCT
GAAGCTGAACCAGCTGTACAGCTGCACTTCTTCCTTGAGTTTTATGGACTCCTGCGATTTTGAG
CTGGAGAATATCTGTGGCATGATCCAAAGTTCACAAGATAGCGCTGACTGGCAGCGGCTTTCAC
AGGTTCTCAGTGGTCCGGAGAATGACCACTCCAACATGGGCCAGTGCAAAGACTCTGGCTTCTT
TATGCACTTCAACACTAGCACTGGGAATGGGGGGATCACAGCGATGCTGGAGAGCAGAGTGCTG
TACCCCAAGAGAGGGTTTCAGTGCGTGGAGTTTTATCTGTATAACAGTGGAAGTGGAAATGGCC
AACTGAACGTCTACACCCGGGAGTACACTGCAGGCCACCAGGATGGCGTTTTGACCCTTCAGAG
AGAAATAAGAGACATACCCACTGGGAGCTGGCAGCTTTACTATGTAACACTGCAAGTGACTGAA
AAATTCCGAGTGGTGTTTGAAGGCGTCGGAGGCCCTGGCGCATCATCGGGTGGTCTGTCTATCG
ATGACATCAATCTCTCGGAAACAAGGTGTCCCCACCACATCTGGCACATACAGAATTTCACTCA
GCTTCTTGGAGGCCAGACCACTGTATACAGTCCTCCATTTTATTCCTCTAAAGGTTACGCTTTT
CAGATTAACCTGGATCTAACATCCCCGACCAATGTAGGGCTTTATTTCCACCTGATCTCCGGGG
CCAATGACGATCAATTACAGTGGCCGTGTCCTTGGCAGCAAGCCACAATGACACTCTTGGATCA
GAATCCTGACATCCGGCAGCGTATGTCCAACCAGCGGAGTATAACCACAGACCCAAAGATGACC
GATGATAATGGAAGCTATCTTTGGGACAGGCCTTCCAAGGTGGGAGTGGAGGCTTTTTTCCCTA
ATGGAACTCAGTTTAGCAGAGGCAGAGGCTATGGAACCAGTGTCTTCATAACCCAAGAGAGGCT
GAAGAGCAGAGAGTTCTTAAAAGGAGATGACGTTTACATCTTACTGACGGTTGAAGATATATCT
CACCTCAATTCTACAGCGGCTGTCCCAGGGCCAGTCCCCACCACCTCGACTGTCCATAATGCCT
GCTCTGAGGTCGAATGTCAGAACGGCGGCATCTGCACTCTCCAAGAAGGCAGAGCTGAGTGCAA
GTGTCCTGCAGGAGAAGACTGGTGGTACATGGGCAAAAGGTGTGAGAAGAGAGGGTCCACCAAG
GACACGATTGTCATTGCTGTGTCTTCCACGGTCACCGTGTTTGCCGTGATGCTGATCATCACCC
TTATCAGCGTCTACTGCACCCGGAGGAAATATCGTAAGAAGGCTAGTGCAAAGACAGCAGCCAT
GAATCTAGAAAACCAACATGCGTTTTGAATATTAACTCGTGCCAGCAGGTGAAACAAAAAGAAA
CCTTCTGTCGTCGTAGAAGAATATTTCGCCCAGGCTGTGCGACGACATTCACAGCATTTCAAAC
CAGACCATCTCTGTAAATAGCTGAGTGCCTAATAAACCATTATTTTGGT

hide sequence

RefSeq Acc Id:

XM_063277123 ⟹ XP_063133193

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	12,641,047 - 12,667,759 (+)	NCBI

RefSeq Acc Id:

XM_063277124 ⟹ XP_063133194

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	12,656,190 - 12,667,759 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001420342	(Get FASTA)	NCBI Sequence Viewer
	NP_037315	(Get FASTA)	NCBI Sequence Viewer
	XP_063133193	(Get FASTA)	NCBI Sequence Viewer
	XP_063133194	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41587	(Get FASTA)	NCBI Sequence Viewer
	AAH81833	(Get FASTA)	NCBI Sequence Viewer
	EDL76105	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000091050
	ENSRNOP00000091050.2
	ENSRNOP00055025268
	ENSRNOP00060016643
GenBank Protein	P28826	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_037315 ⟸ NM_013183
- Peptide Label:	precursor
- UniProtKB:	Q642D0 (UniProtKB/Swiss-Prot), P28826 (UniProtKB/Swiss-Prot), A0A8I6GIQ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDARHWPWFLVFATFLLVSGLPAPEKFVKDIDGGIDQDIFDINEDLGLDLFEGDIKLEASGRNS IIGDNYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWSGEENYISVFKGSGCWSS VGNIHAGKQELSIGTNCDRIATVQHEFLHALGFWHEQSRADRDDYITIVWDRILSGKEHNFNIY NDSVSDSLNVPYDYTSVMHYSKTAFQNGTESTIITKISDFEDVIGQRMDFSDYDLLKLNQLYSC TSSLSFMDSCDFELENICGMIQSSQDSADWQRLSQVLSGPENDHSNMGQCKDSGFFMHFNTSTG NGGITAMLESRVLYPKRGFQCVEFYLYNSGSGNGQLNVYTREYTAGHQDGVLTLQREIRDIPTG SWQLYYVTLQVTEKFRVVFEGVGGPGASSGGLSIDDINLSETRCPHHIWHIQNFTQLLGGQTTV YSPPFYSSKGYAFQINLDLTSPTNVGLYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRM SNQRSITTDPKMTDDNGSYLWDRPSKVGVEAFFPNGTQFSRGRGYGTSVFITQERLKSREFLKG DDVYILLTVEDISHLNSTAAVPGPVPTTSTVHNACSEVECQNGGICTLQEGRAECKCPAGEDWW YMGKRCEKRGSTKDTIVIAVSSTVTVFAVMLIITLISVYCTRRKYRKKASAKTAAMNLENQHAF hide sequence

Ensembl Acc Id:

ENSRNOP00000063916 ⟸ ENSRNOT00000074116

Ensembl Acc Id:

ENSRNOP00000091050 ⟸ ENSRNOT00000118375

RefSeq Acc Id:	XP_063133193 ⟸ XM_063277123
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063133194 ⟸ XM_063277124
- Peptide Label:	isoform X2

RefSeq Acc Id:	NP_001420342 ⟸ NM_001433413
- UniProtKB:	A0A8L2QVK1 (UniProtKB/TrEMBL)

Protein Domains

EGF-like MAM MATH Peptidase M12A

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P28826-F1-model_v2	AlphaFold	P28826	1-704	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700653

Promoter ID:

EPDNEW_R11177

Type:

multiple initiation site

Name:

Mep1b_1

Description:

meprin A subunit beta

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	15,089,989 - 15,090,049	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3081	AgrOrtholog
BioCyc Gene	G2FUF-8204	BioCyc
Ensembl Genes	ENSRNOG00000049345	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00000052995	Ensembl
	ENSRNOG00055018423	UniProtKB/Swiss-Prot
	ENSRNOG00060012398	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000118375	ENTREZGENE
	ENSRNOT00000118375.2	UniProtKB/Swiss-Prot
	ENSRNOT00055031310	UniProtKB/Swiss-Prot
	ENSRNOT00060021094	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.120.200	UniProtKB/Swiss-Prot
	3.40.390.10	UniProtKB/Swiss-Prot
	Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A	UniProtKB/Swiss-Prot
	Laminin	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7108543	IMAGE-MGC_LOAD
InterPro	ConA-like_dom_sf	UniProtKB/Swiss-Prot
	EGF-like_dom	UniProtKB/Swiss-Prot
	MAM_dom	UniProtKB/Swiss-Prot
	MATH/TRAF_dom	UniProtKB/Swiss-Prot
	Meprin	UniProtKB/Swiss-Prot
	MetalloPept_cat_dom_sf	UniProtKB/Swiss-Prot
	Peptidase_M12A	UniProtKB/Swiss-Prot
	Peptidase_Metallo	UniProtKB/Swiss-Prot
	TRAF-like	UniProtKB/Swiss-Prot
KEGG Report	rno:25727	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93578	IMAGE-MGC_LOAD
NCBI Gene	25727	ENTREZGENE
PANTHER	DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING	UniProtKB/Swiss-Prot
	PTHR10127:SF814	UniProtKB/Swiss-Prot
Pfam	Astacin	UniProtKB/Swiss-Prot
	MAM	UniProtKB/Swiss-Prot
	MATH_2	UniProtKB/Swiss-Prot
PhenoGen	Mep1b	PhenoGen
PIRSF	Meprin	UniProtKB/Swiss-Prot
PRINTS	ASTACIN	UniProtKB/Swiss-Prot
	MAMDOMAIN	UniProtKB/Swiss-Prot
PROSITE	ASTACIN	UniProtKB/Swiss-Prot
	EGF_3	UniProtKB/Swiss-Prot
	MAM_1	UniProtKB/Swiss-Prot
	MAM_2	UniProtKB/Swiss-Prot
	MATH	UniProtKB/Swiss-Prot
	ZINC_PROTEASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000049345	RatGTEx
	ENSRNOG00000052995	RatGTEx
	ENSRNOG00055018423	RatGTEx
	ENSRNOG00060012398	RatGTEx
SMART	MAM	UniProtKB/Swiss-Prot
	MATH	UniProtKB/Swiss-Prot
	ZnMc	UniProtKB/Swiss-Prot
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/Swiss-Prot
	SSF49899	UniProtKB/Swiss-Prot
	TRAF domain-like	UniProtKB/Swiss-Prot
TIGR	TC232892
UniProt	A0A8I6GIQ4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QVK1	ENTREZGENE, UniProtKB/TrEMBL
	MEP1B_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q642D0	ENTREZGENE
UniProt Secondary	Q642D0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Mep1b	meprin A subunit beta	LOC100911405	meprin A subunit beta-like	Data merged from RGD:6493229	737654	PROVISIONAL
2016-08-26	Mep1b	meprin A subunit beta	Mep1b	meprin 1 beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-29	LOC100911405	meprin A subunit beta-like	LOC102554362	meprin A subunit beta-like	Data merged from RGD:7695917	737654	PROVISIONAL
2013-12-18	LOC102554362	meprin A subunit beta-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2012-07-05	LOC100911405	meprin A subunit beta-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Mep1b	Meprin 1 beta			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expression is decreased 2.4 fold in SHR compared with WKY rats	1357414

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar