Rps12l12 (ribosomal protein S12-like 12) - Rat Genome Database

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Gene: Rps12l12 (ribosomal protein S12-like 12) Rattus norvegicus
Analyze
Symbol: Rps12l12 (Ensembl: Rps12l3)
Name: ribosomal protein S12-like 12 (Ensembl:ribosomal protein S12-like 3)
RGD ID: 2321715
Description: Predicted to be a structural constituent of ribosome. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in nucleolus and ribosome. Predicted to be part of small-subunit processome; INTERACTS WITH glyphosate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 40S ribosomal protein S12-like; LOC100360642; ribosomal protein S12-like; ribosomal protein S12-like 3; ribosomal protein S12-like 5; Rps12l3; Rps12l5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,944,125 - 137,944,636 (+)NCBIGRCr8
mRatBN7.23117,490,998 - 117,491,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,491,079 - 117,491,477 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03122,817,734 - 122,818,227 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03129,317,438 - 129,317,942 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43117,901,846 - 117,902,244 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3116,307,317 - 116,307,812 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
glyphosate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
translation  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Variants

.
Variants in Rps12l12
16 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000050172   ⟹   ENSRNOP00000093670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3117,491,079 - 117,491,477 (+)Ensembl
RefSeq Acc Id: NM_001408856   ⟹   NP_001395785
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,944,125 - 137,944,636 (+)NCBI
mRatBN7.23117,490,998 - 117,491,509 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395785 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093670
  ENSRNOP00000093670.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000093670   ⟸   ENSRNOT00000050172
RefSeq Acc Id: NP_001395785   ⟸   NM_001408856
- UniProtKB: A0A8I6GKR8 (UniProtKB/TrEMBL)
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-47861 BioCyc
Ensembl Genes ENSRNOG00000033913 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050172 ENTREZGENE
  ENSRNOT00000050172.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
InterPro L30e-like UniProtKB/TrEMBL
  Ribosomal_eS12_CS UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
  Ribosomal_S12e UniProtKB/TrEMBL
NCBI Gene 100360642 ENTREZGENE
PANTHER 40S RIBOSOMAL PROTEIN S12-RELATED UniProtKB/TrEMBL
  PTHR11843 UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/TrEMBL
PhenoGen Rps12l12 PhenoGen
PRINTS RIBSOMALS12E UniProtKB/TrEMBL
PROSITE RIBOSOMAL_S12E UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033913 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
UniProt A0A8I6GKR8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-19 Rps12l12  ribosomal protein S12-like 12  Rps12l5  ribosomal protein S12-like 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-18 Rps12l5  ribosomal protein S12-like 5  Rps12l3  ribosomal protein S12-like 3  Name and Symbol changed 629549 APPROVED
2012-11-07 Rps12l3  ribosomal protein S12-like 3  LOC100360642  ribosomal protein S12-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100360642  ribosomal protein S12-like      Symbol and Name status set to provisional 70820 PROVISIONAL